CN102648389B - 用于动态确定样品空间取向并动态重新定位的装置和方法 - Google Patents
用于动态确定样品空间取向并动态重新定位的装置和方法 Download PDFInfo
- Publication number
- CN102648389B CN102648389B CN201080029227.9A CN201080029227A CN102648389B CN 102648389 B CN102648389 B CN 102648389B CN 201080029227 A CN201080029227 A CN 201080029227A CN 102648389 B CN102648389 B CN 102648389B
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Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01B—MEASURING LENGTH, THICKNESS OR SIMILAR LINEAR DIMENSIONS; MEASURING ANGLES; MEASURING AREAS; MEASURING IRREGULARITIES OF SURFACES OR CONTOURS
- G01B9/00—Measuring instruments characterised by the use of optical techniques
- G01B9/04—Measuring microscopes
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B21/00—Microscopes
- G02B21/24—Base structure
- G02B21/241—Devices for focusing
- G02B21/244—Devices for focusing using image analysis techniques
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01B—MEASURING LENGTH, THICKNESS OR SIMILAR LINEAR DIMENSIONS; MEASURING ANGLES; MEASURING AREAS; MEASURING IRREGULARITIES OF SURFACES OR CONTOURS
- G01B11/00—Measuring arrangements characterised by the use of optical techniques
- G01B11/02—Measuring arrangements characterised by the use of optical techniques for measuring length, width or thickness
- G01B11/026—Measuring arrangements characterised by the use of optical techniques for measuring length, width or thickness by measuring distance between sensor and object
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B21/00—Microscopes
- G02B21/0004—Microscopes specially adapted for specific applications
- G02B21/002—Scanning microscopes
- G02B21/0024—Confocal scanning microscopes (CSOMs) or confocal "macroscopes"; Accessories which are not restricted to use with CSOMs, e.g. sample holders
- G02B21/0032—Optical details of illumination, e.g. light-sources, pinholes, beam splitters, slits, fibers
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B21/00—Microscopes
- G02B21/0004—Microscopes specially adapted for specific applications
- G02B21/002—Scanning microscopes
- G02B21/0024—Confocal scanning microscopes (CSOMs) or confocal "macroscopes"; Accessories which are not restricted to use with CSOMs, e.g. sample holders
- G02B21/0052—Optical details of the image generation
- G02B21/006—Optical details of the image generation focusing arrangements; selection of the plane to be imaged
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B21/00—Microscopes
- G02B21/24—Base structure
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B21/00—Microscopes
- G02B21/24—Base structure
- G02B21/241—Devices for focusing
- G02B21/245—Devices for focusing using auxiliary sources, detectors
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B21/00—Microscopes
- G02B21/16—Microscopes adapted for ultraviolet illumination ; Fluorescence microscopes
Landscapes
- Physics & Mathematics (AREA)
- General Physics & Mathematics (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Optics & Photonics (AREA)
- Engineering & Computer Science (AREA)
- Computer Vision & Pattern Recognition (AREA)
- Microscoopes, Condenser (AREA)
- Automatic Focus Adjustment (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
- Focusing (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US17949809P | 2009-05-19 | 2009-05-19 | |
| US61/179,498 | 2009-05-19 | ||
| PCT/US2010/035253 WO2010135323A1 (en) | 2009-05-19 | 2010-05-18 | Devices and methods for dynamic determination of sample spatial orientation and dynamic repositioning |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102648389A CN102648389A (zh) | 2012-08-22 |
| CN102648389B true CN102648389B (zh) | 2015-04-29 |
Family
ID=42712355
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201080029227.9A Expired - Fee Related CN102648389B (zh) | 2009-05-19 | 2010-05-18 | 用于动态确定样品空间取向并动态重新定位的装置和方法 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20120097835A1 (enExample) |
| EP (2) | EP2433087B1 (enExample) |
| JP (2) | JP2012527651A (enExample) |
