CN102091278A - Selenium- and germanium-enriched lucid ganoderma mycelium snake nano metallothionein capsule - Google Patents
Selenium- and germanium-enriched lucid ganoderma mycelium snake nano metallothionein capsule Download PDFInfo
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Abstract
The invention relates to a selenium- and germanium-enriched lucid ganoderma mycelium snake nano metallothionein capsule which belongs to the technical field of microbial conversion biological pharmacy. Lucid ganoderma belongs to a fungus and has strong selenium- and germanium-enriched ability in addition to containing rich protein polysaccharide vitamin and other active substances; selenium and germanium can effectively eliminate radical and lipid peroxidation and enable unsaturated fatty acid on a cell membrane to be crosslinked into lipofuscin so as to cause the damage of the cell internal structure and function of the cell membrane to cause the turbulence of physiological and biochemical reaction and show pathological changes; snake meat has high protein content, wherein metallothionein in the snake meat is a radial scavenger which is discovered to have highest capability for removing radials in a body so far; and a nano metallothionein capsule prepared from the lucid ganoderma, the selenium, the germanium, and the metallothionein can effectively enhance the immunologic function, lose weight, reduce fat, resist ageing and prolong life.
Description
Technical field:
The rich selenium germanium glossy ganoderma of the present invention mycelium Serpentis class nano metal sulfoprotein capsule is to belong to the microbial transformation biological pharmacy technical field.
Background technology:
Ganoderma is a kind of medicinal fungi of preciousness, be China ancient to have as the mythology Chinese medicine of color top grade, the Ganoderma selenium rich ability is the strongest, culture medium is added Na
2SeO
3Concentration is advisable with 50mg/kg, can make the interior Se content of Ganoderma mycelium up to 8000mg/kg.Ganoderma belongs to fungus, it is except containing rich in protein, polysaccharide, vitamin and other active substances, it also has very strong rich selenium, the ability of rich germanium, and the selenium of institute's enrichment is that organic selenium such as albumen selenium, albumen germanium, polysaccharide selenium, holoside Ge, nucleic acid selenium, nucleic acid germanium, organic germanium exist.Be the biotransformation that carrier carries out selenium, germanium with the Ganderma lucidum at present, it is cheap that exploitation has a form finished product, the utilization fermentation engineering is cultivated the microbial transformation of selenium, germanium resource by the rich selenium of Ganoderma edible fungi, germanium, obtaining the material that is rich in organic selenium, organic germanium, is one of safe and effective approach that organises of selenium, germanium microbial transformation.Ganoderma is described as the good merchantable brand of life lengthening since ancient times, elixir alive for evermore, yet organic selenium in the normal Ganderma lucidum, organic germanium content are very low, if in the culture medium that is rich in inorganic selenium, germanium, insert Ganderma lucidum strain, utilize the rich selenium of Ganderma lucidum, characteristic that the germanium ability is strong that inorganic selenium, germanium are converted into organic selenium, germanium.These two kinds of trace element are on the earth, in great shortage seldom again element in people and the animals and plants, and human body is essential element.Obtain people's needs by this method, the length of melting Ganoderma and organic selenium, germanium is developed as the medicine element that the mankind benefit further.Ganoderma has rich selenium feature, and be rich selenium and the very capable strain of anti-selenium, domestic scholars is passed through the selenium rich ability in the liquid generation culture medium of JINZHENGU, Lentinus Edodes, Hericium erinaceus (Bull. Ex Fr.) Pers. and Ganoderma, selenium rich ability with Ganoderma in the discovery is the strongest, be 10～20 times of other three kinds of edible fungi, can reach between the 500mg/kg selenic tolerance.Up to the present, Ganderma lucidum is that selenium rich ability and anti-selenium are the strongest mushroom in the rich selenium mushroom of being studied.Germanium artificial culture Ganoderma rich in germanium mycelium: after in the nutrition base of cultivating Ganoderma, adding a certain amount of Ge-132 sterilization, meet Red Ganoderma strain constant temperature culture 25d, treat to cover with in the culture medium mycelium, promptly take out mycelium, extract through biological enzyme, again must the Ganoderma rich in germanium concentrated solution through concentrating, be ground into nano powder through lyophilisation and promptly get the germanium-rich glossy ganoderma dry body.
