CN103027930A - Biomass composition capable of forming and slowly releasing short-molecular polysaccharide, preparation method and preparation thereof - Google Patents
Biomass composition capable of forming and slowly releasing short-molecular polysaccharide, preparation method and preparation thereof Download PDFInfo
- Publication number
- CN103027930A CN103027930A CN2012105619165A CN201210561916A CN103027930A CN 103027930 A CN103027930 A CN 103027930A CN 2012105619165 A CN2012105619165 A CN 2012105619165A CN 201210561916 A CN201210561916 A CN 201210561916A CN 103027930 A CN103027930 A CN 103027930A
- Authority
- CN
- China
- Prior art keywords
- preparation
- slow release
- short molecule
- sterilization
- biomass compositions
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 37
- 150000004676 glycans Chemical class 0.000 title claims abstract description 29
- 229920001282 polysaccharide Polymers 0.000 title claims abstract description 29
- 239000005017 polysaccharide Substances 0.000 title claims abstract description 29
- 239000002028 Biomass Substances 0.000 title claims abstract description 23
- 238000002360 preparation method Methods 0.000 title claims abstract description 21
- 239000000463 material Substances 0.000 claims abstract description 29
- 230000001954 sterilising effect Effects 0.000 claims abstract description 23
- 230000002378 acidificating effect Effects 0.000 claims abstract description 17
- 238000004659 sterilization and disinfection Methods 0.000 claims abstract description 16
- 238000002156 mixing Methods 0.000 claims abstract description 8
- 238000005520 cutting process Methods 0.000 claims abstract description 6
- 239000000843 powder Substances 0.000 claims abstract description 6
- 239000002775 capsule Substances 0.000 claims abstract description 4
- 239000008187 granular material Substances 0.000 claims abstract description 4
- 239000006187 pill Substances 0.000 claims abstract description 4
- 241001251949 Xanthium sibiricum Species 0.000 claims description 20
- 241001619461 Poria <basidiomycete fungus> Species 0.000 claims description 18
- 235000013372 meat Nutrition 0.000 claims description 15
- 238000012856 packing Methods 0.000 claims description 12
- 238000002203 pretreatment Methods 0.000 claims description 9
- 230000015572 biosynthetic process Effects 0.000 claims description 6
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 5
- 239000002671 adjuvant Substances 0.000 claims description 4
- 239000008194 pharmaceutical composition Substances 0.000 claims description 3
- 238000013268 sustained release Methods 0.000 claims description 3
- 239000012730 sustained-release form Substances 0.000 claims description 3
- 239000003826 tablet Substances 0.000 claims description 3
- CBENFWSGALASAD-UHFFFAOYSA-N Ozone Chemical compound [O-][O+]=O CBENFWSGALASAD-UHFFFAOYSA-N 0.000 claims description 2
- 238000001914 filtration Methods 0.000 claims description 2
- 239000009609 fructus phyllanthi Substances 0.000 claims description 2
- 239000002245 particle Substances 0.000 claims description 2
- 238000010298 pulverizing process Methods 0.000 claims description 2
- 210000000582 semen Anatomy 0.000 claims description 2
- 235000008599 Poria cocos Nutrition 0.000 abstract description 9
- 238000004519 manufacturing process Methods 0.000 abstract description 6
- 239000003814 drug Substances 0.000 abstract description 2
- 241001619444 Wolfiporia cocos Species 0.000 abstract 6
- 229940079593 drug Drugs 0.000 abstract 1
- 238000000227 grinding Methods 0.000 abstract 1
- 239000012535 impurity Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 description 10
- 125000002057 carboxymethyl group Chemical group [H]OC(=O)C([H])([H])[*] 0.000 description 8
- 239000002253 acid Substances 0.000 description 5
- 230000000259 anti-tumor effect Effects 0.000 description 5
- 238000006243 chemical reaction Methods 0.000 description 5
- 239000002994 raw material Substances 0.000 description 4
- 244000197580 Poria cocos Species 0.000 description 3
- 238000005516 engineering process Methods 0.000 description 3
- 229920001503 Glucan Polymers 0.000 description 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 2
- 229920002472 Starch Polymers 0.000 description 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 2
- 230000002478 diastatic effect Effects 0.000 description 2
- 238000003912 environmental pollution Methods 0.000 description 2
- 230000036039 immunity Effects 0.000 description 2
