CN102612376A - 具有延长的体内功效的生长激素 - Google Patents
具有延长的体内功效的生长激素 Download PDFInfo
- Publication number
- CN102612376A CN102612376A CN2010800357644A CN201080035764A CN102612376A CN 102612376 A CN102612376 A CN 102612376A CN 2010800357644 A CN2010800357644 A CN 2010800357644A CN 201080035764 A CN201080035764 A CN 201080035764A CN 102612376 A CN102612376 A CN 102612376A
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- Prior art keywords
- conjugate
- nhc
- growth hormone
- independently
- patient
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 0 CC(C)(CC(C)(*)CS(O)(=O)=O)CN Chemical compound CC(C)(CC(C)(*)CS(O)(=O)=O)CN 0.000 description 4
- XQHDFSJBINVMNU-UHFFFAOYSA-N CC(C)(C)CC(C)(C)CNC(C(O)=O)=O Chemical compound CC(C)(C)CC(C)(C)CNC(C(O)=O)=O XQHDFSJBINVMNU-UHFFFAOYSA-N 0.000 description 1
- ZHDLMHWOERWHTG-UHFFFAOYSA-N CC(C)(CC(C)(C)CI)CS(NC(F)(F)F)(=O)=O Chemical compound CC(C)(CC(C)(C)CI)CS(NC(F)(F)F)(=O)=O ZHDLMHWOERWHTG-UHFFFAOYSA-N 0.000 description 1
- VKTONDJDDCRXIY-UHFFFAOYSA-N CC(C)(CC(C)(C)N)C(O)=O Chemical compound CC(C)(CC(C)(C)N)C(O)=O VKTONDJDDCRXIY-UHFFFAOYSA-N 0.000 description 1
- BZYAGUBXMZRPGJ-UHFFFAOYSA-N CC(NC(CCC(NCC=O)=O)C(NC)=O)=O Chemical compound CC(NC(CCC(NCC=O)=O)C(NC)=O)=O BZYAGUBXMZRPGJ-UHFFFAOYSA-N 0.000 description 1
- JDYIZMFCKJKDHG-GKAPJAKFSA-N CC(N[C@@H](CCC(NCC(CN)O)=O)C(NC)=O)=O Chemical compound CC(N[C@@H](CCC(NCC(CN)O)=O)C(NC)=O)=O JDYIZMFCKJKDHG-GKAPJAKFSA-N 0.000 description 1
- MEKJWTJPINBGKY-UHFFFAOYSA-N CCCC(C)CC(C)(C)COc(cc1)ccc1C(O)=O Chemical compound CCCC(C)CC(C)(C)COc(cc1)ccc1C(O)=O MEKJWTJPINBGKY-UHFFFAOYSA-N 0.000 description 1
Classifications
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- A61K38/22—Hormones
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Physical Education & Sports Medicine (AREA)
- Endocrinology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Neurology (AREA)
- Rheumatology (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Reproductive Health (AREA)
- Diabetes (AREA)
- Neurosurgery (AREA)
- Virology (AREA)
- Gynecology & Obstetrics (AREA)
- Gastroenterology & Hepatology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Biophysics (AREA)
- Child & Adolescent Psychology (AREA)
- Urology & Nephrology (AREA)
- Transplantation (AREA)
- Heart & Thoracic Surgery (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610416630.6A CN105963710A (zh) | 2009-08-06 | 2010-08-06 | 具有延长的体内功效的生长激素 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP09167350 | 2009-08-06 | ||
| EP09167350.9 | 2009-08-06 | ||
| US23296709P | 2009-08-11 | 2009-08-11 | |
| US61/232967 | 2009-08-11 | ||
| PCT/EP2010/061473 WO2011015649A1 (en) | 2009-08-06 | 2010-08-06 | Growth hormones with prolonged in-vivo efficacy |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610416630.6A Division CN105963710A (zh) | 2009-08-06 | 2010-08-06 | 具有延长的体内功效的生长激素 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN102612376A true CN102612376A (zh) | 2012-07-25 |
Family
ID=41343110
