CN102424625A - Edible and medical fungi blackening agent, its preparation method and application - Google Patents
Edible and medical fungi blackening agent, its preparation method and application Download PDFInfo
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Abstract
The invention discloses an edible and medical fungi blackening agent and specifically relates to the technical field of biological fermentation. Natural components with a blackening effect are fermented by edible and medical fungi so as to obtain zymogeneous bacteria. The bacteria contain higher nutrients than natural raw materials, and contain effective ingredients as well as amino acid, vitamin, trace elements and natural plant melanin which are necessary for the hair growth. The edible and medical fungi blackening agent has a more ideal effect for hair dyeing and blackening than general plant hair dyes, has a wide source of raw materials, requires low price, and can bring benefit for common people. The product provided by the invention contains no chemical hair dye component, is safe and reliable to use, has no toxic and side effect, and is a product which has a health-care function and also can be used to fundamentally treat leukotrichia and alopecia.
Description
Technical field
The invention belongs to technical field of biological fermentation, be specifically related to edible medicinal fungus fermentative prodn blackening agent and production technology thereof.
Background technology
Hair is the important component part of human body, is one of vigorous and graceful important symbol of appearance.Along with the continuous development of social civilization, the improving constantly of social life level, people pursue the perfection of self day by day with healthy, and having a healthy and beautiful healthy hair is the hope that many people dream of.Yet along with present people's rhythm of life is accelerated, WP and stress increase, and factors such as the wretched insufficiency of having a rest, sleep cause the hair desired nutritional unbalance, cause young and middle-aged white hair crowd more and more.White hair has become the important factor that influences people's image and psychosomatic health; China has 1.5～1.8 hundred million hoary and white hair patients approximately; The whole world has 5～600,000,000 hoary and white hair patients approximately; The cause of disease more complicated of white hair, according to research, people's hair is likely owing to supply melanic melanocyte to hair unusual causing is taken place by black bleaching.In addition, obstacle, endocrine disturbance and the melanocyte of heredity, direct stimulation are lost disease and also can be caused white hair, and this also is a chief reason very.
The traditional Chinese medical science is thought " hair is the sign of blood condition ", and " kidney master bone, its sliding sending out " advocates that the food that the white hair patient eats blood rearing interpolating kidney more sends out with Wu Farun.If can cooperate method results of treatment such as Chinese medicine external application, food meals therapy, massage better; Above-mentioned therapy has no side effect, is fit to advantages such as any ages use; But effect is not remarkable in this method short period of time, take effect slow, curative ratio is low, the strict execution such as is difficult to adhere at shortcoming, does not meet the economic and social life rhythm of people in modern; Make majority abandon midway, therefore difficulty is applied.
Hair dyeing is as one of mode of improving looks, and consumer groups constantly enlarge in recent years.Hair dyeing, the blackening agent produced both at home and abroad at present mainly contain chemistry and plant two series products.
Used hair dye is through chemosynthesis mostly at present, though chemical hair dye color and luster nature is easy to operate; Dyeing is firm, but chemical hair dye is a hair scale sheet of opening hair by force, and dying back hair scale sheet can't be closed fully; Cause that hair quality is coarse, withered, bifurcated, easily broken even stop up the hair follicle hole, cause alopecia, simultaneously since most in the chemical hair dye be main raw material with " Ursol D " type chemical substance; Certain toxicity and carinogenicity are arranged; Strong sensitization can be brought out multiple disease, has certain healthy hidden danger.
Human use's natural phant is had hair dyed and is had thousands of years history.Ancient egypt people, Roman, Chinese and Indian used the hair dyeing of plant (juice) pigment very early.Low, safe in utilization characteristics that plant hair dyeing has toxicity become various countries investigator's research focus in recent years.The natural botanical hair dye raw material mainly is the organic substance that from plant, extracts, and few to hair damage though pungency is less relatively, hair dyeing effect has certain limitation, and the fast colours degree is relatively poor, is prone to decolouring, the few and expensive of raw material.
