CN102618452A - 唾液乳杆菌及其代谢物的制备方法和组合物以及应用 - Google Patents
唾液乳杆菌及其代谢物的制备方法和组合物以及应用 Download PDFInfo
- Publication number
- CN102618452A CN102618452A CN2011100344208A CN201110034420A CN102618452A CN 102618452 A CN102618452 A CN 102618452A CN 2011100344208 A CN2011100344208 A CN 2011100344208A CN 201110034420 A CN201110034420 A CN 201110034420A CN 102618452 A CN102618452 A CN 102618452A
- Authority
- CN
- China
- Prior art keywords
- lactobacillus salivarius
- metabolite
- salivarius
- viable bacteria
- composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 241000186869 Lactobacillus salivarius Species 0.000 title claims abstract description 111
- 239000002207 metabolite Substances 0.000 title claims abstract description 59
- 238000002360 preparation method Methods 0.000 title claims abstract description 25
- 239000000203 mixture Substances 0.000 title claims abstract description 17
- 241000894006 Bacteria Species 0.000 claims abstract description 47
- 238000000034 method Methods 0.000 claims abstract description 21
- 206010028980 Neoplasm Diseases 0.000 claims abstract description 18
- 201000011510 cancer Diseases 0.000 claims abstract description 16
- 239000003814 drug Substances 0.000 claims abstract description 13
- 239000000047 product Substances 0.000 claims description 14
- 239000007791 liquid phase Substances 0.000 claims description 12
- 235000013376 functional food Nutrition 0.000 claims description 11
- 235000013305 food Nutrition 0.000 claims description 7
- 239000012263 liquid product Substances 0.000 claims description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 7
- 241001052560 Thallis Species 0.000 claims description 4
- 230000004083 survival effect Effects 0.000 claims description 4
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 3
- 239000002671 adjuvant Substances 0.000 claims description 3
- 244000005700 microbiome Species 0.000 claims description 3
- 210000003296 saliva Anatomy 0.000 claims description 3
- 239000011780 sodium chloride Substances 0.000 claims description 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 239000000872 buffer Substances 0.000 claims 1
- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 claims 1
- 239000002953 phosphate buffered saline Substances 0.000 claims 1
- 231100000025 genetic toxicology Toxicity 0.000 abstract description 9
- 230000001738 genotoxic effect Effects 0.000 abstract description 9
- 238000001727 in vivo Methods 0.000 abstract description 7
- YHQDZJICGQWFHK-UHFFFAOYSA-N 4-nitroquinoline N-oxide Chemical compound C1=CC=C2C([N+](=O)[O-])=CC=[N+]([O-])C2=C1 YHQDZJICGQWFHK-UHFFFAOYSA-N 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 238000009629 microbiological culture Methods 0.000 abstract 1
- 238000004321 preservation Methods 0.000 abstract 1
- 208000003445 Mouth Neoplasms Diseases 0.000 description 10
- 208000012987 lip and oral cavity carcinoma Diseases 0.000 description 10
- 208000017897 Carcinoma of esophagus Diseases 0.000 description 8
- 206010030155 Oesophageal carcinoma Diseases 0.000 description 8
- 230000001580 bacterial effect Effects 0.000 description 8
- 201000005619 esophageal carcinoma Diseases 0.000 description 8
- 230000000694 effects Effects 0.000 description 7
- 201000002313 intestinal cancer Diseases 0.000 description 7
- 230000002265 prevention Effects 0.000 description 7
- 208000005016 Intestinal Neoplasms Diseases 0.000 description 6
- 208000005718 Stomach Neoplasms Diseases 0.000 description 6
- 230000000052 comparative effect Effects 0.000 description 6
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 6
- 230000003902 lesion Effects 0.000 description 6
- 235000015097 nutrients Nutrition 0.000 description 6
- 239000000243 solution Substances 0.000 description 6
- 201000000498 stomach carcinoma Diseases 0.000 description 6
- 239000008399 tap water Substances 0.000 description 6
- 235000020679 tap water Nutrition 0.000 description 6
- 241000700159 Rattus Species 0.000 description 5
- 239000012467 final product Substances 0.000 description 5
- 241000186660 Lactobacillus Species 0.000 description 4
- 230000037396 body weight Effects 0.000 description 4
- 229940039696 lactobacillus Drugs 0.000 description 4
- 239000006041 probiotic Substances 0.000 description 4
- 230000000529 probiotic effect Effects 0.000 description 4
- 235000018291 probiotics Nutrition 0.000 description 4
- 238000001035 drying Methods 0.000 description 3
- 235000014655 lactic acid Nutrition 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 239000012071 phase Substances 0.000 description 3