- 210000000214 mouth Anatomy 0.000 description 2
- 238000012545 processing Methods 0.000 description 2
- 229910052708 sodium Inorganic materials 0.000 description 2
- 239000011734 sodium Substances 0.000 description 2
- 235000019698 starch Nutrition 0.000 description 2
- 239000008107 starch Substances 0.000 description 2
- 241000233866 Fungi Species 0.000 description 1
- 102000014150 Interferons Human genes 0.000 description 1
- 108010050904 Interferons Proteins 0.000 description 1
- BDKZHNJTLHOSDW-UHFFFAOYSA-N [Na].CC(O)=O Chemical compound [Na].CC(O)=O BDKZHNJTLHOSDW-UHFFFAOYSA-N 0.000 description 1
- 238000002835 absorbance Methods 0.000 description 1
- 238000005903 acid hydrolysis reaction Methods 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 230000001093 anti-cancer Effects 0.000 description 1
- 230000000118 anti-neoplastic effect Effects 0.000 description 1
- 230000003471 anti-radiation Effects 0.000 description 1
- 230000000840 anti-viral effect Effects 0.000 description 1
- 230000003197 catalytic effect Effects 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 229910052736 halogen Inorganic materials 0.000 description 1
- 150000002367 halogens Chemical class 0.000 description 1
- 235000008216 herbs Nutrition 0.000 description 1
- 210000000987 immune system Anatomy 0.000 description 1
- 229960001438 immunostimulant agent Drugs 0.000 description 1
- 239000003022 immunostimulating agent Substances 0.000 description 1
- 230000003308 immunostimulating effect Effects 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 230000010354 integration Effects 0.000 description 1
- 229940079322 interferon Drugs 0.000 description 1
- 108010002060 leukoregulin Proteins 0.000 description 1
- TWNIBLMWSKIRAT-VFUOTHLCSA-N levoglucosan Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@H]2CO[C@@H]1O2 TWNIBLMWSKIRAT-VFUOTHLCSA-N 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 230000011987 methylation Effects 0.000 description 1
- 238000007069 methylation reaction Methods 0.000 description 1
- 229920001542 oligosaccharide Polymers 0.000 description 1
- 150000002482 oligosaccharides Chemical class 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 230000002441 reversible effect Effects 0.000 description 1
- FDRCDNZGSXJAFP-UHFFFAOYSA-M sodium chloroacetate Chemical compound [Na+].[O-]C(=O)CCl FDRCDNZGSXJAFP-UHFFFAOYSA-M 0.000 description 1
- 238000000638 solvent extraction Methods 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 238000012549 training Methods 0.000 description 1
Images
Landscapes
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention discloses a biomass composition capable of forming and slowly releasing short-molecular polysaccharide, a preparation method and a preparation of the biomass composition. The biomass composition capable of forming and slowly releasing short-molecular polysaccharide comprises the following components in part by weight: 50-300 parts of Poria cocos and 20-80 parts of acidic material. The preparation method of the biomass composition comprises steps of pretreatment, blending, sterilization and split charging, in particular comprises the following steps: removing impurities from Poria cocos, rinsing and cutting Poria cocos, and performing superfine grinding to Poria cocos for future use; adding the superfine ground acidic material into the treated Poria cocos, mixing the acidic material and Poria cocos uniformly to obtain the target composition; and sterilizing the target composition and carrying out split charging. The preparation of the biomass composition is a powder, a capsule, a granule, a tablet or a pill prepared by adding a pharmaceutically acceptable auxiliary material into the slow-release drug with short-molecular polysaccharide. The biomass composition is simple in manufacturing process, convenient to operate, low in cost, convenient to take, high in absorptivity and long in timeliness.
Description
Technical field
The invention belongs to biological deep process technology field, be specifically related to a kind of different biological raw materials that utilize, especially the biological raw material that is rich in polysaccharide of integration of edible and medicinal herbs, with acid biological raw material compatible combination, by natural acid hydrolysis, macromolecular polysaccharide is become biomass compositions, preparation method and the preparation of forming of short molecule polysaccharide and slow release short molecule polysaccharide.
