CN102510761B - 用于药物递送装置的组件和指示器 - Google Patents
用于药物递送装置的组件和指示器 Download PDFInfo
- Publication number
- CN102510761B CN102510761B CN201080042506.9A CN201080042506A CN102510761B CN 102510761 B CN102510761 B CN 102510761B CN 201080042506 A CN201080042506 A CN 201080042506A CN 102510761 B CN102510761 B CN 102510761B
- Authority
- CN
- China
- Prior art keywords
- indicator
- piston rod
- indicating positions
- ratchet
- assembly
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
- A61M5/31576—Constructional features or modes of drive mechanisms for piston rods
- A61M5/31583—Constructional features or modes of drive mechanisms for piston rods based on rotational translation, i.e. movement of piston rod is caused by relative rotation between the user activated actuator and the piston rod
- A61M5/31585—Constructional features or modes of drive mechanisms for piston rods based on rotational translation, i.e. movement of piston rod is caused by relative rotation between the user activated actuator and the piston rod performed by axially moving actuator, e.g. an injection button
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/3146—Priming, e.g. purging, reducing backlash or clearance
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31533—Dosing mechanisms, i.e. setting a dose
- A61M5/31545—Setting modes for dosing
- A61M5/31548—Mechanically operated dose setting member
- A61M5/31555—Mechanically operated dose setting member by purely axial movement of dose setting member, e.g. during setting or filling of a syringe
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
- A61M5/3159—Dose expelling manners
- A61M5/31593—Multi-dose, i.e. individually set dose repeatedly administered from the same medicament reservoir
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M2005/3125—Details specific display means, e.g. to indicate dose setting
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/58—Means for facilitating use, e.g. by people with impaired vision
- A61M2205/583—Means for facilitating use, e.g. by people with impaired vision by visual feedback
- A61M2205/584—Means for facilitating use, e.g. by people with impaired vision by visual feedback having a color code
Landscapes
- Health & Medical Sciences (AREA)
- Vascular Medicine (AREA)
- Engineering & Computer Science (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP09171134 | 2009-09-23 | ||
| EP09171134.1 | 2009-09-23 | ||
| PCT/EP2010/063842 WO2011036134A2 (en) | 2009-09-23 | 2010-09-21 | Assembly and indicator for a drug delivery device |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102510761A CN102510761A (zh) | 2012-06-20 |
| CN102510761B true CN102510761B (zh) | 2014-07-16 |
Family
ID=41682306
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201080042506.9A Active CN102510761B (zh) | 2009-09-23 | 2010-09-21 | 用于药物递送装置的组件和指示器 |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US9511193B2 (https=) |
| EP (1) | EP2480268B1 (https=) |
| JP (1) | JP5875982B2 (https=) |
| CN (1) | CN102510761B (https=) |
| AU (1) | AU2010299934B2 (https=) |
| BR (1) | BR112012006516B1 (https=) |
| CA (1) | CA2772686C (https=) |
| DK (1) | DK2480268T3 (https=) |
| ES (1) | ES2603749T3 (https=) |
| HU (1) | HUE031031T2 (https=) |
| IL (1) | IL218493A (https=) |
| PL (1) | PL2480268T3 (https=) |
