CN102639114B - 经改善贮藏稳定性的脂质体 - Google Patents

经改善贮藏稳定性的脂质体 Download PDF

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Publication number
CN102639114B
CN102639114B CN201080047402.7A CN201080047402A CN102639114B CN 102639114 B CN102639114 B CN 102639114B CN 201080047402 A CN201080047402 A CN 201080047402A CN 102639114 B CN102639114 B CN 102639114B
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China
Prior art keywords
liposomes
solution
concentration
nacl
internal
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English (en)
Chinese (zh)
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CN102639114A (zh
Inventor
M·W·麦德森
S·A·彼得森
A·F·维克吉格
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BIO-BEDST APS
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BIO-BEDST APS
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
    • A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers comprising non-phosphatidyl surfactants as bilayer-forming substances, e.g. cationic lipids or non-phosphatidyl liposomes coated or grafted with polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Dispersion Chemistry (AREA)
  • Epidemiology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN201080047402.7A 2009-10-23 2010-10-25 经改善贮藏稳定性的脂质体 Expired - Fee Related CN102639114B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DK200901150 2009-10-23
DKPA200901150A DK177529B1 (en) 2009-10-23 2009-10-23 Liposomes with improved storage stability
PCT/DK2010/050283 WO2011047689A2 (en) 2009-10-23 2010-10-25 Liposomes with improved storage stability

Publications (2)

Publication Number Publication Date
CN102639114A CN102639114A (zh) 2012-08-15
CN102639114B true CN102639114B (zh) 2015-04-01

Family

ID=43533079

Family Applications (1)

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CN201080047402.7A Expired - Fee Related CN102639114B (zh) 2009-10-23 2010-10-25 经改善贮藏稳定性的脂质体

Country Status (16)

Country Link
US (1) US9820941B2 (enExample)
EP (1) EP2490671B1 (enExample)
JP (1) JP5778160B2 (enExample)
CN (1) CN102639114B (enExample)
AU (1) AU2010310240B2 (enExample)
CA (1) CA2772973C (enExample)
CY (1) CY1115139T1 (enExample)
DK (2) DK177529B1 (enExample)
ES (1) ES2465565T3 (enExample)
HR (1) HRP20140413T1 (enExample)
PL (1) PL2490671T3 (enExample)
PT (1) PT2490671E (enExample)
RS (1) RS53321B (enExample)
SI (1) SI2490671T1 (enExample)
SM (1) SMT201400065B (enExample)
WO (1) WO2011047689A2 (enExample)

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EP2123258A1 (en) 2008-05-23 2009-11-25 Liplasome Pharma A/S Liposomes for drug delivery
DK177532B1 (en) 2009-09-17 2013-09-08 Bio Bedst Aps Medical use of sPLA2 hydrolysable liposomes
EP2394640A1 (en) * 2010-05-21 2011-12-14 MediGene AG Improved liposomal formulations of lipophilic compounds
JP6263609B2 (ja) * 2014-04-30 2018-01-17 富士フイルム株式会社 リポソーム組成物及びその製造方法
JP6276847B2 (ja) * 2014-04-30 2018-02-07 富士フイルム株式会社 リポソーム組成物及びその製造方法
HRP20202030T1 (hr) * 2014-04-30 2021-02-19 Fujifilm Corporation Liposomska kompozicija i postupak za njeno dobivanje
DK3291797T3 (da) 2015-05-04 2020-09-21 Versantis AG Metode til forberedelse af transmembran ph-gradiente vesikler
US9725769B1 (en) 2016-10-07 2017-08-08 Oncology Venture ApS Methods for predicting drug responsiveness in cancer patients
AU2017258901A1 (en) 2016-12-30 2018-07-19 Allarity Therapeutics Europe ApS Methods for predicting drug responsiveness in cancer patients
AU2019200325A1 (en) * 2018-01-31 2019-08-15 Liplasome Pharma Aps Methods for treating cancer and predicting drug responsiveness in cancer patients
CN110496103B (zh) * 2018-05-18 2022-05-10 上海维洱生物医药科技有限公司 一种多西他赛棕榈酸酯脂质体及其制备方法
TWI874322B (zh) 2018-06-20 2025-03-01 日商富士軟片股份有限公司 包含內含吉西他濱之脂質體組成物及免疫檢查點抑制劑之組合醫藥

Citations (3)

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Publication number Priority date Publication date Assignee Title
US20030170297A1 (en) * 2000-04-12 2003-09-11 Kent Jorgensen Lipid-based drug delivery systems containing phospholipase a2 degradable lipid derivatives for topical application to the skin
US20070014845A1 (en) * 2005-07-01 2007-01-18 Yuanpeng Zhang Liposomal delivery vehicle for hydrophobic drugs
CN101103972A (zh) * 2007-07-13 2008-01-16 陈祥峰 一种奥沙利铂脂质体葡萄糖制剂及其制备方法、应用

