CN102441178B - 做b超使用的中药助影剂 - Google Patents
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Abstract
本发明的做B超使用的中药助影剂，其特征在于：由以下重量份数的原料制成：牡蛎壳10-15份，一匹草5-7份，一年蓬5-7份，干饧糟8-10份，大麦8-10份，大箭4-6份，山青皮4-6份，山矾叶8-10份，枳实5-7份，苍术8-10份，大腹皮4-6份，厚朴5-7份，陈皮6-8份，甘草3-5份，木香4-6份。本发明的有益效果是，使用安全、无痛苦、无创伤、无毒性、服用无不适感和过敏反应，检查时间短(显像时间2分钟)，显像效率高、效果稳定，止血、止痛、止酸，使用方便易行，成本低，口感适中，便于推广使用。
Description
技术领域
本发明涉及一种做B超使用的中药助影剂。
背景技术
超声图像诊断是医学中重要的诊断方法，而B超虽然有动态观察的优点，但由于受到胃肠气体和粘液的干扰，胃肠B超检查现象不清楚，因此消除气泡和粘液是B超胃肠助影剂的主要作用。目前现有的助影剂有的价格太贵，有的显影不佳，有的会导致胃酸反应强烈，对病人造成痛感和不适感，有的显影时间太长，有的口感太苦，难以下咽，这些局限性导致现有药物难以推广使用。
发明内容
本发明为了弥补现有技术的不足，提供了一种价格适中、显影快、显影清晰、服用后无不良反应和感觉、口感适中的做B超使用的中药助影剂。
本发明是通过如下技术方案实现的：
本发明的做B超使用的中药助影剂，其特征在于：由以下重量份数的原料制成：牡蛎壳10-15份，一匹草5-7份，一年蓬5-7份，干饧糟8-10份，大麦8-10份，大箭4-6份，山青皮4-6份，山矾叶8-10份，枳实5-7份，苍术8-10份，大腹皮4-6份，厚朴5-7份，陈皮6-8份，甘草3-5份，木香4-6份。
使用方法：将牡蛎壳粉碎研磨至140目粉末单独包装，其余药物用水煎法，煎三次，合并三次滤液后加热浓缩至200毫升，凉至常温后加入食品防腐剂，制成瓶装或袋装口服液。服用时，先用白开水50-100毫升将牡蛎壳粉末口服，然后将口服液加热，温服，每次一剂。
助影剂中的碳酸钙和胃酸中和后产生二氧化碳气泡，饮水和服用药物后各种中药结合后起到明显的制酸止痛作用，在图像上更清晰，点状强回声反射，看到胃壁层次清晰可见。而且此助影剂服下后.对胃周粘膜起到保护作用，在超声显示屏幕上可见到胃腔大小、形态、十二指肠、胃小弯、胃大弯等处显像明显，各部位病灶清晰可见，并且对胃周脏器如肝、胆、胰腺显示清晰，对胃周有无淋巴结转移亦能明确诊断。
助影剂中的碳酸钙和胃酸中和后产生二氧化碳气泡，呈雪花状浮游现象，由于助影剂中的粘性物质对溃疡、癌肿粘膜表面上能逐渐积聚、融合成索块或光团图像，形成明显的界面，助影剂使胃腔充盈造成胃壁黏膜在声阻抗力方面的差异，从而显示胃的形态、位置、胃腔大小、胃壁厚度、排空时间和病变情况，能显示胃肠功能紊乱，显示小肠、盲肠、结肠各部位的病变。
由于本发明既符合消化道助影剂的要求，又具有一定的药理作用，临床上除用于作消化道助影剂外，还可用于辅助治疗胃肠溃疡、胃肠出血、胃肠疼痛等疾病。本发明助影剂经急性毒性试验、微核试验、精子畸形试验、小鼠睾丸染色体畸变试验，证明无不良反应。