Summary of the invention:
At present known many disease in the process that development takes place with body in the decline of selenium level relevant, these diseases have comprised nervous system, digestion respiratory system, genitourinary system, blood and hundreds of disease of hemopoietic system, endocrine and metabolism, skeletal system, skin and mucosa, visual organ, disturbance of intelligence, senile disease, cardiovascular and cerebrovascular vessel and multiple cancer or the like, differ to establish a capital and cause because lack selenium, but with selenium treatment and auxiliary treatment all is resultful, and this is confirmed by many clinical verifications.Selenium is expressed by glutathion peroxidase GSHpx the function of human body, and the major function of GSHpx is the peroxide H with the human body harmful
2O
2Free radical is decomposed into harmless material, thereby the protection cell is without prejudice.Preventing and treating in the animal liver necrosis, selenic oxidation resistance is bigger 50～500 times than VE.Human organ free radical in aging course destroys each organ of human body, suitably behind the selenium supplement, can partly remove free radical, thus slow down aging, so selenium is the important trace element of life lengthening.Free radical is the one of the main reasons that makes the mankind aging, its main mechanism is lipid peroxidation, promptly in the presence of oxygen, the free radical inducing agent can bring out the inside and outside multiple biochemical component peroxidating of cell, make the unsaturated fatty acid on the cell membrane be cross-linked into lipofuscin, and then cause the damage of cell membrane, cell interior 26S Proteasome Structure and Function, cause the disorder of physiological reaction, show how many pathological changes, harden as blood vessel wall, lenticular opacity etc., therefore every free radical or polyphenoils can removed is with regard to concrete antidotal function.Selenium by antiperoxide and removing free radical, reduces or delays the formation of lipofuscin just, thereby reaches the old and feeble and dead purpose of anti-cell.
Selenic immunologic function mainly comprises cellular immunization, humoral immunization and nonspecific immunity, and aspect cellular immunization, scarce selenium will cause lymphocyte number to reduce, active decline, and immunocompetence fails or is restricted.Studies show that to have the effect of some enzyme systems in the activated lymphocyte in a large number, selenium can promote interior T cell of body and natural killer cell (NK cell) activity obviously to strengthen, and is the reinforcing agent of immunologic function.Selenium can promote lymphocytic emiocytosis to have the lymphokine of regulating action, strengthens lymphocytic antivirus action in addition in addition.Aspect humoral immunization, can improve the ability of IgM (1gM) and immunoglobulin G antibody such as (1gG).Many animal's antibody levels reduce when lacking selenium.Aspect nonspecific immunity, scarce selenium can make the immune system chemotactic, engulfs and the three big processes of killing all have in various degree influence, causes human immunity defence and resistance against diseases decline easy infection.At present medical circle, the selenic anti-cancer of nutrition circle, anticancer, control that cancer, hepatoprotective protect the liver, health care such as anti-senility life-prolonging, immunomodulating, control are sterile and medical aspect effect obtain extensively generally approving of society.Selenium and people's life is more and more closer, and nanometer selenium is the Selenium supplement agent of a kind of renewal after organic selenium, and it removes the activity and the inorganic selenium (Na of free radical
2SeO
3) compare, having improved 5 times, the activity of removing superoxide anion and hydrogen peroxide has increased substantially, and has also significantly improved with the sensitivity that suppresses the tumor aspect aspect immunomodulating.
Germanium is a kind of multiple bioactive trace element that has, and human beings'health is had positive effect, and it has antitumor, anti-inflammatory, antiviral, the anti-ageing physiological action of waiting for a long time.Organic germanium treatment malignant lymphoma, ovarian cancer, cervical cancer, colorectal cancer, carcinoma of prostate and malignant melanoma all have curative effect preferably.Therefore organic germanium is described as " patron saint of human health ".Experimental results show that Ge-132 is not only a kind of immunostimulant, but also be a kind of immunomodulator, that Ge-132 has is anticancer, resisting hypertension, anti-aging effects, by body bring out interferon and strengthen NKT (MK) cytoactive, macrophage activation realizes.Germanium can bring out interferon, and the defendance soma is responsible in activation, thereby regulates immune system, so various cancers are all had significant effect.
