CN102499993A - 一种边缘刚性化人工生物瓣膜的制备方法 - Google Patents
一种边缘刚性化人工生物瓣膜的制备方法 Download PDFInfo
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- CN102499993A CN102499993A CN2011103395343A CN201110339534A CN102499993A CN 102499993 A CN102499993 A CN 102499993A CN 2011103395343 A CN2011103395343 A CN 2011103395343A CN 201110339534 A CN201110339534 A CN 201110339534A CN 102499993 A CN102499993 A CN 102499993A
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- Prior art keywords
- extract
- glutaraldehyde
- buffer solution
- valve
- hank
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
- A61L27/24—Collagen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
- A61F2/2412—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body with soft flexible valve members, e.g. tissue valves shaped like natural valves
- A61F2/2415—Manufacturing methods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
- A61L27/3625—Vascular tissue, e.g. heart valves
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3683—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment
- A61L27/3687—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment characterised by the use of chemical agents in the treatment, e.g. specific enzymes, detergents, capping agents, crosslinkers, anticalcification agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2250/0014—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis
- A61F2250/0029—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis differing in bending or flexure capacity
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/02—Treatment of implants to prevent calcification or mineralisation in vivo
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/20—Materials or treatment for tissue regeneration for reconstruction of the heart, e.g. heart valves
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Transplantation (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Cardiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Medicinal Chemistry (AREA)
- Botany (AREA)
- Molecular Biology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Manufacturing & Machinery (AREA)
- Biophysics (AREA)
- Urology & Nephrology (AREA)
- Zoology (AREA)
- Prostheses (AREA)
- Materials For Medical Uses (AREA)
Abstract
Description
Claims (9)
Priority Applications (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201110339534.3A CN102499993B (zh) | 2011-11-01 | 2011-11-01 | 一种边缘刚性化人工生物瓣膜的制备方法 |
PCT/CN2011/083987 WO2013063842A1 (zh) | 2011-11-01 | 2011-12-14 | 一种边缘刚性化人工生物瓣膜的制备方法 |
AU2011380375A AU2011380375B2 (en) | 2011-11-01 | 2011-12-14 | Method for preparing edge-rigidized artificial biological valve |
BR112014010668-1A BR112014010668B1 (pt) | 2011-11-01 | 2011-12-14 | Método para preparar uma válvula biológica artificial com borda enrijecida |
ES11875085.0T ES2639424T3 (es) | 2011-11-01 | 2011-12-14 | Método para preparar válvula biológica artificial rigidizada en el borde |
IN3683CHN2014 IN2014CN03683A (zh) | 2011-11-01 | 2011-12-14 | |
EP11875085.0A EP2774630B1 (en) | 2011-11-01 | 2011-12-14 | Method for preparing edge-rigidized artificial biological valve |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201110339534.3A CN102499993B (zh) | 2011-11-01 | 2011-11-01 | 一种边缘刚性化人工生物瓣膜的制备方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN102499993A true CN102499993A (zh) | 2012-06-20 |