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DE68901733T2 (de) 1988-03-04 1993-03-25 Takeda Chemical Industries Ltd Liposom-zusammensetzung.
JP2931981B2 (ja) * 1988-03-04 1999-08-09 武田薬品工業株式会社 リポソーム製剤およびその製造法
FI895340A7 (fi) * 1988-11-14 1990-05-15 Bristol Myers Squibb Co Hypertoninen cisplatin-liuos
JPH05194192A (ja) * 1991-08-21 1993-08-03 Shionogi & Co Ltd 分散性の改善された温度感受性ｍｌｖ型リポソ−ム
JPH069374A (ja) * 1992-04-07 1994-01-18 Banyu Pharmaceut Co Ltd リポソ−ム製剤およびその製造法
WO1996010585A1 (en) 1994-09-30 1996-04-11 Inex Pharmaceuticals Corp. Glycosylated protein-liposome conjugates and methods for their preparation
US5858397A (en) 1995-10-11 1999-01-12 University Of British Columbia Liposomal formulations of mitoxantrone
ES2208946T3 (es) * 1996-08-23 2004-06-16 Sequus Pharmaceuticals, Inc. Liposomas que contienen un compuesto de cisplatino.
FR2759293B1 (fr) * 1997-02-11 1999-04-30 Ethypharm Lab Prod Ethiques Microgranules contenant du cisplatine, procede de fabrication, preparation pharmaceutique et utilisation en polychimiotherapie ou en association avec une radiotherapie
AU778659B2 (en) 2000-02-10 2004-12-16 Liplasome Pharma A/S Lipid-based drug delivery systems
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CA2383259A1 (en) 2002-04-23 2003-10-23 Celator Technologies Inc. Synergistic compositions
US20050118250A1 (en) 2001-11-13 2005-06-02 Paul Tardi Lipid carrier compositions with enhanced blood stability
US20040022842A1 (en) 2002-06-03 2004-02-05 Mebiopharm Co., Ltd. Liposome preparations containing oxaliplatin
EP1643971A2 (en) 2003-05-22 2006-04-12 Neopharm, Inc. Liposomal formulations comprising a combination of two or more active agents
GB0312309D0 (en) * 2003-05-29 2003-07-02 Gaslini Children S Hospital G Targeted liposome
US20070286898A1 (en) 2004-08-31 2007-12-13 Astellas Pharma Inc. Intracellular Drug Delivery Improving Liposome
DE602005012155D1 (de) 2004-11-03 2009-02-12 Liplasome Pharma As Arzneimittelabgabesysteme auf lipidbasis mit unnatürlichen phospholipase-a2-abbaubaren lipid-derivaten und ihre therapeutische verwendung
CN101040853B (zh) * 2006-03-22 2010-05-12 上海医药工业研究院 一种草乌甲素多泡脂质体及其制备方法
WO2007107161A2 (en) 2006-03-23 2007-09-27 Liplasome Pharma A/S Lipid based drug delivery systems comprising phospholipase a2 degradable lipids that perform an intramolecular cyclization reaction upon hydrolysis
CN101557801B (zh) 2006-07-14 2013-10-30 Fmc生物聚合物联合股份有限公司 含有低分子量藻酸盐的水凝胶和从其制备的生物构建物
EP2123258A1 (en) * 2008-05-23 2009-11-25 Liplasome Pharma A/S Liposomes for drug delivery

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030170297A1 (en) * 2000-04-12 2003-09-11 Kent Jorgensen Lipid-based drug delivery systems containing phospholipase a2 degradable lipid derivatives for topical application to the skin
US20070014845A1 (en) * 2005-07-01 2007-01-18 Yuanpeng Zhang Liposomal delivery vehicle for hydrophobic drugs
CN101103972A (zh) * 2007-07-13 2008-01-16 陈祥峰 一种奥沙利铂脂质体葡萄糖制剂及其制备方法、应用

Non-Patent Citations (2)

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Thomas L. Andresen,et al..Advanced strategies in liposomal cancer therapy: Problems and prospects of active and tumor specific drug release.《Progress in Lipid Research》.2005,68-97页. *
Triggered actibation and release of liposomal prodrugs and drugs in cancer tissue by secretory phospholipase A2;Andresen，et al.;《Current Drug Delivery》;20051001;第2卷(第4期);353-362页 *

Also Published As

Publication number Publication date
US9820941B2 (en) 2017-11-21
EP2490671B1 (en) 2014-03-05
WO2011047689A2 (en) 2011-04-28
SI2490671T1 (sl) 2014-07-31
US20120219618A1 (en) 2012-08-30
CA2772973C (en) 2017-08-15
CY1115139T1 (el) 2016-12-14
WO2011047689A3 (en) 2011-11-17
PT2490671E (pt) 2014-05-30
CN102639114A (zh) 2012-08-15
SMT201400065B (it) 2014-07-07
JP5778160B2 (ja) 2015-09-16
AU2010310240A1 (en) 2012-03-22
DK200901150A (en) 2011-04-24
HRP20140413T1 (hr) 2014-07-04
ES2465565T3 (es) 2014-06-06
CA2772973A1 (en) 2011-04-28
DK2490671T3 (da) 2014-06-16
DK177529B1 (en) 2013-09-08
PL2490671T3 (pl) 2014-08-29
EP2490671A2 (en) 2012-08-29
AU2010310240B2 (en) 2015-11-26
RS53321B (sr) 2014-10-31
JP2013508315A (ja) 2013-03-07

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