Background technology
Studies have shown that, polysaccharide has antitumor action, namely is proved as far back as the seventies such as pachyman to have antineoplastic action, and it also is proved to be a kind of very strong immunostimulant material simultaneously.But it but is not easy extracting this pachyman with antitumor action from natural Poria cocos, because the pachyman in the natural Poria cocos is to be removed with 1 ~ 2 glucosan that closes with β 1-6 bond by 50 glucosans that close with β 1-3 bond, just can obtain having the pachyman of anti-tumor activity.At present, the preparation pachyman generally is to adopt the molecular design method, the method is take Indian Bread as raw material, obtains the pachyman highly finished product by alkaline solvent extraction, precipitation crude polysaccharides, exquisite technique, obtains having again the pachyman of antitumor action by oxidation, carboxy methylation.This method technique more complicated, the processing cost for preparing pachyman is higher, therefore, has limited to a certain extent the production of pachyman, and the pachyman that obtains is macromole, is difficult for being absorbed by the body.Therefore, exploitation is a kind of can be very important by the method that simple process is made the short molecule pachyman that utilizes of easily being absorbed by the body.
Summary of the invention
The first purpose of the present invention is to provide a kind of also biomass compositions of slow release short molecule polysaccharide that forms; The second purpose is to provide the described also preparation method of the biomass compositions of slow release short molecule polysaccharide that forms; The 3rd purpose is to provide described and forms and preparation that the biomass compositions of slow release short molecule polysaccharide is made.
The first purpose of the present invention is achieved in that and comprises weight portion Poria 50 ~ 300, acidic materials 20 ~ 80.
The second purpose of the present invention be achieved in that comprise pre-treatment, the packing step that is mixed, sterilizes, specifically comprise:
A, pre-treatment: foreign material in Poria, the acidic materials are rejected, respectively through rinsing, peeling, cutting and pulverize for subsequent use;
B, be mixed: will through the Poria after the pre-treatment, acidic materials by weight ratio mixing obtain objective composition;
C, sterilization packing: the objective composition packing of sterilizing is for subsequent use.
The 3rd purpose of the present invention is achieved in that described sustained release pharmaceutical composition with short molecule polysaccharide adds pharmaceutically the acceptable adjuvant and makes powder, capsule, granule, tablet or pill.
The main component pachyman can generate carboxymethyl pachyman by chemical reaction under certain condition in the Poria, carboxymethyl pachyman is a kind of Novel immune regulating action material, can stimulate human immune system's function, inducing and urge to give birth to interferon produces, also be a kind of leukoregulin, have strengthen immunity, antitumor, antiviral, anti-radiation, protect the liver, syngignoscism.
The extraction of edible fungi polysaccharide prepares patent documentation concentrates and to point out, the production process of carboxymethyl pachyman is:
:-CH
2The COOH substitution value is that (mean molecule quantity is 20.0*10 for the carboxymethyl pachyman of 0.01-0.72
4-26.1*10
4).But the method production cost is high, and environmental pollution is large.
Adjuvant carboxymethyl starch sodium among the present invention, under acid (acid edible medicinal material) condition, carry out reversible reaction and generate sodium chloroacetate, then the reaction of halogen acetic acid sodium and pachyman generates carboxymethyl pachyman, pachyman is under acid edible medicinal material, the diastatic effect of human oral cavity simultaneously, can generate oligomeric pachyman, reaction equation is as follows:
Poria does not need suitability for industrialized production and chemical reagent during the main innovate point of this product, reduce production costs and environmental pollution, in human oral cavity, Poria and acid edible medicinal material, carboxymethyl starch sodium are under diastatic catalytic action, directly obtain to have carboxymethyl pachyman and Poria oligosaccharide anticancer, enhancing immunity, this prescription is cheap, increased easily the function of Chinese medicine Poria, improves the Poria added value.
Processing technology of the present invention is simple, easy to operate, cost is low, taking convenience, high, the ageing length of absorbance.
Description of drawings
Fig. 1 is process chart of the present invention.
The specific embodiment
The present invention is further illustrated below in conjunction with drawings and Examples, but never in any form the present invention is limited, and any conversion or replacement based on training centre of the present invention is done all belong to protection scope of the present invention.