| WO (1) | WO2011036134A2 (https=) |
Families Citing this family (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3993169B2 (ja) | 2002-02-11 | 2007-10-17 | アンタレス・ファーマ・インコーポレーテッド | 皮内注射器 |
| WO2006083876A2 (en) | 2005-02-01 | 2006-08-10 | Intelliject, Llc | Devices, systems, and methods for medicament delivery |
| JP5216328B2 (ja) | 2005-01-24 | 2013-06-19 | アンタレス ファーマ インコーポレイテッド | あらかじめ充填された針補助シリンジジェット式注射器 |
| US9022980B2 (en) | 2005-02-01 | 2015-05-05 | Kaleo, Inc. | Medical injector simulation device |
| US8206360B2 (en) | 2005-02-01 | 2012-06-26 | Intelliject, Inc. | Devices, systems and methods for medicament delivery |
| US8231573B2 (en) | 2005-02-01 | 2012-07-31 | Intelliject, Inc. | Medicament delivery device having an electronic circuit system |
| US8361026B2 (en) | 2005-02-01 | 2013-01-29 | Intelliject, Inc. | Apparatus and methods for self-administration of vaccines and other medicaments |
| WO2007131013A1 (en) | 2006-05-03 | 2007-11-15 | Antares Pharma, Inc. | Two-stage reconstituting injector |
| US9144648B2 (en) | 2006-05-03 | 2015-09-29 | Antares Pharma, Inc. | Injector with adjustable dosing |
| EP2268342B1 (en) | 2008-03-10 | 2015-09-16 | Antares Pharma, Inc. | Injector safety device |
| USD994111S1 (en) | 2008-05-12 | 2023-08-01 | Kaleo, Inc. | Medicament delivery device cover |
| EP3581224A1 (en) | 2008-08-05 | 2019-12-18 | Antares Pharma, Inc. | Multiple dosage injector |
| CN102612381B (zh) | 2009-03-20 | 2015-09-09 | 安塔瑞斯制药公司 | 危险试剂注入系统 |
| US9084849B2 (en) | 2011-01-26 | 2015-07-21 | Kaleo, Inc. | Medicament delivery devices for administration of a medicament within a prefilled syringe |
| US8939943B2 (en) | 2011-01-26 | 2015-01-27 | Kaleo, Inc. | Medicament delivery device for administration of opioid antagonists including formulations for naloxone |
| US8627816B2 (en) | 2011-02-28 | 2014-01-14 | Intelliject, Inc. | Medicament delivery device for administration of opioid antagonists including formulations for naloxone |
| US8496619B2 (en) | 2011-07-15 | 2013-07-30 | Antares Pharma, Inc. | Injection device with cammed ram assembly |
| US9220660B2 (en) | 2011-07-15 | 2015-12-29 | Antares Pharma, Inc. | Liquid-transfer adapter beveled spike |
| WO2013134244A2 (en) | 2012-03-06 | 2013-09-12 | Antares Pharma, Inc. | Prefilled syringe with breakaway force feature |
| KR20150011346A (ko) | 2012-04-06 | 2015-01-30 | 안타레스 팔마, 인코퍼레이티드 | 테스토스테론 조성물의 바늘-보조식 젯 주입 투여 장치 및 방법 |
| US9364610B2 (en) | 2012-05-07 | 2016-06-14 | Antares Pharma, Inc. | Injection device with cammed ram assembly |
| US9522235B2 (en) | 2012-05-22 | 2016-12-20 | Kaleo, Inc. | Devices and methods for delivering medicaments from a multi-chamber container |
| CA2896708A1 (en) | 2012-12-27 | 2014-07-03 | Kaleo, Inc. | Devices, systems and methods for locating and interacting with medicament delivery systems |
| ES2969984T3 (es) | 2013-02-11 | 2024-05-23 | Antares Pharma Inc | Dispositivo de inyección por chorro asistido por aguja que tiene fuerza de disparo reducida |
| JP6030803B2 (ja) | 2013-03-11 | 2016-11-24 | アンタレス・ファーマ・インコーポレーテッド | ピニオンシステムを有する用量注射器 |
| WO2014165136A1 (en) | 2013-03-12 | 2014-10-09 | Antares Pharma, Inc. | Constant volume prefilled syringes and kits thereof |
| JP6307528B2 (ja) * | 2013-03-14 | 2018-04-04 | ノートン・ヘルスケア・リミテッド | 医療器具のための投薬機構 |
