CN102612362A - 脂质运载蛋白突变蛋白的控制释放制剂 - Google Patents

脂质运载蛋白突变蛋白的控制释放制剂 Download PDF

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Publication number
CN102612362A
CN102612362A CN2010800348503A CN201080034850A CN102612362A CN 102612362 A CN102612362 A CN 102612362A CN 2010800348503 A CN2010800348503 A CN 2010800348503A CN 201080034850 A CN201080034850 A CN 201080034850A CN 102612362 A CN102612362 A CN 102612362A
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lipocalin
protein
pharmaceutical composition
polymer
lipocalin protein
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Chinese (zh)
Inventor
A·霍尔鲍姆
M·胡尔斯迈尔
H·吉勒
S·B·曼特里普拉加达
K·M·坎贝尔
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Allergan Inc
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Pieris AG
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Priority to CN201610084958.2A priority Critical patent/CN106139123A/zh
Publication of CN102612362A publication Critical patent/CN102612362A/zh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
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    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
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    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
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    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
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    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy

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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Molecular Biology (AREA)
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  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Dermatology (AREA)
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  • Heart & Thoracic Surgery (AREA)
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  • Wood Science & Technology (AREA)
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  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
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CN2010800348503A 2009-08-05 2010-08-05 脂质运载蛋白突变蛋白的控制释放制剂 Pending CN102612362A (zh)

Priority Applications (1)

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CN201610084958.2A CN106139123A (zh) 2009-08-05 2010-08-05 脂质运载蛋白突变蛋白的控制释放制剂

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US23136509P 2009-08-05 2009-08-05
US61/231,365 2009-08-05
PCT/EP2010/061436 WO2011015634A2 (en) 2009-08-05 2010-08-05 Controlled release formulations of lipocalin muteins

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CN201610084958.2A Pending CN106139123A (zh) 2009-08-05 2010-08-05 脂质运载蛋白突变蛋白的控制释放制剂

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US (1) US20120201873A1 (enExample)
EP (2) EP2461800A2 (enExample)
JP (2) JP2013501033A (enExample)
KR (1) KR20120099371A (enExample)
CN (2) CN102612362A (enExample)
AU (2) AU2010280688A1 (enExample)
BR (1) BR112012002709A2 (enExample)
CA (1) CA2770149A1 (enExample)
IN (1) IN2012DN00407A (enExample)
RU (1) RU2012107812A (enExample)
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CN109462982A (zh) * 2016-02-16 2019-03-12 斯特朗布里奇都柏林有限公司 生理条件下具有较差溶解度的维多瑞肽用于治疗肢端肥大症、肢端肥大症癌症、sst-r5表达型肿瘤、ii型糖尿病、高血糖症和激素相关肿瘤

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