CN102639134A - 使用基质金属蛋白酶-2抑制剂治疗动脉瘤样扩张、血管壁薄弱、特别是腹主动脉瘤和胸主动脉瘤的方法 - Google Patents

使用基质金属蛋白酶-2抑制剂治疗动脉瘤样扩张、血管壁薄弱、特别是腹主动脉瘤和胸主动脉瘤的方法 Download PDF

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Publication number
CN102639134A
CN102639134A CN2010800545319A CN201080054531A CN102639134A CN 102639134 A CN102639134 A CN 102639134A CN 2010800545319 A CN2010800545319 A CN 2010800545319A CN 201080054531 A CN201080054531 A CN 201080054531A CN 102639134 A CN102639134 A CN 102639134A
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Prior art keywords
vessel wall
compound
inhibitors
treatment
angiotensin
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CN2010800545319A
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Chinese (zh)
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A.J.J.伍德
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Symphony Evolution Inc
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Symphony Evolution Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

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  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CN2010800545319A 2009-10-01 2010-09-30 使用基质金属蛋白酶-2抑制剂治疗动脉瘤样扩张、血管壁薄弱、特别是腹主动脉瘤和胸主动脉瘤的方法 Pending CN102639134A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US24784309P 2009-10-01 2009-10-01
US61/247,843 2009-10-01
PCT/US2010/050907 WO2011041545A1 (en) 2009-10-01 2010-09-30 Methods of treating aneurysmal dilatation, blood vessel wall weakness and specifically abdominal aortic and thoracic aneurysm using matrix metalloprotease-2 inhibitors

Publications (1)

Publication Number Publication Date
CN102639134A true CN102639134A (zh) 2012-08-15

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CN2010800545319A Pending CN102639134A (zh) 2009-10-01 2010-09-30 使用基质金属蛋白酶-2抑制剂治疗动脉瘤样扩张、血管壁薄弱、特别是腹主动脉瘤和胸主动脉瘤的方法

Country Status (6)

Country Link
US (2) US20120270884A1 (https=)
EP (1) EP2482817A1 (https=)
JP (1) JP2013506684A (https=)
CN (1) CN102639134A (https=)
CA (1) CA2774389A1 (https=)
WO (1) WO2011041545A1 (https=)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107417629A (zh) * 2017-08-09 2017-12-01 苏州楚凯药业有限公司 动脉瘤抑制剂xl784的制备方法
CN108947850A (zh) * 2018-07-23 2018-12-07 蚌埠中实化学技术有限公司 一种3,4,5-三氟苯胺的制备方法
CN111500721A (zh) * 2020-04-20 2020-08-07 青岛大学附属医院 Tace在腹主动脉瘤腔内修复术后内漏诊断中的应用
CN112569219A (zh) * 2019-09-30 2021-03-30 中国科学院上海药物研究所 用于治疗动脉相关疾病的药物及其用途

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2774389A1 (en) * 2009-10-01 2011-04-07 Symphony Evolution, Inc. Methods of treating aneurysmal dilatation, blood vessel wall weakness and specifically abdominal aortic and thoracic aneurysm using matrix metalloprotease-2 inhibitors
WO2013059302A1 (en) * 2011-10-17 2013-04-25 Nationwide Children's Hospital, Inc. Products and methods for aortic abdominal aneurysm
EP3693460A1 (en) * 2012-07-27 2020-08-12 Ionis Pharmaceuticals, Inc. Modulation of renin-angiotensin system (ras) related diseases by angiotensinogen
WO2014028334A1 (en) * 2012-08-11 2014-02-20 Symphony Evolution, Inc. Selective mmp inhibitors
US9791461B2 (en) 2012-10-30 2017-10-17 Tohoku University Method for testing for cardiovascular disease with cyclophilin A
CN113817735A (zh) 2015-10-08 2021-12-21 Ionis制药公司 用于调节血管紧张素原表达的化合物和方法
US11376248B2 (en) * 2017-06-30 2022-07-05 Georgia State University Research Foundation, Inc. Treatment of aneurysms
EP3675880B1 (en) 2017-09-01 2023-06-07 The Johns Hopkins University Targeted epigenetic therapy for inherited aortic aneurysm condition
EP4136092B1 (en) 2020-11-18 2024-07-31 Ionis Pharmaceuticals, Inc. Compounds and methods for modulating angiotensinogen expression

