CN102459260B - 1H-吡唑并[4,3-c]异喹啉衍生物、其制备方法及其治疗用途 - Google Patents

1H-吡唑并[4,3-c]异喹啉衍生物、其制备方法及其治疗用途 Download PDF

Info

Publication number
CN102459260B
CN102459260B CN201080028355.1A CN201080028355A CN102459260B CN 102459260 B CN102459260 B CN 102459260B CN 201080028355 A CN201080028355 A CN 201080028355A CN 102459260 B CN102459260 B CN 102459260B
Authority
CN
China
Prior art keywords
pyrazolo
difluorophenyl
isoquinoline
amino
piperidin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN201080028355.1A
Other languages
English (en)
Chinese (zh)
Other versions
CN102459260A (zh
Inventor
G.德莱特雷
S.德普雷茨
F.哈利
L.西奥
F.汤普森
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Sanofi Aventis France
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis France filed Critical Sanofi Aventis France
Publication of CN102459260A publication Critical patent/CN102459260A/zh
Application granted granted Critical
Publication of CN102459260B publication Critical patent/CN102459260B/zh
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CN201080028355.1A 2009-04-24 2010-04-22 1H-吡唑并[4,3-c]异喹啉衍生物、其制备方法及其治疗用途 Expired - Fee Related CN102459260B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR0901995A FR2944792B1 (fr) 2009-04-24 2009-04-24 Derives de 1h-pyrazolo[4,3-c]isoquinoleines, leur preparation et leur application en therapeutique
FR09/01995 2009-04-24
PCT/FR2010/050773 WO2010122272A1 (fr) 2009-04-24 2010-04-22 DERIVES DE 1-PYRAZOLO[4,3-c]ISOQUINOLEINES, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE

Publications (2)

Publication Number Publication Date
CN102459260A CN102459260A (zh) 2012-05-16
CN102459260B true CN102459260B (zh) 2015-06-10

Family

ID=41259738

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201080028355.1A Expired - Fee Related CN102459260B (zh) 2009-04-24 2010-04-22 1H-吡唑并[4,3-c]异喹啉衍生物、其制备方法及其治疗用途

Country Status (26)

Country Link
US (1) US8461175B2 (da)
EP (1) EP2421864B1 (da)
JP (1) JP5722880B2 (da)
KR (1) KR101675609B1 (da)
CN (1) CN102459260B (da)
AR (1) AR076393A1 (da)
AU (1) AU2010240742B2 (da)
BR (1) BRPI1013724A2 (da)
CA (1) CA2791947A1 (da)
CY (1) CY1115678T1 (da)
DK (1) DK2421864T3 (da)
ES (1) ES2515240T3 (da)
FR (1) FR2944792B1 (da)
HK (2) HK1167387A1 (da)
HR (1) HRP20141058T1 (da)
IL (1) IL215733A (da)
MX (1) MX2011011246A (da)
MY (1) MY156362A (da)
PL (1) PL2421864T3 (da)
PT (1) PT2421864E (da)
RU (1) RU2530775C2 (da)
SG (1) SG175338A1 (da)
SI (1) SI2421864T1 (da)
TW (1) TWI468405B (da)
UY (1) UY32575A (da)
WO (1) WO2010122272A1 (da)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109020972B (zh) * 2018-10-08 2021-03-09 广东石油化工学院 一种三唑并[1，5-a]喹啉衍生物的制备方法
WO2023039510A1 (en) * 2021-09-10 2023-03-16 The Trustees Of Columbia University In The City Of New York Gpx4 inhibitors and uses thereof

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2185255A (en) * 1986-01-14 1987-07-15 Roussel Lab Ltd Pyrazolo-isoquinoline compounds
US20040097541A1 (en) * 2002-07-03 2004-05-20 Aventis Pharma Deutschland Gmbh Pyrazoloisoquinoline derivatives for inhibiting NFkappaB-inducing kinase
CN1802373A (zh) * 2003-07-03 2006-07-12 安万特药物公司 作为激酶抑制剂的吡唑并异喹啉衍生物
US20070032515A1 (en) * 2003-07-23 2007-02-08 Exelixis, Inc. Anaplastic lymphoma kinase modulators and methods of use
WO2007060198A1 (en) * 2005-11-25 2007-05-31 Palau Pharma, S. A. Pyrazoloisoquinoline derivatives

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7132428B2 (en) * 2003-07-03 2006-11-07 Aventis Pharmaceuticals Inc. Pyrazoloisoquinoline derivative as kinase inhibitors for the treatment of various disorders

