CN102459300B - 用于治疗用途的新的7-脱氮嘌呤核苷 - Google Patents

用于治疗用途的新的7-脱氮嘌呤核苷 Download PDF

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Publication number
CN102459300B
CN102459300B CN201080027802.1A CN201080027802A CN102459300B CN 102459300 B CN102459300 B CN 102459300B CN 201080027802 A CN201080027802 A CN 201080027802A CN 102459300 B CN102459300 B CN 102459300B
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ddd
nmr
pharmaceutically acceptable
compound according
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Chinese (zh)
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CN102459300A (zh
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A.布尔德里奥克斯
M.霍塞克
P.瑙斯
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Institute of Organic Chemistry and Biochemistry of ASCR vvi
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Institute of Organic Chemistry and Biochemistry of ASCR vvi
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/14—Pyrrolo-pyrimidine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN201080027802.1A 2009-04-22 2010-04-19 用于治疗用途的新的7-脱氮嘌呤核苷 Active CN102459300B (zh)

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Applications Claiming Priority (3)

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US17165609P 2009-04-22 2009-04-22
US61/171,656 2009-04-22
PCT/CZ2010/000050 WO2010121576A2 (en) 2009-04-22 2010-04-19 Novel 7-deazapurine nucleosides for therapeutic uses

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CN102459300A CN102459300A (zh) 2012-05-16
CN102459300B true CN102459300B (zh) 2014-12-10

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US (3) US9321800B2 (https=)
EP (1) EP2421879B1 (https=)
JP (2) JP5721275B2 (https=)
CN (2) CN102459300B (https=)
AU (3) AU2010238985B2 (https=)
CA (2) CA2966647A1 (https=)
DK (1) DK2421879T3 (https=)
ES (1) ES2437917T3 (https=)
HR (1) HRP20131021T1 (https=)
MX (1) MX2011011160A (https=)
NZ (2) NZ700583A (https=)
PL (1) PL2421879T3 (https=)
PT (1) PT2421879E (https=)
SI (1) SI2421879T1 (https=)
WO (1) WO2010121576A2 (https=)