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WO2003106381A2 (en) * 2002-06-12 2003-12-24 Exelixis, Inc. Human adam-10 inhibitors
US20040215172A1 (en) * 2003-04-25 2004-10-28 Jack Chu In situ blood vessel and aneurysm treatment
EP1516598A1 (en) * 2003-09-19 2005-03-23 Medtronic Vascular, Inc. Device for delivering of therapeutics to treat aneurysms
EP1600181A2 (en) * 2004-05-27 2005-11-30 Medtronic Vascular, Inc. Methods and compounds for treatment of aneurysmal tissue
WO2007050793A2 (en) * 2005-10-25 2007-05-03 The Johns Hopkins University Methods and compositions for the treatment of marfan syndrome and associated disorders
US20080207552A1 (en) * 2002-03-29 2008-08-28 Anges Mg, Inc. Decoy compositions for treating and preventing brain diseases and disorders

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EP0963432A4 (en) 1996-08-29 2002-11-20 Univ California KUZ, NEW FAMILY OF METALLOPROTEASES
US5922546A (en) 1997-08-25 1999-07-13 Smithkline Beecham Corporation Human disintegrin metalloprotease KUZ gene
WO1999032150A1 (en) * 1997-12-23 1999-07-01 Warner-Lambert Company Ace inhibitor-mmp inhibitor combinations
AUPP584198A0 (en) * 1998-09-14 1998-10-08 Fujisawa Pharmaceutical Co., Ltd. New use
JP2009502179A (ja) * 2005-07-29 2009-01-29 インペリアル イノベーションズ リミテッド 化合物
CA2774389A1 (en) * 2009-10-01 2011-04-07 Symphony Evolution, Inc. Methods of treating aneurysmal dilatation, blood vessel wall weakness and specifically abdominal aortic and thoracic aneurysm using matrix metalloprotease-2 inhibitors

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080207552A1 (en) * 2002-03-29 2008-08-28 Anges Mg, Inc. Decoy compositions for treating and preventing brain diseases and disorders
WO2003106381A2 (en) * 2002-06-12 2003-12-24 Exelixis, Inc. Human adam-10 inhibitors
US20040215172A1 (en) * 2003-04-25 2004-10-28 Jack Chu In situ blood vessel and aneurysm treatment
EP1516598A1 (en) * 2003-09-19 2005-03-23 Medtronic Vascular, Inc. Device for delivering of therapeutics to treat aneurysms
EP1600181A2 (en) * 2004-05-27 2005-11-30 Medtronic Vascular, Inc. Methods and compounds for treatment of aneurysmal tissue
WO2007050793A2 (en) * 2005-10-25 2007-05-03 The Johns Hopkins University Methods and compositions for the treatment of marfan syndrome and associated disorders

Non-Patent Citations (1)

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李春平: "基质金属蛋白酶及其组织抑制剂在腹动脉瘤发病中的作用", 《现代临床普通外科》 *

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107417629A (zh) * 2017-08-09 2017-12-01 苏州楚凯药业有限公司 动脉瘤抑制剂xl784的制备方法
CN107417629B (zh) * 2017-08-09 2020-02-07 苏州楚凯药业有限公司 动脉瘤抑制剂xl784的制备方法
CN108947850A (zh) * 2018-07-23 2018-12-07 蚌埠中实化学技术有限公司 一种3,4,5-三氟苯胺的制备方法
CN108947850B (zh) * 2018-07-23 2021-05-18 蚌埠中实化学技术有限公司 一种3,4,5-三氟苯胺的制备方法
CN112569219A (zh) * 2019-09-30 2021-03-30 中国科学院上海药物研究所 用于治疗动脉相关疾病的药物及其用途
CN112569219B (zh) * 2019-09-30 2023-05-02 中国科学院上海药物研究所 用于治疗动脉相关疾病的药物及其用途
CN111500721A (zh) * 2020-04-20 2020-08-07 青岛大学附属医院 Tace在腹主动脉瘤腔内修复术后内漏诊断中的应用

Also Published As

Publication number Publication date
JP2013506684A (ja) 2013-02-28
WO2011041545A1 (en) 2011-04-07
CA2774389A1 (en) 2011-04-07
US20120270884A1 (en) 2012-10-25
EP2482817A1 (en) 2012-08-08
US20110082114A1 (en) 2011-04-07

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Application publication date: 20120815