IN2012DN02695A - - Google Patents

Download PDF

Info

Publication number
IN2012DN02695A
IN2012DN02695A IN2695DEN2012A IN2012DN02695A IN 2012DN02695 A IN2012DN02695 A IN 2012DN02695A IN 2695DEN2012 A IN2695DEN2012 A IN 2695DEN2012A IN 2012DN02695 A IN2012DN02695 A IN 2012DN02695A
Authority
IN
India
Prior art keywords
pyrimidin
hydroxy
reacting
butyl
methyl
Prior art date
Application number
Inventor
Ji-Han Kim
Joon-Kwang Lee
Byoung-Wug Yoo
Ok-Kyoung Choi
Hak-Won Kim
Sun-Hwa Lee
Original Assignee
Boryung Pharm
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from KR20100005945A external-priority patent/KR101058284B1/en
Application filed by Boryung Pharm filed Critical Boryung Pharm
Publication of IN2012DN02695A publication Critical patent/IN2012DN02695A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/34—One oxygen atom
    • C07D239/36—One oxygen atom as doubly bound oxygen atom or as unsubstituted hydroxy radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings

Abstract

The present invention provides a method for preparing 2-(2-n-butyl-4-hydroxy-6-methyl-pyrimidin-5-yl)-N,N-dimethylacetamide, comprising reacting a compound of the following formula 2 with pentanamidine or a salt thereof in the presence of a base. [Formula 2] wherein R1 represents C1-C6 linear or branched alkyl or C3-C6 cycloalkyl. Further, the present invention provides a method for preparing 2-(2-n-butyl-4-hydroxy-6-methyl-pyrimidin-5-yl)-N,N-dimethylacetamide, comprising the steps of: a) reacting 2-(2-n-butyl-4-hydroxy-6-methyl-pyrimidin-5-yl)-acetic acid with a haloformate compound in the presence of a base, and b) reacting the product of Step a) with dimethylamine.
IN2695DEN2012 2010-01-21 2011-01-20 IN2012DN02695A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
KR20100005725 2010-01-21
KR20100005945A KR101058284B1 (en) 2010-01-22 2010-01-22 Novel Process for the Preparation of 2- (2-N-butyl-4-hydroxy-6-methyl-pyrimidin-5-yl) -N, N-dimethylacetamide
PCT/KR2011/000401 WO2011090323A2 (en) 2010-01-21 2011-01-20 Novel preparation method of 2-(2-n-butyl-4-hydroxy-6-methyl-pyrimidin-5-yl)-n,n-dimethylacetamide

Publications (1)

Publication Number Publication Date
IN2012DN02695A true IN2012DN02695A (en) 2015-09-04

Family

ID=44307398

Family Applications (1)

Application Number Title Priority Date Filing Date
IN2695DEN2012 IN2012DN02695A (en) 2010-01-21 2011-01-20

Country Status (3)

Country Link
CN (2) CN104610164B (en)
IN (1) IN2012DN02695A (en)
WO (1) WO2011090323A2 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20140096514A (en) * 2013-01-28 2014-08-06 보령제약 주식회사 Composition for preventing or treating of cancer
JP6068765B2 (en) 2013-03-14 2017-01-25 ボリュン ファーマスーティカル カンパニー リミテッド Pharmaceutical combination preparation
CN104478811B (en) * 2014-11-14 2017-01-25 浙江浙邦制药有限公司 Fimasartan intermediate preparation method
CN107973784B (en) * 2017-11-16 2021-08-24 珠海市海瑞德生物科技有限公司 Synthesis method of fimasartan
CN113121484A (en) * 2019-12-31 2021-07-16 复星弘创(苏州)医药科技有限公司 Method for preparing coumarin compound with 3-substituted acylaminoalkyl, product and related intermediate thereof
CN113336709B (en) * 2021-06-25 2022-06-03 上海立科化学科技有限公司 Preparation method of N, N-dimethylacetamide

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR19990081093A (en) * 1998-04-25 1999-11-15 조생현 Pyrimidinone compound, pharmaceutical composition containing the same, and preparation method thereof
JP4268871B2 (en) * 2001-09-21 2009-05-27 ボリョン ファーマシューティカル カンパニー リミテッド Method for producing pyrimidinone compounds and pharmaceutically acceptable salts thereof
KR100521980B1 (en) * 2002-10-10 2005-10-17 보령제약 주식회사 The preparation method for pyrimidinone compound and trihydrate of the salt of the pyrimidinone compound

Also Published As

Publication number Publication date
CN104610164A (en) 2015-05-13
WO2011090323A3 (en) 2011-11-10
WO2011090323A2 (en) 2011-07-28
CN102666496B (en) 2015-05-20
CN104610164B (en) 2018-03-16
CN102666496A (en) 2012-09-12

Similar Documents

Publication Publication Date Title
IN2012DN02695A (en)
NZ599587A (en) Method for producing dabigatran etexilate
IN2014CN01136A (en)
MX2011009127A (en) Substituted nicotinamides as kcnq2/3 modulators.
MX2013011429A (en) Novel imidazo-oxazine compound or salt thereof.
EP3330254A3 (en) Method and process for preparation and production of deuterated omega-diphenylurea
MX2013000295A (en) Process of preparing a thrombin specific inhibitor.
MX352470B (en) Malonic acid di-salts and a method for preparing malonyl dihalides.
SG158829A1 (en) New process for the synthesis of agomelatine
MX2018007106A (en) Method for producing aromatic amide derivative.
MX348228B (en) Crystalline 6,7-unsaturated-7-carbamoyl morphinane derivative, and method for producing same.
JO2818B1 (en) New Process for the synthesis of agomelatine
UA105822C2 (en) Normal;heading 1;heading 2;heading 3;AZOLE DERIVATIVE, METHOD FOR PRODUCING THEREOF, AGENT COMPRISING AZOLE DERIVATIVE FOR AGRICULTURAL AND HORTICULTURAL APPLICATIONS, AND INDUSTRIAL MATERIAL PROTECTANT
MX2013007938A (en) Novel bicyclic compound or salt thereof.
IN2015DN02424A (en)
NZ709362A (en) Process for the preparation of 1-([1,3]dioxolan-4-ylmethyl)-1h-pyrazol-3-ylamine
JO2821B1 (en) New Process for the synthesis of agomelatine
MX2012001067A (en) Processes for the alkylation of pyrazoles.
IN2012DN00361A (en)
MX2013001458A (en) Method for enzymatic synthesis of (7s)-3,4-dimethoxybicyclo[4.2.0 ]octa-1,3,5-triene-7-carboxylic acid or the esters thereof, and use for the synthesis of ivabradine and the salts thereo.
MX2015006828A (en) Method for producing 4-haloalkyl -3-mercapto-substituted 2-hydroxy-benzoic acid derivatives.
MX342390B (en) Process for the preparation of 3-haloalkylpyrazoles.
UA111329C2 (en) Process for the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid
HK1150319A1 (en) Novel method for the production of sulphonylpyrroles as hdac inhibitors
JO3189B1 (en) Novel method for SYNTHESISING (2E)-3-(3,4-DIMETHOXYPHENYL)PROP-2-ENENITRILE, AND USE FOR SYNTHESISING IVABRADINE AND THE ADDED SALTS THEREOF WITH A PHARMACEUTICALLY ACCEPTABLE ACID