In a word, propaganda has hair washing, the profit that crow sends out function and sends out, nourishes product etc. on the current market, no matter is external application or product for oral administration, and product really natural, effective, that safety has no side effect is few.Especially in recent years, the hair dye of each famous brand, the frequent quality defects of blackening agent make people when using hair dyeing, blackening agent, have many doubts.People are eager, and expectation has natural element to process, the appearance of blackening and beautifying hair product safely and effectively.
Summary of the invention
In order to address the above problem, be to overcome the deficiency of chemical hair dye and general botanical hair dye order of the present invention, give full play to the function of food (medicine) with bacterium, produce more safe and reliable, healthy novel blackening agent.The prepared hair dyeing of the present invention, blackening agent are nutritious; Contain 30～40% protein, 17 seed amino acids, 15～20% active polysaccharide; 0.1～1.76% triterpene compound; And contain mineral elements such as abundant VITAMINs and calcium, magnesium, zinc, often use can significantly improve immune function of human body, has the kidney of guarantor benefit lung, liver protecting, hypoglycemic, reducing blood-fat, improves gastrointestinal function, endocrine regulation; Smearing scalp parallel port clothes with this product and can grow black sending out in 30 days naturally, is a kind of product that promptly has nourishing function can fundamentally administer white hair again.Above-mentioned purpose of the present invention realizes through following technique means:
The blackening agent that the present invention adopts food (medicine) to produce with the bacterium fermentation technique; Culture medium raw material adopts to have plant, animal, the medicinal fungi scientific matching that crow sends out, profit is sent out effect and forms in the classical traditional Chinese medical science; And carry out liquid or solid fermentation with fungal bacterial strain; The mycelium and the fermented liquid that acquisition are contained various active composition and nutrition are processed blackening agent, wherein:
Described culture medium dry powder raw material is the mixture of black rice and following one or more materials: black soya bean, Semen Sesami Nigrum, Formica fusca, glossy ganoderma, genseng, Tuber Fleeceflower Root, Radix Angelicae Sinensis, mulberries, Ginkgo Leaf.
Described fungi fermentation bacterial strain is the mixture of following 1～3 kind of fungi: Cordyceps militaris (L.) Link. [Cordyceps militaris (Lex.Fr) Link]; Entomophyte (Sphaeria sinensis); Red ganoderma (Ganoderma lucidum); Ganoderma sinense Zhao, Xu et Zhang (Ganoderma neo-japonicum Imazeki); Black Ganoderma (Ganoderma); Phaeopoms obliquus (Inonqqus obliquus); Laetiporus sulphureus (Bull. Ex Fr.) Bond. Et Singer. [Laetiporus sulphureus (Fr.) Murrill]; Black fungus (Auricularia or Wood ear); Coprinus comatus bacterium [Copyinds comatus (MUII.Fr) Gray].
The present invention adopts a kind of novel food (medicine) to use bacterium culture medium dry powder, comprises black rice and auxiliary material, and wherein the quality percentage composition of black rice is 1～90%; Wherein said auxiliary material is made up of in the following component one or more by weight: black soya bean 1～50, Semen Sesami Nigrum 1～40, Formica fusca 1～10; Glossy ganoderma 1～20, genseng 0.1～8, Tuber Fleeceflower Root 1～30; Radix Angelicae Sinensis 1～20, mulberries 1～20, Ginkgo Leaf 1～20;
The invention still further relates to a kind of food (medicine) and use the bacterium blackening agent; It is characterized in that using above-mentioned food (medicine) to use bacterium culture medium dry powder; Method through fungi fermentation makes; It is characterized in that fermented bacterium is 1～3 kind of following fungi, total inoculum size of bacterial classification is 4～10% of a culture medium dry powder total mass: Cordyceps militaris (L.) Link., entomophyte, red ganoderma, Ganoderma sinense Zhao, Xu et Zhang, Black Ganoderma, Phaeopoms obliquus, Laetiporus sulphureus (Bull. Ex Fr.) Bond. Et Singer., black fungus, Coprinus comatus bacterium.