本发明药物对小鼠的急性毒性试验：取18-22克小鼠20只，雌雄各半，用本发明药液于上午8时一次性灌胃给药，给药容量为0.4mg/10g，连续观察10天，记录逐日的小鼠毒性反应及死亡数。实验结果表明，给小鼠灌药后，首先出现运动减少，很快恢复正常，无动物死亡现象。逐渐增加给药量，每喂入一次观察10天。给药容量为140ml/kg时，仍无动物死亡现象。给小鼠灌胃给药200ml/kg，按公斤体重计算，相当于成人每日用量(100g，相当于1.43ml/kg)的140倍。按动物系数折算，相当于70kg成人每日用量的15倍以上，则动物于一周内死亡，表明其LD50必大于200ml/kg。其结果显示小鼠给药的最大耐受量在200ml/kg以上，口服给药很安全。证明本发明口服安全性很大。
典型病例：
病例1张女土，53岁，因腹痛、呕吐、便血两天来诊，经口服本发明助影剂后，在普通B超屏幕上显示，十二指肠变形，并在十二指肠前壁可见明显水肿及溃疡面，明确诊断此患者患有十二指肠溃疡，须住院治疗。
病例2汤先生：46岁，胃疼恶心、不想进食，经口服本发明助影剂后，发现胃体侧有以明确糜烂面，诊断患者是胃内出血，配合药物治疗一周后好转出院。
经80例临床服用，能明确诊断各种胃肠疾病。口服本品2分钟内即可排除胃部气泡、消除粘液，使胃壁结构显示清晰，清楚显示胃部不同病变，显像效果好，分辨力高，图像稳定，用各种普通B超仪器即可进行胃部B超检查，而且具有健脾消食，除胀止痛作用。根据临床诊断实验，显影优良清晰显影率93％，显影一般清晰显影率7％，诊断出浅表性胃炎、肥厚性胃炎、胃粘膜脱垂、胃癌、幽门部肿瘤、胃下垂及十二指肠炎等。该药物也可以对肠道中下段疾病以及腹膜后病变诊断。与胃镜检查相比较，浅表性胃炎诊断符合率95％，胃癌符合率90％。
本发明的有益效果是，使用安全、无痛苦、无创伤、无毒性、服用无不适感和过敏反应，检查时间短(显像时间2分钟)，显像效率高、效果稳定，止血、止痛、止酸，使用方便易行，成本低，口感适中，便于推广使用。
具体实施方式
实施例1
本发明的做B超使用的中药助影剂，由以下重量的原料制成：牡蛎壳12克，一匹草6克，一年蓬6克，干饧糟9克，大麦9克，大箭5克，山青皮5克，山矾叶9克，枳实6克，苍术9克，大腹皮5克，厚朴6克，陈皮7克，甘草4克，木香5克。
使用方法：将牡蛎壳粉碎研磨至140目粉末单独包装，其余药物用水煎法，煎三次，合并三次滤液后加热浓缩至200毫升，凉至常温后加入食品防腐剂，制成瓶装或袋装口服液。服用时，先用白开水50-100毫升将牡蛎壳粉末口服，然后将口服液加热，温服，每次一剂。
实施例2
本发明的做B超使用的中药助影剂，由以下重量的原料制成：牡蛎壳10克，一匹草5克，一年蓬5克，干饧糟8克，大麦8克，大箭4克，山青皮4克，山矾叶8克，枳实5克，苍术8克，大腹皮4克，厚朴5克，陈皮6克，甘草3克，木香4克。
其余与实施例1相同。
实施例3
本发明的做B超使用的中药助影剂，由以下重量的原料制成：牡蛎壳15克，一匹草7克，一年蓬7克，干饧糟10克，大麦10克，大箭6克，山青皮6克，山矾叶10克，枳实7克，苍术10克，大腹皮6克，厚朴7克，陈皮8克，甘草5克，木香6克。
其余与实施例1相同。
Claims (1)
1.一种做B超使用的中药助影剂，其特征在于：由以下重量份数的原料药制成：牡蛎壳10-15份，一匹草5-7份，一年蓬5-7份，干饧糟8-10份，大麦8-10份，大箭4-6份，山青皮4-6份，山矾叶8-10份，枳实5-7份，苍术8-10份，大腹皮4-6份，厚朴5-7份，陈皮6-8份，甘草3-5份，木香4-6份。
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| CN104800864A (zh) * | 2015-04-24 | 2015-07-29 | 郑敏 | 一种胃b超显像剂 |
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