Of the present invention form and the biomass compositions of slow release short molecule polysaccharide comprises weight portion Poria 50 ~ 300, acidic materials 20 ~ 80.
Described acidic materials are one or more in Fructus Tamarindi Indicae, Semen Ziziphi Spinosae, Fructus Crataegi, citric acid, the Fructus Phyllanthi.
Of the present invention formation and the preparation method of the biomass compositions of slow release short molecule polysaccharide is characterized in that comprising pre-treatment, the packing step that is mixed, sterilizes, and specifically comprises:
A, pre-treatment: foreign material in Poria, the acidic materials are rejected, respectively through rinsing, peeling, cutting and pulverize for subsequent use;
B, be mixed: will through the Poria after the pre-treatment, acidic materials by weight ratio mixing obtain objective composition;
C, sterilization packing: the objective composition packing of sterilizing is for subsequent use.
Described rinsing is the flowing water rinsing.
Described cutting is not with Siberian cocklebur meat for first the Siberian cocklebur skin being peelled off as far as possible, and the bronzing Siberian cocklebur meat of inner white Siberian cocklebur meat with nearly skin place is separated, and cuts into slices respectively or fourth.
Described pulverizing is micronizing, and powder particle diameter is less than 75 μ m.
Described sterilization is a kind of in dry heat sterilization, ozone sterilization, high pressure steam sterilization, ultraviolet disinfection, filtration sterilization, the high-temp steam sterilizing.
Of the present invention formation and the preparation of the biomass compositions of slow release short molecule polysaccharide is characterized in that described sustained release pharmaceutical composition with short molecule polysaccharide adds pharmaceutically the acceptable adjuvant and makes powder, capsule, granule, tablet or pill.
Embodiment 1
Foreign material in Poria, the acidic materials are rejected, respectively through the flowing water rinsing, the Siberian cocklebur skin is peelled off, be not with Siberian cocklebur meat as far as possible, inner white Siberian cocklebur meat and the near bronzing Siberian cocklebur meat at skin place are separated, cut into slices respectively or fourth, carry out micronizing; Mixing obtains objective composition by weight ratio; With the objective composition packing of sterilizing.
Embodiment 2
Foreign material in Poria, the acidic materials are rejected, respectively through the flowing water rinsing, the Siberian cocklebur skin is peelled off, be not with Siberian cocklebur meat as far as possible, inner white Siberian cocklebur meat and the near bronzing Siberian cocklebur meat at skin place are separated, cut into slices respectively or fourth, carry out micronizing; Mixing obtains objective composition by weight ratio; With the objective composition packing of sterilizing.
Embodiment 3
Foreign material in Poria, the acidic materials are rejected, respectively through the flowing water rinsing, the Siberian cocklebur skin is peelled off, be not with Siberian cocklebur meat as far as possible, inner white Siberian cocklebur meat and the near bronzing Siberian cocklebur meat at skin place are separated, cut into slices respectively or fourth, carry out micronizing; Mixing obtains objective composition by weight ratio; With the objective composition packing of sterilizing.
Claims (8)
1. one kind can form the also biomass compositions of slow release short molecule polysaccharide, it is characterized in that comprising weight portion Poria 50 ~ 300, acidic materials 20 ~ 80.
2. the also biomass compositions of slow release short molecule polysaccharide that forms according to claim 1 is characterized in that described acidic materials are one or more in Fructus Tamarindi Indicae, Semen Ziziphi Spinosae, Fructus Crataegi, citric acid, the Fructus Phyllanthi.
3. claimed in claim 1 formation and the preparation method of the biomass compositions of slow release short molecule polysaccharide is characterized in that comprising pre-treatment, the packing step that is mixed, sterilizes, and specifically comprises:
A, pre-treatment: foreign material in Poria, the acidic materials are rejected, respectively through rinsing, peeling, cutting and pulverize for subsequent use;
B, be mixed: will through the Poria after the pre-treatment, acidic materials by weight ratio mixing obtain objective composition;
C, sterilization packing: the objective composition packing of sterilizing is for subsequent use.
4. the also preparation method of the biomass compositions of slow release short molecule polysaccharide that forms according to claim 3 is characterized in that described rinsing is the flowing water rinsing.