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AU2010330823A1 (en) * 2009-12-18 2012-07-05 Joslin Diabetes Center, Inc. Beta-cell replication promoting compounds and methods of their use
CN102319254B (zh) * 2011-07-20 2013-06-19 上海交通大学 5-碘代杀菌核素在制备抗肿瘤药物中的应用
CZ305466B6 (cs) * 2013-11-04 2015-10-14 Ústav organické chemie a biochemie Akademie věd České republiky, v. v. i. Substituované 7-deazapurinové ribonukleosidy pro terapeutické použití
ES2792036T3 (es) 2014-11-14 2020-11-06 Nerviano Medical Sciences Srl Derivados de 6-amino-7-biciclo-7-deaza-purina como inhibidores de cinasa
CN109790143A (zh) 2016-05-10 2019-05-21 C4医药公司 用于靶蛋白降解的胺连接的c3-戊二酰亚胺降解决定子体
EP4491236A3 (en) 2016-05-10 2025-04-02 C4 Therapeutics, Inc. Heterocyclic degronimers for target protein degradation
EP3454862B1 (en) 2016-05-10 2024-09-11 C4 Therapeutics, Inc. Spirocyclic degronimers for target protein degradation
CN109641874A (zh) 2016-05-10 2019-04-16 C4医药公司 用于靶蛋白降解的c3-碳连接的戊二酰亚胺降解决定子体
CA3029170C (en) 2016-06-29 2021-02-16 Ustav Organicke Chemie A Biochemie Av Cr, V.V.I. Substituted thienopyrrolopyrimidine ribonucleosides for therapeutic use
CZ307334B6 (cs) 2016-08-02 2018-06-13 Ăšstav organickĂ© chemie a biochemie AV ÄŚR, v.v.i. Substituované heteropentadieno-pyrrolopyrimidinové ribonukleosidy pro terapeutické použití
US11168090B2 (en) 2017-01-18 2021-11-09 Array Biopharma Inc. Substituted pyrazolo[1,5-a]pyrazines as RET kinase inhibitors
EP4717317A2 (en) 2017-06-20 2026-04-01 C4 Therapeutics, Inc. N/o-linked degrons and degronimers for protein degradation
US11072628B2 (en) 2017-10-19 2021-07-27 Universiteit Gent Nucleoside analogues for the treatment of parasitic infections
WO2019143991A1 (en) * 2018-01-18 2019-07-25 Array Biopharma Inc. SUBSTITUTED PYRAZOLO[3,4-d]PYRIMIDINE COMPOUNDS AS RET KINASE INHIBITORS
CN111615514B (zh) 2018-01-18 2022-10-11 奥瑞生物药品公司 作为ret激酶抑制剂的取代的吡唑并[4,3-c]吡啶化合物
EP3740491A1 (en) 2018-01-18 2020-11-25 Array Biopharma, Inc. Substituted pyrrolo[2,3-d]pyrimidines compounds as ret kinase inhibitors
CZ308104B6 (cs) 2018-03-12 2020-01-08 Ăšstav organickĂ© chemie a biochemie AV ÄŚR, v. v. i. Pyridinopyrrolopyrimidinové ribonukleosidy pro terapeutické použití
WO2020033288A1 (en) * 2018-08-07 2020-02-13 Merck Sharp & Dohme Corp. Prmt5 inhibitors
EP3849986B1 (en) 2018-09-10 2022-06-08 Array Biopharma, Inc. Fused heterocyclic compounds as ret kinase inhibitors
MX2021015772A (es) * 2019-06-18 2022-01-31 Taiho Pharmaceutical Co Ltd Compuesto de carbonato novedoso que tiene esqueleto de pirrolopirimidina o sal farmaceuticamente aceptable del mismo.
WO2021164848A1 (en) * 2020-02-17 2021-08-26 Katholieke Universiteit Leuven Novel 6-substituted 7-deazapurines and corresponding nucleosides as medicaments
KR102639275B1 (ko) * 2021-06-08 2024-02-21 퓨쳐메디신 주식회사 다중 표적 인산화효소 저해 활성을 갖는 뉴클레오사이드 유도체 및 이를 포함하는 암의 예방 및 치료용 약학적 조성물
WO2023052468A1 (en) 2021-09-28 2023-04-06 Universiteit Antwerpen Nucleoside analogues for the treatment of parasitic infections

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CN1653077A (zh) * 2002-05-06 2005-08-10 健亚生物科技公司 治疗c型肝炎病毒感染的核苷衍生物
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CA2759131A1 (en) 2010-10-28
CN104497084A (zh) 2015-04-08
AU2015205885B2 (en) 2017-04-06
US20150218201A1 (en) 2015-08-06
EP2421879B1 (en) 2013-09-04
JP5721275B2 (ja) 2015-05-20
NZ700583A (en) 2016-04-29
US9321800B2 (en) 2016-04-26
US10294262B2 (en) 2019-05-21
NZ596301A (en) 2014-10-31
HK1209129A1 (en) 2016-03-24
CN104497084B (zh) 2018-06-05
AU2017204148A1 (en) 2017-07-06
AU2015205885A1 (en) 2015-09-03
US9624257B2 (en) 2017-04-18
ES2437917T3 (es) 2014-01-15
DK2421879T3 (da) 2013-11-25
CA2966647A1 (en) 2010-10-28
AU2017204148B2 (en) 2018-12-06
AU2010238985A1 (en) 2011-12-01
JP6087889B2 (ja) 2017-03-01
WO2010121576A3 (en) 2011-06-16
PL2421879T3 (pl) 2014-02-28
US20160318970A1 (en) 2016-11-03
HRP20131021T1 (hr) 2014-01-31
CA2759131C (en) 2017-06-20
SI2421879T1 (sl) 2014-01-31
EP2421879A2 (en) 2012-02-29
HK1166325A1 (en) 2012-12-14
PT2421879E (pt) 2013-12-09
CN102459300A (zh) 2012-05-16
JP2012524731A (ja) 2012-10-18
JP2015013901A (ja) 2015-01-22
US20170240584A1 (en) 2017-08-24
MX2011011160A (es) 2012-01-27
AU2010238985B2 (en) 2015-04-23
WO2010121576A2 (en) 2010-10-28

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