CN102639688B - 组装中空纤维生物反应器的方法 - Google Patents

组装中空纤维生物反应器的方法 Download PDF

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Publication number
CN102639688B
CN102639688B CN201080045888.0A CN201080045888A CN102639688B CN 102639688 B CN102639688 B CN 102639688B CN 201080045888 A CN201080045888 A CN 201080045888A CN 102639688 B CN102639688 B CN 102639688B
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CN
China
Prior art keywords
membrane
cell growth
cells
housing
hollow fiber
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN201080045888.0A
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English (en)
Chinese (zh)
Other versions
CN102639688A (zh
Inventor
F·戴尔伯格
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Terumo BCT Inc
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Terumo BCT Inc
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Publication date
Application filed by Terumo BCT Inc filed Critical Terumo BCT Inc
Publication of CN102639688A publication Critical patent/CN102639688A/zh
Application granted granted Critical
Publication of CN102639688B publication Critical patent/CN102639688B/zh
Expired - Fee Related legal-status Critical Current
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M25/00—Means for supporting, enclosing or fixing the microorganisms, e.g. immunocoatings
    • C12M25/10—Hollow fibers or tubes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D63/00—Apparatus in general for separation processes using semi-permeable membranes
    • B01D63/02—Hollow fibre modules
    • B01D63/021—Manufacturing thereof
    • B01D63/0233—Manufacturing thereof forming the bundle
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D63/00—Apparatus in general for separation processes using semi-permeable membranes
    • B01D63/02—Hollow fibre modules
    • B01D63/031—Two or more types of hollow fibres within one bundle or within one potting or tube-sheet
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D67/00—Processes specially adapted for manufacturing semi-permeable membranes for separation processes or apparatus
    • B01D67/0081—After-treatment of organic or inorganic membranes
    • B01D67/009—After-treatment of organic or inorganic membranes with wave-energy, particle-radiation or plasma
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D71/00—Semi-permeable membranes for separation processes or apparatus characterised by the material; Manufacturing processes specially adapted therefor
    • B01D71/06—Organic material
    • B01D71/44—Polymers obtained by reactions only involving carbon-to-carbon unsaturated bonds, not provided for in a single one of groups B01D71/26-B01D71/42
    • B01D71/441—Polyvinylpyrrolidone
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D71/00—Semi-permeable membranes for separation processes or apparatus characterised by the material; Manufacturing processes specially adapted therefor
    • B01D71/06—Organic material
    • B01D71/66—Polymers having sulfur in the main chain, with or without nitrogen, oxygen or carbon only
    • B01D71/68—Polysulfones; Polyethersulfones
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2313/00—Details relating to membrane modules or apparatus
    • B01D2313/04—Specific sealing means

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  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Manufacturing & Machinery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Sustainable Development (AREA)
  • Physics & Mathematics (AREA)
  • Plasma & Fusion (AREA)
  • Inorganic Chemistry (AREA)
  • Immunology (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • External Artificial Organs (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)
CN201080045888.0A 2009-10-12 2010-10-04 组装中空纤维生物反应器的方法 Expired - Fee Related CN102639688B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US25075809P 2009-10-12 2009-10-12
US61/250,758 2009-10-12
PCT/IB2010/002517 WO2011045644A1 (en) 2009-10-12 2010-10-04 Method of assembling a hollow fiber bioreactor

Publications (2)

Publication Number Publication Date
CN102639688A CN102639688A (zh) 2012-08-15
CN102639688B true CN102639688B (zh) 2014-12-31

Family

ID=43640470

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201080045888.0A Expired - Fee Related CN102639688B (zh) 2009-10-12 2010-10-04 组装中空纤维生物反应器的方法

Country Status (5)

Country Link
US (1) US20120205041A1 (cg-RX-API-DMAC7.html)
EP (1) EP2488629B1 (cg-RX-API-DMAC7.html)
JP (1) JP5819835B2 (cg-RX-API-DMAC7.html)
CN (1) CN102639688B (cg-RX-API-DMAC7.html)
WO (1) WO2011045644A1 (cg-RX-API-DMAC7.html)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103917098A (zh) 2011-02-22 2014-07-09 明尼苏达大学董事会 二氧化硅封装的生物材料
US9534236B2 (en) * 2013-03-08 2017-01-03 Regents Of The University Of Minnesota Membranes for wastewater-generated energy and gas
US10035719B2 (en) 2014-10-15 2018-07-31 Regents Of The University Of Minnesota System and membrane for wastewater-generated energy and gas
EP3830239A1 (en) 2018-08-16 2021-06-09 TERUMO Kabushiki Kaisha Cell culture substrate
EP3830238A1 (en) 2018-08-16 2021-06-09 TERUMO Kabushiki Kaisha Cell culture substrate
JP7315653B2 (ja) 2018-08-16 2023-07-26 テルモ株式会社 細胞培養基材
EP3830237A1 (en) 2018-08-16 2021-06-09 TERUMO Kabushiki Kaisha Cell culture substrate
EP3887497A1 (en) 2018-12-20 2021-10-06 TERUMO Kabushiki Kaisha Cell culture substrate
JP7348281B2 (ja) 2018-12-20 2023-09-20 テルモ株式会社 細胞培養基材
JP7595066B2 (ja) 2019-09-20 2024-12-05 テルモ株式会社 タンパク質吸着剤の被覆状態またはタンパク質の吸着状態の評価方法
JP2023072702A (ja) 2020-06-18 2023-05-25 テルモ株式会社 細胞培養基材
KR20230042266A (ko) * 2020-07-29 2023-03-28 엘지전자 주식회사 나노셀룰로오스 지지체 및 그의 제조 방법
JPWO2023120710A1 (cg-RX-API-DMAC7.html) * 2021-12-23 2023-06-29

