CN102459208A - N-(2,6-二甲基-4-吗啉-4-基-苯基)-3,3-二甲基-丁酰胺的稳定形式 - Google Patents
N-(2,6-二甲基-4-吗啉-4-基-苯基)-3,3-二甲基-丁酰胺的稳定形式 Download PDFInfo
- Publication number
- CN102459208A CN102459208A CN2010800321765A CN201080032176A CN102459208A CN 102459208 A CN102459208 A CN 102459208A CN 2010800321765 A CN2010800321765 A CN 2010800321765A CN 201080032176 A CN201080032176 A CN 201080032176A CN 102459208 A CN102459208 A CN 102459208A
- Authority
- CN
- China
- Prior art keywords
- dimethyl
- phenyl
- compound
- yulocrotine
- morpholine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Images
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/06—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals
- C07D295/073—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals with the ring nitrogen atoms and the substituents separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
- C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Neurology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Cosmetics (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DKPA200900597 | 2009-05-11 | ||
DKPA200900597 | 2009-05-11 | ||
PCT/DK2010/050101 WO2010130260A2 (en) | 2009-05-11 | 2010-05-11 | Stable forms of n-(2,6-dimethyl-4-morpholin-4-yl-phenyl)-3,3-dimethyl-butyramide |
Publications (1)
Publication Number | Publication Date |
---|---|
CN102459208A true CN102459208A (zh) | 2012-05-16 |
Family
ID=42237259
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN2010800321765A Pending CN102459208A (zh) | 2009-05-11 | 2010-05-11 | N-(2,6-二甲基-4-吗啉-4-基-苯基)-3,3-二甲基-丁酰胺的稳定形式 |
Country Status (23)
Country | Link |
---|---|
EP (1) | EP2430008A2 (es) |
JP (1) | JP2012526152A (es) |
KR (1) | KR20120022934A (es) |
CN (1) | CN102459208A (es) |
AR (1) | AR076556A1 (es) |
AU (1) | AU2010246724B2 (es) |
BR (1) | BRPI1013930A2 (es) |
CA (1) | CA2761383A1 (es) |
CL (1) | CL2011002814A1 (es) |
CO (1) | CO6460741A2 (es) |
CR (1) | CR20110590A (es) |
DO (1) | DOP2011000351A (es) |
EA (1) | EA201171381A1 (es) |
GE (1) | GEP20146006B (es) |
IL (1) | IL216148A0 (es) |
MA (1) | MA33351B1 (es) |
MX (1) | MX2011011885A (es) |
NZ (1) | NZ596738A (es) |
SG (1) | SG175968A1 (es) |
TN (1) | TN2011000557A1 (es) |
TW (1) | TW201041857A (es) |
WO (1) | WO2010130260A2 (es) |
ZA (1) | ZA201108112B (es) |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TWI357901B (en) * | 2004-03-12 | 2012-02-11 | Lundbeck & Co As H | Substituted morpholine and thiomorpholine derivati |
KR20090079191A (ko) * | 2006-08-23 | 2009-07-21 | 밸리언트 파마슈티컬즈 인터내셔널 | 칼륨 채널 조절제로서 4-(n-아자사이클로알킬) 아닐리드의 유도체 |
BRPI0814180A2 (pt) * | 2007-08-01 | 2015-01-27 | Lundbeck & Co As H | Método para reduzir os sintomas de, ou para tratar, um ou mais distúrbios nos quais o sistema dopaminérgico está desregulado |
-
2010
- 2010-05-06 TW TW099114459A patent/TW201041857A/zh unknown
- 2010-05-10 AR ARP100101588A patent/AR076556A1/es unknown
- 2010-05-11 KR KR1020117026958A patent/KR20120022934A/ko not_active Application Discontinuation
- 2010-05-11 CN CN2010800321765A patent/CN102459208A/zh active Pending
- 2010-05-11 BR BRPI1013930A patent/BRPI1013930A2/pt not_active IP Right Cessation
- 2010-05-11 JP JP2012510116A patent/JP2012526152A/ja active Pending
- 2010-05-11 EA EA201171381A patent/EA201171381A1/ru unknown
- 2010-05-11 MX MX2011011885A patent/MX2011011885A/es not_active Application Discontinuation
- 2010-05-11 EP EP10719726A patent/EP2430008A2/en not_active Withdrawn
- 2010-05-11 GE GEAP201012498A patent/GEP20146006B/en unknown
- 2010-05-11 CA CA2761383A patent/CA2761383A1/en not_active Abandoned
- 2010-05-11 SG SG2011082492A patent/SG175968A1/en unknown
- 2010-05-11 NZ NZ596738A patent/NZ596738A/xx not_active IP Right Cessation
- 2010-05-11 WO PCT/DK2010/050101 patent/WO2010130260A2/en active Application Filing
- 2010-05-11 AU AU2010246724A patent/AU2010246724B2/en not_active Ceased
- 2010-05-11 MA MA34435A patent/MA33351B1/fr unknown