When above-mentioned blackening agent, used culture medium dry powder raw material and fermented bacterium used by following condition, effect was better:
The culture medium dry powder raw material mixes as follows by the quality percentage composition:
Black rice 10～80
The auxiliary material surplus
Wherein, auxiliary material is made up of one or more following materials by weight: black soya bean 10～45, Semen Sesami Nigrum 5～30, Formica fusca 2～8, glossy ganoderma 2～20, genseng 1～7, Tuber Fleeceflower Root 1～20, Radix Angelicae Sinensis 3～15, mulberries 2～15, Ginkgo Leaf 2～18;
Its fermented bacterium is 1～2 kind in Cordyceps militaris (L.) Link., entomophyte, red ganoderma, Ganoderma sinense Zhao, Xu et Zhang, Black Ganoderma, Phaeopoms obliquus, Laetiporus sulphureus (Bull. Ex Fr.) Bond. Et Singer., black fungus, the Coprinus comatus bacterium, and inoculum size is 4～10% of a culture medium dry powder total mass.
When above-mentioned blackening agent, used culture medium dry powder raw material and fermented bacterium used by following condition, best results: the culture medium dry powder raw material mixed as follows by the quality percentage composition:
Black rice 15～65
The auxiliary material surplus
Wherein, auxiliary material is mixed as follows by one or more following materials by weight: black soya bean 15～40, Semen Sesami Nigrum 6～28, Formica fusca 3～7; Ganoderma spore powder or Ganoderma powder 5～15, genseng 2～6, Tuber Fleeceflower Root 8～18; Radix Angelicae Sinensis 5～10, mulberries 4～12, Ginkgo Leaf 4～15;
Its fermented bacterium is Cordyceps militaris (L.) Link. or Black Ganoderma, and inoculum size is 4～10% of a culture medium dry powder total mass.
The preparation method of above-mentioned blackening agent, its step of preparation process is following:
(a) with pulverizing behind the various culture medium raw material proportional mixing;
(b) in the mixture of step a gained, add the water of 1～10 times of quality, make substratum after the sterilization;
(c) in the substratum of step b gained, insert fermented bacterium in proportion;
(d) under 20～27 ℃ of conditions, cultivated 10～60 days, obtain tunning;
(e) tunning that steps d obtained is centrifugal, collecting precipitation thing and centrifugate are processed the blackening agent product respectively.
Among the above-mentioned preparation method, the described pulverized size of step a will be selected according to different fermentation process, when adopting liquid fermentation process, then with raw material pulverizing to 40～100 orders, when adopting solid fermentation method, then with raw material pulverizing to 1～2mm.
Among the above-mentioned preparation method, the described water pH of step b is 7～8 o'clock, and the blackening agent effect that makes is preferable.
Among the above-mentioned preparation method, the described centrifugal product of step e is handled preferable through following manner, and throw out is processed oral blackening agent product, and described centrifugate is processed the blackening agent product of external application.
Among the above-mentioned preparation method, the formulation of the blackening agent product described in the step e is: electuary, pill, tablet, capsule, paste, decoction, syrup, aerosol.
Above-mentioned blackening agent can be applied in hair dyeing widely, crow sends out, treats fields such as white hair.
Product according to the invention can not only be had hair dyed, and can bear black sending out again, fundamentally removes white hair; Reach the black purpose of sending out all over the face; The effect that having takes stopgap measures effects a permanent cure, its mechanism are to be used to make plant, animal, the fungi raw material that the hair dyeing crow sends out, after food (medicine) is with the bacterium fermentation; Can significantly improve nutrition and effective constituent in the raw material, the effect of 1+1＞2 is arranged.As in raw material, adding 5% Ganoderma spore powder, having important anti-tumor activity and improving content that three of immunizing power pastes compounds is 0.01% and behind fungi fermentation, can be increased to 0.67%, improves 67 times.Have significantly antitumorly, antiviral, improve body immunity, repair the corrupted cell, blood sugar regulation blood matter, SUV, function such as hypotensive, and the skin of can also moistening, appearance is pleased the pool, and the hairdressing crow sends out, and eliminates senile plaque.Modern medicine study shows; Food (medicine) is used relevant with its function with the outbreak of bacterium hairdressing crow, it can see through skin surface and promote the skin blood microcirculation, and deep layer is moistened the hair papilla of skin of head; Improve ball top portion hair matricyte nutrition supply level; Effectively remove seborrheic plug, dirt and other the bad metabolite that stops up in the hair follicle, activate hair papilla cell, make it recover the melanic function of secretion.
