GEP20146006B - Stable forms of n-(2,6-dimethyl-4-morpholin-4-yl-phenyl)-3,3- dimethyl-butyramide - Google Patents

Stable forms of n-(2,6-dimethyl-4-morpholin-4-yl-phenyl)-3,3- dimethyl-butyramide

Info

Publication number
GEP20146006B
GEP20146006B GEAP201012498A GEAP2010012498A GEP20146006B GE P20146006 B GEP20146006 B GE P20146006B GE AP201012498 A GEAP201012498 A GE AP201012498A GE AP2010012498 A GEAP2010012498 A GE AP2010012498A GE P20146006 B GEP20146006 B GE P20146006B
Authority
GE
Georgia
Prior art keywords
dimethyl
butyramide
phenyl
morpholin
stable forms
Prior art date
Application number
GEAP201012498A
Other languages
English (en)
Inventor
De Diego Heidi Lopez
Karin Liltorp
Svend Treppendahl
Original Assignee
H Lundbeck As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42237259&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=GEP20146006(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by H Lundbeck As filed Critical H Lundbeck As
Publication of GEP20146006B publication Critical patent/GEP20146006B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/06—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals
    • C07D295/073—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals with the ring nitrogen atoms and the substituents separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Cosmetics (AREA)
GEAP201012498A 2009-05-11 2010-05-11 Stable forms of n-(2,6-dimethyl-4-morpholin-4-yl-phenyl)-3,3- dimethyl-butyramide GEP20146006B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DKPA200900597 2009-05-11

Publications (1)

Publication Number Publication Date
GEP20146006B true GEP20146006B (en) 2014-01-10

Family

ID=42237259

Family Applications (1)

Application Number Title Priority Date Filing Date
GEAP201012498A GEP20146006B (en) 2009-05-11 2010-05-11 Stable forms of n-(2,6-dimethyl-4-morpholin-4-yl-phenyl)-3,3- dimethyl-butyramide

Country Status (23)

Country Link
EP (1) EP2430008A2 (es)
JP (1) JP2012526152A (es)
KR (1) KR20120022934A (es)
CN (1) CN102459208A (es)
AR (1) AR076556A1 (es)
AU (1) AU2010246724B2 (es)
BR (1) BRPI1013930A2 (es)
CA (1) CA2761383A1 (es)
CL (1) CL2011002814A1 (es)
CO (1) CO6460741A2 (es)
CR (1) CR20110590A (es)
DO (1) DOP2011000351A (es)
EA (1) EA201171381A1 (es)
GE (1) GEP20146006B (es)
IL (1) IL216148A0 (es)
MA (1) MA33351B1 (es)
MX (1) MX2011011885A (es)
NZ (1) NZ596738A (es)
SG (1) SG175968A1 (es)
TN (1) TN2011000557A1 (es)
TW (1) TW201041857A (es)
WO (1) WO2010130260A2 (es)
ZA (1) ZA201108112B (es)

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI349666B (en) * 2004-03-12 2011-10-01 Lundbeck & Co As H Substituted morpholine and thiomorpholine derivatives
MX2009002002A (es) * 2006-08-23 2009-07-22 Valeant Pharmaceuticals Int Derivados de 4-(n-azacicloalquil) anilidas como moduladores de canal de potasio.
CA2694887A1 (en) * 2007-08-01 2009-02-05 Henriette Husum Bak-Jensen Use of kncq potassium channel openers for reducing symptoms of or treating disorders or conditions wherein the dopaminergic system is disrupted

Also Published As

Publication number Publication date
JP2012526152A (ja) 2012-10-25
AU2010246724B2 (en) 2013-03-21
TN2011000557A1 (en) 2013-05-24
CL2011002814A1 (es) 2012-04-13
IL216148A0 (en) 2012-01-31
AR076556A1 (es) 2011-06-22
SG175968A1 (en) 2011-12-29
WO2010130260A2 (en) 2010-11-18
MX2011011885A (es) 2011-12-06
MA33351B1 (fr) 2012-06-01
WO2010130260A9 (en) 2012-10-18
BRPI1013930A2 (pt) 2019-09-24
WO2010130260A3 (en) 2011-06-16
TW201041857A (en) 2010-12-01
DOP2011000351A (es) 2012-01-31
EP2430008A2 (en) 2012-03-21
NZ596738A (en) 2013-04-26
CR20110590A (es) 2012-02-22
CA2761383A1 (en) 2010-11-18
EA201171381A1 (ru) 2012-05-30
CN102459208A (zh) 2012-05-16
CO6460741A2 (es) 2012-06-15
AU2010246724A1 (en) 2011-12-08
KR20120022934A (ko) 2012-03-12
ZA201108112B (en) 2013-01-30

Similar Documents

Publication Publication Date Title
HK1194071A1 (en) Certain triazolopyrazines, compositions thereof and methods of use therefor
MX2012006549A (es) Composiciones y metodos que comprenden variantes de proteasa.
MX339878B (es) Nuevas formas solidas de clorhidrato de bendamustina.
EP2248171A4 (en) SEMICONDUCTOR CONSTRUCTIONS AND METHODS OF FORMING SEMICONDUCTOR CONSTRUCTIONS
EP2437602A4 (en) OPHTHALMIC FORMULATIONS, METHOD FOR THE PRODUCTION THEREOF AND METHOD FOR THEIR USE
GEP20146114B (en) New crystalline form vi of agomelatine, preparation method and application thereof
IL220343B (en) Polymer and protein conjugates and their use to create cross-linked structures
MY152437A (en) Oral care compositions
MX2013002784A (es) Heteroarilos fusionados y sus usos.
MX2011010012A (es) NUEVOS ANTICUERPOS ANTI-A5ß1 Y SUS USOS.
HK1184181A1 (en) POLYETHERAMINES, COMPOSITIONS INCLUDING POLYETHERAMINES, AND METHODS OF g MAKING
WO2011086584A3 (en) Improved process for the preparation of amide intermediates and their use thereof
MX2012007379A (es) Anticuerpos anti-bv8 y usos de los mismos.
EP2442826A4 (en) INFLUENZA VACCINE, COMPOSITION, AND METHODS OF USE
HK1167240A1 (zh) 使用芳基哌嗪類化合物的組合，合成和方法
BRPI0920995A2 (pt) catalisador de metal carregado e método de preparação do mesmo.
EP2447365A4 (en) CELL-FREE PROTEIN SYNTHESIS, CELL-FREE PROTEIN SYNTHESIS, AND PROTEIN SYNTHESIS METHOD
MX361011B (es) Inhibidores de amida hidrolasa de ácido graso.
EP2445873A4 (en) PROTEASE INHIBITORS, COMPOSITIONS COMPRISING THE SAME, AND METHODS OF USE
GB2488494B (en) Solution, use and method of preparation thereof
WO2010111421A3 (en) Isoform nell-1 peptide
GEP20146006B (en) Stable forms of n-(2,6-dimethyl-4-morpholin-4-yl-phenyl)-3,3- dimethyl-butyramide
EP2279221A4 (en) ORGANO-NEUTRALIZED SILICONE GEL, METHOD FOR THE PRODUCTION AND USE THEREOF
EP2507222A4 (en) SALACINOL AND PONCORANOL HOMOLOGOUS, DERIVATIVES THEREOF AND METHOD FOR THEIR SYNTHESIS
TH149037B (th) ธรอสโตคัยทริด, องค์ประกอบของกรดอะมิโน, และวิธีการของการทำและการใช้ของ สิ่งนั้น