CN102625708A - Pi3激酶抑制剂及其用途 - Google Patents

Pi3激酶抑制剂及其用途 Download PDF

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Publication number
CN102625708A
CN102625708A CN201080048947XA CN201080048947A CN102625708A CN 102625708 A CN102625708 A CN 102625708A CN 201080048947X A CN201080048947X A CN 201080048947XA CN 201080048947 A CN201080048947 A CN 201080048947A CN 102625708 A CN102625708 A CN 102625708A
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ring
nitrogen
unit
oxygen
sulfur
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Chinese (zh)
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牛德强
拉塞尔·C·彼得
尤斯温德·辛格
阿瑟·F·克卢格
霍尔木兹·马兹迪亚斯尼
朱振东
乔立新
凯文·孔茨
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Avila Therapeutics Inc
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Avila Therapeutics Inc
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CN201080048947XA 2009-09-09 2010-09-09 Pi3激酶抑制剂及其用途 Pending CN102625708A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US24094709P 2009-09-09 2009-09-09
US61/240,947 2009-09-09
US37139610P 2010-08-06 2010-08-06
US61/371,396 2010-08-06
PCT/US2010/048317 WO2011031896A2 (en) 2009-09-09 2010-09-09 Pi3 kinase inhibitors and uses thereof

Publications (1)

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CN102625708A true CN102625708A (zh) 2012-08-01

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CN201080048947XA Pending CN102625708A (zh) 2009-09-09 2010-09-09 Pi3激酶抑制剂及其用途

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US (1) US20110230476A1 (https=)
EP (1) EP2475375A4 (https=)
JP (1) JP2013504325A (https=)
KR (1) KR20120063515A (https=)
CN (1) CN102625708A (https=)
AU (1) AU2010292198A1 (https=)
BR (1) BR112012008385A2 (https=)
CA (1) CA2773848A1 (https=)
IL (1) IL218555A0 (https=)
MX (1) MX339584B (https=)
NZ (2) NZ598808A (https=)
PH (1) PH12012500491A1 (https=)
RU (1) RU2595718C2 (https=)
SG (2) SG10201405598QA (https=)
TW (2) TW201609747A (https=)
WO (1) WO2011031896A2 (https=)

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CN103501610A (zh) * 2011-03-09 2014-01-08 西建阿维拉米斯研究公司 Pi3激酶抑制剂和其用途
CN105189456A (zh) * 2013-03-15 2015-12-23 亚瑞克西斯制药公司 Kras g12c的共价抑制剂
WO2016173562A1 (zh) * 2015-04-30 2016-11-03 江苏挪贝肽医药科技有限公司 PI4KIIIα蛋白及相关的膜蛋白复合体在治疗阿尔茨海默病中的应用
CN106755343A (zh) * 2016-12-01 2017-05-31 北京致成生物医学科技有限公司 胰腺癌预后诊断分子标记物
CN107406488A (zh) * 2014-12-24 2017-11-28 凯思生物技术公司 用于治疗呼吸系统疾病的新型PI3Kγ抑制剂肽
CN108884046A (zh) * 2016-02-12 2018-11-23 葛兰素史克知识产权开发有限公司 作为激酶活性的抑制剂的化学化合物
US10273207B2 (en) 2013-03-15 2019-04-30 Araxes Pharma Llc Covalent inhibitors of kras G12C
US10280172B2 (en) 2016-09-29 2019-05-07 Araxes Pharma Llc Inhibitors of KRAS G12C mutant proteins
US10370386B2 (en) 2013-10-10 2019-08-06 Araxes Pharma Llc Substituted quinolines as inhibitors of KRAS G12C
US10377743B2 (en) 2016-10-07 2019-08-13 Araxes Pharma Llc Inhibitors of RAS and methods of use thereof
US10428064B2 (en) 2015-04-15 2019-10-01 Araxes Pharma Llc Fused-tricyclic inhibitors of KRAS and methods of use thereof
CN112533917A (zh) * 2018-04-10 2021-03-19 神经孔疗法股份有限公司 作为vps34的抑制剂的吗啉衍生物
CN113045582A (zh) * 2021-02-05 2021-06-29 中国药科大学 Parp-1/pi3k双靶点抑制剂或其药学上可接受的盐及其制备方法与用途
CN113754680A (zh) * 2021-09-28 2021-12-07 云白药征武科技(上海)有限公司 一种α氟代酰基哌嗪衍生物及其制备和应用
CN117396470A (zh) * 2021-04-09 2024-01-12 巴塞尔大学 作为pi3k的可逆和不可逆共价抑制剂的三嗪衍生物

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WO2012154610A1 (en) * 2011-05-06 2012-11-15 Intellikine, Llc Reactive pi3k kinase inhibitors and uses thereof
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US8889716B2 (en) 2011-05-10 2014-11-18 Chdi Foundation, Inc. Transglutaminase TG2 inhibitors, pharmaceutical compositions, and methods of use thereof
US9138436B2 (en) 2011-07-13 2015-09-22 Pharmacyclics Llc Inhibitors of Bruton's tyrosine kinase
KR20140069235A (ko) 2011-09-27 2014-06-09 노파르티스 아게 돌연변이체 idh의 억제제로서의 3-피리미딘-4-일-옥사졸리딘-2-온
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US20150204846A1 (en) * 2012-05-15 2015-07-23 New York University Phosphatidylinositol-3-kinase c2 beta modulators and methods of use thereof
WO2014012093A1 (en) * 2012-07-13 2014-01-16 Wake Forest University Health Sciences Prostate cancer targeted prodrugs and methods of use thereof
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KR102083700B1 (ko) 2012-08-21 2020-03-02 옵코 파마슈티칼스, 엘엘씨 리포좀 제제
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ME03455B (me) 2012-09-10 2020-01-20 Principia Biopharma Inc Jedinjenja pirazolopirimidina kao inhibitori kinaze
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CN113754680A (zh) * 2021-09-28 2021-12-07 云白药征武科技(上海)有限公司 一种α氟代酰基哌嗪衍生物及其制备和应用
CN113754680B (zh) * 2021-09-28 2022-07-22 云白药征武科技(上海)有限公司 一种α氟代酰基哌嗪衍生物及其制备和应用

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