CN102510752B - 含有大环内酯类免疫抑制药物的新颖的药物组合物 - Google Patents

含有大环内酯类免疫抑制药物的新颖的药物组合物 Download PDF

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Publication number
CN102510752B
CN102510752B CN201080042067.1A CN201080042067A CN102510752B CN 102510752 B CN102510752 B CN 102510752B CN 201080042067 A CN201080042067 A CN 201080042067A CN 102510752 B CN102510752 B CN 102510752B
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tacrolimus
pharmaceutical composition
skin
microemulsion
amphiphilic
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CN201080042067.1A
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Chinese (zh)
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CN102510752A (zh
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亚历山德拉·赛宾·巴贝尔·戈贝尔
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Bai Yi Pharmaceutical Co ltd
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This Co Ltd Of Si Jinnuo Mick
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/40—Concentrating samples
    • G01N1/4055—Concentrating samples by solubility techniques
    • G01N2001/4061—Solvent extraction

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Dispersion Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Transplantation (AREA)
  • Biomedical Technology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
CN201080042067.1A 2009-10-08 2010-10-07 含有大环内酯类免疫抑制药物的新颖的药物组合物 Active CN102510752B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP09012724.2 2009-10-08
EP09012724A EP2308468A1 (en) 2009-10-08 2009-10-08 Novel pharmaceutical composition comprising a macrolide immunosuppressant drug
PCT/EP2010/064965 WO2011042485A1 (en) 2009-10-08 2010-10-07 Novel pharmaceutical composition comprising a macrolide immunosuppressant drug

Publications (2)

Publication Number Publication Date
CN102510752A CN102510752A (zh) 2012-06-20
CN102510752B true CN102510752B (zh) 2015-08-05

Family

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CN201080042067.1A Active CN102510752B (zh) 2009-10-08 2010-10-07 含有大环内酯类免疫抑制药物的新颖的药物组合物

Country Status (12)

Country Link
US (1) US8574562B2 (enExample)
EP (2) EP2308468A1 (enExample)
JP (1) JP5764792B2 (enExample)
KR (1) KR101790257B1 (enExample)
CN (1) CN102510752B (enExample)
AU (1) AU2010305404B2 (enExample)
BR (1) BR112012007332B1 (enExample)
CA (1) CA2774720C (enExample)
ES (1) ES2552803T3 (enExample)
IN (1) IN2012DN01559A (enExample)
MX (1) MX2012003800A (enExample)
WO (1) WO2011042485A1 (enExample)

Cited By (1)

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CN109310770A (zh) * 2016-06-03 2019-02-05 埃维克辛公司 包含多不饱和酮和钙调磷酸酶抑制剂的联合疗法

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US10265265B2 (en) 2007-03-15 2019-04-23 Drug Delivery Solutions Limited Topical composition
TW201309306A (zh) * 2011-06-23 2013-03-01 參天製藥股份有限公司 含有玻尿酸或其鹽及丙二醇之點眼液
AU2014209141B2 (en) 2013-01-24 2018-05-10 Palvella Therapeutics, Inc. Compositions for transdermal delivery of mTOR inhibitors
CN103830178B (zh) * 2014-03-18 2017-01-11 深圳劲创生物技术有限公司 一种蒜氨酸微乳及其制备方法和应用
US10525012B2 (en) * 2015-08-11 2020-01-07 Eyesiu Medicines B.V. Pegylated lipid nanoparticle with bioactive lipophilic compound
JP6932180B2 (ja) * 2016-04-04 2021-09-08 エムシー２・セラピューティクス・リミテッドＭＣ２ Ｔｈｅｒａｐｅｕｔｉｃｓ Ｌｉｍｉｔｅｄ タクロリムスを含む局所組成物
CN106074386A (zh) * 2016-08-31 2016-11-09 佛山市弘泰药物研发有限公司 一种依维莫司自微乳制剂及其制备方法
CA3037582A1 (en) 2016-09-21 2018-03-29 Avexxin As Pharmaceutical composition
JP7108631B2 (ja) 2017-01-06 2022-07-28 パルヴェラ セラピューティクス、インク． ｍＴＯＲ阻害剤の無水組成物およびその使用方法
EP3691654A4 (en) 2017-09-25 2021-11-24 Surface Pharmaceuticals, Inc. OPHTHALMIC PHARMACEUTICAL COMPOSITIONS AND METHODS FOR TREATMENT OF EYE SURFACE DISEASES
EP3542788A1 (en) 2018-03-19 2019-09-25 MC2 Therapeutics Limited Topical composition comprising calcipotriol and betamethasone dipropionate
WO2019233722A1 (en) 2018-06-08 2019-12-12 Almirall, S.A. Pharmaceutical composition comprising tacrolimus
JP2021530463A (ja) 2018-07-02 2021-11-11 パルヴェラ セラピューティクス、インク． ｍＴＯＲ阻害剤の無水組成物および使用方法
CA3124945A1 (en) 2018-12-27 2020-07-02 Surface Ophthalmics, Inc. Ophthalmic pharmaceutical compositions and methods for treating ocular surface disease
WO2021148619A1 (en) * 2020-01-22 2021-07-29 Bausch Health Ireland Limited Topical compositions comprising a macrolide immunosuppressant
TWI769745B (zh) * 2021-03-19 2022-07-01 國泰醫療財團法人國泰綜合醫院 醫藥組成物與製藥用途
WO2022240598A1 (en) 2021-05-10 2022-11-17 Surface Ophthalmics, Inc. Use of chondroitin sulfate for relieving ocular pain
US12440510B2 (en) 2021-05-10 2025-10-14 Surface Ophthalmics, Inc. Use of chondroitin sulfate for relieving ocular pain
BE1030538B1 (nl) 2022-05-18 2023-12-19 Bogaert Gina Van Liposomaal preparaat met ingekapselde hormonen, werkwijze voor de productie en gebruik ervan
KR102727647B1 (ko) * 2023-11-28 2024-11-08 장병모 칼시뉴린 억제제를 포함하는 피부질환의 예방 또는 치료용 약학적 조성물