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2185255A (en) * 1986-01-14 1987-07-15 Roussel Lab Ltd Pyrazolo-isoquinoline compounds
US20040097541A1 (en) * 2002-07-03 2004-05-20 Aventis Pharma Deutschland Gmbh Pyrazoloisoquinoline derivatives for inhibiting NFkappaB-inducing kinase
CN1802373A (zh) * 2003-07-03 2006-07-12 安万特药物公司 作为激酶抑制剂的吡唑并异喹啉衍生物
US20070032515A1 (en) * 2003-07-23 2007-02-08 Exelixis, Inc. Anaplastic lymphoma kinase modulators and methods of use
WO2007060198A1 (en) * 2005-11-25 2007-05-31 Palau Pharma, S. A. Pyrazoloisoquinoline derivatives

Also Published As

Publication number Publication date
HRP20141058T1 (hr) 2014-12-19
TWI468405B (zh) 2015-01-11
UY32575A (es) 2010-11-30
AR076393A1 (es) 2011-06-08
DK2421864T3 (da) 2014-11-10
MX2011011246A (es) 2012-02-13
HK1167387A1 (en) 2012-11-30
IL215733A0 (en) 2012-01-31
US8461175B2 (en) 2013-06-11
CN102459260A (zh) 2012-05-16
AU2010240742B2 (en) 2015-11-19
RU2530775C2 (ru) 2014-10-10
AU2010240742A1 (en) 2011-11-17
SI2421864T1 (sl) 2014-11-28
EP2421864A1 (fr) 2012-02-29
JP2012524766A (ja) 2012-10-18
WO2010122272A1 (fr) 2010-10-28
PL2421864T3 (pl) 2014-12-31
CA2791947A1 (fr) 2010-10-28
PT2421864E (pt) 2014-10-07
IL215733A (en) 2014-02-27
CY1115678T1 (el) 2017-01-25
FR2944792A1 (fr) 2010-10-29
SG175338A1 (en) 2011-11-28
KR20120007060A (ko) 2012-01-19
US20120115898A1 (en) 2012-05-10
ES2515240T3 (es) 2014-10-29
TW201041887A (en) 2010-12-01
KR101675609B1 (ko) 2016-11-11
BRPI1013724A2 (pt) 2016-04-05
JP5722880B2 (ja) 2015-05-27
RU2011147658A (ru) 2013-05-27
HK1170736A1 (en) 2013-03-08
FR2944792B1 (fr) 2011-05-20
MY156362A (en) 2016-02-15
EP2421864B1 (fr) 2014-08-06

Similar Documents

Publication Publication Date Title
CN106061973B (zh) 吡咯并[2,3-d]嘧啶基、吡咯并[2,3-b]吡嗪基和吡咯并[2,3-d]吡啶基丙烯酰胺
CN103228653B (zh) 被取代的多环性氨基甲酰基吡啶酮衍生物的前药
CN103025724B (zh) 哌啶衍生物
CN102858767B (zh) 作为syk抑制剂的氨基嘧啶
TWI447120B (zh) 噻吩并三唑并苯二氮呯化合物、其醫藥上之用途
WO2021219072A1 (zh) 作为kras抑制剂的杂环化合物的制备及其应用方法
CN102143959B (zh) 丙型肝炎病毒抑制剂
CN102803249B (zh) 丙型肝炎病毒抑制剂
CN113999226A (zh) 作为kras抑制剂的杂环化合物的制备及其应用方法
CN101687875A (zh) 吡咯并嘧啶-7-酮衍生物和它们作为药物的用途
CN107820494B (zh) 核受体调节剂
JP7038063B2 (ja) ピラゾロ［１，５－ａ］ピリミジニルカルボキサミド化合物および医学的障害の処置におけるその使用
CN104619709A (zh) 作为tnf活性调节剂的咪唑并吡啶衍生物
CN108137547A (zh) 可用作TNFα调节剂的杂环化合物
CN103814020B (zh) 治疗活性组合物和它们的使用方法
CA2877999A1 (en) Heterocyclic modulators of lipid synthesis
CN109641906A (zh) 杂芳基取代的氨基吡啶化合物
WO2022135470A1 (zh) 作为kras抑制剂的杂环化合物的制备及其应用方法
CN102459250A (zh) 丙型肝炎病毒抑制剂
CN101679357A (zh) 取代的杂环衍生物及其组合物和作为抗菌剂的药物用途
TW200418861A (en) Pyrrolopyridazine derivatives
CA3075880A1 (en) Tetrahydro-imidazo quinoline compositions as cbp/p300 inhibitors
JP2019510790A5 (da)
CN103328451B (zh) 降低β-淀粉样物质生成的化合物
CN107635992A (zh) 用作tnf抑制剂的三环杂环化合物

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
REG Reference to a national code

Ref country code: HK

Ref legal event code: DE

Ref document number: 1170736

Country of ref document: HK

C14 Grant of patent or utility model
GR01 Patent grant
REG Reference to a national code

Ref country code: HK

Ref legal event code: GR

Ref document number: 1170736

Country of ref document: HK

CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20150610

Termination date: 20180422

CF01 Termination of patent right due to non-payment of annual fee