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2010800357644A Pending CN102612376A (zh) | 2009-08-06 | 2010-08-06 | 具有延长的体内功效的生长激素 |
| CN201610416630.6A Pending CN105963710A (zh) | 2009-08-06 | 2010-08-06 | 具有延长的体内功效的生长激素 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610416630.6A Pending CN105963710A (zh) | 2009-08-06 | 2010-08-06 | 具有延长的体内功效的生长激素 |
Country Status (5)
| Country | Link |
|---|---|
| US (4) | US8841249B2 (https=) |
| EP (1) | EP2461831B1 (https=) |
| JP (2) | JP6086528B2 (https=) |
| CN (2) | CN102612376A (https=) |
| WO (1) | WO2011015649A1 (https=) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7495087B2 (en) | 1997-07-14 | 2009-02-24 | Bolder Biotechnology, Inc. | Cysteine muteins in the C-D loop of human interleukin-11 |
| ATE375363T1 (de) | 1997-07-14 | 2007-10-15 | Bolder Biotechnology Inc | Derivate des wachstumshormons und verwandte proteine |
| BR122013003013B8 (pt) | 1999-01-14 | 2021-07-06 | Bolder Biotechnology Inc | proteína isolada monopeguilada do hormônio do crescimento e método para sua obtenção |
| JP6086528B2 (ja) * | 2009-08-06 | 2017-03-01 | ノヴォ・ノルディスク・ヘルス・ケア・アーゲー | 長期のインビボ有効性を有する成長ホルモン |
| JP5980689B2 (ja) | 2010-01-22 | 2016-08-31 | ノヴォ・ノルディスク・ヘルス・ケア・アーゲー | 安定な成長ホルモン化合物 |
| CN118767117A (zh) | 2010-01-22 | 2024-10-15 | 诺沃—诺迪斯克保健股份有限公司 | 体内功效延长的生长激素 |
| AU2012210624A1 (en) | 2011-01-26 | 2013-07-11 | Novo Nordisk A/S | Leptin derivatives |
| US9320777B2 (en) | 2011-05-13 | 2016-04-26 | Bolder Biotechnology, Inc. | Methods and use of growth hormone supergene family protein analogs for treatment of radiation exposure |
| US10064951B2 (en) * | 2012-03-30 | 2018-09-04 | Hanmi Science Co., Ltd. | Liquid formulation of highly concentrated long-acting human growth hormone conjugate |
| US11045523B2 (en) | 2013-04-05 | 2021-06-29 | Novo Nordisk Healthcare Ag | Formulation of growth hormone albumin-binder conjugate |
| MX371328B (es) | 2013-08-30 | 2020-01-27 | Aprilbio Co Ltd | Constructo de fusion de la fraccion efectora del fragmento de union a antigeno (fab) de anti-albumina de suero y su metodo de preparacion. |
| SI3348635T1 (sl) | 2015-09-08 | 2021-08-31 | Jcr Pharmaceuticals Co., Ltd. | Novi mutant humanega serumskega albumina |
| US11229683B2 (en) | 2015-09-18 | 2022-01-25 | Bolder Biotechnology, Inc. | Hematopoietic growth factor proteins and analogs thereof and angiotensin converting enzyme inhibitors for treatment of radiation exposure |
| EP3431508A4 (en) | 2016-03-14 | 2019-08-14 | JCR Pharmaceuticals Co., Ltd. | SERUM ALBUMIN-20-K-GROWTH HORMONE FUSION PROTEIN |
| US10738338B2 (en) | 2016-10-18 | 2020-08-11 | The Research Foundation for the State University | Method and composition for biocatalytic protein-oligonucleotide conjugation and protein-oligonucleotide conjugate |
| WO2021075526A1 (ja) | 2019-10-17 | 2021-04-22 | Jcrファーマ株式会社 | 血清アルブミンと成長ホルモンの融合蛋白質の製造方法 |
| US20220378882A1 (en) | 2019-10-30 | 2022-12-01 | Jcr Pharmaceuticals Co., Ltd. | Aqueous pharmaceutical composition containing fusion protein of serum albumin and growth hormone |
