CN102586170B - 前原条和中内胚层细胞 - Google Patents

前原条和中内胚层细胞 Download PDF

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Publication number
CN102586170B
CN102586170B CN201210020574.6A CN201210020574A CN102586170B CN 102586170 B CN102586170 B CN 102586170B CN 201210020574 A CN201210020574 A CN 201210020574A CN 102586170 B CN102586170 B CN 102586170B
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China
Prior art keywords
cells
expression
mesendoderm
cell
hours
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Expired - Lifetime
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CN201210020574.6A
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English (en)
Chinese (zh)
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CN102586170A (zh
Inventor
凯文·艾伦·达穆尔
艾伦·D·阿古尼克
苏珊·埃利泽
依文特·克鲁恩
伊曼纽尔·E·贝特格
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Viacit Corp
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Viacit Corp
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Priority claimed from US11/021,618 external-priority patent/US7510876B2/en
Application filed by Viacit Corp filed Critical Viacit Corp
Priority claimed from CNA2005800300838A external-priority patent/CN101014702A/zh
Publication of CN102586170A publication Critical patent/CN102586170A/zh
Application granted granted Critical
Publication of CN102586170B publication Critical patent/CN102586170B/zh
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0603—Embryonic cells ; Embryoid bodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0603—Embryonic cells ; Embryoid bodies
    • C12N5/0606—Pluripotent embryonic cells, e.g. embryonic stem cells [ES]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/90—Serum-free medium, which may still contain naturally-sourced components
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/16—Activin; Inhibin; Mullerian inhibiting substance
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/02—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from embryonic cells

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Gynecology & Obstetrics (AREA)
  • Developmental Biology & Embryology (AREA)
  • Reproductive Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Materials For Medical Uses (AREA)
CN201210020574.6A 2004-07-09 2005-07-08 前原条和中内胚层细胞 Expired - Lifetime CN102586170B (zh)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US58656604P 2004-07-09 2004-07-09
US60/586,566 2004-07-09
US58794204P 2004-07-14 2004-07-14
US60/587,942 2004-07-14
US11/021,618 2004-12-23
US11/021,618 US7510876B2 (en) 2003-12-23 2004-12-23 Definitive endoderm
US69336405P 2005-06-23 2005-06-23
US60/693,364 2005-06-23
CNA2005800300838A CN101014702A (zh) 2004-07-09 2005-07-08 前原条和中内胚层细胞

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CNA2005800300838A Division CN101014702A (zh) 2004-07-09 2005-07-08 前原条和中内胚层细胞

Publications (2)

Publication Number Publication Date
CN102586170A CN102586170A (zh) 2012-07-18
CN102586170B true CN102586170B (zh) 2019-11-29

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
CN201210020574.6A Expired - Lifetime CN102586170B (zh) 2004-07-09 2005-07-08 前原条和中内胚层细胞

Country Status (10)

Country Link
EP (2) EP3505622A1 (https=)
JP (7) JP5433879B2 (https=)
CN (1) CN102586170B (https=)
AU (1) AU2005271944B2 (https=)
CA (1) CA2573354C (https=)
DK (2) DK1773986T3 (https=)
ES (2) ES2754038T3 (https=)
MX (1) MX2007000317A (https=)
NZ (1) NZ582597A (https=)
WO (1) WO2006017134A2 (https=)

