CN102441180A - 一种胃肠b超显像剂 - Google Patents
一种胃肠b超显像剂 Download PDFInfo
- Publication number
- CN102441180A CN102441180A CN2012100013727A CN201210001372A CN102441180A CN 102441180 A CN102441180 A CN 102441180A CN 2012100013727 A CN2012100013727 A CN 2012100013727A CN 201210001372 A CN201210001372 A CN 201210001372A CN 102441180 A CN102441180 A CN 102441180A
- Authority
- CN
- China
- Prior art keywords
- gastrointestinal
- developer
- weight
- ultrasonic
- stomach
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 230000002496 gastric effect Effects 0.000 title claims abstract description 26
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 21
- POJWUDADGALRAB-UHFFFAOYSA-N allantoin Chemical compound NC(=O)NC1NC(=O)NC1=O POJWUDADGALRAB-UHFFFAOYSA-N 0.000 claims abstract description 14
- 239000003814 drug Substances 0.000 claims abstract description 12
- 235000019387 fatty acid methyl ester Nutrition 0.000 claims abstract description 8
- 229940051841 polyoxyethylene ether Drugs 0.000 claims abstract description 8
- 229920000056 polyoxyethylene ether Polymers 0.000 claims abstract description 8
- POJWUDADGALRAB-PVQJCKRUSA-N Allantoin Natural products NC(=O)N[C@@H]1NC(=O)NC1=O POJWUDADGALRAB-PVQJCKRUSA-N 0.000 claims abstract description 7
- 229960000458 allantoin Drugs 0.000 claims abstract description 7
- 229940057995 liquid paraffin Drugs 0.000 claims abstract description 6
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims abstract description 6
- 229920000053 polysorbate 80 Polymers 0.000 claims abstract description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 5
- 239000000706 filtrate Substances 0.000 claims abstract description 4
- VYQNWZOUAUKGHI-UHFFFAOYSA-N monobenzone Chemical compound C1=CC(O)=CC=C1OCC1=CC=CC=C1 VYQNWZOUAUKGHI-UHFFFAOYSA-N 0.000 claims description 4
- 239000002994 raw material Substances 0.000 claims description 4
- 210000000582 semen Anatomy 0.000 claims description 4
- 238000000034 method Methods 0.000 claims description 3
- 229920000136 polysorbate Polymers 0.000 claims description 2
- 238000003756 stirring Methods 0.000 claims 1
- 210000002784 stomach Anatomy 0.000 abstract description 12
- 238000003745 diagnosis Methods 0.000 abstract description 9
- 229940079593 drug Drugs 0.000 abstract description 6
- 210000003097 mucus Anatomy 0.000 abstract description 6
- 230000001737 promoting effect Effects 0.000 abstract description 3
- 210000000936 intestine Anatomy 0.000 abstract description 2
- 230000008855 peristalsis Effects 0.000 abstract description 2
- 230000001105 regulatory effect Effects 0.000 abstract description 2
- 238000002604 ultrasonography Methods 0.000 abstract description 2
- 241000132012 Atractylodes Species 0.000 abstract 1
- 244000037364 Cinnamomum aromaticum Species 0.000 abstract 1