| KR20210095781A (ko) | 2020-01-24 | 2021-08-03 | 주식회사 에이프릴바이오 | 항원결합 단편 및 생리활성 이펙터 모이어티로 구성된 융합 컨스트럭트를 포함하는 다중결합항체 및 이를 포함하는 약학조성물 |
| US11752539B2 (en) * | 2020-01-27 | 2023-09-12 | Panduit Corp. | Embossing system |
| KR20250075985A (ko) * | 2023-11-22 | 2025-05-29 | 한도숙 | 상처 치료 또는 피부 주름형성 억제용 조성물 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1867360A (zh) * | 2003-09-19 | 2006-11-22 | 诺沃挪第克公司 | 治疗肽的清蛋白结合型衍生物 |
| CN101495155A (zh) * | 2006-07-07 | 2009-07-29 | 诺沃-诺迪斯克保健股份有限公司 | 新的蛋白结合物及其制备方法 |
Family Cites Families (107)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| GB8610551D0 (en) | 1986-04-30 | 1986-06-04 | Hoffmann La Roche | Polypeptide & protein derivatives |
| JPH0665280B2 (ja) | 1987-03-04 | 1994-08-24 | 味の素株式会社 | タンパクゲル化剤及びそれを用いるタンパクのゲル化方法 |
| ATE198353T1 (de) | 1988-08-24 | 2001-01-15 | American Cyanamid Co | Stabilisierung von somatotropinen durch modifikation von cystein-resten durch orts- spezifische mutagenese oder chemische derivatisierung |
| US5534617A (en) | 1988-10-28 | 1996-07-09 | Genentech, Inc. | Human growth hormone variants having greater affinity for human growth hormone receptor at site 1 |
| EP0397834B1 (en) | 1988-10-28 | 2000-02-02 | Genentech, Inc. | Method for identifying active domains and amino acid residues in polypeptides and hormone variants |
| US6780613B1 (en) | 1988-10-28 | 2004-08-24 | Genentech, Inc. | Growth hormone variants |
| JPH04504246A (ja) | 1989-03-20 | 1992-07-30 | ザ・ジェネラル・ホスピタル・コーポレーション | インシュリン刺激ホルモン |
| DE3930696A1 (de) | 1989-09-14 | 1991-03-28 | Hoechst Ag | Gallensaeurederivate, verfahren zu ihrer herstellung, verwendung als arzneimittel |
| ATE164852T1 (de) | 1990-01-24 | 1998-04-15 | Douglas I Buckley | Glp-1-analoga verwendbar in der diabetesbehandlung |
| US5545618A (en) | 1990-01-24 | 1996-08-13 | Buckley; Douglas I. | GLP-1 analogs useful for diabetes treatment |
| US5951972A (en) | 1990-05-04 | 1999-09-14 | American Cyanamid Company | Stabilization of somatotropins and other proteins by modification of cysteine residues |
| JP2849773B2 (ja) | 1990-08-27 | 1999-01-27 | 天野製薬株式会社 | ストレプトミセス属由来のトランスグルタミナーゼの製造法 |
| DK220890D0 (da) | 1990-09-14 | 1990-09-14 | Ole Buchardt | Fremgangsmaade til fremstilling af c-terminalt amiderede peptider |
| CA2405246A1 (en) | 1990-12-03 | 1992-06-11 | Genentech, Inc. | Enrichment method for variant proteins with alterred binding properties |
| IT1251895B (it) | 1991-09-27 | 1995-05-26 | Eniricerche Spa | Mutanti dell'ormone della crescita umano e loro impiego |
| EP0555649B1 (en) | 1992-01-14 | 2004-12-08 | Ajinomoto Co., Inc. | Gene encoding transglutaminase derived from fish |
| ZA936811B (en) | 1992-10-28 | 1995-03-15 | Upjohn Co | Somatotropin modifications |
| US5359030A (en) | 1993-05-10 | 1994-10-25 | Protein Delivery, Inc. | Conjugation-stabilized polypeptide compositions, therapeutic delivery and diagnostic formulations comprising same, and method of making and using the same |