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5369012A (en) * 1992-03-26 1994-11-29 The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration Method of making a membrane having hydrophilic and hydrophobic surfaces for adhering cells or antibodies by using atomic oxygen or hydroxyl radicals
JP2003245526A (ja) * 2001-12-19 2003-09-02 Toray Ind Inc 中空糸膜およびその製造方法、中空糸膜モジュールおよびその製造方法
CN101203315A (zh) * 2005-03-24 2008-06-18 希乐克公司 纤维材料和复合材料
CN101549179A (zh) * 2009-04-30 2009-10-07 浙江大学 人工肝用多孔砖式填充支架型反应器

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS63196286A (ja) * 1987-02-12 1988-08-15 Sumitomo Electric Ind Ltd 細胞培養用基材
JPS63198980A (ja) * 1987-02-13 1988-08-17 Sumitomo Electric Ind Ltd 細胞培養用基材
US5015585A (en) * 1988-02-23 1991-05-14 Robinson James R Method and apparatus for culturing and diffusively oxygenating cells on isotropic membranes
JPH0315382A (ja) * 1989-06-14 1991-01-23 Terumo Corp 細胞培養用基材、細胞培養用基材ユニット、バイオリアクターおよび体外循環式治療器
JPH05308953A (ja) * 1992-05-13 1993-11-22 Asahi Medical Co Ltd 細胞培養膜
DE19932439C2 (de) * 1999-07-12 2002-06-13 Sefar Ag Rueschlikon Bioreaktor
JP2002065246A (ja) * 2000-06-15 2002-03-05 Sumitomo Bakelite Co Ltd 細胞培養基質、その製造方法及び細胞培養方法
US6617152B2 (en) * 2001-09-04 2003-09-09 Corning Inc Method for creating a cell growth surface on a polymeric substrate
ES2737433T3 (es) * 2002-08-21 2020-01-14 Toray Industries Sustrato de membrana modificado con adsorción reducida de plaquetas
JP2004208692A (ja) * 2002-12-17 2004-07-29 Toray Ind Inc 三次元細胞培養基材および細胞製剤の製造方法
JP2004305840A (ja) * 2003-04-03 2004-11-04 Toyobo Co Ltd 中空糸膜の保存方法
EP1795254B1 (en) * 2004-08-10 2014-05-21 Nipro Corporation Process for production of a polysulfone type selectively permeable hollow fiber membrane module
US20080299337A1 (en) * 2006-02-09 2008-12-04 Isoflux, Inc. Method for the formation of surfaces on the inside of medical devices
WO2009015420A1 (en) * 2007-07-27 2009-02-05 The University Of Sydney Biological functionalisation of substrates
EP2168614B1 (en) * 2008-09-25 2012-02-15 Gambro Lundia AB Hybrid bioartificial kidney
EP2168666A1 (en) * 2008-09-25 2010-03-31 Gambro Lundia AB Irradiated membrane for cell expansion

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5369012A (en) * 1992-03-26 1994-11-29 The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration Method of making a membrane having hydrophilic and hydrophobic surfaces for adhering cells or antibodies by using atomic oxygen or hydroxyl radicals
JP2003245526A (ja) * 2001-12-19 2003-09-02 Toray Ind Inc 中空糸膜およびその製造方法、中空糸膜モジュールおよびその製造方法
CN101203315A (zh) * 2005-03-24 2008-06-18 希乐克公司 纤维材料和复合材料
CN101549179A (zh) * 2009-04-30 2009-10-07 浙江大学 人工肝用多孔砖式填充支架型反应器

Also Published As

Publication number Publication date
US20120205041A1 (en) 2012-08-16
EP2488629A1 (en) 2012-08-22
EP2488629B1 (en) 2020-03-11
JP2013507143A (ja) 2013-03-04
CN102639688A (zh) 2012-08-15
JP5819835B2 (ja) 2015-11-24
WO2011045644A1 (en) 2011-04-21

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Granted publication date: 20141231