CN102459208A - N-(2,6-二甲基-4-吗啉-4-基-苯基)-3,3-二甲基-丁酰胺的稳定形式 - Google Patents

N-(2,6-二甲基-4-吗啉-4-基-苯基)-3,3-二甲基-丁酰胺的稳定形式 Download PDF

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Publication number
CN102459208A
CN102459208A CN2010800321765A CN201080032176A CN102459208A CN 102459208 A CN102459208 A CN 102459208A CN 2010800321765 A CN2010800321765 A CN 2010800321765A CN 201080032176 A CN201080032176 A CN 201080032176A CN 102459208 A CN102459208 A CN 102459208A
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CN
China
Prior art keywords
dimethyl
phenyl
compound
yulocrotine
morpholine
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Pending
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CN2010800321765A
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English (en)
Chinese (zh)
Inventor
S·特雷彭达尔
K·利尔托普
H·洛佩斯德迪戈
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H Lundbeck AS
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H Lundbeck AS
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42237259&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CN102459208(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by H Lundbeck AS filed Critical H Lundbeck AS
Publication of CN102459208A publication Critical patent/CN102459208A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/06—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals
    • C07D295/073—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals with the ring nitrogen atoms and the substituents separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Cosmetics (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
CN2010800321765A 2009-05-11 2010-05-11 N-(2,6-二甲基-4-吗啉-4-基-苯基)-3,3-二甲基-丁酰胺的稳定形式 Pending CN102459208A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DKPA200900597 2009-05-11
DKPA200900597 2009-05-11
PCT/DK2010/050101 WO2010130260A2 (en) 2009-05-11 2010-05-11 Stable forms of n-(2,6-dimethyl-4-morpholin-4-yl-phenyl)-3,3-dimethyl-butyramide

Publications (1)

Publication Number Publication Date
CN102459208A true CN102459208A (zh) 2012-05-16

Family

ID=42237259

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2010800321765A Pending CN102459208A (zh) 2009-05-11 2010-05-11 N-(2,6-二甲基-4-吗啉-4-基-苯基)-3,3-二甲基-丁酰胺的稳定形式

Country Status (23)

Country Link
EP (1) EP2430008A2 (es)
JP (1) JP2012526152A (es)
KR (1) KR20120022934A (es)
CN (1) CN102459208A (es)
AR (1) AR076556A1 (es)
AU (1) AU2010246724B2 (es)
BR (1) BRPI1013930A2 (es)
CA (1) CA2761383A1 (es)
CL (1) CL2011002814A1 (es)
CO (1) CO6460741A2 (es)
CR (1) CR20110590A (es)
DO (1) DOP2011000351A (es)
EA (1) EA201171381A1 (es)
GE (1) GEP20146006B (es)
IL (1) IL216148A0 (es)
MA (1) MA33351B1 (es)
MX (1) MX2011011885A (es)
NZ (1) NZ596738A (es)
SG (1) SG175968A1 (es)
TN (1) TN2011000557A1 (es)
TW (1) TW201041857A (es)
WO (1) WO2010130260A2 (es)
ZA (1) ZA201108112B (es)

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI357901B (en) * 2004-03-12 2012-02-11 Lundbeck & Co As H Substituted morpholine and thiomorpholine derivati
KR20090079191A (ko) * 2006-08-23 2009-07-21 밸리언트 파마슈티컬즈 인터내셔널 칼륨 채널 조절제로서 ４-(ｎ-아자사이클로알킬) 아닐리드의 유도체
BRPI0814180A2 (pt) * 2007-08-01 2015-01-27 Lundbeck & Co As H Método para reduzir os sintomas de, ou para tratar, um ou mais distúrbios nos quais o sistema dopaminérgico está desregulado

Also Published As

Publication number Publication date
MA33351B1 (fr) 2012-06-01
WO2010130260A3 (en) 2011-06-16
ZA201108112B (en) 2013-01-30
CO6460741A2 (es) 2012-06-15
SG175968A1 (en) 2011-12-29
CA2761383A1 (en) 2010-11-18
WO2010130260A2 (en) 2010-11-18
AR076556A1 (es) 2011-06-22
EP2430008A2 (en) 2012-03-21
IL216148A0 (en) 2012-01-31
EA201171381A1 (ru) 2012-05-30
GEP20146006B (en) 2014-01-10
DOP2011000351A (es) 2012-01-31
KR20120022934A (ko) 2012-03-12
CL2011002814A1 (es) 2012-04-13
JP2012526152A (ja) 2012-10-25
MX2011011885A (es) 2011-12-06
TW201041857A (en) 2010-12-01
AU2010246724B2 (en) 2013-03-21
BRPI1013930A2 (pt) 2019-09-24
WO2010130260A9 (en) 2012-10-18
AU2010246724A1 (en) 2011-12-08
TN2011000557A1 (en) 2013-05-24
NZ596738A (en) 2013-04-26
CR20110590A (es) 2012-02-22

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