| JP3758187B2 (ja) | 1994-01-28 | 2006-03-22 | 味の素株式会社 | マガキ由来のトランスグルタミナーゼ |
| DE69535037T2 (de) | 1994-08-26 | 2006-12-07 | Novozymes A/S | Mikrobielle transglutaminasen, ihre herstellung und ihre verwendung |
| EP0785276A4 (en) | 1994-09-29 | 2002-01-09 | Ajinomoto Kk | MODIFICATION OF A PEPTIDE AND A PROTEIN |
| DE4437604A1 (de) | 1994-10-21 | 1996-04-25 | Basf Ag | Konjugate aus einem Poly- oder Oligopeptid und einer niedermolekularen lipophilen Verbindung |
| WO1996022366A1 (en) | 1995-01-19 | 1996-07-25 | Novo Nordisk A/S | Transglutaminases from oomycetes |
| JP3669390B2 (ja) | 1995-02-09 | 2005-07-06 | 味の素株式会社 | バチルス属細菌由来のトランスグルタミナーゼ |
| US5869602A (en) | 1995-03-17 | 1999-02-09 | Novo Nordisk A/S | Peptide derivatives |
| CA2230492C (en) | 1995-09-21 | 2009-05-26 | Genentech, Inc. | Human growth hormone variants |
| US6268343B1 (en) | 1996-08-30 | 2001-07-31 | Novo Nordisk A/S | Derivatives of GLP-1 analogs |
| EP0929576A1 (en) | 1996-08-30 | 1999-07-21 | Novo Nordisk A/S | Glp-2 derivatives |
| US6458924B2 (en) | 1996-08-30 | 2002-10-01 | Novo Nordisk A/S | Derivatives of GLP-1 analogs |
| IL128332A0 (en) | 1996-08-30 | 2000-01-31 | Novo Nordisk As | GLP-1 derivatives |
| US6620916B1 (en) | 1996-09-26 | 2003-09-16 | Ajinomoto Co., Inc. | Modified physiologically active proteins and medicinal compositions containing the same |
| US5985627A (en) | 1997-02-28 | 1999-11-16 | Carlsberg Laboratory | Modified carboxypeptidase |
| ATE375363T1 (de) | 1997-07-14 | 2007-10-15 | Bolder Biotechnology Inc | Derivate des wachstumshormons und verwandte proteine |
| US6136536A (en) | 1997-10-29 | 2000-10-24 | Genetics Institute, Inc. | Rapid generation of stable mammalian cell lines producing high levels of recombinant proteins |
| EP1062240B1 (en) | 1998-02-27 | 2010-04-28 | Novo Nordisk A/S | N-terminally modified glp-1 derivatives |
| JP2003522099A (ja) | 1998-02-27 | 2003-07-22 | ノボ ノルディスク アクティーゼルスカブ | 遅延作用プロファイルを有するglp−1のglp−1誘導体及びエキセンジン |
| EP1061946B1 (en) | 1998-02-27 | 2004-04-28 | Novo Nordisk A/S | Glp-1 derivatives with helix-content exceeding 25 %, forming partially structured micellar-like aggregates |
| AU2610599A (en) | 1998-02-27 | 1999-09-15 | Novo Nordisk A/S | N-terminally truncated glp-1 derivatives |
| AU2712899A (en) | 1998-02-27 | 1999-09-15 | Novo Nordisk A/S | Glp-2 derivatives with helix-content exceeding 25 percent, forming partially structured micellar-like aggregates |
| US6656922B2 (en) | 1998-05-28 | 2003-12-02 | Mediplex Corporation, Korea | Oral delivery of macromolecules |
| US6358705B1 (en) | 1998-07-16 | 2002-03-19 | Novo Nordisk A/S | Method of making proteins in transformed yeast cells |
| DE69922043T2 (de) | 1998-12-07 | 2005-11-24 | Société de Conseils de Recherches et d'Applications Scientifiques S.A.S. | Glp-1 analoge |
| CA2363712C (en) | 1999-05-17 | 2011-05-10 | Conjuchem Inc. | Long lasting insulinotropic peptides |
