CN102427727A - 神经变性和神经炎症的治疗 - Google Patents

神经变性和神经炎症的治疗 Download PDF

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Publication number
CN102427727A
CN102427727A CN2010800215056A CN201080021505A CN102427727A CN 102427727 A CN102427727 A CN 102427727A CN 2010800215056 A CN2010800215056 A CN 2010800215056A CN 201080021505 A CN201080021505 A CN 201080021505A CN 102427727 A CN102427727 A CN 102427727A
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disease
compound
experimenter
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neurodegeneration
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马特维·卢卡舍夫
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Biogen MA Inc
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Biogen Idec MA Inc
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
    • A61K9/2846—Poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
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CN2010800215056A 2009-04-29 2010-04-29 神经变性和神经炎症的治疗 Pending CN102427727A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US17379709P 2009-04-29 2009-04-29
US61/173,797 2009-04-29
US17527009P 2009-05-04 2009-05-04
US61/175,270 2009-05-04
PCT/US2010/001282 WO2010126605A1 (en) 2009-04-29 2010-04-29 Treatment of neurodegeneration and neuroinflammation

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CN201410648177.2A Division CN104523673A (zh) 2009-04-29 2010-04-29 神经变性和神经炎症的治疗

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CN102427727A true CN102427727A (zh) 2012-04-25

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CN201410648177.2A Pending CN104523673A (zh) 2009-04-29 2010-04-29 神经变性和神经炎症的治疗

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US (3) US20120165404A1 (enExample)
EP (3) EP3466420A1 (enExample)
JP (3) JP2012525385A (enExample)
CN (2) CN102427727A (enExample)
AU (1) AU2010242064A1 (enExample)
CA (1) CA2760133A1 (enExample)
HK (1) HK1255133A1 (enExample)
NZ (2) NZ595941A (enExample)
WO (1) WO2010126605A1 (enExample)

Cited By (4)

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CN103173544A (zh) * 2013-03-05 2013-06-26 浙江大学 Leber病之线粒体T3866C检测试剂盒及应用
CN103768045A (zh) * 2013-10-30 2014-05-07 苏州大学附属第一医院 富马酸二甲酯在制备治疗蛛网膜下腔出血后早期脑损伤药物的应用
CN105142628A (zh) * 2012-12-21 2015-12-09 比奥根玛公司 氘取代的富马酸盐衍生物
CN105813634A (zh) * 2013-12-12 2016-07-27 阿尔米雷尔有限公司 包含反丁烯二酸二甲酯的药物组合物