- 235000014489 Cinnamomum aromaticum Nutrition 0.000 abstract 1
- 244000183685 Citrus aurantium Species 0.000 abstract 1
- 235000007716 Citrus aurantium Nutrition 0.000 abstract 1
- 244000077995 Coix lacryma jobi Species 0.000 abstract 1
- RUPBZQFQVRMKDG-UHFFFAOYSA-M Didecyldimethylammonium chloride Chemical compound [Cl-].CCCCCCCCCC[N+](C)(C)CCCCCCCCCC RUPBZQFQVRMKDG-UHFFFAOYSA-M 0.000 abstract 1
- 240000004670 Glycyrrhiza echinata Species 0.000 abstract 1
- 235000001453 Glycyrrhiza echinata Nutrition 0.000 abstract 1
- 235000006200 Glycyrrhiza glabra Nutrition 0.000 abstract 1
- 235000017382 Glycyrrhiza lepidota Nutrition 0.000 abstract 1
- GXCLVBGFBYZDAG-UHFFFAOYSA-N N-[2-(1H-indol-3-yl)ethyl]-N-methylprop-2-en-1-amine Chemical compound CN(CCC1=CNC2=C1C=CC=C2)CC=C GXCLVBGFBYZDAG-UHFFFAOYSA-N 0.000 abstract 1
- 244000236658 Paeonia lactiflora Species 0.000 abstract 1
- 235000008598 Paeonia lactiflora Nutrition 0.000 abstract 1
- 244000272264 Saussurea lappa Species 0.000 abstract 1
- 235000006784 Saussurea lappa Nutrition 0.000 abstract 1
- 241001078983 Tetradium ruticarpum Species 0.000 abstract 1
- 238000001914 filtration Methods 0.000 abstract 1
- 229940010454 licorice Drugs 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 230000008961 swelling Effects 0.000 abstract 1
- 201000010099 disease Diseases 0.000 description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 230000003187 abdominal effect Effects 0.000 description 2
- 238000001514 detection method Methods 0.000 description 2
- 239000003925 fat Substances 0.000 description 2
- 210000001035 gastrointestinal tract Anatomy 0.000 description 2
- 210000000056 organ Anatomy 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 210000001835 viscera Anatomy 0.000 description 2
- 208000012895 Gastric disease Diseases 0.000 description 1
- 208000007882 Gastritis Diseases 0.000 description 1
- 208000018522 Gastrointestinal disease Diseases 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 238000002405 diagnostic procedure Methods 0.000 description 1
- 208000010643 digestive system disease Diseases 0.000 description 1
- 239000003995 emulsifying agent Substances 0.000 description 1
- 230000001804 emulsifying effect Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 210000001156 gastric mucosa Anatomy 0.000 description 1
- 208000018685 gastrointestinal system disease Diseases 0.000 description 1
- 239000004519 grease Substances 0.000 description 1
- 235000014593 oils and fats Nutrition 0.000 description 1
- 210000001711 oxyntic cell Anatomy 0.000 description 1
- 231100000915 pathological change Toxicity 0.000 description 1
- 230000036285 pathological change Effects 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
Landscapes
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