| US6309663B1 (en) | 1999-08-17 | 2001-10-30 | Lipocine Inc. | Triglyceride-free compositions and methods for enhanced absorption of hydrophilic therapeutic agents |
| EP1198565A1 (en) | 1999-07-07 | 2002-04-24 | Maxygen Aps | A method for preparing modified polypeptides |
| EP1076066A1 (en) | 1999-07-12 | 2001-02-14 | Zealand Pharmaceuticals A/S | Peptides for lowering blood glucose levels |
| US6528486B1 (en) | 1999-07-12 | 2003-03-04 | Zealand Pharma A/S | Peptide agonists of GLP-1 activity |
| GB2355009A (en) | 1999-07-30 | 2001-04-11 | Univ Glasgow | Peptides conjugated to bile acids/salts |
| US20040001827A1 (en) | 2002-06-28 | 2004-01-01 | Dennis Mark S. | Serum albumin binding peptides for tumor targeting |
| WO2001051071A2 (en) | 2000-01-11 | 2001-07-19 | Novo Nordisk A/S | Transepithelial delivery of glp-1 derivatives |
| DE60138364D1 (de) | 2000-02-11 | 2009-05-28 | Bayer Healthcare Llc | Gerinnungsfaktor vii oder viia konjugate |
| US20020142964A1 (en) | 2000-11-02 | 2002-10-03 | Nissen Torben Lauesgaard | Single-chain polypeptides |
| BR0116024A (pt) | 2000-12-07 | 2005-12-13 | Lilly Co Eli | Proteìna de fusão heteróloga e uso da mesma |
| US20060183197A1 (en) | 2001-01-11 | 2006-08-17 | Andersen Kim V | Variant growth hormone molecules conjugated with macromolecules compounds |
| EP1352062A2 (en) | 2001-01-11 | 2003-10-15 | Maxygen Aps | Improved growth hormone molecules |
| FR2819810B1 (fr) | 2001-01-23 | 2004-05-28 | Pf Medicament | Peptides non glycosyles derives de la proteine g du vrs et leur utilisation dans un vaccin |
| US6858580B2 (en) | 2001-06-04 | 2005-02-22 | Nobex Corporation | Mixtures of drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same |
| AU2002316811A1 (en) | 2001-06-28 | 2003-03-03 | Novo Nordisk A/S | Stable formulation of modified glp-1 |
| JP2004537580A (ja) | 2001-08-10 | 2004-12-16 | エピックス メディカル, インコーポレイテッド | 延長された循環半減期を有するポリペプチド結合体 |
| AR036711A1 (es) | 2001-10-05 | 2004-09-29 | Bayer Corp | Peptidos que actuan como agonistas del receptor del glp-1 y como antagonistas del receptor del glucagon y sus metodos de uso farmacologico |
| AP2004003050A0 (en) | 2001-11-20 | 2004-06-30 | Pharmacia Corp | Chemically modified human growth hormone conjugates |
| JP2003199569A (ja) | 2001-12-17 | 2003-07-15 | Food Industry Research & Development Inst | ストレプトベルティシリウム・ラダカヌムのトランスグルタミナーゼ遺伝子及び該遺伝子によってコードされるトランスグルタミナーゼ |
| US20050100963A1 (en) | 2002-03-01 | 2005-05-12 | Dyax Corporation | KDR and VEGF/KDR binding peptides and their use in diagnosis and therapy |
| IL164266A0 (en) | 2002-04-10 | 2005-12-18 | Lilly Co Eli | Treatment of gastroparesis |
| SI1499719T1 (sl) | 2002-04-30 | 2011-03-31 | Bayer Healthcare Llc | Polipeptidne variante faktorja VII ali VIIa |
| DE60332358D1 (de) | 2002-09-09 | 2010-06-10 | Hanall Pharmaceutical Co Ltd | Protease-resistente modifizierte interferon alpha polypeptide |
| US20060018972A1 (en) * | 2002-11-26 | 2006-01-26 | Upm Pharmaceuticals, Inc. | Aqueous sustained-release drug delivery system for highly water-soluble electrolytic drugs |