| KR (1) | KR20120039547A (enExample) |
| CN (1) | CN102648389B (enExample) |
| AU (1) | AU2010249729A1 (enExample) |
| CA (1) | CA2762684A1 (enExample) |
| SG (1) | SG176579A1 (enExample) |
| WO (1) | WO2010135323A1 (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI721486B (zh) | 2017-03-07 | 2021-03-11 | 美商伊路米納有限公司 | 用於使用光源配置之改進的聚焦追蹤的系統和方法 |
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| DE102017203492A1 (de) * | 2017-03-03 | 2018-09-06 | Witec Wissenschaftliche Instrumente Und Technologie Gmbh | Verfahren und Vorrichtung zur Abbildung einer Probenoberfläche |
| JP6245177B2 (ja) * | 2012-10-15 | 2017-12-13 | ソニー株式会社 | 画像取得装置およびスライド傾き測定方法 |
| KR102003202B1 (ko) * | 2012-10-18 | 2019-07-24 | 칼 짜이스 엑스-레이 마이크로스코피, 인크. | 결정학적 그레인 배향 맵핑 능력을 가진 실험실 x-레이 마이크로-단층촬영 시스템 |
| US10844424B2 (en) | 2013-02-20 | 2020-11-24 | Bionano Genomics, Inc. | Reduction of bias in genomic coverage measurements |
| CN105229168B (zh) | 2013-02-20 | 2020-07-17 | 生物纳米基因有限公司 | 纳米流体中分子的表征 |
| CN103674839B (zh) * | 2013-11-12 | 2016-01-06 | 清华大学 | 一种基于光斑检测的可视化样品定位操作系统及方法 |
| CN106029909B (zh) | 2014-02-18 | 2021-02-02 | 生物纳米基因公司 | 测定核酸结构信息的改进方法 |
| CN106164295B (zh) | 2014-02-25 | 2020-08-11 | 生物纳米基因公司 | 减小基因组覆盖测量中的偏差 |
| WO2016022359A1 (en) * | 2014-08-06 | 2016-02-11 | Cellomics, Inc. | Image-based laser autofocus system |
| CN104197847A (zh) * | 2014-09-19 | 2014-12-10 | 孙维 | 一种传感器 |
| US9921399B2 (en) | 2015-03-31 | 2018-03-20 | General Electric Company | System and method for continuous, asynchronous autofocus of optical instruments |
| JP6590366B2 (ja) * | 2015-09-25 | 2019-10-16 | オリンパス株式会社 | 顕微鏡装置、オートフォーカス装置、及び、オートフォーカス方法 |
| WO2017120161A1 (en) * | 2016-01-07 | 2017-07-13 | Arkema Inc. | Object position independent method to measure the thickness of coatings deposited on curved objects moving at high rates |
| DE102016212019A1 (de) * | 2016-07-01 | 2018-01-04 | Carl Zeiss Microscopy Gmbh | Neigungsmessung und -korrektur des Deckglases im Strahlengang eines Mikroskops |
| CN106324795B (zh) * | 2016-09-29 | 2018-10-16 | 电子科技大学 | 一种检测仪显微镜多视野自动快速对焦方法 |
| US11385180B2 (en) | 2017-03-03 | 2022-07-12 | Witec Wissenschaftliche Instrumente Und Technologie Gmbh | Method and device for imaging a specimen surface |
| NL2018853B1 (en) | 2017-05-05 | 2018-11-14 | Illumina Inc | Systems and methods for improved focus tracking using a hybrid mode light source |
| NL2018854B1 (en) | 2017-05-05 | 2018-11-14 | Illumina Inc | Systems and methodes for improved focus tracking using blocking structures |
| US10416430B2 (en) | 2017-05-10 | 2019-09-17 | Applejack 199 L.P. | Focusing of optical devices |
| CN107189940A (zh) * | 2017-05-19 | 2017-09-22 | 上海理工大学 | 基于激光的自动化快速复温装置 |
| CN108020163B (zh) * | 2017-12-26 | 2020-01-31 | 中国科学技术大学 | 一种显微追踪微粒三维位移的装置 |
| NL2020618B1 (en) | 2018-01-12 | 2019-07-18 | Illumina Inc | Real time controller switching |
| EP3614192A1 (en) * | 2018-08-20 | 2020-02-26 | Till GmbH | Microscope device |
| EP3850329A4 (en) | 2018-09-10 | 2022-06-22 | Fluidigm Canada Inc. | APPARATUS AND METHOD FOR AUTO-FOCUSING SAMPLE IMAGING |
| DE102018131427B4 (de) * | 2018-12-07 | 2021-04-29 | Leica Microsystems Cms Gmbh | Verfahren zur automatischen Positionsermittlung auf einer Probenanordnung und entsprechendes Mikroskop, Computerprogramm und Computerprogrammprodukt |
| DE102019109832B3 (de) * | 2019-04-12 | 2020-04-23 | Leica Microsystems Cms Gmbh | Lichtblattmikroskop und Verfahren zum Erfassen einer Messgröße |
| US11086118B2 (en) * | 2019-04-29 | 2021-08-10 | Molecular Devices, Llc | Self-calibrating and directional focusing systems and methods for infinity corrected microscopes |
| CA3134331A1 (en) * | 2019-05-08 | 2020-11-12 | Tuan-Shu Ho | Optical system and detection method therof |
| DE102019113975B4 (de) * | 2019-05-24 | 2023-10-19 | Abberior Instruments Gmbh | Verfahren und Vorrichtung zum Überwachen des Fokuszustands eines Mikroskops sowie Mikroskop |
| CN110260783B (zh) * | 2019-07-10 | 2020-11-10 | 中国工程物理研究院机械制造工艺研究所 | 一种干涉显微镜自动对焦装置及方法 |
