CN102470120A - 用于保护眼球的内部结构抵抗紫外线或用于用跨上皮交联技术治疗圆锥角膜的眼用溶液 - Google Patents

用于保护眼球的内部结构抵抗紫外线或用于用跨上皮交联技术治疗圆锥角膜的眼用溶液 Download PDF

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Publication number
CN102470120A
CN102470120A CN2010800328001A CN201080032800A CN102470120A CN 102470120 A CN102470120 A CN 102470120A CN 2010800328001 A CN2010800328001 A CN 2010800328001A CN 201080032800 A CN201080032800 A CN 201080032800A CN 102470120 A CN102470120 A CN 102470120A
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concentration
milligram
riboflavin
acid
milliliter
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Pending
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CN2010800328001A
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English (en)
Chinese (zh)
Inventor
萨尔瓦托雷·特罗伊西
安东尼奥·德·普雷特
奇罗·卡鲁索
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Renato San Severino
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Renato San Severino
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Priority claimed from IT000052A external-priority patent/ITVA20090052A1/it
Priority claimed from IT000044A external-priority patent/ITVA20100044A1/it
Application filed by Renato San Severino filed Critical Renato San Severino
Publication of CN102470120A publication Critical patent/CN102470120A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A61K31/203—Retinoic acids ; Salts thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4415—Pyridoxine, i.e. Vitamin B6
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A61K31/51—Thiamines, e.g. vitamin B1
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/525—Isoalloxazines, e.g. riboflavins, vitamin B2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN2010800328001A 2009-07-27 2010-07-23 用于保护眼球的内部结构抵抗紫外线或用于用跨上皮交联技术治疗圆锥角膜的眼用溶液 Pending CN102470120A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
ITVA2009A000052 2009-07-27
IT000052A ITVA20090052A1 (it) 2009-07-27 2009-07-27 Composizione per il trattamento del cheratocono con tecnica di cross-linking trans-epiteliale o per proteggere strutture interne del globo oculare da raggi uv-a
ITVA2010A000044 2010-05-20
IT000044A ITVA20100044A1 (it) 2010-05-20 2010-05-20 Soluzione oftalmica per proteggere strutture interne del globo oculare da raggi uv-a o per il trattamento del cheratocono con tecnica di cross-linking trans-epiteliale
PCT/EP2010/060752 WO2011012557A1 (en) 2009-07-27 2010-07-23 Ophthalmic solution for protecting internal structures of the eyeball against uv-a rays or for the treatment of keratoconus with a trans-epithelial cross-linking technique

Publications (1)

Publication Number Publication Date
CN102470120A true CN102470120A (zh) 2012-05-23

Family

ID=42575807

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2010800328001A Pending CN102470120A (zh) 2009-07-27 2010-07-23 用于保护眼球的内部结构抵抗紫外线或用于用跨上皮交联技术治疗圆锥角膜的眼用溶液

Country Status (13)