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DE19853487A1 (de) 1998-11-19 2000-05-25 Fumapharm Ag Muri Verwendung von Dialkylfumaraten
WO2005023241A1 (en) 2003-09-09 2005-03-17 Fumapharm Ag The use of fumaric acid derivatives for treating cardiac insufficiency, and asthma
SI2801354T1 (sl) * 2004-10-08 2017-07-31 Forward Pharma A/S Farmacevtske sestave z nadzorovanim sproščanjem, ki zajemajo ester fumarne kisline
DK2653873T3 (da) 2007-02-08 2022-07-25 Biogen Ma Inc Sammensætninger og anvendelser til behandling af multipel sklerose
PT2139467T (pt) * 2007-02-08 2016-12-16 Biogen Ma Inc Neuroproteção em doenças desmielinizantes
DK2334378T3 (da) 2008-08-19 2014-07-07 Xenoport Inc Prodrugs af methylhydrogenfumarat, farmaceutiske sammensætninger deraf og fremgangsmåder til anvendelse
KR101699912B1 (ko) 2009-01-09 2017-01-25 포워드 파마 에이/에스 1종 이상의 푸마르산 에스테르를 침식 매트릭스에 함유하는 제제
JPWO2010098429A1 (ja) 2009-02-27 2012-09-06 国立大学法人大阪大学 免疫アジュバント組成物、及びその利用
EP3466420A1 (en) * 2009-04-29 2019-04-10 Biogen MA Inc. Dimethyl fumarate for the treatment of friedreich ataxia
US20140142095A1 (en) * 2011-04-28 2014-05-22 Serket Pharma, Llc Agents useful for treating friedreich's ataxia and other neurodegenerative diseases
EP2713724A4 (en) * 2011-05-26 2015-03-11 Biogen Idec Inc METHODS OF TREATING MULTIPLE SCLEROSIS AND PRESERVING AND / OR INCREASING MYELINE CONTENT
JP6385273B6 (ja) 2011-06-08 2023-12-15 バイオジェン・エムエイ・インコーポレイテッド 高純度結晶性ジメチルフマラートの調製方法
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CN113244185A (zh) * 2012-02-07 2021-08-13 比奥根玛公司 含有富马酸二甲酯的药物组合物
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JP2015527372A (ja) * 2012-08-22 2015-09-17 ゼノポート，インコーポレイティド 副作用を低減させるモノメチルフマレートおよびそのプロドラッグの投与方法
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CN105452213B (zh) 2013-03-14 2017-09-22 阿尔克梅斯制药爱尔兰有限公司 富马酸酯前体药物及其在治疗多种疾病中的应用
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TW201516020A (zh) 2013-09-06 2015-05-01 Xenoport Inc （ｎ，ｎ－二乙基胺甲醯基）甲基（２ｅ）丁－２－烯－１，４－二酸甲酯之晶形、合成方法及用途
CA2940845C (en) 2014-02-24 2019-09-24 Alkermes Pharma Ireland Limited Sulfonamide and sulfinamide prodrugs of fumarates and their use in treating various diseases
US10098863B2 (en) 2014-02-28 2018-10-16 Banner Life Sciences Llc Fumarate esters
US9636318B2 (en) 2015-08-31 2017-05-02 Banner Life Sciences Llc Fumarate ester dosage forms
US9326947B1 (en) 2014-02-28 2016-05-03 Banner Life Sciences Llc Controlled release fumarate esters
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MA40990A (fr) * 2014-11-19 2017-09-26 Biogen Ma Inc Formulations de matrice pharmaceutique comprenant du fumarate de diméthyle
AU2015381240A1 (en) 2015-02-08 2017-07-06 Alkermes Pharma Ireland Limited Monomethylfumarate prodrug compositions
MA41785A (fr) 2015-03-20 2018-01-23 Biogen Ma Inc Procédés et compositions pour l'administration intraveineuse de fumarates pour le traitement de maladies neurologiques
WO2017056107A1 (en) * 2015-09-28 2017-04-06 Natco Pharma Ltd Pharmaceutical compositions of dimethyl fumarate
GR1009149B (el) * 2016-10-25 2017-10-31 Φαρματεν Αβεε Φαρμακευτικα σκευασματα που περιλαμβανουν εναν εστερα φουμαρικου οξεως και μεθοδος παραγωγης αυτων
JP7084689B2 (ja) * 2016-12-08 2022-06-15 公益財団法人東京都医学総合研究所 脳組織の異常を伴う非ヒト動物の作製方法およびその利用
MA49448A (fr) 2017-06-23 2020-04-29 Almirall Sa Compositions pharmaceutiques contenant du fumarate de diméthyle
US11382889B2 (en) * 2018-04-19 2022-07-12 Institut D'investigació Biomèdica De Bellvitge (Idibell) NRF2 activators for the prevention and/or treatment of axonal degeneration
CN108904779B (zh) * 2018-09-29 2019-12-03 南华大学 曲普瑞林的新应用
CN109364058A (zh) * 2018-12-05 2019-02-22 中南大学湘雅医院 富马酸酯及其可药用盐在制备治疗铁死亡相关疾病的药物中的应用
US20220087942A1 (en) 2019-05-31 2022-03-24 Curacle Co., Ltd. Enteric tablet containing dimethyl fumarate
WO2021092536A1 (en) * 2019-11-08 2021-05-14 The Children's Hospital Of Philadelphia Compositions and methods for treating macrophage activation syndrome
CN113117081B (zh) * 2019-12-30 2024-12-24 上海海洋大学 ZC3H12b基因或蛋白的用途及一种肝脏疾病动物模型的建立方法
WO2021142062A1 (en) 2020-01-10 2021-07-15 Banner Life Sciences Llc Fumarate ester dosage forms with enhanced gastrointestinal tolerability
WO2022203432A1 (ko) 2021-03-25 2022-09-29 주식회사 큐라클 특정 약동학적 매개변수를 나타내는 디메틸푸마레이트를 유효성분으로 함유한 약학적 조성물
CN115487297A (zh) * 2021-06-17 2022-12-20 清华大学 治疗神经元蜡样质脂褐质沉积症的方法和药物

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Cited By (7)

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Publication number Priority date Publication date Assignee Title
CN105142628A (zh) * 2012-12-21 2015-12-09 比奥根玛公司 氘取代的富马酸盐衍生物
CN103173544A (zh) * 2013-03-05 2013-06-26 浙江大学 Leber病之线粒体T3866C检测试剂盒及应用
CN103173544B (zh) * 2013-03-05 2015-01-28 浙江大学 Leber病之线粒体T3866C检测试剂盒及应用
CN103768045A (zh) * 2013-10-30 2014-05-07 苏州大学附属第一医院 富马酸二甲酯在制备治疗蛛网膜下腔出血后早期脑损伤药物的应用
CN105813634A (zh) * 2013-12-12 2016-07-27 阿尔米雷尔有限公司 包含反丁烯二酸二甲酯的药物组合物
CN114159421A (zh) * 2013-12-12 2022-03-11 阿尔米雷尔有限公司 包含反丁烯二酸二甲酯的药物组合物
CN114159421B (zh) * 2013-12-12 2023-08-25 阿尔米雷尔有限公司 包含反丁烯二酸二甲酯的药物组合物

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NZ617130A (en) 2015-06-26
JP2016175926A (ja) 2016-10-06
NZ595941A (en) 2014-02-28
CN104523673A (zh) 2015-04-22
HK1255133A1 (en) 2019-08-09
EP3466420A1 (en) 2019-04-10
EP3318249A1 (en) 2018-05-09
EP2424357A4 (en) 2012-10-10
EP2424357A1 (en) 2012-03-07
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