PT2421864E - Derivados de 1-pirazolo[4,3-c]isoquinolinas, sua preparação e sua aplicação terapêutica - Google Patents

Derivados de 1-pirazolo[4,3-c]isoquinolinas, sua preparação e sua aplicação terapêutica Download PDF

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Publication number
PT2421864E
PT2421864E PT107237232T PT10723723T PT2421864E PT 2421864 E PT2421864 E PT 2421864E PT 107237232 T PT107237232 T PT 107237232T PT 10723723 T PT10723723 T PT 10723723T PT 2421864 E PT2421864 E PT 2421864E
Authority
PT
Portugal
Prior art keywords
pyrazolo
preparation
therapeutic use
isoquinoline derivatives
isoquinoline
Prior art date
Application number
PT107237232T
Other languages
English (en)
Inventor
Laurent Schio
Fabienne Thompson
Frank Halley
Georges Delettre
Stéphanie Deprets
Original Assignee
Sanofi Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Sa filed Critical Sanofi Sa
Publication of PT2421864E publication Critical patent/PT2421864E/pt

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
PT107237232T 2009-04-24 2010-04-22 Derivados de 1-pirazolo[4,3-c]isoquinolinas, sua preparação e sua aplicação terapêutica PT2421864E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0901995A FR2944792B1 (fr) 2009-04-24 2009-04-24 Derives de 1h-pyrazolo[4,3-c]isoquinoleines, leur preparation et leur application en therapeutique

Publications (1)

Publication Number Publication Date
PT2421864E true PT2421864E (pt) 2014-10-07

Family

ID=41259738

Family Applications (1)

Application Number Title Priority Date Filing Date
PT107237232T PT2421864E (pt) 2009-04-24 2010-04-22 Derivados de 1-pirazolo[4,3-c]isoquinolinas, sua preparação e sua aplicação terapêutica

Country Status (26)

Country Link
US (1) US8461175B2 (pt)
EP (1) EP2421864B1 (pt)
JP (1) JP5722880B2 (pt)
KR (1) KR101675609B1 (pt)
CN (1) CN102459260B (pt)
AR (1) AR076393A1 (pt)
AU (1) AU2010240742B2 (pt)
BR (1) BRPI1013724A2 (pt)
CA (1) CA2791947A1 (pt)
CY (1) CY1115678T1 (pt)
DK (1) DK2421864T3 (pt)
ES (1) ES2515240T3 (pt)
FR (1) FR2944792B1 (pt)
HK (2) HK1167387A1 (pt)
HR (1) HRP20141058T1 (pt)
IL (1) IL215733A (pt)
MX (1) MX2011011246A (pt)
MY (1) MY156362A (pt)
PL (1) PL2421864T3 (pt)
PT (1) PT2421864E (pt)
RU (1) RU2530775C2 (pt)
SG (1) SG175338A1 (pt)
SI (1) SI2421864T1 (pt)
TW (1) TWI468405B (pt)
UY (1) UY32575A (pt)
WO (1) WO2010122272A1 (pt)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109020972B (zh) * 2018-10-08 2021-03-09 广东石油化工学院 一种三唑并[1，5-a]喹啉衍生物的制备方法
WO2023039510A1 (en) * 2021-09-10 2023-03-16 The Trustees Of Columbia University In The City Of New York Gpx4 inhibitors and uses thereof

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8600752D0 (en) * 1986-01-14 1986-02-19 Roussel Lab Ltd Chemical compounds
DE10229762A1 (de) * 2002-07-03 2004-01-22 Aventis Pharma Deutschland Gmbh Pyrazoloisoquinolinenderivaten zur Inhibierung von NFkappaB-induzierende Kinase
WO2005012301A1 (en) * 2003-07-03 2005-02-10 Aventis Pharmaceuticals Inc. Pyrazoloisoquinoline derivatives as kinase inhibitors
US7132428B2 (en) * 2003-07-03 2006-11-07 Aventis Pharmaceuticals Inc. Pyrazoloisoquinoline derivative as kinase inhibitors for the treatment of various disorders
AU2004259012C1 (en) * 2003-07-23 2012-08-02 Exelixis, Inc. Anaplastic lymphoma kinase modulators and methods of use
AR058223A1 (es) * 2005-11-25 2008-01-23 Palau Pharma Sa Un comuesto de derivados de pirazoloisoquinolina, un procedimiento para l a preparacion de dicho compuesto y una composicion farmaceutica que comprende dicho compuesto

Also Published As

Publication number Publication date
JP5722880B2 (ja) 2015-05-27
CN102459260B (zh) 2015-06-10
MY156362A (en) 2016-02-15
JP2012524766A (ja) 2012-10-18
US8461175B2 (en) 2013-06-11
DK2421864T3 (da) 2014-11-10
CA2791947A1 (fr) 2010-10-28
RU2011147658A (ru) 2013-05-27
KR101675609B1 (ko) 2016-11-11
US20120115898A1 (en) 2012-05-10
HRP20141058T1 (hr) 2014-12-19
KR20120007060A (ko) 2012-01-19
TWI468405B (zh) 2015-01-11
FR2944792A1 (fr) 2010-10-29
UY32575A (es) 2010-11-30
WO2010122272A1 (fr) 2010-10-28
CN102459260A (zh) 2012-05-16
IL215733A (en) 2014-02-27
BRPI1013724A2 (pt) 2016-04-05
MX2011011246A (es) 2012-02-13
SG175338A1 (en) 2011-11-28
AR076393A1 (es) 2011-06-08
HK1170736A1 (en) 2013-03-08
PL2421864T3 (pl) 2014-12-31
HK1167387A1 (en) 2012-11-30
AU2010240742A1 (en) 2011-11-17
IL215733A0 (en) 2012-01-31
ES2515240T3 (es) 2014-10-29
TW201041887A (en) 2010-12-01
CY1115678T1 (el) 2017-01-25
FR2944792B1 (fr) 2011-05-20
AU2010240742B2 (en) 2015-11-19
RU2530775C2 (ru) 2014-10-10
EP2421864A1 (fr) 2012-02-29
EP2421864B1 (fr) 2014-08-06
SI2421864T1 (sl) 2014-11-28

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