JP2013510324A - 高効率タンパク質発現の分泌タンパク質バイオマーカー - Google Patents

高効率タンパク質発現の分泌タンパク質バイオマーカー Download PDF

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JP2013510324A
JP2013510324A JP2012538076A JP2012538076A JP2013510324A JP 2013510324 A JP2013510324 A JP 2013510324A JP 2012538076 A JP2012538076 A JP 2012538076A JP 2012538076 A JP2012538076 A JP 2012538076A JP 2013510324 A JP2013510324 A JP 2013510324A
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protein
subunit
cell
factor
precursor
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Japanese (ja)
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ホスラー，パトリツク
コレイア，アイバン・アール
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Abbott Laboratories
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Abbott Laboratories
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • C12Q1/04—Determining presence or kind of microorganism; Use of selective media for testing antibiotics or bacteriocides; Compositions containing a chemical indicator therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
    • G01N33/5023—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects on expression patterns
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56966—Animal cells

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Cell Biology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Toxicology (AREA)
  • Virology (AREA)
  • Wood Science & Technology (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
JP2012538076A 2009-11-09 2010-11-09 高効率タンパク質発現の分泌タンパク質バイオマーカー Pending JP2013510324A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US25952709P 2009-11-09 2009-11-09
US61/259,527 2009-11-09
US12/941,347 2010-11-08
US12/941,347 US8524458B2 (en) 2009-11-09 2010-11-08 Secretory protein biomarkers for high efficiency protein expression
PCT/US2010/055953 WO2011057239A2 (en) 2009-11-09 2010-11-09 Secretory protein biomarkers for high efficiency protein expression

Publications (1)

Publication Number Publication Date
JP2013510324A true JP2013510324A (ja) 2013-03-21

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JP2012538076A Pending JP2013510324A (ja) 2009-11-09 2010-11-09 高効率タンパク質発現の分泌タンパク質バイオマーカー

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Country Link
US (2) US8524458B2 (enExample)
EP (1) EP2499254A2 (enExample)
JP (1) JP2013510324A (enExample)
KR (1) KR20120115494A (enExample)
CN (1) CN102666873A (enExample)
AU (1) AU2010314922A1 (enExample)
BR (1) BR112012010976A2 (enExample)
CA (1) CA2778254A1 (enExample)
IL (1) IL219518A0 (enExample)
IN (1) IN2012DN03358A (enExample)
MX (1) MX2012005380A (enExample)
RU (1) RU2012124114A (enExample)
WO (1) WO2011057239A2 (enExample)
ZA (1) ZA201202966B (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2016059359A (ja) * 2014-09-22 2016-04-25 東洋紡株式会社 バイオマーカーを用いた組換えタンパク質生産量の予測方法

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3255054A1 (en) * 2016-06-06 2017-12-13 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Method for the purification of biological macromolecular complexes
CN108467890A (zh) * 2018-05-02 2018-08-31 首都医科大学附属北京天坛医院 Vat1基因及vat1基因的干扰物的应用和应用vat1基因的产品
CN109470756B (zh) * 2018-10-11 2020-08-25 昆明理工大学 测定14-3-3蛋白与质膜H+-ATPase蛋白互作的电化学方法
CN117099743B (zh) * 2023-07-11 2025-12-05 吉林大学 一种snx6基因不表达的异种移植供体及制备方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008054514A2 (en) * 2006-04-21 2008-05-08 Wyeth Differential expression profiling analysis of cell culture phenotypes and the uses thereof

Family Cites Families (12)