-
2011
- 2011-11-03 IL IL216148A patent/IL216148A0/en unknown
- 2011-11-04 TN TNP2011000557A patent/TN2011000557A1/en unknown
- 2011-11-04 ZA ZA2011/08112A patent/ZA201108112B/en unknown
- 2011-11-10 CL CL2011002814A patent/CL2011002814A1/es unknown
- 2011-11-11 DO DO2011000351A patent/DOP2011000351A/es unknown
- 2011-11-11 CR CR20110590A patent/CR20110590A/es unknown
- 2011-11-11 CO CO11153611A patent/CO6460741A2/es not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
MA33351B1 (fr) | 2012-06-01 |
WO2010130260A3 (en) | 2011-06-16 |
ZA201108112B (en) | 2013-01-30 |
CO6460741A2 (es) | 2012-06-15 |
SG175968A1 (en) | 2011-12-29 |
CA2761383A1 (en) | 2010-11-18 |
WO2010130260A2 (en) | 2010-11-18 |
AR076556A1 (es) | 2011-06-22 |
EP2430008A2 (en) | 2012-03-21 |
IL216148A0 (en) | 2012-01-31 |
EA201171381A1 (ru) | 2012-05-30 |
GEP20146006B (en) | 2014-01-10 |
DOP2011000351A (es) | 2012-01-31 |
KR20120022934A (ko) | 2012-03-12 |
CL2011002814A1 (es) | 2012-04-13 |
JP2012526152A (ja) | 2012-10-25 |
MX2011011885A (es) | 2011-12-06 |
TW201041857A (en) | 2010-12-01 |
AU2010246724B2 (en) | 2013-03-21 |
BRPI1013930A2 (pt) | 2019-09-24 |
WO2010130260A9 (en) | 2012-10-18 |
AU2010246724A1 (en) | 2011-12-08 |
TN2011000557A1 (en) | 2013-05-24 |
NZ596738A (en) | 2013-04-26 |
CR20110590A (es) | 2012-02-22 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
Fuller et al. | Effect of co‐activation of tongue protrudor and retractor muscles on tongue movements and pharyngeal airflow mechanics in the rat | |
DE69434872T2 (de) | Neue Behandlungsmethoden durch Verwendung von Phenethylderivaten | |
CN102014908A (zh) | 具有组合的sert、5-ht3和5-ht1a活性的化合物的治疗用途 | |
Sebban et al. | Effects of phencyclidine (PCP) and MK 801 on the EEGq in the prefrontal cortex of conscious rats; antagonism by clozapine, and antagonists of AMPA‐, α1‐and 5‐HT2A‐receptors | |
Engebretsen et al. | Cardiotoxicity and late onset seizures with citalopram overdose | |
KR20220046511A (ko) | 염증반응을 예방 치료하는 뉴클레오시드류 유도체 및 그 응용 | |
Ruíz et al. | Anticonvulsant activity of Casimiroa edulis in comparison to phenytoin and phenobarbital | |
CN106562952A (zh) | 氯胺酮在治疗重性抑郁障碍中的应用 | |
CN101816766B (zh) | 一种用于治疗抑郁症的中药组合物 | |
DE69636048T2 (de) | Inhibitoren der zellenadhäsion und zelleninfiltration | |
CN102459208A (zh) | N-(2,6-二甲基-4-吗啉-4-基-苯基)-3,3-二甲基-丁酰胺的稳定形式 | |
Chiu et al. | The effect of anticonvulsant drugs on convulsions triggered by direct stimulation of the brainstem | |
CN110272349A (zh) | 一种2’-羟基-3苯基苯丙酮化合物及其制备方法和用途 | |
CN104211645B (zh) | 嘧啶类衍生物及其应用 | |
EP3233825B1 (en) | Diarylmethylidene piperidine derivatives and their use as delta opioid receptor agonists | |
CN1541093A (zh) | 联用的5-ht1a激动剂和选择性5-羟色胺再吸收抑制剂的新应用 | |
CN1826105B (zh) | 安非他明组合物在生产认知能力损伤的药剂中的应用 | |
US20100286138A1 (en) | Stable forms of N-(2,6-Dimethyl-4-morpholin-4-yl-phenyl)-3,3-dimethyl-butyramide | |
DE60130677T2 (de) | 1-(2-m-methansulfonamidophenylethyl)-4-(m-trifluoromethylphenyl)piperazine und ihre akzeptablen pharmazeutischen salze und solvate und ihre verwendung zur behandlung von inkontinenz | |
DE2520644A1 (de) | Neue benzoesaeurederivate | |
EP4190322A1 (en) | Compound for preventing and treating psychiatric disorders and use thereof | |
EP1667769A2 (de) | Verwendung von galanthamin und seinen derivaten zum herstellen von arzneimitteln | |
CN109310691A (zh) | 用于快速开始抗抑郁作用的给药方案 | |
CN110467597B (zh) | 芳烷环胺类衍生物及其在多靶点抗抑郁症药物中的应用 | |
IE44654B1 (en) | N-propargyl-piperonylamine and its preparation and use |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
REG | Reference to a national code |
Ref country code: HK Ref legal event code: DE Ref document number: 1170731 Country of ref document: HK |
|
C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20120516 |
|
REG | Reference to a national code |
Ref country code: HK Ref legal event code: WD Ref document number: 1170731 Country of ref document: HK |