CN102499993B CN102499993B (zh) | 2014-01-15 |
Family
ID=46212166
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201110339534.3A Active CN102499993B (zh) | 2011-11-01 | 2011-11-01 | 一种边缘刚性化人工生物瓣膜的制备方法 |
Country Status (7)
Country | Link |
---|---|
EP (1) | EP2774630B1 (zh) |
CN (1) | CN102499993B (zh) |
AU (1) | AU2011380375B2 (zh) |
BR (1) | BR112014010668B1 (zh) |
ES (1) | ES2639424T3 (zh) |
IN (1) | IN2014CN03683A (zh) |
WO (1) | WO2013063842A1 (zh) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN107007887A (zh) * | 2017-02-27 | 2017-08-04 | 杭州启明医疗器械有限公司 | 一种交联人工生物瓣膜及其制备方法 |
CN111467574A (zh) * | 2020-04-21 | 2020-07-31 | 四川大学 | 基于edc/nhs活化和重组人源胶原蛋白修饰的生物瓣膜材料及其制备方法 |
CN114258310A (zh) * | 2019-12-09 | 2022-03-29 | 爱德华兹生命科学公司 | 生物假体组织制备 |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8579964B2 (en) | 2010-05-05 | 2013-11-12 | Neovasc Inc. | Transcatheter mitral valve prosthesis |
US9554897B2 (en) | 2011-04-28 | 2017-01-31 | Neovasc Tiara Inc. | Methods and apparatus for engaging a valve prosthesis with tissue |
US9308087B2 (en) | 2011-04-28 | 2016-04-12 | Neovasc Tiara Inc. | Sequentially deployed transcatheter mitral valve prosthesis |
US9345573B2 (en) | 2012-05-30 | 2016-05-24 | Neovasc Tiara Inc. | Methods and apparatus for loading a prosthesis onto a delivery system |
US9572665B2 (en) | 2013-04-04 | 2017-02-21 | Neovasc Tiara Inc. | Methods and apparatus for delivering a prosthetic valve to a beating heart |
CN108882981B (zh) | 2016-01-29 | 2021-08-10 | 内奥瓦斯克迪亚拉公司 | 用于防止流出阻塞的假体瓣膜 |
WO2018090148A1 (en) | 2016-11-21 | 2018-05-24 | Neovasc Tiara Inc. | Methods and systems for rapid retraction of a transcatheter heart valve delivery system |
CA3073834A1 (en) | 2017-08-25 | 2019-02-28 | Neovasc Tiara Inc. | Sequentially deployed transcatheter mitral valve prosthesis |
WO2019092736A1 (en) * | 2017-11-13 | 2019-05-16 | Meril Life Sciences Pvt Ltd | Anti-calcification of a tissue |
CA3135753C (en) | 2019-04-01 | 2023-10-24 | Neovasc Tiara Inc. | Controllably deployable prosthetic valve |
EP3952792A4 (en) | 2019-04-10 | 2023-01-04 | Neovasc Tiara Inc. | HEART VALVE PROSTHESIS WITH NATURAL BLOOD FLOW |
AU2020279750B2 (en) | 2019-05-20 | 2023-07-13 | Neovasc Tiara Inc. | Introducer with hemostasis mechanism |
AU2020295566B2 (en) | 2019-06-20 | 2023-07-20 | Neovasc Tiara Inc. | Low profile prosthetic mitral valve |
CN115998955A (zh) * | 2022-12-09 | 2023-04-25 | 首都医科大学附属北京安贞医院 | 一种静脉桥的醛铬复合交联方法 |
CN117563049B (zh) * | 2024-01-15 | 2024-05-03 | 北京佰仁医疗科技股份有限公司 | 用于后巩膜加固的眼科生物补片及其制备 |
Citations (5)
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WO2001021228A1 (en) * | 1999-09-22 | 2001-03-29 | Baxter International Inc. | Cardiac valve and method for preparing a biological tissue |
EP0888142B1 (en) * | 1996-03-04 | 2003-05-28 | Edwards Lifesciences Corporation | Nonpolymeric epoxy compounds for cross-linking biological tissue and bioprosthetic grafts prepared thereby |
CN101161293A (zh) * | 2006-10-12 | 2008-04-16 | 胡盛寿 | 异种生物组织材料的抗钙化改性方法 |
CN101184516A (zh) * | 2005-03-25 | 2008-05-21 | 爱德华兹生命科学公司 | 对生物假体组织进行处理以缓解植入后钙化 |
CN102114269A (zh) * | 2011-02-22 | 2011-07-06 | 微创医疗器械(上海)有限公司 | 一种异氰基封端型防钙化人工生物瓣及其制备方法 |
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2011
- 2011-11-01 CN CN201110339534.3A patent/CN102499993B/zh active Active