Country Link
US (1) US9192594B2 (https=)
EP (1) EP2459186B1 (https=)
JP (1) JP2013500302A (https=)
KR (1) KR20120038520A (https=)
CN (1) CN102470120A (https=)
AU (1) AU2010277668A1 (https=)
BR (1) BR112012001998B8 (https=)
CA (1) CA2805511C (https=)
ES (1) ES2441227T3 (https=)
PT (1) PT2459186E (https=)
RU (1) RU2540481C2 (https=)
WO (1) WO2011012557A1 (https=)
ZA (1) ZA201201122B (https=)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9622911B2 (en) 2010-09-30 2017-04-18 Cxl Ophthalmics, Llc Ophthalmic treatment device, system, and method of use
US9023092B2 (en) 2011-08-23 2015-05-05 Anthony Natale Endoscopes enhanced with pathogenic treatment
US8668727B2 (en) 2011-08-23 2014-03-11 Anthony Natale Systems and methods for treating pathogenic infection
CN102429767B (zh) * 2011-08-25 2016-03-09 广东福地新视野光电技术有限公司 激光角膜热成形术系统
ITMI20120355A1 (it) * 2012-03-07 2013-09-08 Ciro Caruso Sostanza colorante per uso diagnostico oftalmologico
EP2830627B1 (en) 2012-03-29 2024-05-01 Epion Therapeutics, Inc. Ocular treatment solutions, delivery devices and delivery augmentation methods
WO2013148895A1 (en) 2012-03-29 2013-10-03 Cxl Ophthalmics, Llc Ocular cross-linking system and method for sealing corneal wounds
ES2986057T3 (es) 2012-03-29 2024-11-08 Epion Therapeutics Inc Composiciones y métodos para tratar o prevenir enfermedades asociadas al estrés oxidativo
ITRM20130248A1 (it) * 2013-04-24 2014-10-25 Medivis S R L Formulazioni di riboflavina per il cross-linking transepiteliale.
RU2683651C2 (ru) * 2013-06-18 2019-04-01 Иван Дмитриевич Захаров Лекарственное средство для лечения кератоконуса и других дегенеративных заболеваний роговицы и фармацевтические препараты на его основе
US9931199B2 (en) * 2014-05-05 2018-04-03 Roberto Gustavo ALBERTAZZI Methods and apparatus for treating keratoconus
RU2556791C1 (ru) * 2014-06-09 2015-07-20 федеральное государственное бюджетное учреждение "Межотраслевой научно-технический комплекс "Микрохирургия глаза" имени академика С.Н. Федорова" Министерства здравоохранения Российской Федерации Способ лечения кератоконуса
KR102706856B1 (ko) * 2015-07-21 2024-09-19 아베드로 인코퍼레이티드 광증감제로 눈을 치료하기 위한 시스템 및 방법
EP3585393A4 (en) 2017-02-21 2020-12-30 Avedro, Inc. FORMULAS FOR EYE TREATMENTS
IT201900011985A1 (it) * 2019-07-17 2021-01-17 Vision Eng Italy Srl Formulazione liquida, in particolare per trattare un tessuto corneale
IT201900021849A1 (it) 2019-11-21 2021-05-21 Bf Res S R L Lente a contatto morbida e confezione comprendente tale lente a contatto
WO2024225436A1 (ja) * 2023-04-28 2024-10-31 株式会社メドレックス 眼科用組成物
CN118845755B (zh) * 2024-08-27 2025-08-15 山东第一医科大学附属眼科研究所(山东省眼科研究所、山东第一医科大学附属青岛眼科医院) 大豆异黄酮在制备用于治疗圆锥角膜药物中的应用

Citations (6)

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CN1106669A (zh) * 1994-10-10 1995-08-16 华中理工大学 一种防治白内障的滴眼液
WO1998001136A1 (en) * 1996-07-09 1998-01-15 Baylor College Of Medicine Formulations of vesicant drugs and methods of use thereof
WO2001037851A2 (en) * 1999-11-25 2001-05-31 Simonelli, Giuseppe Use of ubiquinone q10 for the local treatment and prevention of post-surgical ophthalmologic pathologies
WO2002017879A1 (en) * 2000-08-29 2002-03-07 Chopra Raj K Palatable oral coenzyme q liquid
JP2005247777A (ja) * 2004-03-05 2005-09-15 Taisho Pharmaceut Co Ltd 眼科用剤
WO2009001396A1 (en) * 2007-06-26 2008-12-31 Sooft Italia Spa Disposable sterile ocular solution for corneal cross- linking of cheratocone, and process for production thereof