Beneficial effect:
Before this patent product, do not see food is arranged (medicine) hair dyeing, hair blackening product of being prepared from the bacterium fermentation method.This product does not contain any chemistry hair dyeing composition, and is safe in utilization, do not have to appoint and closes toxic side effect, can not only be used to smear oral yet safety.Smearing also, the oral crow that can grow nature in 30 days sends out.
Below in conjunction with several embodiment, the present invention done further describing.
Embodiment
Following non-limiting example can make those of ordinary skill in the art more fully understand the present invention, but does not limit the present invention in any way.
TP described in the following embodiment like no specified otherwise, is ordinary method; Said raw material all can obtain from commercial sources.
Black rice, black soya bean, Semen Sesami Nigrum are available from the market of farm produce;
Formica fusca is purchased the pure Formica fusca powder factory in the Heng County, Guangxi;
Ganoderma spore powder, Ganoderma powder are purchased in glossy ganoderma base, Guan County, Shandong;
Tuber Fleeceflower Root, genseng, Radix Angelicae Sinensis, mulberries, Ginkgo Leaf are available from the shop of Chinese medicines;
Cordyceps militaris spawn, Black Ganoderma bacterial classification are purchased the precious gill fungus fungus development centre in LiaoNing, China province Dalian;
Embodiment 1
(1) preparation of edible medicinal fungus blackening agent
(a) get black rice 1750g, black soya bean 700g, Semen Sesami Nigrum 525g, Tuber Fleeceflower Root 350g, Radix Angelicae Sinensis 175g that fresh nothing goes mouldy, be crushed to 100 orders after mixing;
(b) in the mixture of step a gained, add the tap water of 35000ml pH7.5, high pressure steam sterilization under 127 ℃ of conditions, pressure 1.2kg/cm
2, make substratum after keeping 40min;
(c) after the substratum of step b gained is cooled to 30 ℃, aseptic condition inserts Black Ganoderma liquid spawn, thalline content 40wt%, the 350g that weighs (the thalline weight in wet base is weighed as 140g) down;
(d) culture condition: 27 ± 1 ℃, tank pressure 0.7～0.8kg/cm
2, air flow 1: the 1v/v/ branch, stop fermentation after 10 days, again through 3000 rev/mins, after centrifugal 10 minutes, obtain fermentation mycelium and fermented liquid;
(e) with the fermentation mycelium that steps d obtained, in 40～50 ℃ of oven dry 24h, be crushed to below the 100nm through nanometer Chinese medicine cell wall breaking kibbler, make blackening agent oral preparation raw material.
(f) with fermented liquid that steps d obtained with haplo-effect concentrator vacuum concentration to 1.2～1.35, make the blackening agent paste raw materials.
(2) finished product detection
Use nitrogen determination to record that protein contnt is 30% in the product; HPLC (High Performance Liquid Chromatography, HPLC) detection contains 17 seed amino acids; The phenolsulfuric acid method records and contains 15% active polysaccharide, and HPLC records triterpene compound 0.1%.
(3) effect detection
People's hair dyeing test: with making the blackening agent paste raw materials, smear scalp every day once, massage 10 minutes, and oral 2g/ time, every day 3 times, after 30 days, the blackening of white hair root.Hair dyeing person's basic condition table is as shown in table 1, and efficient having reached more than 95% wherein arranged in 80 different crowds of accepting to detect.