5. according to claim 4 formation and the preparation method of the biomass compositions of slow release short molecule polysaccharide, it is characterized in that described cutting is for peelling off the Siberian cocklebur skin first, be not with Siberian cocklebur meat as far as possible, the bronzing Siberian cocklebur meat of inner white Siberian cocklebur meat with nearly skin place is separated, cut into slices respectively or fourth.
6. the also preparation method of the biomass compositions of slow release short molecule polysaccharide that forms according to claim 4 is characterized in that described pulverizing is micronizing, and powder particle diameter is less than 75 μ m.
7. according to claim 3 formation and the preparation method of the biomass compositions of slow release short molecule polysaccharide is characterized in that described sterilization is a kind of in dry heat sterilization, ozone sterilization, high pressure steam sterilization, ultraviolet disinfection, filtration sterilization, the high-temp steam sterilizing.
8. a claim 1 or 2 described formation and the preparations of the biomass compositions of slow release short molecule polysaccharide is characterized in that described sustained release pharmaceutical composition with short molecule polysaccharide adds pharmaceutically the acceptable adjuvant and makes powder, capsule, granule, tablet or pill.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210561916.5A CN103027930B (en) | 2012-12-22 | 2012-12-22 | Biomass composition capable of forming and slowly releasing short-molecular polysaccharide, preparation method and preparation thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210561916.5A CN103027930B (en) | 2012-12-22 | 2012-12-22 | Biomass composition capable of forming and slowly releasing short-molecular polysaccharide, preparation method and preparation thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103027930A true CN103027930A (en) | 2013-04-10 |
| CN103027930B CN103027930B (en) | 2015-06-24 |
Family
ID=48015659
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201210561916.5A Expired - Fee Related CN103027930B (en) | 2012-12-22 | 2012-12-22 | Biomass composition capable of forming and slowly releasing short-molecular polysaccharide, preparation method and preparation thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN103027930B (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106188324A (en) * | 2016-07-13 | 2016-12-07 | 武汉大学 | The preparation of hydroxyethyl pachyman and as the application of slow releasing tablet framework material |
| CN113774098A (en) * | 2021-09-03 | 2021-12-10 | 武汉工程大学 | Carboxymethyl pachyman with different degrees of substitution as well as preparation method and application thereof |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1104450A (en) * | 1994-06-13 | 1995-07-05 | 北京市营养源研究所 | Health-care nutrient food for diet and its production |
| CN1613483A (en) * | 2003-11-05 | 2005-05-11 | 汪昌荣 | Cold preventing medicine |
| CN102091278A (en) * | 2010-09-08 | 2011-06-15 | 成进学 | Selenium- and germanium-enriched lucid ganoderma mycelium snake nano metallothionein capsule |
| CN102524624A (en) * | 2012-01-19 | 2012-07-04 | 湖南明园蜂业科技有限公司 | Bee product with function of improving sleeping and preparation method thereof |
-
2012
- 2012-12-22 CN CN201210561916.5A patent/CN103027930B/en not_active Expired - Fee Related
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1104450A (en) * | 1994-06-13 | 1995-07-05 | 北京市营养源研究所 | Health-care nutrient food for diet and its production |
| CN1613483A (en) * | 2003-11-05 | 2005-05-11 | 汪昌荣 | Cold preventing medicine |
| CN102091278A (en) * | 2010-09-08 | 2011-06-15 | 成进学 | Selenium- and germanium-enriched lucid ganoderma mycelium snake nano metallothionein capsule |
| CN102524624A (en) * | 2012-01-19 | 2012-07-04 | 湖南明园蜂业科技有限公司 | Bee product with function of improving sleeping and preparation method thereof |
Non-Patent Citations (3)
| Title |
|---|
| 《药膳食疗》 20040731 万青 "养心安神 莫忘酸枣仁" 第39页 1-8 , * |
| 万青: ""养心安神 莫忘酸枣仁"", 《药膳食疗》 * |
| 王占华 等: "山楂茯苓煎治疗婴幼儿腹泻165例", 《北京中医杂志》 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106188324A (en) * | 2016-07-13 | 2016-12-07 | 武汉大学 | The preparation of hydroxyethyl pachyman and as the application of slow releasing tablet framework material |