- 2011-12-14 BR BR112014010668-1A patent/BR112014010668B1/pt active IP Right Grant
- 2011-12-14 ES ES11875085.0T patent/ES2639424T3/es active Active
- 2011-12-14 IN IN3683CHN2014 patent/IN2014CN03683A/en unknown
- 2011-12-14 AU AU2011380375A patent/AU2011380375B2/en active Active
- 2011-12-14 EP EP11875085.0A patent/EP2774630B1/en active Active
- 2011-12-14 WO PCT/CN2011/083987 patent/WO2013063842A1/zh active Application Filing
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EP0888142B1 (en) * | 1996-03-04 | 2003-05-28 | Edwards Lifesciences Corporation | Nonpolymeric epoxy compounds for cross-linking biological tissue and bioprosthetic grafts prepared thereby |
WO2001021228A1 (en) * | 1999-09-22 | 2001-03-29 | Baxter International Inc. | Cardiac valve and method for preparing a biological tissue |
CN101184516A (zh) * | 2005-03-25 | 2008-05-21 | 爱德华兹生命科学公司 | 对生物假体组织进行处理以缓解植入后钙化 |
CN101161293A (zh) * | 2006-10-12 | 2008-04-16 | 胡盛寿 | 异种生物组织材料的抗钙化改性方法 |
CN102114269A (zh) * | 2011-02-22 | 2011-07-06 | 微创医疗器械(上海)有限公司 | 一种异氰基封端型防钙化人工生物瓣及其制备方法 |
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《Biomaterials》 19991031 Hsing-Wen Sung etal. "Mechanical properties of a porcine aortic valve fixed with a naturally occurring crosslinking agent" 第1759-1772页 1-9 第20卷, 第19期 * |
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《皮革与化工》 20081231 易宗俊等 "栲胶的化学改性及其应用研究进展" 第4-10页 1-9 第25卷, 第6期 * |
HSING-WEN SUNG ETAL.: ""Mechanical properties of a porcine aortic valve fixed with a naturally occurring crosslinking agent"", 《BIOMATERIALS》 * |
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Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN107007887A (zh) * | 2017-02-27 | 2017-08-04 | 杭州启明医疗器械有限公司 | 一种交联人工生物瓣膜及其制备方法 |
CN107007887B (zh) * | 2017-02-27 | 2020-10-02 | 杭州启明医疗器械股份有限公司 | 一种交联人工生物瓣膜及其制备方法 |
CN114258310A (zh) * | 2019-12-09 | 2022-03-29 | 爱德华兹生命科学公司 | 生物假体组织制备 |
CN111467574A (zh) * | 2020-04-21 | 2020-07-31 | 四川大学 | 基于edc/nhs活化和重组人源胶原蛋白修饰的生物瓣膜材料及其制备方法 |
CN111467574B (zh) * | 2020-04-21 | 2021-01-26 | 四川大学 | 基于edc/nhs活化和重组人源胶原蛋白修饰的生物瓣膜材料及其制备方法 |
Also Published As
Publication number | Publication date |
---|---|
EP2774630A4 (en) | 2015-07-22 |
IN2014CN03683A (zh) | 2015-09-04 |
BR112014010668B1 (pt) | 2019-04-02 |
WO2013063842A1 (zh) | 2013-05-10 |
EP2774630B1 (en) | 2017-07-05 |
BR112014010668A2 (pt) | 2017-12-05 |
AU2011380375A1 (en) | 2014-05-29 |
EP2774630A1 (en) | 2014-09-10 |
ES2639424T3 (es) | 2017-10-26 |
AU2011380375B2 (en) | 2015-09-17 |
CN102499993B (zh) | 2014-01-15 |
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Address after: 201203 Shanghai City Newton Road, Pudong New Area Zhangjiang hi tech Park No. 501 Applicant after: Shanghai MicroPort Medical Equipment (Group) Co., Ltd. Address before: 201203 Shanghai City Newton Road, Pudong New Area Zhangjiang hi tech Park No. 501 Applicant before: Weichuang Medical Equipment (Shanghai) Co., Ltd. |
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Effective date of registration: 20160425 Address after: 201203 Shanghai City Newton Road, Pudong New Area Zhangjiang hi tech Park No. 501 Patentee after: SHANGHAI MINIMALLY INVASIVE XINTONG MEDICAL TECHNOLOGY CO., LTD. Address before: 201203 Shanghai City Newton Road, Pudong New Area Zhangjiang hi tech Park No. 501 Patentee before: Shanghai MicroPort Medical Equipment (Group) Co., Ltd. |