Table 1 hair dyeing test effect
Embodiment 2
(1) preparation of edible medicinal fungus blackening agent
(a) get black rice 700g, black soya bean 1050g, Semen Sesami Nigrum 700g, Ganoderma spore powder 350g, Tuber Fleeceflower Root 350g, the Ginkgo Leaf 350g that fresh nothing goes mouldy and be crushed to 100 orders after mixing;
(b) in the mixture of step a gained, add the pH7.5 tap water of 35000ml, high pressure steam sterilization under 127 ℃ of conditions, pressure 1.2kg/cm
2, make substratum after keeping 40min;
(c) after the substratum of step b gained is cooled to 30 ℃, aseptic condition inserts Black Ganoderma liquid spawn, thalline content 40wt%, the 350g that weighs (the thalline weight in wet base is weighed as 140g) down;
(d) culture condition: 27 ± 1 ℃, tank pressure 0.7～0.8kg/cm
2, air flow 1: the 1v/v/ branch, stop fermentation after 10 days, again through 3000 rev/mins, after centrifugal 10 minutes, obtain fermentation mycelium and fermented liquid;
(e) with the fermentation mycelium that steps d obtained, in 40～50 ℃ of oven dry 24h, be crushed to below the 100nm through nanometer Chinese medicine cell wall breaking kibbler, make blackening agent oral preparation raw material.
(f) with fermented liquid that steps d obtained with haplo-effect concentrator vacuum concentration to 1.2～1.35, make the blackening agent paste raw materials.
(2) finished product detection
Use nitrogen determination to record that protein contnt is 35% in the product; HPLC detects and contains 17 seed amino acids; The phenolsulfuric acid method records and contains 17% active polysaccharide, and HPLC records triterpene compound 1.76%.
(3) effect detection
People's hair dyeing test: with making the blackening agent paste raw materials, smear scalp every day once, massage 10 minutes, and oral blackening agent raw material 1.5g/ time, every day 3 times, after 30 days, the blackening of white hair root grows black fine hair.Hair dyeing person's basic condition table is as shown in table 2, and efficient having reached more than 97% wherein arranged in 120 different crowds of accepting to detect.
Table 2 hair dyeing test effect
Embodiment 3
(1) preparation of edible medicinal fungus blackening agent
(a) preparing culture medium: get black rice 525g, black soya bean 700g, Semen Sesami Nigrum 525g, Formica fusca 175g Ganoderma spore powder 350g, Tuber Fleeceflower Root 525g, Radix Angelicae Sinensis 175g, mulberries 175g, the Ginkgo Leaf 175g genseng 175g that fresh nothing goes mouldy and be crushed to 100 orders after mixing.
(b) in the mixture of step a gained, add the pH7.5 tap water of 35000ml, high pressure steam sterilization under 127 ℃ of conditions, pressure 1.2kg/cm
2, make substratum after keeping 40min;
(c) after the substratum of step b gained is cooled to 30 ℃, aseptic condition inserts Cordyceps militaris (L.) Link. liquid spawn, thalline content 40wt%, the 350g that weighs (the thalline weight in wet base is weighed as 140g) down;
(d) culture condition: 27 ± 1 ℃, tank pressure 0.7～0.8kg/cm
2, air flow 1: the 1v/v/ branch, stop fermentation after 10 days, again through 3000 rev/mins, after centrifugal 10 minutes, obtain fermentation mycelium and fermented liquid;
(e) with the fermentation mycelium that steps d obtained, in 40～50 ℃ of oven dry 24h, be crushed to below the 100nm through nanometer Chinese medicine cell wall breaking kibbler, make blackening agent oral preparation raw material.
(f) with fermented liquid that steps d obtained with haplo-effect concentrator vacuum concentration to 1.2～1.35, make the blackening agent paste raw materials.
(2) finished product detection
Use nitrogen determination to record that protein contnt is 37% in the product; HPLC detects and contains 17 seed amino acids; The phenolsulfuric acid method records and contains 20% active polysaccharide, and HPLC records triterpene compound 1%.
(3) effect detection
People's hair dyeing test: with making the blackening agent paste raw materials, smear scalp every day once, massage 10 minutes, and oral blackening agent raw material 1.5g/ time, every day 3 times, after 30 days, the blackening of white hair root grows black fine hair.Hair dyeing person's basic condition table is as shown in table 3, and efficient having reached more than 92% wherein arranged in 100 different crowds of accepting to detect.