本发明涉及一种显像剂，特别涉及一种胃肠B超显像剂，是由以下重量份原料药制备而成：白术20g、木香20g、白芍20g、陈皮20g、炒麦芽20g、肉桂10g、薏苡仁10g、枳壳10g、吴茱萸10g、甘草6g，分别加10倍量和8倍量水，提取两次，每次2小时，过滤，合并滤液，浓缩到100ml，加入5g液状石蜡、2g脂肪酸甲酯聚氧乙烯醚、2g的吐温80、1g癸甲氯铵、5g甘油、1g尿囊素，混匀，装瓶即得。本发明具有行气消胀、理气和胃的功能，快速消除胃肠内气泡，促进胃肠蠕动，清除胃肠粘液，使胃腔内无回声暗区，排除声波阻抗对胃肠B超诊断的干扰，提高胃肠B超的清晰度，胃壁各层结构清晰，病灶显示突出，减少漏诊、错诊的几率。
Description
技术领域
本发明涉及一种显像剂，特别是涉及一种胃肠B超显像剂。
背景技术
在临床检测中，B超检测可以清晰的显示腹部实质性脏器以及各脏器周围组织的各种断面图像，从而使早期的疾病得到明确的诊断，B超检测已成为临床医学中不可或缺的诊断方法；但是，胃肠B超检测也有其局限性，由于胃肠道内壁的特殊结构、腔内多有粘液和气体残存，而超声检查对于气体干扰的影响较大，腹部胃肠道等空腔脏器病变因空腔脏器内气体干扰，致使超声波被反射，使胃肠道病变部位模糊不清，从而影响图像质量，容易发生漏诊、误诊等现象。
发明内容
为了解决胃肠B超检测过程中因胃内壁气体残留而引起的诊断不准确的问题，本发明提供了一种作用快速，行气消胀、对胃病患者兼有治疗作用的胃肠B超显像剂。
本发明的胃肠B超显像剂，是由以下重量份原料药制备而成：白术20g、木香20g、厚朴20g、白芍20g、陈皮20g、炒麦芽20g、肉桂10g、薏苡仁10g、枳壳10g、吴茱萸10g、甘草6g 、液体石蜡5g、脂肪酸甲酯聚氧乙烯醚2g、吐温80 2g、癸甲氯铵1g、甘油5g、尿囊素1g。
制备方法
（1）分别加10倍量和8倍量水，提取两次，每次2小时，过滤，合并滤液，浓缩到100ml；
（2）取步聚（1）的浓缩液，加入5g液状石蜡、2g脂肪酸甲酯聚氧乙烯醚、2g吐温80、1g癸甲氯铵、5g甘油、1g尿囊素，混匀，装瓶。
上述本发明的原料中，所述的脂肪酸甲酯聚氧乙烯醚为乳化剂，吐温80是表面活性剂，它们相互配合可以乳化油脂。由于人体胃肠内存在大量的油性物，造成现有的显像剂不能去除油脂，使显像剂不能彻底到达胃内的细小缝隙，加入脂肪酸甲酯聚氧乙烯醚和吐温80后，便可使胃肠壁内的油脂乳化，从而达到乳化油脂，充分充盈的目的。
上述原料中，所述的癸甲氯铵为杀菌剂，可以起到杀菌消毒的作用。
上述原料中，甘油和尿囊素可以起到滋润胃壁细胞，修复皮肤内壁，降低药剂对胃肠内壁的刺激的作用。
本发明的胃肠B超显像剂，通过加入一定量的中药提取物，起到行气消胀、理气和胃的功能，能够快速消除胃肠内气泡，促进胃肠蠕动，清除胃肠内粘液，使胃腔内无回声暗区，排除声波阻抗对胃肠B超诊断的干扰，提高胃肠B超的清晰度，胃壁各层结构清晰，病灶显示突出，减少漏诊、错诊的几率。
药效观察试验
检测标准：
优良：显像剂充盈良好，胃壁内无气泡和粘液干扰，胃粘膜面显示清晰，胃壁五层结构清晰可辨。
一般：显像剂充盈良好，胃壁内有少量气泡和粘液干扰，粘膜面显示较清晰，胃壁五层结构尚清晰，但不影响检测。
不良：胃腔内有大量气泡和粘液，粘膜面显示不清，胃壁层次无法辨认，影响检测。
药效观察结果:
通过对医院来诊胃炎病人4280例进行统计，其中优良2123例，一般1732例，总有效率为90.07%，具有统计学意义。
具体实施方式：
下面结合实施例对本发明做进一步的说明。
取原料药：白术20g、木香20g、厚朴20g、白芍20g、陈皮20g、炒麦芽20g、肉桂10g、薏苡仁10g、枳壳10g、吴茱萸10g、甘草6g；分别加10倍量和8倍量水，提取两次，每次2小时，过滤，合并滤液，浓缩到100ml；加入5g液状石蜡、2g脂肪酸甲酯聚氧乙烯醚、2g的吐温80、1g癸甲氯铵、5g甘油、1g尿囊素，混匀，装瓶，即得。
Claims (2)
1.一种胃肠B超显像剂，其特征是由下列重量份原料药制备而成：白术20g、木香20g、厚朴20g、白芍20g、陈皮20g、炒麦芽20g、肉桂10g、薏苡仁10g、枳壳10g、吴茱萸10g、甘草6g、液体石蜡5g、脂肪酸甲酯聚氧乙烯醚2g、吐温80 2g、癸甲氯铵1g、甘油5g、尿囊素1g。
2.如权利要求1所述的胃肠B超显像剂，其特征在于所述显像剂采用以下方法制备而成：
（1）取白术20g、木香20g、厚朴20g、白芍20g、陈皮20g、炒麦芽20g、肉桂10g、薏苡仁10g、枳壳10g、吴茱萸10g、甘草6g分别加10倍量和8倍量水，提取两次，过滤，合并滤液，浓缩至100ml；
（2）取步聚（1）的浓缩液，加入5g液状石蜡、2g脂肪酸甲酯聚氧乙烯醚、2g吐温80、1g癸甲氯铵、5g甘油、1g尿囊素，搅拌均匀，装瓶，即得。
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201210001372 CN102441180B (zh) | 2012-01-05 | 2012-01-05 | 一种胃肠b超显像剂 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201210001372 CN102441180B (zh) | 2012-01-05 | 2012-01-05 | 一种胃肠b超显像剂 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102441180A true CN102441180A (zh) | 2012-05-09 |
| CN102441180B CN102441180B (zh) | 2013-01-23 |
Family
ID=46004435
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 201210001372 Active CN102441180B (zh) | 2012-01-05 | 2012-01-05 | 一种胃肠b超显像剂 |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN102441180B (zh) |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103611173A (zh) * | 2013-12-02 | 2014-03-05 | 刘叶 | 胃肠b超显像剂 |