| JP2007524579A (ja) | 2003-02-19 | 2007-08-30 | ソシエテ・ドゥ・コンセイユ・ドゥ・ルシェルシュ・エ・ダプリカーション・シャンティフィック・エス・ア・エス | Glp−1の類似体 |
| BRPI0409976A (pt) | 2003-05-09 | 2006-05-09 | Novo Nordisk As | composto, métodos para retardar a progressão de igt diabetes do tipo 2, para retardar a progressão de diabetes do tipo 2 para diabetes que requer insulina, para tratar obesidade ou prevenir excesso de peso para regular o apetite para induzir saciedade, para prevenir ganho de peso após se ter tido sucesso em perder peso, para aumentar dispêndio de energia, para tratar uma doença ou estado e para tratar bulimia, composição farmacêutica, e, uso de um composto |
| EP1503283A1 (en) * | 2003-08-01 | 2005-02-02 | Hewlett-Packard Development Company, L.P. | Data processing system and method |
| EP1654004A2 (en) | 2003-08-08 | 2006-05-10 | Novo Nordisk A/S | Synthesis and application of new structural well defined branched polymers as conjugating agents for peptides |
| KR101241862B1 (ko) * | 2003-09-19 | 2013-03-13 | 노보 노르디스크 에이/에스 | 신규 glp-1 유도체 |
| RU2401276C2 (ru) | 2003-09-19 | 2010-10-10 | Ново Нордиск А/С | Производные глюкагон-подобного пептида-1 (glp-1) |
| JP2007537981A (ja) | 2003-09-19 | 2007-12-27 | ノボ ノルディスク アクティーゼルスカブ | 新規の血漿タンパク質親和性タグ |
| CN100580087C (zh) | 2003-10-10 | 2010-01-13 | 诺和诺德医疗保健公司 | 肽的缀合 |
| MXPA06006745A (es) | 2003-12-18 | 2006-08-18 | Novo Nordisk As | Compuestos glp-1 novedosos. |
| JP2007537142A (ja) | 2003-12-18 | 2007-12-20 | ノボ ノルディスク アクティーゼルスカブ | アルブミン様物質に結合した新規のglp−1類似物 |
| WO2005077407A1 (en) * | 2004-01-16 | 2005-08-25 | Barnes-Jewish Hospital | Targeted atherosclerosis treatment |
| EP2033662B1 (en) | 2004-01-21 | 2012-10-17 | Novo Nordisk Health Care AG | Transglutaminase mediated conjugation of peptides |
| US20070105770A1 (en) * | 2004-01-21 | 2007-05-10 | Novo Nordisk A/S | Transglutaminase mediated conjugation of peptides |
| US7906137B2 (en) | 2004-05-21 | 2011-03-15 | Mediplex Corporation, Korea | Delivery agents for enhancing mucosal absorption of therapeutic agents |
| MXPA06015049A (es) | 2004-07-08 | 2007-02-08 | Novo Nordisk As | Marcadores prolongadores de polipeptidos que comprenden una porcion tetrazol. |
| JP2008507990A (ja) | 2004-08-02 | 2008-03-21 | ノボ ノルディスク ヘルス ケア アクチェンゲゼルシャフト | Fviiの抱合体 |
| JP2008511610A (ja) | 2004-08-31 | 2008-04-17 | ファルマシア・アンド・アップジョン・カンパニー・エルエルシー | グリセロール分岐のポリエチレングリコール−ヒト成長ホルモン結合体、それらの製造方法及び使用方法 |
| US7893017B2 (en) | 2004-10-07 | 2011-02-22 | Novo Nordisk A/S | Protracted GLP-1 compounds |
| US7998930B2 (en) | 2004-11-04 | 2011-08-16 | Hanall Biopharma Co., Ltd. | Modified growth hormones |
| JP5755398B2 (ja) | 2005-03-18 | 2015-07-29 | ノヴォ ノルディスク アー/エス | 伸長されたglp−1化合物 |
| WO2006097536A2 (en) | 2005-03-18 | 2006-09-21 | Novo Nordisk A/S | Dimeric peptide agonists of the glp-1 receptor |
| TWI372629B (en) | 2005-03-18 | 2012-09-21 | Novo Nordisk As | Acylated glp-1 compounds |