| CN112113501A (zh) * | 2020-10-12 | 2020-12-22 | 中国科学院生物物理研究所 | 一种基于干涉测量的单分子轴向定位装置及其工作方法 |
| CN112987292B (zh) * | 2021-04-15 | 2021-08-10 | 中国人民解放军国防科技大学 | 基于点阵光斑质心偏差信息的计算机辅助装调方法及装置 |
| EP4092462A1 (en) * | 2021-05-18 | 2022-11-23 | Leica Instruments (Singapore) Pte. Ltd. | Laser assisted autofocus |
| CN115854891A (zh) * | 2021-09-26 | 2023-03-28 | 深圳中科飞测科技股份有限公司 | 一种检测方法、检测系统及计算机可读存储介质 |
| CN115876077A (zh) * | 2021-09-26 | 2023-03-31 | 深圳中科飞测科技股份有限公司 | 一种检测方法、检测系统及计算机可读存储介质 |
| CN114414589A (zh) * | 2022-02-23 | 2022-04-29 | 湖北九峰山实验室 | 一种用于芯片缺陷检测的系统 |
| KR20230139684A (ko) * | 2022-03-28 | 2023-10-05 | 주식회사 스타노스 | 광학현미경을 위한 자동 초점 장치 및 자동 초점 유지 방법 |
| CN114647058B (zh) * | 2022-05-18 | 2022-09-06 | 合肥金星智控科技股份有限公司 | 焦点调整方法、焦点调整装置、libs检测系统和存储介质 |
| CN115717859B (zh) * | 2022-11-16 | 2023-09-29 | 南京博视医疗科技有限公司 | 一种点扫描光学系统激光标定方法及其装置 |
| CN116540395A (zh) * | 2023-04-28 | 2023-08-04 | 广东粤港澳大湾区黄埔材料研究院 | 一种可锁定成像焦面的激发模组、显微镜及显微成像系统 |
| WO2025072986A1 (de) * | 2023-10-04 | 2025-04-10 | Akrima Gmbh | Anbaugerät für ein mikroskop |
| BE1032505B1 (nl) * | 2024-04-03 | 2025-11-03 | Soleras Advanced Coatings Bvba | Reflectometersysteem en werkwijze voor het bepalen van een reflectie |
| WO2025213063A1 (en) * | 2024-04-05 | 2025-10-09 | Fei Deutschland Gmbh | Systems and methods for autofocusing images |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5784164A (en) * | 1997-03-20 | 1998-07-21 | Zygo Corporation | Method and apparatus for automatically and simultaneously determining best focus and orientation of objects to be measured by broad-band interferometric means |
| US6172349B1 (en) * | 1997-03-31 | 2001-01-09 | Kla-Tencor Corporation | Autofocusing apparatus and method for high resolution microscope system |
| CN1926460A (zh) * | 2004-04-28 | 2007-03-07 | 奥林巴斯株式会社 | 激光聚光光学系统 |
| CN101281289A (zh) * | 2007-12-29 | 2008-10-08 | 青岛海信电器股份有限公司 | 自动聚焦方法 |
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2010
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- 2010-05-18 KR KR20117030283A patent/KR20120039547A/ko not_active Withdrawn
- 2010-05-18 EP EP20100725926 patent/EP2433087B1/en not_active Revoked
- 2010-05-18 CA CA2762684A patent/CA2762684A1/en not_active Abandoned
- 2010-05-18 WO PCT/US2010/035253 patent/WO2010135323A1/en not_active Ceased
- 2010-05-18 AU AU2010249729A patent/AU2010249729A1/en not_active Abandoned
- 2010-05-18 EP EP15151827.1A patent/EP2881701A1/en not_active Withdrawn
- 2010-05-18 SG SG2011085693A patent/SG176579A1/en unknown
- 2010-05-18 CN CN201080029227.9A patent/CN102648389B/zh not_active Expired - Fee Related
- 2010-05-18 JP JP2012511961A patent/JP2012527651A/ja active Pending
-
2014
- 2014-08-23 JP JP2014169962A patent/JP2015028637A/ja active Pending
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5784164A (en) * | 1997-03-20 | 1998-07-21 | Zygo Corporation | Method and apparatus for automatically and simultaneously determining best focus and orientation of objects to be measured by broad-band interferometric means |
| US6172349B1 (en) * | 1997-03-31 | 2001-01-09 | Kla-Tencor Corporation | Autofocusing apparatus and method for high resolution microscope system |
| CN1926460A (zh) * | 2004-04-28 | 2007-03-07 | 奥林巴斯株式会社 | 激光聚光光学系统 |
| CN101281289A (zh) * | 2007-12-29 | 2008-10-08 | 青岛海信电器股份有限公司 | 自动聚焦方法 |
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| 一种全自动显微镜快速聚焦方法;罗丽等;《光学仪器》;20090228;第31卷(第1期);全文 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI721486B (zh) | 2017-03-07 | 2021-03-11 | 美商伊路米納有限公司 | 用於使用光源配置之改進的聚焦追蹤的系統和方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| SG176579A1 (en) | 2012-01-30 |
| EP2433087A1 (en) | 2012-03-28 |
| EP2433087B1 (en) | 2015-01-21 |
| JP2015028637A (ja) | 2015-02-12 |
| KR20120039547A (ko) | 2012-04-25 |
| CN102648389A (zh) | 2012-08-22 |
| JP2012527651A (ja) | 2012-11-08 |
| AU2010249729A1 (en) | 2011-12-15 |
| WO2010135323A1 (en) | 2010-11-25 |
| US20120097835A1 (en) | 2012-04-26 |
| CA2762684A1 (en) | 2010-11-25 |
| EP2881701A1 (en) | 2015-06-10 |
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