CN102666496B - 2-(2-正丁基-4-羟基-6-甲基-嘧啶-5-基)-n,n-二甲基乙酰胺的制备方法 - Google Patents

2-(2-正丁基-4-羟基-6-甲基-嘧啶-5-基)-n,n-二甲基乙酰胺的制备方法 Download PDF

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Publication number
CN102666496B
CN102666496B CN201180004629.8A CN201180004629A CN102666496B CN 102666496 B CN102666496 B CN 102666496B CN 201180004629 A CN201180004629 A CN 201180004629A CN 102666496 B CN102666496 B CN 102666496B
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China
Prior art keywords
formula
compound
preparation
methyl
butyl
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Expired - Fee Related
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CN201180004629.8A
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English (en)
Chinese (zh)
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CN102666496A (zh
Inventor
金知汉
李濬光
柳炳旭
崔沃卿
金学元
李宜和
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Boryung Pharmaceutical Co Ltd
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Boryung Pharmaceutical Co Ltd
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Priority claimed from KR20100005945A external-priority patent/KR101058284B1/ko
Application filed by Boryung Pharmaceutical Co Ltd filed Critical Boryung Pharmaceutical Co Ltd
Priority to CN201410817307.0A priority Critical patent/CN104610164B/zh
Publication of CN102666496A publication Critical patent/CN102666496A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/34—One oxygen atom
    • C07D239/36—One oxygen atom as doubly bound oxygen atom or as unsubstituted hydroxy radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
CN201180004629.8A 2010-01-21 2011-01-20 2-(2-正丁基-4-羟基-6-甲基-嘧啶-5-基)-n,n-二甲基乙酰胺的制备方法 Expired - Fee Related CN102666496B (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201410817307.0A CN104610164B (zh) 2010-01-21 2011-01-20 2‑(2‑正丁基‑4‑羟基‑6‑甲基‑嘧啶‑5‑基)‑n,n‑二甲基乙酰胺的制备方法

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
KR10-2010-0005725 2010-01-21
KR20100005725 2010-01-21
KR20100005945A KR101058284B1 (ko) 2010-01-22 2010-01-22 2-(2-ｎ-부틸-4-히드록시-6-메틸-피리미딘-5-일)-Ｎ,Ｎ-디메틸아세트아미드의 신규한 제조방법
KR10-2010-0005945 2010-01-22
PCT/KR2011/000401 WO2011090323A2 (en) 2010-01-21 2011-01-20 Novel preparation method of 2-(2-n-butyl-4-hydroxy-6-methyl-pyrimidin-5-yl)-n,n-dimethylacetamide

Related Child Applications (1)

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CN201410817307.0A Division CN104610164B (zh) 2010-01-21 2011-01-20 2‑(2‑正丁基‑4‑羟基‑6‑甲基‑嘧啶‑5‑基)‑n,n‑二甲基乙酰胺的制备方法

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CN102666496A CN102666496A (zh) 2012-09-12
CN102666496B true CN102666496B (zh) 2015-05-20

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CN201180004629.8A Expired - Fee Related CN102666496B (zh) 2010-01-21 2011-01-20 2-(2-正丁基-4-羟基-6-甲基-嘧啶-5-基)-n,n-二甲基乙酰胺的制备方法
CN201410817307.0A Expired - Fee Related CN104610164B (zh) 2010-01-21 2011-01-20 2‑(2‑正丁基‑4‑羟基‑6‑甲基‑嘧啶‑5‑基)‑n,n‑二甲基乙酰胺的制备方法

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CN (2) CN102666496B (https=)
IN (1) IN2012DN02695A (https=)
WO (1) WO2011090323A2 (https=)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20140096514A (ko) * 2013-01-28 2014-08-06 보령제약 주식회사 암 예방 또는 치료용 조성물
US9592233B2 (en) 2013-03-14 2017-03-14 Boryung Pharmaceutical Co., Ltd. Pharmaceutical combination drug
CN104478811B (zh) * 2014-11-14 2017-01-25 浙江浙邦制药有限公司 一种非马沙坦中间体的制备方法
CN107973784B (zh) * 2017-11-16 2021-08-24 珠海市海瑞德生物科技有限公司 一种非马沙坦的合成方法
CN113121484A (zh) * 2019-12-31 2021-07-16 复星弘创(苏州)医药科技有限公司 一种制备3-位被酰胺基烷基取代的香豆素类化合物的方法及其产物和相关中间体
CN113336709B (zh) * 2021-06-25 2022-06-03 上海立科化学科技有限公司 一种n,n-二甲基乙酰胺的制备方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1558906A (zh) * 2001-09-21 2004-12-29 保宁制药株式会社 嘧啶酮化合物及其药学上可接受的盐的制备方法
CN1195741C (zh) * 1998-04-25 2005-04-06 保宁制药株式会社 嘧啶酮化合物,包含该化合物的药物组合物以及制备该化合物的方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100521980B1 (ko) * 2002-10-10 2005-10-17 보령제약 주식회사 피리미디논 화합물 및 이의 염의 삼수화물의 제조 방법

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1195741C (zh) * 1998-04-25 2005-04-06 保宁制药株式会社 嘧啶酮化合物,包含该化合物的药物组合物以及制备该化合物的方法
CN1558906A (zh) * 2001-09-21 2004-12-29 保宁制药株式会社 嘧啶酮化合物及其药学上可接受的盐的制备方法

Also Published As

Publication number Publication date
CN102666496A (zh) 2012-09-12
CN104610164B (zh) 2018-03-16
CN104610164A (zh) 2015-05-13
WO2011090323A3 (en) 2011-11-10
WO2011090323A2 (en) 2011-07-28
IN2012DN02695A (https=) 2015-09-04

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