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US7625753B2 (en) 2003-12-23 2009-12-01 Cythera, Inc. Expansion of definitive endoderm cells
US8647873B2 (en) 2004-04-27 2014-02-11 Viacyte, Inc. PDX1 expressing endoderm
CN103898047B (zh) 2003-12-23 2020-03-03 维亚希特公司 定形内胚层
US7985585B2 (en) 2004-07-09 2011-07-26 Viacyte, Inc. Preprimitive streak and mesendoderm cells
US8586357B2 (en) 2003-12-23 2013-11-19 Viacyte, Inc. Markers of definitive endoderm
US7541185B2 (en) 2003-12-23 2009-06-02 Cythera, Inc. Methods for identifying factors for differentiating definitive endoderm
US20050266554A1 (en) 2004-04-27 2005-12-01 D Amour Kevin A PDX1 expressing endoderm
US8187878B2 (en) 2004-08-13 2012-05-29 University Of Georgia Research Foundation, Inc. Methods for increasing definitive endoderm differentiation of pluripotent human embryonic stem cells with PI-3 kinase inhibitors
AU2005322007B2 (en) * 2004-12-23 2011-06-30 Viacyte, Inc. Expansion of definitive endoderm cells
FI20055398A0 (fi) 2005-07-08 2005-07-08 Suomen Punainen Risti Veripalv Menetelmä solupopulaatioiden evaluoimiseksi
WO2007051038A2 (en) 2005-10-27 2007-05-03 Cythera, Inc. Pdx1-expressing dorsal and ventral foregut endoderm
SG170021A1 (en) 2006-02-23 2011-04-29 Novocell Inc Compositions and methods useful for culturing differentiable cells
US7695965B2 (en) 2006-03-02 2010-04-13 Cythera, Inc. Methods of producing pancreatic hormones
US11254916B2 (en) 2006-03-02 2022-02-22 Viacyte, Inc. Methods of making and using PDX1-positive pancreatic endoderm cells
JP6110048B2 (ja) 2006-03-02 2017-04-05 ヴィアサイト，インコーポレイテッド 内分泌前駆細胞、膵臓ホルモン発現細胞及びそれらの製造方法
AU2007277364B2 (en) 2006-07-26 2010-08-12 Viacyte, Inc. Methods of producing pancreatic hormones
WO2008048647A1 (en) * 2006-10-17 2008-04-24 Cythera, Inc. Modulation of the phosphatidylinositol-3-kinase pathway in the differentiation of human embryonic stem cells
US7695963B2 (en) 2007-09-24 2010-04-13 Cythera, Inc. Methods for increasing definitive endoderm production
US8895300B2 (en) 2008-11-04 2014-11-25 Viacyte, Inc. Scalable primate pluripotent stem cell aggregate suspension culture and differentiation thereof
US8008075B2 (en) 2008-11-04 2011-08-30 Viacyte, Inc. Stem cell aggregate suspension compositions and methods of differentiation thereof
JP2012508584A (ja) 2008-11-14 2012-04-12 ヴィアサイト，インコーポレイテッド ヒト多能性幹細胞由来膵臓細胞のカプセル化
JP5694946B2 (ja) * 2008-12-03 2015-04-01 インターナショナル ステム セル コーポレイション 幹細胞から分化細胞を得る方法
EP3976236A1 (en) 2019-05-31 2022-04-06 W.L. Gore & Associates Inc. A biocompatible membrane composite
CA3139292C (en) 2019-05-31 2025-06-10 Viacyte, Inc. CELL ENCAPSULATION DEVICES WITH REGULATED OXYGEN DIFFUSION DISTANCES
CN114173837A (zh) 2019-05-31 2022-03-11 W.L.戈尔及同仁股份有限公司 生物相容性膜复合材料
EP3975926A1 (en) 2019-05-31 2022-04-06 W.L. Gore & Associates, Inc. A biocompatible membrane composite
CN116057185A (zh) 2020-08-15 2023-05-02 雷杰纳荣制药公司 治疗具有编码降钙素受体(calcr)的变体核酸分子的受试者的肥胖症

Citations (1)

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CN1439049A (zh) * 2000-04-27 2003-08-27 杰龙公司 衍生自多能干细胞的肝细胞谱系细胞

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Also Published As

Publication number Publication date
JP2016119919A (ja) 2016-07-07
CA2573354C (en) 2015-02-24
JP2008505643A (ja) 2008-02-28
ES2716827T3 (es) 2019-06-17
JP5433879B2 (ja) 2014-03-05
EP1773986B1 (en) 2019-01-16
ES2754038T3 (es) 2020-04-15
CN102586170A (zh) 2012-07-18
JP5956388B2 (ja) 2016-07-27
JP6077044B2 (ja) 2017-02-08
JP7161665B2 (ja) 2022-10-27
JP2022142795A (ja) 2022-09-30
DK2341147T3 (da) 2019-11-11
JP2018027099A (ja) 2018-02-22
JP2020103321A (ja) 2020-07-09
WO2006017134A3 (en) 2007-01-18
EP1773986A2 (en) 2007-04-18
DK1773986T3 (en) 2019-04-08
JP6473708B2 (ja) 2019-02-20
JP7525102B2 (ja) 2024-07-30
AU2005271944A1 (en) 2006-02-16
NZ582597A (en) 2011-08-26
JP2013212121A (ja) 2013-10-17
CA2573354A1 (en) 2006-02-16
WO2006017134A2 (en) 2006-02-16
JP6777620B2 (ja) 2020-10-28
JP2015130889A (ja) 2015-07-23
EP3505622A1 (en) 2019-07-03
MX2007000317A (es) 2007-03-26
AU2005271944B2 (en) 2012-02-16

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