| CN104189926A (zh) * | 2014-08-06 | 2014-12-10 | 丁艳 | 胃b超快速显像剂 |
| CN104667305A (zh) * | 2015-02-12 | 2015-06-03 | 郝爱华 | 一种胃肠b超显像剂 |
| CN104758957A (zh) * | 2015-02-12 | 2015-07-08 | 郝爱华 | 胃肠b超显像剂 |
| CN104800864A (zh) * | 2015-04-24 | 2015-07-29 | 郑敏 | 一种胃b超显像剂 |
| CN105664189A (zh) * | 2016-03-09 | 2016-06-15 | 于春英 | 一种胃b超显像剂及其制备工艺 |
| DE102023125435A1 (de) | 2022-10-13 | 2024-04-18 | Shandong Branden Medical Device Co., Ltd. | Zweikomponenten-Hilfswicklungsmittel für die Magensonographie und Herstellungsverfahren davon |
| DE102023125436A1 (de) | 2022-10-12 | 2024-04-18 | Shandong Branden Medical Device Co., Ltd. | Entwicklungsmittel für die gastrointestinale Sonographie und Herstellungsverfahren davon |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1098943A (zh) * | 1994-02-23 | 1995-02-22 | 孙伯敬 | 中药胃b超显像液 |
| CN1106702A (zh) * | 1994-08-08 | 1995-08-16 | 段庆银 | 胃肠b超快速显像剂 |
| CN1285225A (zh) * | 2000-06-22 | 2001-02-28 | 刘志娟 | 胃b超显像粉及其工艺 |
| CN101422622A (zh) * | 2008-12-09 | 2009-05-06 | 秦峰 | 一种b超使用的中药助影剂及其制备方法 |
| CN102068707A (zh) * | 2011-01-10 | 2011-05-25 | 张洪英 | 一种b超使用的中药助影剂及其制备方法 |
-
2012
- 2012-01-05 CN CN 201210001372 patent/CN102441180B/zh active Active
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1098943A (zh) * | 1994-02-23 | 1995-02-22 | 孙伯敬 | 中药胃b超显像液 |
| CN1106702A (zh) * | 1994-08-08 | 1995-08-16 | 段庆银 | 胃肠b超快速显像剂 |
| CN1285225A (zh) * | 2000-06-22 | 2001-02-28 | 刘志娟 | 胃b超显像粉及其工艺 |
| CN101422622A (zh) * | 2008-12-09 | 2009-05-06 | 秦峰 | 一种b超使用的中药助影剂及其制备方法 |
| CN102068707A (zh) * | 2011-01-10 | 2011-05-25 | 张洪英 | 一种b超使用的中药助影剂及其制备方法 |
Non-Patent Citations (2)
| Title |
|---|
| 《江苏中医》 19951231 伦知见 《中药超声显像剂在胃"B超"检查中的应用》 1-2 第16卷, 第7期 * |
| 伦知见: "《中药超声显像剂在胃"B超"检查中的应用》", 《江苏中医》, vol. 16, no. 7, 31 December 1995 (1995-12-31) * |
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103611173A (zh) * | 2013-12-02 | 2014-03-05 | 刘叶 | 胃肠b超显像剂 |
| CN103611173B (zh) * | 2013-12-02 | 2015-05-13 | 刘叶 | 胃肠b超显像剂 |
| CN104189926A (zh) * | 2014-08-06 | 2014-12-10 | 丁艳 | 胃b超快速显像剂 |
| CN104667305A (zh) * | 2015-02-12 | 2015-06-03 | 郝爱华 | 一种胃肠b超显像剂 |
| CN104758957A (zh) * | 2015-02-12 | 2015-07-08 | 郝爱华 | 胃肠b超显像剂 |
| CN104800864A (zh) * | 2015-04-24 | 2015-07-29 | 郑敏 | 一种胃b超显像剂 |
| CN105664189A (zh) * | 2016-03-09 | 2016-06-15 | 于春英 | 一种胃b超显像剂及其制备工艺 |
| DE102023125436A1 (de) | 2022-10-12 | 2024-04-18 | Shandong Branden Medical Device Co., Ltd. | Entwicklungsmittel für die gastrointestinale Sonographie und Herstellungsverfahren davon |
| DE102023125435A1 (de) | 2022-10-13 | 2024-04-18 | Shandong Branden Medical Device Co., Ltd. | Zweikomponenten-Hilfswicklungsmittel für die Magensonographie und Herstellungsverfahren davon |
Also Published As
| Publication number | Publication date |
|---|---|
| CN102441180B (zh) | 2013-01-23 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102441180B (zh) | 一种胃肠b超显像剂 | |