Carnis Serpentis not only delicious flavour is good to eat, and has abundant nutrition and multiple macroelement calcium, phosphorus, sodium, magnesium and trace elements iron, zinc, manganese, selenium, copper etc., it is the highest to contain proteinic amount with beef in meat products, and contained protein is compared with beef in the Carnis Serpentis, even above beef, particularly protein content beats by miles beef in the Agkistrodon halys Carnis Serpentis, and protein is the basis of life.In these extended familys of protein, find the protein that a class has special construction and function, i.e. metallothionein (Metallotnioneinmt).The strongest free radical scavenger of removing interior free yl ability that it is up to now to be found.Because it has strong oxidizing force and can prevent lipid peroxidation, becomes the bodyguard of life and health, it can remove ultra-oxygen anion free radical, can remove hydroxyl radical free radical again.Free radical is independently free of existing or several not molecule, atom, group or the ion of sharing electron, and it is extremely unstable, very active, and oxidation reaction easily takes place.Human body at every moment all produces free radical, and the instant changes, and only it just plays illeffects when free radical too much is in unbalanced state.The harm of free radical is its special unsaturated chain of attacking unsaturated fatty acid, chain-react causes lipid peroxidation (ROOH), chain-react causes vital DNA (deoxyribonucleic acid) of life (DNA) and ribonucleic acid (RNA) structural change, produce the lipid peroxidation of biomembrane (cell membrane), cause the cell function forfeiture, cause the cellularity damage and cause various diseases, as autoimmune diseasees such as rheumatism, arthritis, lupus erythematosus, the arteriosclerosis that causes, hematopathy, oncosis or the like.Metallothionein is to remove the strongest free radical scavenger of hydroxyl radical free radical ability, also has the releasing heavy metal poisoning simultaneously, the important function of protection internal organs.
The present invention is further described below in conjunction with examples of implementation:
(1) embodiment 1:
Cordyceps, Radix Panacis Quinquefolii, Fructus Lycii, the Radix Polygoni Multiflori, Fructus Amomi, Flos Carthami, Rhizoma Polygonati, Fructus Mori, Fructus Ligustri Lucidi, Semen Cuscutae, Fructus Rubi, Radix Angelicae Sinensis, the Radix Astragali, Fructus Schisandrae Chinensis, Rhizoma Dioscoreae, Fructus Psoraleae, Semen Ziziphi Spinosae, Caulis Bambusae In Taenia, Arillus Longan, Semen Sesami Nigrum, the Cortex Eucommiae, Radix Glycyrrhizae be totally 22 flavor Chinese medicines, each 100g, respectively account for 3.64%, clean through soaking, become nanotechnology level powder with nanotechnology device porphyrize; Nanometer selenium 30g accounts for 1%; The dry mycelium 20g of organic germanium accounts for 0.72%; Agkistrodon halys 500g accounts for 18.2%;
Product is used: the vital base and primordial QI consolidating stomach function regulating stomach of waking up, appearance black hair, slow down aging, resisting fatigue, disease-relieving and physique enhancing.
Embodiment 2:
Fructus Crataegi, Radix Salviae Miltiorrhizae, each 150g of Rhizoma Chuanxiong respectively account for 14.8%; Radix Polygoni Multiflori 100g accounts for 9.8%; Radix Et Rhizoma Rhei 250g accounts for 24.6%; Agkistrodon 200g accounts for 19.7%; Nanometer selenium 10g accounts for 1%; The dry mycelium 5g of organic germanium accounts for 0.5%;
Product is used: curing hyperlipemia, Weight-reducing and lipid-lowering lengthens one's life.