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USRE30985E (en) 1978-01-01 1982-06-29 Serum-free cell culture media
US4560655A (en) 1982-12-16 1985-12-24 Immunex Corporation Serum-free cell culture medium and process for making same
US4657866A (en) 1982-12-21 1987-04-14 Sudhir Kumar Serum-free, synthetic, completely chemically defined tissue culture media
US4767704A (en) 1983-10-07 1988-08-30 Columbia University In The City Of New York Protein-free culture medium
GB8516415D0 (en) 1985-06-28 1985-07-31 Celltech Ltd Culture of animal cells
US4927762A (en) 1986-04-01 1990-05-22 Cell Enterprises, Inc. Cell culture medium with antioxidant
US5302517A (en) * 1987-06-16 1994-04-12 The Board Of Regents Of The University Of Nebraska Method of controlling the expression of a gene in a cell culture, cell culture vector used in the method and method of making the vector
DE68925971T2 (de) 1988-09-23 1996-09-05 Cetus Oncology Corp Zellenzuchtmedium für erhöhtes zellenwachstum, zur erhöhung der langlebigkeit und expression der produkte
US5122469A (en) 1990-10-03 1992-06-16 Genentech, Inc. Method for culturing Chinese hamster ovary cells to improve production of recombinant proteins
US20050272055A1 (en) * 2000-02-01 2005-12-08 Rina Das Method of treating lethal shock induced by toxic agents and diagnosing exposure to toxic agents by measuring distinct pattern in the levels of expression of specific genes
US8242057B2 (en) * 2006-06-26 2012-08-14 Cleveland Biolabs, Inc. Methods for identifying modulators of apoptosis
EP2304434A2 (en) * 2008-06-04 2011-04-06 ProteoSys AG Protein biomarkers for in vitro testing of developmental toxicity and embryotoxicity of chemical substances

Patent Citations (2)

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Publication number Priority date Publication date Assignee Title
WO2008054514A2 (en) * 2006-04-21 2008-05-08 Wyeth Differential expression profiling analysis of cell culture phenotypes and the uses thereof
JP2009534036A (ja) * 2006-04-21 2009-09-24 ワイス 細胞培養表現型の示差的発現プロファイリング分析およびその使用

Non-Patent Citations (2)

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JPN5013002688; ＳＭＡＬＥＳ　Ｃ　Ｍ: 'ＣＯＭＰＡＲＡＴＩＶＥ　ＰＲＯＴＥＯＭＩＣ　ＡＮＡＬＹＳＩＳ　ＯＦ　ＧＳ-ＮＳＯ　ＭＵＲＩＮＥ　ＭＹＥＬＯＭＡ　ＣＥＬＬ　ＬＩＮＥＳ　ＷＩＴＨ　ＶＡＲＹＩＮＧ　ＲＥＣＯＭＢＩＮＡＮＴ　以下備考' ＢＩＯＴＥＣＨＮＯＬＯＧＹ　ＡＮＤ　ＢＩＯＥＮＧＩＮＥＥＲＩＮＧ Ｖ８８　Ｎ４, 20041120, Ｐ４７４-４８８ *
JPN5013002691; ＷＡＮＧ　ＸＩＡＯ-ＰＩＮＧ: 'ＣＯ-ＥＸＰＲＥＳＳＩＯＮ　ＯＦ　ＨＥＡＴ　ＳＨＯＣＫ　ＰＲＯＴＥＩＮ　７０　ＡＮＤ　ＧＬＵＣＯＳＥ-ＲＥＧＵＬＡＴＥＤ　ＰＲＯＴＥＩＮ　９４　以下備考' ＷＯＲＬＤ　ＪＯＵＲＮＡＬ　ＯＦ　ＧＡＳＴＲＯＥＮＴＥＲＯＬＯＧＹ Ｖ１１　Ｎ２３, 20050621, Ｐ３６０１-３６０４ *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2016059359A (ja) * 2014-09-22 2016-04-25 東洋紡株式会社 バイオマーカーを用いた組換えタンパク質生産量の予測方法

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MX2012005380A (es) 2012-05-29
CN102666873A (zh) 2012-09-12
AU2010314922A1 (en) 2012-05-31
WO2011057239A3 (en) 2011-06-30
US8524458B2 (en) 2013-09-03
KR20120115494A (ko) 2012-10-18
EP2499254A2 (en) 2012-09-19
IL219518A0 (en) 2012-06-28
WO2011057239A2 (en) 2011-05-12
BR112012010976A2 (pt) 2016-08-16
IN2012DN03358A (enExample) 2015-10-23
RU2012124114A (ru) 2013-12-20
CA2778254A1 (en) 2011-05-12
US20110236906A1 (en) 2011-09-29
US20140004531A1 (en) 2014-01-02
ZA201202966B (en) 2012-12-27

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