- 239000006228 supernatant Substances 0.000 description 3
- 239000003826 tablet Substances 0.000 description 3
- 241001465754 Metazoa Species 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 238000001914 filtration Methods 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 238000011081 inoculation Methods 0.000 description 2
- 208000002741 leukoplakia Diseases 0.000 description 2
- 230000002503 metabolic effect Effects 0.000 description 2
- -1 nitroquinoline-1-oxide compound Chemical class 0.000 description 2
- 239000008363 phosphate buffer Substances 0.000 description 2
- 235000014101 wine Nutrition 0.000 description 2
- FRXSZNDVFUDTIR-UHFFFAOYSA-N 6-methoxy-1,2,3,4-tetrahydroquinoline Chemical compound N1CCCC2=CC(OC)=CC=C21 FRXSZNDVFUDTIR-UHFFFAOYSA-N 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 201000003741 Gastrointestinal carcinoma Diseases 0.000 description 1
- PPQNQXQZIWHJRB-UHFFFAOYSA-N Methylcholanthrene Chemical compound C1=CC=C2C3=CC4=CC=C(C)C(CC5)=C4C5=C3C=CC2=C1 PPQNQXQZIWHJRB-UHFFFAOYSA-N 0.000 description 1
- 241000283977 Oryctolagus Species 0.000 description 1
- 241000283973 Oryctolagus cuniculus Species 0.000 description 1
- 235000010627 Phaseolus vulgaris Nutrition 0.000 description 1
- 244000046052 Phaseolus vulgaris Species 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 238000010171 animal model Methods 0.000 description 1
- 235000013405 beer Nutrition 0.000 description 1
- 230000000975 bioactive effect Effects 0.000 description 1
- 235000008429 bread Nutrition 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 239000006285 cell suspension Substances 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 235000009508 confectionery Nutrition 0.000 description 1
- 235000015140 cultured milk Nutrition 0.000 description 1
- 239000008367 deionised water Substances 0.000 description 1
- 229910021641 deionized water Inorganic materials 0.000 description 1
- 239000006196 drop Substances 0.000 description 1
- 210000003608 fece Anatomy 0.000 description 1
- 238000000855 fermentation Methods 0.000 description 1
- 230000004151 fermentation Effects 0.000 description 1
- 235000015203 fruit juice Nutrition 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 235000021581 juice product Nutrition 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000007937 lozenge Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 235000013622 meat product Nutrition 0.000 description 1
- 235000013336 milk Nutrition 0.000 description 1
- 239000008267 milk Substances 0.000 description 1
- 210000004080 milk Anatomy 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 210000000214 mouth Anatomy 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- 235000021110 pickles Nutrition 0.000 description 1
- 239000006187 pill Substances 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 239000010865 sewage Substances 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 235000021262 sour milk Nutrition 0.000 description 1
- 235000013599 spices Nutrition 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000008719 thickening Effects 0.000 description 1
- 210000004881 tumor cell Anatomy 0.000 description 1
- 210000001215 vagina Anatomy 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
- A61K35/741—Probiotics
- A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
- A61K35/747—Lactobacilli, e.g. L. acidophilus or L. brevis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/135—Bacteria or derivatives thereof, e.g. probiotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
- C12N1/205—Bacterial isolates
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2400/00—Lactic or propionic acid bacteria
- A23V2400/11—Lactobacillus
- A23V2400/181—Salivarius
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
- C12R2001/225—Lactobacillus
Abstract
Description
Claims (10)
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201110034420.8A CN102618452B (zh) | 2011-02-01 | 2011-02-01 | 唾液乳杆菌及其代谢物的制备方法和组合物以及应用 |
US13/982,965 US20130309212A1 (en) | 2011-02-01 | 2012-01-17 | Lactobacillus salivarius and method for preparing metabolite thereof, composition of lactobacillus salivarius and metabolite thereof and use of the composition |
PCT/CN2012/070474 WO2012103785A1 (zh) | 2011-02-01 | 2012-01-17 | 唾液乳杆菌及其代谢物的制备方法和组合物以及应用 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201110034420.8A CN102618452B (zh) | 2011-02-01 | 2011-02-01 | 唾液乳杆菌及其代谢物的制备方法和组合物以及应用 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN102618452A true CN102618452A (zh) | 2012-08-01 |
CN102618452B CN102618452B (zh) | 2014-06-25 |
Family
ID=46558666