Embodiment 3:
Radix Panacis Quinquefolii, each 150g of Radix Notoginseng respectively account for 13.7%; Ganoderma 350g accounts for 32%; Radix Salviae Miltiorrhizae 230g accounts for 21%; Pallas pit viper powder 200g accounts for 18.2%; Nanometer selenium 10g accounts for 0.9%; The dry mycelium 5g of organic germanium accounts for 0.5%;
Product is used: prevent and treat coronary heart disease.
Embodiment 4:
Flos Chrysanthemi, Flos Inulae, the Radix Angelicae Dahuricae, Radix Achyranthis Bidentatae, each 150g of Fructus Rubi respectively account for 13.5%; Herba Ecliptae, each 75g of Semen sesami Niger respectively account for 6.7%; Spend snake powder 200g in vain, account for 17.9%; Nanometer selenium 10g accounts for 0.8%; The dry mycelium 5g of organic germanium accounts for 0.4%;
Product is used: it is early white to control senilism, nourishing the liver and kidney, black beard and hair.
Embodiment 5:
Cortex Cinnamomi, Poria, Rhizoma Alismatis, the Rhizoma Atractylodis Macrocephalae, Rhizoma Dioscoreae, the Radix Astragali, Fructus Lycii, Radix Angelicae Sinensis, YUANLAO, each 100g of Stamen Nelumbinis respectively account for 6.4%; Fructus Corni, each 150g of Semen Ziziphi Spinosae respectively account for 9.3%; Ophidia black snake powder 250g accounts for 15.9%; Nanometer selenium 15g accounts for 1%; The dry mycelium 8g of organic germanium accounts for 0.5%;
Product is used: mends vital essence, increases spirit, and black beard and hair, happy blood lengthens one's life.
Embodiment 6:
Agkistrodon halys, each 200g of the Radix Polygoni Multiflori respectively account for 15.1%; Poria, YUANLAO, Radix Achyranthis Bidentatae, Radix Angelicae Sinensis, Fructus Lycii, Semen Cuscutae, Fructus Psoraleae, Fructus Schisandrae Chinensis, the Radix Paeoniae Alba, Fructus Corni, Radix Ophiopogonis, each 50g respectively accounted for 3.8%; Fructus Rubi, Semen Plantaginis, Radix Ginseng, the Rhizoma Atractylodis Macrocephalae, Radix Glycyrrhizae Preparata, life be each 30g (ripe), respectively accounts for 2.2%; The Cortex Eucommiae, the Radix Astragali, each 60g of the accurate Rhizoma Dioscoreae of stir-fry respectively account for 4.5%; Nanometer selenium 10g accounts for 0.8%; The dry mycelium 5g of organic germanium accounts for 0.5%;
Product is used: kidney-tonifying and brain tonic, benefiting QI for activating blood circulation blood stasis dispelling prevent senile dementia.
Embodiment 7:
Radix Asparagi (removing the heart), YUANLAO (removing the heart), Rhizoma Dioscoreae, each 100g of crust halberd respectively account for 4.6%; Halloysitum Rubrum, Semen Plantaginis, Rhizoma Acori Graminei, Semen Platycladi, Rhizoma Alismatis, Fructus Zanthoxyli (going order to fry), Radix Rehmanniae Preparata, the Radix Rehmanniae, Fructus Lycii, Poria, Fructus Rubi, Radix Angelicae Sinensis, Cortex Lycii, Radix Ginseng, each 50g of Fructus Schisandrae Chinensis respectively account for 2.3%; Herba Cistanches, pallas pit viper powder, the Cortex Eucommiae (stir-fry), Semen Cuscutae (steeping in wine), each 200g of Radix Achyranthis Bidentatae (steeping in wine) respectively account for 9.2%; Nanometer selenium 15g accounts for 0.8%; The dry mycelium 10g of organic germanium accounts for 0.5%;
Product is used: warming the kidney to activate YANG, nourishing kidney are smart by force, with invigorating heart and kidney, also turn round and look at the liver spleen, life lengthening.Be applicable to the middle-aged and elderly people deficiency of both YIN and YANG, early whitening of beard and hair, soreness of waist and knee joint, energy decay, forgetful insomnia.
