CY1115678T1 - ΠΑΡΑΓΩΓΑ ΤΩΝ 1-ΠΥΡΑΖΟΛΟ[4,3-c]ΙΣΟΚΙΝΟΛΙΝΩΝ, Η ΠΑΡΑΣΚΕΥΗ ΤΟΥΣ ΚΑΙ Η ΘΕΡΑΠΕΥΤΙΚΗ ΤΟΥΣ ΕΦΑΡΜΟΓΗ - Google Patents
ΠΑΡΑΓΩΓΑ ΤΩΝ 1-ΠΥΡΑΖΟΛΟ[4,3-c]ΙΣΟΚΙΝΟΛΙΝΩΝ, Η ΠΑΡΑΣΚΕΥΗ ΤΟΥΣ ΚΑΙ Η ΘΕΡΑΠΕΥΤΙΚΗ ΤΟΥΣ ΕΦΑΡΜΟΓΗInfo
- Publication number
- CY1115678T1 CY1115678T1 CY20141100897T CY141100897T CY1115678T1 CY 1115678 T1 CY1115678 T1 CY 1115678T1 CY 20141100897 T CY20141100897 T CY 20141100897T CY 141100897 T CY141100897 T CY 141100897T CY 1115678 T1 CY1115678 T1 CY 1115678T1
- Authority
- CY
- Cyprus
- Prior art keywords
- group
- tyrazolo
- iskinolins
- preparation
- production
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
- A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Η εφεύρεση σχετίζεται με μία ένωση με τον τύπο (I) στον οποίο: το R1 αντιπροσωπεύει μία ομάδα φαινυλίου η οποία είναι ενδεχομένως υποκατεστημένη με ένα ή με περισσότερα άτομα αλογόνου, το R2 αντιπροσωπεύει: -ένα άτομο υδρογόνου ή αλογόνου ή μία κυανοομάδα, -μία ομάδα -C(=O)Y στην οποία το Υ αντιπροσωπεύει ένα άτομο υδρογόνου, μία ομάδα -ΝΗ2 ή -ORa, μία ομάδα -C(=S)NH2, -μία ομάδα -C(=NH)NH-OH, -μία ομάδα -CH2OH ή -CH2F, -μία ομάδα -CH=N-OH, -μία ομάδα -CH=CH2 ή -C=C-R3, -μία ομάδα Η ή Η το Ra αντιπροσωπεύει ένα άτομο υδρογόνου ή μία ομάδα (C1-C4)αλκυλίου, το R3 αντιπροσωπεύει ένα άτομο υδρογόνου ή μία ομάδα (C1-C4) αλκυλίου, το R4 αντιπροσωπεύει μία ομάδα -ΝΗ2, (C1-C4)αλκυλίου, (C1-C4) φθοροαλκυλίου ή (C3-C7)κυκλοαλκυλίου.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0901995A FR2944792B1 (fr) | 2009-04-24 | 2009-04-24 | Derives de 1h-pyrazolo[4,3-c]isoquinoleines, leur preparation et leur application en therapeutique |
| EP10723723.2A EP2421864B1 (fr) | 2009-04-24 | 2010-04-22 | DERIVES DE 1-PYRAZOLO[4,3-c]ISOQUINOLEINES, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1115678T1 true CY1115678T1 (el) | 2017-01-25 |
Family
ID=41259738
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20141100897T CY1115678T1 (el) | 2009-04-24 | 2014-10-30 | ΠΑΡΑΓΩΓΑ ΤΩΝ 1-ΠΥΡΑΖΟΛΟ[4,3-c]ΙΣΟΚΙΝΟΛΙΝΩΝ, Η ΠΑΡΑΣΚΕΥΗ ΤΟΥΣ ΚΑΙ Η ΘΕΡΑΠΕΥΤΙΚΗ ΤΟΥΣ ΕΦΑΡΜΟΓΗ |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US8461175B2 (el) |
| EP (1) | EP2421864B1 (el) |
| JP (1) | JP5722880B2 (el) |
| KR (1) | KR101675609B1 (el) |
| CN (1) | CN102459260B (el) |
| AR (1) | AR076393A1 (el) |
| AU (1) | AU2010240742B2 (el) |
| BR (1) | BRPI1013724A2 (el) |
| CA (1) | CA2791947A1 (el) |
| CY (1) | CY1115678T1 (el) |
| DK (1) | DK2421864T3 (el) |
| ES (1) | ES2515240T3 (el) |
| FR (1) | FR2944792B1 (el) |
| HK (2) | HK1167387A1 (el) |
| HR (1) | HRP20141058T1 (el) |
| IL (1) | IL215733A (el) |
| MX (1) | MX2011011246A (el) |
| MY (1) | MY156362A (el) |
| PL (1) | PL2421864T3 (el) |
| PT (1) | PT2421864E (el) |
| RU (1) | RU2530775C2 (el) |
| SG (1) | SG175338A1 (el) |
| SI (1) | SI2421864T1 (el) |
| TW (1) | TWI468405B (el) |
| UY (1) | UY32575A (el) |
| WO (1) | WO2010122272A1 (el) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109020972B (zh) * | 2018-10-08 | 2021-03-09 | 广东石油化工学院 | 一种三唑并[1，5-a]喹啉衍生物的制备方法 |