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201110034420.8A Active CN102618452B (zh) | 2011-02-01 | 2011-02-01 | 唾液乳杆菌及其代谢物的制备方法和组合物以及应用 |
Country Status (3)
Country | Link |
---|---|
US (1) | US20130309212A1 (zh) |
CN (1) | CN102618452B (zh) |
WO (1) | WO2012103785A1 (zh) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103289926A (zh) * | 2013-05-30 | 2013-09-11 | 中国农业科学院哈尔滨兽医研究所 | 一株唾液乳杆菌菌株及其应用 |
CN105624071A (zh) * | 2016-03-17 | 2016-06-01 | 青岛根源生物技术集团有限公司 | 一株唾液乳杆菌xjp2及其应用 |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10413576B2 (en) | 2014-05-05 | 2019-09-17 | Giovanni Mogna | Therapy for use in the treatment of tumors, acquired immunodeficiency syndrome and leukemias by dual immune biostimulation |
CA2946464A1 (en) | 2014-05-05 | 2015-11-12 | Giovanni Mogna | Adjunctive therapy to chemotherapy treatments for tumors, acquired immunodeficiency syndrome and leukemias |
ES2898876T3 (es) | 2018-01-26 | 2022-03-09 | Probisearch S L U | Composición que comprende una nueva cepa de Lactobacillus salivarius y método para la prevención y el tratamiento de otitis e infecciones respiratorias de vías altas |
WO2019169181A1 (en) * | 2018-02-28 | 2019-09-06 | Evelo Biosciences, Inc. | Compositions and methods for treating cancer using lactobacillus salivarius |
KR102136335B1 (ko) * | 2020-03-24 | 2020-07-22 | (주)메디톡스 | 간기능 개선 또는 지방축적 억제 미생물 및 그의 용도 |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1639317A (zh) * | 2001-07-26 | 2005-07-13 | 营养健康有限公司 | 益生菌唾液乳杆菌菌株 |
CN101538545A (zh) * | 2009-04-08 | 2009-09-23 | 内蒙古蒙牛乳业(集团)股份有限公司 | 一种唾液乳杆菌及其食品组合物 |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK1498039T3 (da) * | 2002-03-29 | 2012-10-15 | Frente Internat Co Ltd | Vitale cellepræparater, som indeholder mælkesyrebakterie som aktivt stof, og mælkesyrebakterieholdige fødevareprodukter |
-
2011
- 2011-02-01 CN CN201110034420.8A patent/CN102618452B/zh active Active
-
2012
- 2012-01-17 WO PCT/CN2012/070474 patent/WO2012103785A1/zh active Application Filing
- 2012-01-17 US US13/982,965 patent/US20130309212A1/en not_active Abandoned
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1639317A (zh) * | 2001-07-26 | 2005-07-13 | 营养健康有限公司 | 益生菌唾液乳杆菌菌株 |
CN101538545A (zh) * | 2009-04-08 | 2009-09-23 | 内蒙古蒙牛乳业(集团)股份有限公司 | 一种唾液乳杆菌及其食品组合物 |
Non-Patent Citations (3)
Title |
---|
JUN ZHU等: "Immunomodulatory effects of novel bifidobacterium and lactobacillus strains on murine macrophage cells", 《AFRICAN JOURNAL OF MICROBIOLOGY RESEARCH》 * |
王芳 等: "高效液相色谱法测定唾液乳杆菌脱基因毒性作用", 《分析化学》 * |
高颖 等: "唾液乳杆菌利用低聚果糖的代谢过程研究", 《中国酿造》 * |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103289926A (zh) * | 2013-05-30 | 2013-09-11 | 中国农业科学院哈尔滨兽医研究所 | 一株唾液乳杆菌菌株及其应用 |
CN103289926B (zh) * | 2013-05-30 | 2015-08-26 | 中国农业科学院哈尔滨兽医研究所 | 一株唾液乳杆菌菌株及其应用 |
CN105624071A (zh) * | 2016-03-17 | 2016-06-01 | 青岛根源生物技术集团有限公司 | 一株唾液乳杆菌xjp2及其应用 |
Also Published As
Publication number | Publication date |
---|---|
WO2012103785A1 (zh) | 2012-08-09 |
CN102618452B (zh) | 2014-06-25 |
US20130309212A1 (en) | 2013-11-21 |
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Owner name: CHINA AGRICULTURAL UNIVERSITY Free format text: FORMER OWNER: REN FAZHENG Effective date: 20150312 |
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Inventor after: Ren Fazheng Inventor after: Jiang Lu Inventor after: Wang Fang Inventor after: Zhang Ming Inventor after: Guo Huiyuan Inventor after: Zhu Jun Inventor before: Zhang Ming Inventor before: Jiang Lu Inventor before: Wang Fang Inventor before: Ren Fazheng Inventor before: Guo Huiyuan Inventor before: Zhu Jun |
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Free format text: CORRECT: INVENTOR; FROM: ZHANG MING JIANG LU WANG FANG REN FAZHENG GUO HUIYUAN ZHU JUN TO: REN FAZHENG JIANG LU WANG FANG ZHANG MING GUO HUIYUAN ZHU JUN |
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Effective date of registration: 20150312 Address after: 100083 Haidian District Qinghua East Road, No. 17, Beijing Patentee after: China Agricultural University Address before: 100083 Haidian District Tsinghua East Road, China Agricultural University, No. 17,, 303 Patentee before: Ren Fazheng |
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Effective date of registration: 20170816 Address after: 100081, room 3, floor 1, building 11, 315 South Main Street, Haidian District, Beijing, Zhongguancun Patentee after: Beijing Yiyuan Biological Technology Co. Ltd. Address before: 100083 Haidian District Qinghua East Road, No. 17, Beijing Patentee before: China Agricultural University |
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