Embodiment 8:
Ripe Radix Rehmanniae 1500g respectively accounts for 44.8%; Fructus Schisandrae Chinensis, YUANLAO (removing the heart), each 200g of Folium Pyrrosiae respectively account for 6%; Radix Asparagi (removing the heart) 600g accounts for 17.9%; Rhizoma Acori Graminei 300g accounts for 9%; Poria 100g accounts for 3%; Cortex Cinnamomi 50g accounts for 1.5%; Ophidia black snake powder 120g respectively accounts for 3.6%; Nanometer selenium 30g accounts for 0.9%; The dry mycelium 15g of organic germanium accounts for 0.4%; Naja Fel Serpentis 30g accounts for 0.9%;
Product is used: remove disease and make eye bright.
(2) dispensing information
The various embodiments described above side handles with nanoscale particle diameter ultramicronising device, absorbance wherein for oral administration will increase substantially, because its big specific surface area, increased the surface area that is exposed in the medium, promoted the dissolving of medicine to absorb, because reducing of particle diameter increased medicine distribution in vivo, also just improved the biology degree of receiving of medicine widely.General Chinese medicine is not before carrying out nanotechnology, and its cell wall is complete, and very little a part of penetration cell wall is only arranged in its effective ingredient, the stripping and the utilization that is absorbed by the body.Take the Chinese medicine after nanotechnology is processed, make the cell wall breaking cellular wall, make more middle pharmaceutically active ingredient discharge the utilization that is absorbed by the body, thereby just improved the bioavailability of Chinese medicine widely, and acquire surprised curing protrusion effect.Each Chinese medicinal formulae embathes and dries lyophilisation, carries out the superfine makeup again and puts processing, makes 800 mesh sieves, and the micropowder of medium particle diameter 0.5～10um is encapsulated, every 0.5g, and every day, one after each meal was two, and logotype 30 days was a course of treatment.
(3) 1, Serpentis metalloid sulfoprotein capsule content measurement result table 1:
| The trace element kind | Unit | Content |
| Zinc Zn | mg/kg | 6.95 |
| Ferrum Fe | mg/kg | 1.35 |
| Strontium Sr | mg/kg | 2.36 |
| Manganese Mn | mg/kg | 87.23 |
| Calcium Ca | mg/kg | 14.59 |
| Magnesium Mg | mg/kg | 13.85 |
| Germanium Ge | mg/kg | 0.35 |
| Selenium Se | mg/kg | 0.27 |
2, total sugar total acid and total shape measurement result admittedly:
Total sugar 1.1%; Total acid 1.25%; Total shape 14.9mg/kg admittedly.
3, physics and chemistry and sanitary index testing result table 2:
| Project | Unit | Detect | The result |
| Arsenic | (in As, mg/L) | ≤0.5 | ＜0.2 |
| Plumbous | (in Pb, mg/L) | ≤0.1 | ＜0.3 |
| Copper | (in Cu, mg/L) | ≤10 | ＜5 |
| Total number of bacteria | (individual/ml) | ≤100 | ＜10 |
| Coliform | (individual/100ml) | ≤6 | ＜3 |
| Cause flora | Must not detect | Do not detect |
(4) case is selected
This group has patient's 438 examples, all is selected from community clinic, male 279 examples, women 159 examples, 35～72 years old age, 56 years old mean age.Wherein 136 routine hyperlipidemia, hypercholesterolemia person, 150 routine hypertriglyceridemias, 152 routine high beta-lipoproteinemias.All are participated in the patient and carry out complete physical examination, and optical fundus, electrocardiogram, the Chest X-rays of X line, hematuria routine examination, blood fat, blood viscosity, serum glutamic pyruvic transminase and blood glucose, cholesterolemia, triglyceride, beta lipoprotein are measured.