| RU2007145085A (ru) * | 2005-06-15 | 2009-07-20 | Ново Нордиск Хелс Кеа Аг (Ch) | Опосредованное трансглютаминазой коньюгирование гормона роста |
| EP1893632B1 (en) | 2005-06-17 | 2015-08-12 | Novo Nordisk Health Care AG | Selective reduction and derivatization of engineered factor vii proteins comprising at least one non-native cysteine |
| CN101263225A (zh) | 2005-08-18 | 2008-09-10 | 诺沃-诺迪斯克保健股份有限公司 | 改进转谷氨酰胺酶的底物特异性 |
| JP5486809B2 (ja) | 2006-02-14 | 2014-05-07 | ノボ ノルディスク ヘルス ケア アーゲー | C末端におけるポリペプチドの結合 |
| KR100739988B1 (ko) * | 2006-06-28 | 2007-07-16 | 주식회사 하이닉스반도체 | 플래쉬 메모리 소자의 제조방법 |
| EP2046736B1 (en) | 2006-07-27 | 2019-06-12 | Emisphere Technologies, Inc. | Arylsulfanyl compounds and compositions for delivering active agents |
| JP2010500886A (ja) | 2006-08-18 | 2010-01-14 | ノボ ノルディスク ヘルス ケア アーゲー | 改善された特異性を有するトランスグルタミナーゼ変異体 |
| US20080095837A1 (en) | 2006-08-31 | 2008-04-24 | Emisphere Technologies, Inc. | Human growth hormone formulations |
| AU2007289344B2 (en) | 2006-08-31 | 2011-04-14 | Novartis Ag | Pharmaceutical compositions comprising hGH for oral delivery |
| JP5390404B2 (ja) | 2007-02-16 | 2014-01-15 | エミスフェアー・テクノロジーズ・インク | 活性薬剤を送達するための環状部分を有する化合物及び組成物 |
| US20100261637A1 (en) * | 2007-09-05 | 2010-10-14 | Novo Nordisk A/S | Peptides derivatized with a-b-c-d- and their therapeutical use |
| KR20110039348A (ko) | 2008-08-06 | 2011-04-15 | 노보 노르디스크 헬스 케어 악티엔게젤샤프트 | 연장된 생체내 효능을 가지는 콘쥬게이트된 단백질 |
| US8637647B2 (en) | 2008-09-12 | 2014-01-28 | Novo Nordisk A/S | Method of acylating a peptide or protein |
| JP5816097B2 (ja) | 2009-01-22 | 2015-11-18 | ノヴォ・ノルディスク・ヘルス・ケア・アーゲー | 安定な成長ホルモン化合物 |
| EP2398822B1 (en) | 2009-02-19 | 2013-01-02 | Novo Nordisk A/S | Modification of factor viii |
| JP6086528B2 (ja) * | 2009-08-06 | 2017-03-01 | ノヴォ・ノルディスク・ヘルス・ケア・アーゲー | 長期のインビボ有効性を有する成長ホルモン |
| CN118767117A (zh) * | 2010-01-22 | 2024-10-15 | 诺沃—诺迪斯克保健股份有限公司 | 体内功效延长的生长激素 |
-
2010
- 2010-08-06 JP JP2012523348A patent/JP6086528B2/ja active Active
- 2010-08-06 CN CN2010800357644A patent/CN102612376A/zh active Pending
- 2010-08-06 WO PCT/EP2010/061473 patent/WO2011015649A1/en not_active Ceased
- 2010-08-06 EP EP10743085.2A patent/EP2461831B1/en active Active
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-
2020
- 2020-04-28 US US16/860,703 patent/US20200306382A1/en not_active Abandoned
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1867360A (zh) * | 2003-09-19 | 2006-11-22 | 诺沃挪第克公司 | 治疗肽的清蛋白结合型衍生物 |
| CN101495155A (zh) * | 2006-07-07 | 2009-07-29 | 诺沃-诺迪斯克保健股份有限公司 | 新的蛋白结合物及其制备方法 |
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| JP2016190871A (ja) | 2016-11-10 |
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| US8841249B2 (en) | 2014-09-23 |
| EP2461831B1 (en) | 2018-11-21 |
| CN105963710A (zh) | 2016-09-28 |
| EP2461831A1 (en) | 2012-06-13 |
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| US20180221501A1 (en) | 2018-08-09 |
| US20120172303A1 (en) | 2012-07-05 |
| US20200306382A1 (en) | 2020-10-01 |
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