Table 3 hair dyeing test effect
Embodiment 4
(1) preparation of edible medicinal fungus blackening agent
(a) preparing culture medium: get black rice 1750g, black soya bean 700g, Semen Sesami Nigrum 525g, Tuber Fleeceflower Root 350g, Radix Angelicae Sinensis 175g that fresh nothing goes mouldy, be crushed to 1-2mm after mixing;
(b) in the mixture of step a gained, add the pH7.5 tap water of 3500ml, high pressure steam sterilization under 127 ℃ of conditions, pressure 1.2kg/cm
2, make substratum after keeping 40min;
(c) after the substratum of step b gained is cooled to 30 ℃, aseptic condition inserts down the Cordyceps militaris spawn weight in wet base 350g that weighs;
(d) culture condition: cultivate for 27 ± 1 ℃ and stop fermentation after 45 days;
(e) with the fermented liquid that steps d obtained, in 40～50 ℃ of oven dry 24h, be crushed to below the 100nm through nanometer Chinese medicine cell wall breaking kibbler, make the blackening agent raw material;
(f) with fermented liquid that steps d obtained with haplo-effect concentrator vacuum concentration to 1.2～1.35, make the blackening agent paste raw materials.
(2) finished product detection
Use nitrogen determination to record that protein contnt is 32% in the product; HPLC detects and contains 17 seed amino acids; The phenolsulfuric acid method records and contains 18% active polysaccharide, and HPLC records triterpene compound 0.2%.
(3) effect detection
People's hair dyeing test: with making the paste blackening agent, smear scalp every day once, massage 10 minutes, and oral blackening agent raw material 1.5g/ time, every day 3 times, after 30 days, the blackening of white hair root grows black fine hair.Hair dyeing person's basic condition table is as shown in table 4, and efficient having reached more than 93% wherein arranged in 100 different crowds of accepting to detect.
Table 4 hair dyeing test effect
Visible by the foregoing description: the food that the present invention relates to (medicine) is with the bacterium blackening agent of having hair dyed, and by having natural component that crow sends out effect through edible, medicinal fungi fermentation, obtains Zymocyte.Contain the required amino acid of the nutrition higher, effective ingredient and natural on-off cycles of hair growth, natural phant melanochrome etc. in this mycoplasma, do not contain and appoint combination hair dye composition than natural matter.Send out with its hair dyeing crow more desirable more than general botanical hair dye effect, and the raw materials used easy purchase of the present invention, the source is wide, price is low, safely, have no side effect, be a kind of nourishing function that promptly has, can administer the product of hoariness and alopecia again.
Claims (10)
1. an edible medicinal fungus dehydrated medium comprises black rice and auxiliary material, and wherein the quality percentage composition of black rice is 1～90%, and wherein said auxiliary material is made up of in the following component one or more by weight:
2. edible medicinal fungus blackening agent is characterized in that using the edible medicinal fungus dehydrated medium of claim 1, makes through fungi fermentation, it is characterized in that fermented bacterium is 1～3 kind of following fungi, and inoculum size is 4～10% of a dehydrated medium total mass:
Cordyceps militaris (L.) Link. [Cordyceps militaris (Lex.Fr) Link]; Entomophyte (Sphaeria sinensis); Red ganoderma (Ganoderma lucidum); Ganoderma sinense Zhao, Xu et Zhang (Ganoderma neo-japonicum Imazeki); Black Ganoderma (Ganoderma); Phaeopoms obliquus (Inonqqus obliquus); Laetiporus sulphureus (Bull. Ex Fr.) Bond. Et Singer. [Laetiporus sulphureus (Fr.) Murrill]; Black fungus (Auricularia or Wood ear); Coprinus comatus bacterium [Copyinds comatus (MUII.Fr) Gray].