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ITMI981586A1 (it) * 1998-07-10 2000-01-10 Giorgio Panin Vitamina e e suoi esteri per l'uso nel trattamento topico di patologie delle mucose
US6291519B1 (en) * 1998-10-14 2001-09-18 Novartis Ag Method of preventing damage to eye tissue
RU2201213C1 (ru) * 2001-07-04 2003-03-27 Общество с ограниченной ответственностью "Научно-экспериментальное производство Микрохирургия глаза" Глазные капли "карнозин"
JP5147156B2 (ja) * 2003-08-08 2013-02-20 ロート製薬株式会社 角膜障害抑制剤
GB0404693D0 (en) * 2004-03-02 2004-04-07 Univ London Pharmaceutical preparations for the treatment of ocular surface and other disorders
ITMI20052036A1 (it) * 2005-10-26 2007-04-27 Professional Dietetics Srl Composizioni farmaceutiche oftalmiche a base di amminoacidi e sodio ialuronato

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1106669A (zh) * 1994-10-10 1995-08-16 华中理工大学 一种防治白内障的滴眼液
WO1998001136A1 (en) * 1996-07-09 1998-01-15 Baylor College Of Medicine Formulations of vesicant drugs and methods of use thereof
WO2001037851A2 (en) * 1999-11-25 2001-05-31 Simonelli, Giuseppe Use of ubiquinone q10 for the local treatment and prevention of post-surgical ophthalmologic pathologies
WO2002017879A1 (en) * 2000-08-29 2002-03-07 Chopra Raj K Palatable oral coenzyme q liquid
JP2005247777A (ja) * 2004-03-05 2005-09-15 Taisho Pharmaceut Co Ltd 眼科用剤
WO2009001396A1 (en) * 2007-06-26 2008-12-31 Sooft Italia Spa Disposable sterile ocular solution for corneal cross- linking of cheratocone, and process for production thereof

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《AMERICAN JOURNAL OF OPHTHALMOLOGY》 20020226 GREGOR WOLLENSAK等 "Riboflavin/Ultraviolet-A-induced Collagen Crosslinking for the Treatment of Keratoconus" 620-627 1-10 第135卷, 第5期 *
ALAN R.GABY: ""Nutritional Therapies for Ocular Disorders: Part Three"", 《ALTERNATIVE MEDICINE REVIEW》, vol. 13, no. 3, 31 December 2008 (2008-12-31), pages 191 - 204, XP008117502 *
GREGOR WOLLENSAK等: ""Riboflavin/Ultraviolet-A–induced Collagen Crosslinking for the Treatment of Keratoconus"", 《AMERICAN JOURNAL OF OPHTHALMOLOGY》, vol. 135, no. 5, 26 February 2002 (2002-02-26), pages 620 - 627, XP002496965, DOI: 10.1016/S0002-9394(02)02220-1 *
冯金玲等: ""抗氧化剂联合接触镜治疗圆锥角膜急性水肿期"", 《临床眼科杂志》, vol. 8, no. 5, 31 December 2000 (2000-12-31) *
叶波等: ""紫外线诱发人晶体上皮细胞凋亡及其抑制的研究"", 《江西医学院学报》, vol. 41, no. 5, 31 December 2001 (2001-12-31) *

Also Published As

Publication number Publication date
WO2011012557A1 (en) 2011-02-03
ZA201201122B (en) 2013-05-29
RU2012106178A (ru) 2013-09-10
AU2010277668A8 (en) 2012-04-19
BR112012001998A2 (pt) 2017-01-31
EP2459186B1 (en) 2013-10-09
EP2459186A1 (en) 2012-06-06
BR112012001998B8 (pt) 2021-05-25
AU2010277668A1 (en) 2012-03-01
BR112012001998B1 (pt) 2020-12-01
PT2459186E (pt) 2013-12-24
CA2805511A1 (en) 2011-02-03
RU2540481C2 (ru) 2015-02-10
US9192594B2 (en) 2015-11-24
JP2013500302A (ja) 2013-01-07
ES2441227T3 (es) 2014-02-03
KR20120038520A (ko) 2012-04-23
US20120121567A1 (en) 2012-05-17
CA2805511C (en) 2017-04-11

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Application publication date: 20120523