Citations (6)

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GB2315216A (en) * 1993-10-05 1998-01-28 Ciba Geigy Ag Microemulsion preconcentrates comprising FK 506
US20030143250A1 (en) * 1988-09-16 2003-07-31 Birgit Hauer Pharmaceutical compositions comprising cyclosporins
WO2006062334A1 (en) * 2004-12-06 2006-06-15 Hanmi Pharm. Co., Ltd. Oral micro-emulsion composition comprising tacrolimus
WO2006123354A2 (en) * 2005-02-02 2006-11-23 Mega Lifesciences Pvt. Ltd. Oral pharmaceutical composition
EP1929996A2 (en) * 2004-11-09 2008-06-11 Novagali Pharma SA Ophthalmic emulsions containing an immunosuppressive agent
US20090074786A1 (en) * 2005-02-09 2009-03-19 Macusight, Inc. Formulations for treating ocular diseases and conditions

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PH26083A (en) * 1987-11-09 1992-02-06 Sandoz Ltd 11, 28-dioxa-4-azatricyclo [22.3.1.04.9) octacos-18-ene derivatives and pharmaceutical compositions containing them and method of use thereof
CH686761A5 (de) * 1993-05-27 1996-06-28 Sandoz Ag Galenische Formulierungen.
EP0786986B1 (en) * 1994-10-26 2002-03-20 Novartis AG Use of an unsaturated fatty alcohol
GB9723669D0 (en) * 1997-11-07 1998-01-07 Univ Aberdeen Skin penetration enhancing components
DE10036871A1 (de) * 2000-07-28 2002-02-14 Pharmasol Gmbh Dispersionen zur Formulierung wenig oder schwer löslicher Wirkstoffe
ATE468107T1 (de) * 2001-11-01 2010-06-15 Yissum Res Dev Co Verfahren und zusammensetzung zur behandlung von trockenen augen
BR0117197A (pt) * 2001-12-14 2004-12-14 Jagotec Ag Formulação de medicamento contendo ciclosporina aplicação do mesmo
JP2008506656A (ja) * 2004-07-16 2008-03-06 ノバルティス アクチエンゲゼルシャフト 皮膚透過性の亢進のためのステロイドの使用
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Patent Citations (6)

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US20030143250A1 (en) * 1988-09-16 2003-07-31 Birgit Hauer Pharmaceutical compositions comprising cyclosporins
GB2315216A (en) * 1993-10-05 1998-01-28 Ciba Geigy Ag Microemulsion preconcentrates comprising FK 506
EP1929996A2 (en) * 2004-11-09 2008-06-11 Novagali Pharma SA Ophthalmic emulsions containing an immunosuppressive agent
WO2006062334A1 (en) * 2004-12-06 2006-06-15 Hanmi Pharm. Co., Ltd. Oral micro-emulsion composition comprising tacrolimus
WO2006123354A2 (en) * 2005-02-02 2006-11-23 Mega Lifesciences Pvt. Ltd. Oral pharmaceutical composition
US20090074786A1 (en) * 2005-02-09 2009-03-19 Macusight, Inc. Formulations for treating ocular diseases and conditions

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109310770A (zh) * 2016-06-03 2019-02-05 埃维克辛公司 包含多不饱和酮和钙调磷酸酶抑制剂的联合疗法

Also Published As

Publication number Publication date
CA2774720A1 (en) 2011-04-14
BR112012007332A2 (pt) 2016-10-04
US20120184511A1 (en) 2012-07-19
CA2774720C (en) 2017-05-23
WO2011042485A1 (en) 2011-04-14
BR112012007332B1 (pt) 2021-07-13
JP5764792B2 (ja) 2015-08-19
CN102510752A (zh) 2012-06-20
EP2485714B1 (en) 2015-09-09
EP2485714A1 (en) 2012-08-15
KR20120093865A (ko) 2012-08-23
AU2010305404B2 (en) 2015-04-02
MX2012003800A (es) 2012-06-28
KR101790257B1 (ko) 2017-10-26
IN2012DN01559A (enExample) 2015-06-05
ES2552803T3 (es) 2015-12-02
EP2308468A1 (en) 2011-04-13
AU2010305404A1 (en) 2012-03-08
JP2013507337A (ja) 2013-03-04
US8574562B2 (en) 2013-11-05

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