(5) clinical observation result
1, have 54% in the 136 routine hypercholesterolemias of finishing 45 day course of treatment, hyperlipemia, promptly 74 routine patients have decline in various degree, drop to following 50 examples (36.7%) of 250mg/dl, and average fall is 4mg; 60 examples 90 days later check person's 46 examples (77%) have in various degree and to descend, following 30 examples (43%) of decline 250mg/dl, average fall is 35mg;
2,150 routine triglyceride mass formed by blood stasis patients checked in the time of 45 days, and 90 examples (60%) have decline in various degree, and wherein 38 examples drop to below the 150mg/dl, and average fall is 5mg; Check after 90 days, have 68 examples (76%) that in various degree decline is arranged among the 92 routine patients, drop to following person's 36 examples of 150mg/dl (39%), average fall is 52mg;
3,152 examples are finished 100 examples (65%) among the high beta-lipoproteinemia patient of 54 day course of treatment in various degree decline, and wherein 36 examples drop to below the 60mg, and average fall is 62mg; 86 examples person's 10,000 day course of treatment 60 examples (70%) have decline in various degree, and wherein 24 examples (28%) drop to below the 600mg, and average fall is 135mg;
(6) discuss
It is rare to adopt rich selenium germanium glossy ganoderma biological bacteria microbiological transformation technology to obtain on the earth, be difficult to the organic selenium that can strengthen immune function of human body or the nanometer selenium of acquisition in people and the animals and plants food, the dry mycelium of organic germanium or organic germanium and be rich in nano-powder and the Chinese medicinal formulae of the high Agkistrodon halys of rich in protein and other Serpentis, by the peroxidating of the powerful removing of selenium germanium free radical, especially the metallothionein in the protein, potent removing interior free yl and peroxide, pharmaceutically active ingredient fully discharges in making, with the effective biological bacteria of Ganoderma, selenium germanium trace element, unsaturated fatty acid, vitamin, the organic combination of polysaccharide.Elements such as selenium, germanium, zinc, magnesium, manganese suppress or delay the absorption of high lipid food in intestinal, remove blood vessel superabundant fats and deleterious deposit, reduce serum cholesterol and triglyceride utilization rate, suppress the diastatic activity of intestinal, quicken the body fat metabolism, promote the wriggling of intestinal.Obtain satisfied effect according to clinical experiment.
Claims (8)
1. rich selenium germanium glossy ganoderma mycelium Serpentis class nano metal sulfoprotein capsule is characterized in that: be made up of following prescription
Cordyceps, Radix Panacis Quinquefolii, Fructus Lycii, the Radix Polygoni Multiflori, Fructus Amomi, Flos Carthami, Rhizoma Polygonati, Fructus Mori, Fructus Ligustri Lucidi, Semen Cuscutae, Fructus Rubi, Radix Angelicae Sinensis, the Radix Astragali, Fructus Schisandrae Chinensis, Rhizoma Dioscoreae, Fructus Psoraleae, Semen Ziziphi Spinosae, Caulis Bambusae In Taenia, Arillus Longan, Semen Sesami Nigrum, the Cortex Eucommiae, Radix Glycyrrhizae be totally 22 flavor Chinese medicines, each 50～150g, respectively account for 1～8%, clean through soaking, become nanotechnology level powder with nanotechnology device porphyrize; Nanometer selenium 20～40g accounts for 0.5～1.5%; The dry mycelium 10～30g of organic germanium accounts for 0.4～1%; Agkistrodon halys 450～550g accounts for 13～23%.
2. according to claim 1, rich selenium germanium glossy ganoderma mycelium Serpentis class nano metal sulfoprotein capsule is characterized in that: be made up of following prescription
Fructus Crataegi, Radix Salviae Miltiorrhizae, each 100～200g of Rhizoma Chuanxiong respectively account for 9～19%; Radix Polygoni Multiflori 80～120g accounts for 4～14%; Radix Et Rhizoma Rhei 200～300g accounts for 19～29%; Agkistrodon 150～250g accounts for 14～24%; Nanometer selenium 5～15g accounts for 0.5～1.5%; The dry mycelium 2～8g of organic germanium accounts for 0.2～0.8%.