| EP2968787B1 (en) * | 2013-03-14 | 2020-04-29 | Norton Healthcare Limited | Dispensing mechanism for a medical device |
| GB2511806A (en) | 2013-03-14 | 2014-09-17 | Norton Healthcare Ltd | Dispensing mechanism for a medical device |
| MX2015012901A (es) | 2013-03-14 | 2016-04-04 | Norton Healthcare Ltd | Mecanismo de dispensacion para un dispositivo medico. |
| AR097610A1 (es) * | 2013-09-03 | 2016-04-06 | Sanofi Sa | Mecanismo para un dispositivo de administración de medicamento, y dispositivo de administración de medicamento que comprende el mecanismo |
| US9517307B2 (en) | 2014-07-18 | 2016-12-13 | Kaleo, Inc. | Devices and methods for delivering opioid antagonists including formulations for naloxone |
| EP3242698A1 (en) * | 2015-01-08 | 2017-11-15 | Novo Nordisk A/S | Drug injection device with visual end-of-contents indicator system |
| EP3274021B1 (en) | 2015-03-24 | 2024-02-14 | Kaleo, Inc. | Devices and methods for delivering a lyophilized medicament |
| JP6830067B2 (ja) | 2015-06-30 | 2021-02-17 | カレオ,インコーポレイテッド | プレフィルドシリンジ内の医薬を投与する自動注射器 |
| WO2018119218A1 (en) | 2016-12-23 | 2018-06-28 | Kaleo, Inc. | Medicament delivery device and methods for delivering drugs to infants and children |
| JP2020507841A (ja) | 2017-01-17 | 2020-03-12 | カレオ,インコーポレイテッド | 無線接続及び事象検出を伴う薬剤送達デバイス |
| US11400227B2 (en) * | 2017-04-07 | 2022-08-02 | Novo Nordisk A/S | End-of-content mechanism |
| WO2020018433A1 (en) | 2018-07-16 | 2020-01-23 | Kaleo, Inc. | Medicament delivery devices with wireless connectivity and compliance detection |
| US12478739B2 (en) | 2018-12-29 | 2025-11-25 | Kaleo, Inc. | Devices and methods for delivery of substances within a prefilled syringe |
| WO2021030210A1 (en) | 2019-08-09 | 2021-02-18 | Kaleo, Inc. | Devices and methods for delivery of substances within a prefilled syringe |
| US12268847B1 (en) | 2021-02-10 | 2025-04-08 | Kaleo, Inc. | Devices and methods for delivery of substances within a medicament container |
| WO2026052878A1 (en) * | 2024-09-09 | 2026-03-12 | Sanofi | Drug delivery device |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1035055A (zh) * | 1988-02-10 | 1989-08-30 | D.C.Paf1988有限公司 | 用于施以定量液体的剂量装置 |
| US6030363A (en) * | 1994-12-02 | 2000-02-29 | Science Incorporated | Medicament dispenser |
| CN1933864A (zh) * | 2004-03-30 | 2007-03-21 | 伊莱利利公司 | 具有由最终药剂的给药激活的弹簧驱动锁定零件的药物分配设备 |
| WO2008154616A1 (en) * | 2007-06-12 | 2008-12-18 | Becton, Dickinson And Company | Syringe with disabling mechanism |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US533575A (en) | 1895-02-05 | wilkens | ||
| US2695023A (en) * | 1952-01-04 | 1954-11-23 | Pfizer & Co C | Hypodermic syringe |
| CH548212A (de) * | 1972-08-03 | 1974-04-30 | Compaselect Gmbh | Injektionsspritze. |
| DE3715340C2 (de) * | 1987-05-08 | 1995-10-19 | Haselmeier Wilhelm Fa | Injektionsgerät |
| US4973318A (en) * | 1988-02-10 | 1990-11-27 | D.C.P. Af 1988 A/S | Disposable syringe |
| US5226895A (en) | 1989-06-05 | 1993-07-13 | Eli Lilly And Company | Multiple dose injection pen |
| GB9007113D0 (en) | 1990-03-29 | 1990-05-30 | Sams Bernard | Dispensing device |
| DK0525525T3 (da) | 1991-07-24 | 1995-10-02 | Medico Dev Investment Co | Injektor |
| DK175491D0 (da) | 1991-10-18 | 1991-10-18 | Novo Nordisk As | Apparat |