| CN106188324B (en) * | 2016-07-13 | 2018-11-23 | 武汉大学 | Hydroxyethyl pachyman preparation and its as sustained release tablets framework material application |
| CN113774098A (en) * | 2021-09-03 | 2021-12-10 | 武汉工程大学 | Carboxymethyl pachyman with different degrees of substitution as well as preparation method and application thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN103027930B (en) | 2015-06-24 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Joseph et al. | A galactomannan polysaccharide from Punica granatum imparts in vitro and in vivo anticancer activity | |
| CN102145022B (en) | Lucid ganoderma composition with effects of enhancing immunity and resisting radiation and preparation method thereof | |
| CN102823885B (en) | Sea cucumber chewable tablets and preparation method thereof | |
| Algethami et al. | Bee pollen: Clinical trials and patent applications | |
| CN104432075B (en) | A kind of leaf of Moringa oral liquid and preparation method thereof | |
| Zhang et al. | Recent developments in stigma maydis polysaccharides: Isolation, structural characteristics, biological activities and industrial application | |
| CN105077232A (en) | Dendrobium officinale and fructus lycii capsule and preparation method thereof | |
| CN101560267A (en) | Preparation method of polysaccharide selenite | |
| CN105504079A (en) | Process for producing astragalus polysaccharide by using ultrasonic technology | |
| CN104622946A (en) | Gynura bicolor heat-clearing buccal tablet and preparation method thereof | |
| CN103027930B (en) | Biomass composition capable of forming and slowly releasing short-molecular polysaccharide, preparation method and preparation thereof | |
| CN104031156A (en) | Selfheal polysaccharide zinc chelate as well as preparation method and application thereof to anti-cancer drug | |
| CN105732834A (en) | Brown algae fucoidan extraction and purification method | |
| CN105011152A (en) | Dendrobium officinale and siraitia grosvenorii capsule and preparation method thereof | |
| CN106728208A (en) | A kind of ginseng and lucid ganoderma polysaccharide triterpene preparation and preparation method thereof | |
| WO2020000828A1 (en) | Gracilaria lemaneiformis polysaccharide having significant hypolipidemic activity and preparation method therefor and use thereof | |
| CN102772573A (en) | Oral liquid for strengthening immunity and resisting virus and preparation method thereof | |
| JP6700516B2 (en) | Method for extracting high molecular polysaccharides from licorice root | |
| CN101857614B (en) | Leucosceptoside A and preparation method and application thereof | |
| CN103565960B (en) | A kind of semi-bionic extraction technology prepares the method for Semen Hoveniae extract (Fructus Hoveniae extract) | |
| CN101953987B (en) | Chinese medicinal composition for improving chicken immunity and preparation method thereof | |
| KR20170136785A (en) | Composition for enhancing the bioavailability of fat-soluble vitamins | |
| CN105440148A (en) | Process for producing astragalus polysaccharide by using water extraction technology | |
| CN101375698A (en) | Kudzu root tea and preparation method thereof | |
| CN102949312A (en) | AlfafaAlfalfa skin cream |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C53 | Correction of patent of invention or patent application | ||
| CB02 | Change of applicant information |
Address after: 665000 Yunnan province city Simao district is the wood River Industrial Park Applicant after: PUER SONGMAO PHARMACEUTICAL Co.,Ltd. Address before: 665000 Simao city of Yunnan province Simao Pu'er City Zhenxing Road No. 144 Applicant before: PUER SONGMAO PHARMACEUTICAL Co.,Ltd. |
|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CP01 | Change in the name or title of a patent holder | ||
| CP01 | Change in the name or title of a patent holder |
Address after: 665000 Yunnan province city Simao district is the wood River Industrial Park Patentee after: PUER SONGMAO DIANCAO LIUWEI PHARMACEUTICAL CO.,LTD. Address before: 665000 Yunnan province city Simao district is the wood River Industrial Park Patentee before: PUER SONGMAO PHARMACEUTICAL Co.,Ltd. |
|
| CB03 | Change of inventor or designer information | ||
| CB03 | Change of inventor or designer information |
Inventor after: Liu Bao Inventor after: Zhou Zhengfeng Inventor before: Liu Bao |
|
| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20150624 Termination date: 20211222 |