3. blackening agent according to claim 2 is characterized in that, and is described,
The culture medium dry powder raw material mixes as follows by the quality percentage composition:
Black rice 10～80
The auxiliary material surplus
Wherein, auxiliary material is made up of one or more following materials by weight:
Its fermented bacterium is 1～2 kind in Cordyceps militaris (L.) Link., entomophyte, red ganoderma, Ganoderma sinense Zhao, Xu et Zhang, Black Ganoderma, Phaeopoms obliquus, Laetiporus sulphureus (Bull. Ex Fr.) Bond. Et Singer., black fungus, the Coprinus comatus bacterium, and inoculum size is 4～10% of a culture medium dry powder total mass.
4. blackening agent according to claim 3 is characterized in that, and is described,
The culture medium dry powder raw material mixes as follows by the quality percentage composition:
Black rice 15～65
The auxiliary material surplus
Wherein, auxiliary material is mixed as follows by one or more following materials by weight:
Its fermented bacterium is Cordyceps militaris (L.) Link. or Black Ganoderma, and inoculum size is 4～10% of a culture medium dry powder total mass.
5. like the preparation method of the described blackening agent of claim 2～4, it is characterized in that process step is following:
(a) with pulverizing behind the various culture medium dry powder raw material proportional mixing;
(b) in the mixture of step a gained, add the water of 1～10 times of quality, make substratum after the sterilization;
(c) in the substratum of step b gained, insert fermented bacterium in proportion;
(d) under 20～27 ℃ of conditions, cultivated 10～60 days, obtain tunning;
(e) tunning that steps d obtained is centrifugal, collecting precipitation thing and centrifugate are processed the blackening agent product respectively.
6. the preparation method of blackening agent according to claim 5 is characterized in that, the pulverization conditions described in the step a is: adopt liquid fermentation process, then with raw material pulverizing to 40～100 orders, adopt solid fermentation method, then with raw material pulverizing to 1～2mm.
7. the preparation method of blackening agent according to claim 6 is characterized in that, the water pH described in the step b is 7～8.
8. the preparation method of blackening agent according to claim 5 is characterized in that, the throw out described in the step e is processed oral blackening agent product, and described centrifugate is processed the blackening agent product of external application.
9. the preparation method of blackening agent according to claim 5 is characterized in that, the formulation of the blackening agent product described in the step e is: electuary, pill, tablet, capsule, paste, decoction, syrup, aerosol.
10. the application in the white hair is sent out, treated to blackening agent as claimed in claim 2 hair dyeing, crow.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102766658A (en) * | 2012-07-30 | 2012-11-07 | 南京农业大学 | Production process of Jew's ear melanin by fermentation and products of Jew's ear melanin |
| CN102766658B (en) * | 2012-07-30 | 2014-05-21 | 南京农业大学 | Production process of Jew's ear melanin by fermentation and products of Jew's ear melanin |
| CN104303830A (en) * | 2014-09-28 | 2015-01-28 | 铜陵市香江食用菌种植有限责任公司 | Planting method of Pleurotus eryngii |
| CN104434695A (en) * | 2014-12-16 | 2015-03-25 | 常熟市联创化学有限公司 | Novel hair dye |
| CN104689203A (en) * | 2015-03-21 | 2015-06-10 | 石汝花 | Capsule for treating alopecia and preparation method thereof |
| CN107041903A (en) * | 2016-02-05 | 2017-08-15 | 中国中医科学院中药研究所 | Prepared fleece flower root Habitat producing processes integrated new method |
| CN107041903B (en) * | 2016-02-05 | 2021-03-09 | 中国中医科学院中药研究所 | Integrated new method for processing and concocting radix Polygoni Multiflori Preparata in producing area |
| CN107156801A (en) * | 2016-03-08 | 2017-09-15 | 及长城 | A kind of active mycelium group compound with hair tonic and preparation method thereof |
| CN107258971A (en) * | 2017-05-24 | 2017-10-20 | 天津瑞特医疗保健用品开发有限公司 | With alopecia-stopping, black hair, hair tonic, the compound black tea sugar of face-nursing function and its preparation method and application |
| CN107184517A (en) * | 2017-06-02 | 2017-09-22 | 天津郁美净集团有限公司 | One kind shield hair composition and preparation method thereof |
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