| US5279585A (en) | 1992-02-04 | 1994-01-18 | Becton, Dickinson And Company | Medication delivery pen having improved dose delivery features |
| US5391157A (en) * | 1992-10-20 | 1995-02-21 | Eli Lilly And Company | End of dose indicator |
| US5320609A (en) | 1992-12-07 | 1994-06-14 | Habley Medical Technology Corporation | Automatic pharmaceutical dispensing syringe |
| US5383865A (en) | 1993-03-15 | 1995-01-24 | Eli Lilly And Company | Medication dispensing device |
| ZA941881B (en) | 1993-04-02 | 1995-09-18 | Lilly Co Eli | Manifold medication injection apparatus and method |
| US5582598A (en) | 1994-09-19 | 1996-12-10 | Becton Dickinson And Company | Medication delivery pen with variable increment dose scale |
| CA2206734A1 (en) * | 1994-12-02 | 1996-06-06 | Science Incorporated | Medicament dispenser |
| JP3568959B2 (ja) | 1995-03-07 | 2004-09-22 | イーライ・リリー・アンド・カンパニー | 再利用可能な投薬装置 |
| US5674204A (en) | 1995-09-19 | 1997-10-07 | Becton Dickinson And Company | Medication delivery pen cap actuated dose delivery clutch |
| US5688251A (en) | 1995-09-19 | 1997-11-18 | Becton Dickinson And Company | Cartridge loading and priming mechanism for a pen injector |
| US6110149A (en) | 1996-09-13 | 2000-08-29 | Novo Nordisk A/S | Syringe |
| DE19730999C1 (de) | 1997-07-18 | 1998-12-10 | Disetronic Licensing Ag | Dosierknopfsicherung an einer Vorrichtung zur dosierten Verabreichung eines injizierbaren Produkts |
| US5921966A (en) | 1997-08-11 | 1999-07-13 | Becton Dickinson And Company | Medication delivery pen having an improved clutch assembly |
| DE69900026T2 (de) | 1998-01-30 | 2001-05-10 | Novo Nordisk As | Eine injektionsspritze |
| US5961495A (en) | 1998-02-20 | 1999-10-05 | Becton, Dickinson And Company | Medication delivery pen having a priming mechanism |
| US6221053B1 (en) | 1998-02-20 | 2001-04-24 | Becton, Dickinson And Company | Multi-featured medication delivery pen |
| US6248095B1 (en) | 1998-02-23 | 2001-06-19 | Becton, Dickinson And Company | Low-cost medication delivery pen |
| JP2000070368A (ja) * | 1998-08-27 | 2000-03-07 | Shimadzu Corp | 針無注射器 |
| CA2378325C (en) | 1999-08-05 | 2008-09-30 | Becton, Dickinson And Company | Medication delivery pen |
| GB0002095D0 (en) * | 2000-01-28 | 2000-03-22 | Novartis Ag | Device |
| GB0007071D0 (en) | 2000-03-24 | 2000-05-17 | Sams Bernard | One-way clutch mechanisms and injector devices |
| US6663602B2 (en) | 2000-06-16 | 2003-12-16 | Novo Nordisk A/S | Injection device |
| US6899699B2 (en) | 2001-01-05 | 2005-05-31 | Novo Nordisk A/S | Automatic injection device with reset feature |
| DK2258424T3 (da) | 2001-05-16 | 2013-02-18 | Lilly Co Eli | Indretning til injektion af lægemidler |
| GB0200444D0 (en) * | 2002-01-10 | 2002-02-27 | Owen Mumford Ltd | Improvements relating to medical injection devices |
| JP2005532129A (ja) | 2002-07-10 | 2005-10-27 | ノボ・ノルデイスク・エー/エス | 投与量設定リミッタを備える注入器 |
| DE10232411A1 (de) * | 2002-07-17 | 2004-02-05 | Disetronic Licensing Ag | Verabreichungsgerät mit verstellbarem Dosieranschlag |
| US7112187B2 (en) * | 2002-09-24 | 2006-09-26 | Shl Medical Ab | Injecting device |
| GB0304823D0 (en) | 2003-03-03 | 2003-04-09 | Dca Internat Ltd | Improvements in and relating to a pen-type injector |
| GB2410188B (en) * | 2004-01-23 | 2006-01-25 | Medical House Plc | Injection device |