| WO2023039510A1 (en) * | 2021-09-10 | 2023-03-16 | The Trustees Of Columbia University In The City Of New York | Gpx4 inhibitors and uses thereof |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8600752D0 (en) * | 1986-01-14 | 1986-02-19 | Roussel Lab Ltd | Chemical compounds |
| DE10229762A1 (de) * | 2002-07-03 | 2004-01-22 | Aventis Pharma Deutschland Gmbh | Pyrazoloisoquinolinenderivaten zur Inhibierung von NFkappaB-induzierende Kinase |
| US7132428B2 (en) * | 2003-07-03 | 2006-11-07 | Aventis Pharmaceuticals Inc. | Pyrazoloisoquinoline derivative as kinase inhibitors for the treatment of various disorders |
| ATE386034T1 (de) * | 2003-07-03 | 2008-03-15 | Aventis Pharma Inc | Pyrazoloisoquinolinenderivaten als kinase inhibitoren |
| CA2532800C (en) * | 2003-07-23 | 2013-06-18 | Exelixis, Inc. | Anaplastic lymphoma kinase modulators and methods of use |
| AR058223A1 (es) * | 2005-11-25 | 2008-01-23 | Palau Pharma Sa | Un comuesto de derivados de pirazoloisoquinolina, un procedimiento para l a preparacion de dicho compuesto y una composicion farmaceutica que comprende dicho compuesto |
-
2009
- 2009-04-24 FR FR0901995A patent/FR2944792B1/fr not_active Expired - Fee Related
-
2010
- 2010-04-22 MY MYPI2011005108A patent/MY156362A/en unknown
- 2010-04-22 SG SG2011077963A patent/SG175338A1/en unknown
- 2010-04-22 BR BRPI1013724A patent/BRPI1013724A2/pt not_active IP Right Cessation
- 2010-04-22 US US13/265,981 patent/US8461175B2/en not_active Expired - Fee Related
- 2010-04-22 WO PCT/FR2010/050773 patent/WO2010122272A1/fr active Application Filing
- 2010-04-22 RU RU2011147658/04A patent/RU2530775C2/ru not_active IP Right Cessation
- 2010-04-22 EP EP10723723.2A patent/EP2421864B1/fr active Active
- 2010-04-22 KR KR1020117027900A patent/KR101675609B1/ko active IP Right Grant
- 2010-04-22 JP JP2012506551A patent/JP5722880B2/ja not_active Expired - Fee Related
- 2010-04-22 MX MX2011011246A patent/MX2011011246A/es active IP Right Grant
- 2010-04-22 PT PT107237232T patent/PT2421864E/pt unknown
- 2010-04-22 SI SI201030757T patent/SI2421864T1/sl unknown
- 2010-04-22 CA CA2791947A patent/CA2791947A1/fr not_active Abandoned
- 2010-04-22 ES ES10723723.2T patent/ES2515240T3/es active Active
- 2010-04-22 PL PL10723723T patent/PL2421864T3/pl unknown
- 2010-04-22 CN CN201080028355.1A patent/CN102459260B/zh not_active Expired - Fee Related
- 2010-04-22 DK DK10723723.2T patent/DK2421864T3/da active
- 2010-04-22 AU AU2010240742A patent/AU2010240742B2/en not_active Ceased
- 2010-04-23 AR ARP100101357A patent/AR076393A1/es unknown
- 2010-04-23 TW TW99112914A patent/TWI468405B/zh not_active IP Right Cessation
- 2010-04-23 UY UY0001032575A patent/UY32575A/es not_active Application Discontinuation
-
2011
- 2011-10-11 IL IL215733A patent/IL215733A/en not_active IP Right Cessation
-
2012
- 2012-08-15 HK HK12108001.6A patent/HK1167387A1/xx not_active IP Right Cessation
- 2012-11-14 HK HK12111574.7A patent/HK1170736A1/xx not_active IP Right Cessation
-
2014
- 2014-10-30 CY CY20141100897T patent/CY1115678T1/el unknown
- 2014-11-03 HR HRP20141058AT patent/HRP20141058T1/hr unknown
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