| CN103611173B (zh) | 胃肠b超显像剂 | |
| CN104127892B (zh) | 一种医用超声耦合剂及制备方法 | |
| CN103495187B (zh) | 一种用于b超的中药胃肠助影剂及其制备方法 | |
| CN102441178B (zh) | 做b超使用的中药助影剂 | |
| CN104383183A (zh) | 一种治疗非酒精性脂肪肝的药物组合物 | |
| CN104189926A (zh) | 胃b超快速显像剂 | |
| CN104138605A (zh) | 一种胃b超快速显像剂 | |
| CN104667305A (zh) | 一种胃肠b超显像剂 | |
| CN104800864A (zh) | 一种胃b超显像剂 | |
| CN104436247A (zh) | 一种利用超声检测胃肠疾病的造影剂及其制备方法 | |
| CN107551283A (zh) | 一种肠胃超声助显剂及其制备方法 | |
| CN1879843A (zh) | 一种治疗慢性胆囊炎的中药组合物及其制备方法 | |
| CN111053924B (zh) | 胃肠超声造影剂 | |
| CN104758957A (zh) | 胃肠b超显像剂 | |
| CN106075477A (zh) | 一种彩超用助影药物 | |
| CN113521121A (zh) | 一种中药杜仲在体表和内脏微循环调控中的应用 | |
| CN105343565A (zh) | 一种治疗深部真菌感染的中药 | |
| CN116832111B (zh) | 一种消除颈动脉斑块的中药制剂及其制备方法 | |
| CN105664189A (zh) | 一种胃b超显像剂及其制备工艺 | |
| CN106177346A (zh) | 一种调理脾胃的中药组合物及其制备方法和应用 | |
| CN106955332A (zh) | 一种改善肝硬化患者肠粘膜屏障的灌肠液 | |
| CN101306119A (zh) | 假酸浆水煎服治急、慢性前列腺疾病 | |
| CN105998842A (zh) | 一种治疗气滞血瘀型胆囊炎的中药制剂 | |
| CN104147268A (zh) | 一种治疗肝胆结石的中药组合物及其制剂 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| ASS | Succession or assignment of patent right |
Owner name: RUDONG TECHNOLOGY CENTER Free format text: FORMER OWNER: WANG HUI Effective date: 20131211 |
|
| C41 | Transfer of patent application or patent right or utility model | ||
| COR | Change of bibliographic data |
Free format text: CORRECT: ADDRESS; FROM: 250031 JINAN, SHANDONG PROVINCE TO: 226400 NANTONG, JIANGSU PROVINCE |
|
| TR01 | Transfer of patent right |
Effective date of registration: 20131211 Address after: 226400 No. 66 Youyi West Road, dug Town, Rudong County, Jiangsu, Nantong Patentee after: Rudong science and Technology Center Address before: 250031 ultrasonic diagnosis department, General Hospital of Jinan Military Area, Tianqiao District, Ji'nan, Shandong Patentee before: Wang Hui |
|
| TR01 | Transfer of patent right |
Effective date of registration: 20200409 Address after: No. 10, Fandi South Road, juegang Town, Rudong County, Nantong City, Jiangsu Province Patentee after: Rudong industrial and commercial information consulting service center Address before: 226400 No. 66 Youyi West Road, dug Town, Rudong County, Jiangsu, Nantong Patentee before: Rudong science and Technology Center |
|
| TR01 | Transfer of patent right | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20210817 Address after: 226400 No.8, wisdom Avenue, Donghu scenic area, Dayu Town, Rudong County, Nantong City, Jiangsu Province Patentee after: Nantong Donghu International Travel Agency Co., Ltd Address before: 226400 No.10 Fandi South Road, juegang Town, Rudong County, Nantong City, Jiangsu Province Patentee before: Rudong industrial and commercial information consulting service center |
|
| TR01 | Transfer of patent right |