3. according to claim 2, rich selenium germanium glossy ganoderma mycelium Serpentis class nano metal sulfoprotein capsule is characterized in that: be made up of following prescription
Radix Panacis Quinquefolii, each 100～200g of Radix Notoginseng respectively account for 8～18%; Ganoderma 300～400g accounts for 27～37%; Radix Salviae Miltiorrhizae 180～280g accounts for 16～26%; Pallas pit viper powder 150～250g accounts for 13～23%; Nanometer selenium 5～15g accounts for 0.4～1.3%; The dry mycelium 2～8g of organic germanium accounts for 0.2～0.8%.
4. according to claim 3, rich selenium germanium glossy ganoderma mycelium Serpentis class nano metal sulfoprotein capsule is characterized in that: be made up of following prescription
Flos Chrysanthemi, Flos Inulae, the Radix Angelicae Dahuricae, Radix Achyranthis Bidentatae, each 100～200g of Fructus Rubi respectively account for 7～18%; Herba Ecliptae, each 50～100g of Semen sesami Niger respectively account for 2～13%; Spend snake powder 180～220g in vain, account for 12～23%; Nanometer selenium 5～15g accounts for 0.4～1.4%; The dry mycelium 2～8g of organic germanium accounts for 0.1～0.7%.
5. according to claim 4, rich selenium germanium glossy ganoderma mycelium Serpentis class nano metal sulfoprotein capsule is characterized in that: be made up of following prescription
Cortex Cinnamomi, Poria, Rhizoma Alismatis, the Rhizoma Atractylodis Macrocephalae, Rhizoma Dioscoreae, the Radix Astragali, Fructus Lycii, Radix Angelicae Sinensis, YUANLAO, each 80～120g of Stamen Nelumbinis respectively account for 1～11%; Fructus Corni, each 100～200g of Semen Ziziphi Spinosae respectively account for 4～14%; Ophidia black snake powder 200～300g accounts for 10～20%; Nanometer selenium 10～20g accounts for 0.5～1.5%; The dry mycelium 3～13g of organic germanium accounts for 0.2～0.8%.
6. according to claim 5, rich selenium germanium glossy ganoderma mycelium Serpentis class nano metal sulfoprotein capsule is characterized in that: be made up of following prescription
Agkistrodon halys, each 150～250g of the Radix Polygoni Multiflori respectively account for 9～19%; Poria, YUANLAO, Radix Achyranthis Bidentatae, Radix Angelicae Sinensis, Fructus Lycii, Semen Cuscutae, Fructus Psoraleae, Fructus Schisandrae Chinensis, the Radix Paeoniae Alba, Fructus Corni, Radix Ophiopogonis be 20～80g respectively, respectively accounts for 1～7%; Fructus Rubi, Semen Plantaginis, Radix Ginseng, the Rhizoma Atractylodis Macrocephalae, Radix Glycyrrhizae Preparata, life be each 20～40g (ripe), respectively accounts for 1～3%; The Cortex Eucommiae, the Radix Astragali, each 20～100g of the accurate Rhizoma Dioscoreae of stir-fry respectively account for 1～9%; Nanometer selenium 5～15g accounts for 0.2～1.2%; The dry mycelium 2～8g of organic germanium accounts for 0.2～0.6%.
7. according to claim 6, rich selenium germanium glossy ganoderma mycelium Serpentis class nano metal sulfoprotein capsule is characterized in that: be made up of following prescription
Radix Asparagi (removing the heart), YUANLAO (removing the heart), Rhizoma Dioscoreae, each 50～150g of crust halberd respectively account for 1～9%; Halloysitum Rubrum, Semen Plantaginis, Rhizoma Acori Graminei, Semen Platycladi, Rhizoma Alismatis, Fructus Zanthoxyli (going order to fry), Radix Rehmanniae Preparata, the Radix Rehmanniae, Fructus Lycii, Poria, Fructus Rubi, Radix Angelicae Sinensis, Cortex Lycii, Radix Ginseng, each 20～80g of Fructus Schisandrae Chinensis respectively account for 1～4%; Herba Cistanches, pallas pit viper powder, the Cortex Eucommiae (stir-fry), Semen Cuscutae (steeping in wine), each 150～250g of Radix Achyranthis Bidentatae (steeping in wine) respectively account for 4～14%; Nanometer selenium 10～20g accounts for 0.2～1.2%; The dry mycelium 5～15g of organic germanium accounts for 0.2～0.8%.