| HUE045180T2 (hu) * | 2004-03-30 | 2019-12-30 | Lilly Co Eli | Gyógyszeradagoló készülék az utolsó adag beadása által aktivált rugós zárolófunkcióval |
| DE102004063648A1 (de) * | 2004-12-31 | 2006-07-20 | Tecpharma Licensing Ag | Injektions- oder Infusionsgerät mit Lebensdauer-Ermittlungseinrichtung |
| WO2006130491A2 (en) * | 2005-05-27 | 2006-12-07 | Stryker Corporation | Hand-held fluid delivery device with sensors to determine fluid pressure and volume of fluid delivered to intervertebral discs during discography |
| US7304603B2 (en) | 2006-02-17 | 2007-12-04 | Science, Engineering And Technology Associates Corporation | Radar apparatus and processing method for detecting human carried explosive devices |
| HUE060243T2 (hu) | 2006-09-15 | 2023-02-28 | Ypsomed Ag | Injekciós eszköz továbbfejlesztett továbbítóelemmel |
| US8647309B2 (en) * | 2008-05-02 | 2014-02-11 | Sanofi-Aventis Deutschland Gmbh | Medication delivery device |
-
2010
- 2010-09-21 AU AU2010299934A patent/AU2010299934B2/en active Active
- 2010-09-21 HU HUE10762886A patent/HUE031031T2/en unknown
- 2010-09-21 BR BR112012006516A patent/BR112012006516B1/pt active IP Right Grant
- 2010-09-21 DK DK10762886.9T patent/DK2480268T3/en active
- 2010-09-21 WO PCT/EP2010/063842 patent/WO2011036134A2/en not_active Ceased
- 2010-09-21 US US13/392,882 patent/US9511193B2/en active Active
- 2010-09-21 EP EP10762886.9A patent/EP2480268B1/en active Active
- 2010-09-21 CA CA2772686A patent/CA2772686C/en not_active Expired - Fee Related
- 2010-09-21 PL PL10762886T patent/PL2480268T3/pl unknown
- 2010-09-21 JP JP2012530238A patent/JP5875982B2/ja active Active
- 2010-09-21 CN CN201080042506.9A patent/CN102510761B/zh active Active
- 2010-09-21 ES ES10762886.9T patent/ES2603749T3/es active Active
-
2012
- 2012-03-05 IL IL218493A patent/IL218493A/en active IP Right Grant
-
2016
- 2016-11-01 US US15/340,037 patent/US10413678B2/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1035055A (zh) * | 1988-02-10 | 1989-08-30 | D.C.Paf1988有限公司 | 用于施以定量液体的剂量装置 |
| US6030363A (en) * | 1994-12-02 | 2000-02-29 | Science Incorporated | Medicament dispenser |
| CN1933864A (zh) * | 2004-03-30 | 2007-03-21 | 伊莱利利公司 | 具有由最终药剂的给药激活的弹簧驱动锁定零件的药物分配设备 |
| WO2008154616A1 (en) * | 2007-06-12 | 2008-12-18 | Becton, Dickinson And Company | Syringe with disabling mechanism |
Also Published As
| Publication number | Publication date |
|---|---|
| DK2480268T3 (en) | 2016-12-12 |
| CA2772686C (en) | 2018-01-02 |
| JP2013505094A (ja) | 2013-02-14 |
| HK1173687A1 (zh) | 2013-05-24 |
| BR112012006516B1 (pt) | 2019-12-31 |
| WO2011036134A2 (en) | 2011-03-31 |
| HUE031031T2 (en) | 2017-06-28 |
| IL218493A (en) | 2014-07-31 |
| US20120271243A1 (en) | 2012-10-25 |
| US10413678B2 (en) | 2019-09-17 |
| BR112012006516A2 (pt) | 2016-04-26 |
| AU2010299934A1 (en) | 2012-04-12 |
| EP2480268A2 (en) | 2012-08-01 |
| US9511193B2 (en) | 2016-12-06 |
| US20170043099A1 (en) | 2017-02-16 |
| EP2480268B1 (en) | 2016-08-17 |
| CN102510761A (zh) | 2012-06-20 |
| WO2011036134A3 (en) | 2011-06-23 |
| AU2010299934B2 (en) | 2014-08-14 |
| CA2772686A1 (en) | 2011-03-31 |
| ES2603749T3 (es) | 2017-03-01 |
| PL2480268T3 (pl) | 2017-03-31 |
| IL218493A0 (en) | 2012-04-30 |
| JP5875982B2 (ja) | 2016-03-02 |
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