8. according to claim 7, rich selenium germanium glossy ganoderma mycelium Serpentis class nano metal sulfoprotein capsule is characterized in that: be made up of following prescription
Ripe Radix Rehmanniae 1400～1600g respectively accounts for 39～49%; Fructus Schisandrae Chinensis, YUANLAO (removing the heart), each 150～250g of Folium Pyrrosiae respectively account for 1～11%; Radix Asparagi (removing the heart) 500～700g accounts for 12～23%; Rhizoma Acori Graminei 250～350g accounts for 4～14%; Poria 50～150g accounts for 1～5%; Cortex Cinnamomi 20～80g accounts for 0.5～3%; Ophidia black snake powder 100～140g respectively accounts for 1～7%; Nanometer selenium 20～40g accounts for 0.4～1.4%; The dry mycelium 10～20g of organic germanium accounts for 0.2～0.6%; Naja Fel Serpentis 20～40g accounts for 0.4～1.4%.
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102424625A (en) * | 2011-08-30 | 2012-04-25 | 大连百祥聚生物科技有限公司 | Edible and medical fungi blackening agent, its preparation method and application |
| CN103027930A (en) * | 2012-12-22 | 2013-04-10 | 普洱淞茂制药股份有限公司 | Biomass composition capable of forming and slowly releasing short-molecular polysaccharide, preparation method and preparation thereof |
| CN103301201A (en) * | 2013-06-28 | 2013-09-18 | 苏州菩芸生物科技有限公司 | Chinese herbal compound for improving auxiliary anti-tumor of immunity |
| CN103404591A (en) * | 2013-06-28 | 2013-11-27 | 成进学 | Selenium-germanium-rich spirulina enzyme yogurt |
| CN104193842A (en) * | 2014-08-19 | 2014-12-10 | 西藏天虹科技股份有限责任公司 | Method for extracting lucid ganoderma mycelia polysaccharide germanium |
| CN105768072A (en) * | 2016-02-19 | 2016-07-20 | 南通蛇类治疗研究所 | Senescence-preventing, aging-resisting and hair-darkening beverage |
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| CN1569123A (en) * | 2004-04-30 | 2005-01-26 | 成进学 | Oral functional Chinese medicine intensified by snake, bee, macroelement and microelement and its preparation |
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Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102424625A (en) * | 2011-08-30 | 2012-04-25 | 大连百祥聚生物科技有限公司 | Edible and medical fungi blackening agent, its preparation method and application |
| CN103027930A (en) * | 2012-12-22 | 2013-04-10 | 普洱淞茂制药股份有限公司 | Biomass composition capable of forming and slowly releasing short-molecular polysaccharide, preparation method and preparation thereof |
| CN103027930B (en) * | 2012-12-22 | 2015-06-24 | 普洱淞茂制药股份有限公司 | Biomass composition capable of forming and slowly releasing short-molecular polysaccharide, preparation method and preparation thereof |
| CN103301201A (en) * | 2013-06-28 | 2013-09-18 | 苏州菩芸生物科技有限公司 | Chinese herbal compound for improving auxiliary anti-tumor of immunity |
| CN103404591A (en) * | 2013-06-28 | 2013-11-27 | 成进学 | Selenium-germanium-rich spirulina enzyme yogurt |
| CN103301201B (en) * | 2013-06-28 | 2015-02-18 | 苏州菩芸生物科技有限公司 | Chinese herbal compound for improving auxiliary anti-tumor of immunity |
| CN104193842A (en) * | 2014-08-19 | 2014-12-10 | 西藏天虹科技股份有限责任公司 | Method for extracting lucid ganoderma mycelia polysaccharide germanium |
| CN105768072A (en) * | 2016-02-19 | 2016-07-20 | 南通蛇类治疗研究所 | Senescence-preventing, aging-resisting and hair-darkening beverage |
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Application publication date: 20110615 |