CN102772573A - Oral liquid for strengthening immunity and resisting virus and preparation method thereof - Google Patents
Oral liquid for strengthening immunity and resisting virus and preparation method thereof Download PDFInfo
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- CN102772573A CN102772573A CN2012102839110A CN201210283911A CN102772573A CN 102772573 A CN102772573 A CN 102772573A CN 2012102839110 A CN2012102839110 A CN 2012102839110A CN 201210283911 A CN201210283911 A CN 201210283911A CN 102772573 A CN102772573 A CN 102772573A
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- flos lonicerae
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Abstract
The invention discloses oral liquid for strengthening immunity and resisting virus and a preparation method of the oral liquid, which relate to the field of a health-care product. The oral liquid for strengthening immunity and resisting virus is prepared by combining five frequently-used traditional Chinese medicine raw materials, such as flos lonicerae, astragalus mongholicus, fructus lycii, fructus ligustri lucidi and radix glycyrrhiza. The preparation method of the oral liquid, provided by the invention, comprises five steps of: pretreatment, extraction, ethanol precipitation, water precipitation and preparation. The raw materials of the oral liquid prepared by the method contain astragalus mongholicus, fructus ligustri lucidi and fructus lycii which are capable of strengthening immunity, and flos lonicerae and radix glycyrrhiza which have a good effect of resisting virus, so that the oral liquid provided by the invention has the effects of strengthening immunity and resisting virus.
Description
Technical field
The present invention relates to field of health care products, be specifically related to a kind of enhancing immunity and antiviral oral liquid and preparation method thereof.
Background technology
In recent years, be accompanied by the popular on a large scale of viral disease each time such as SARS, bird flu, influenza A, all drive the panic buying tide of consumers in general's enantiopathy cytotoxic drug, especially anti virus herb." poison " of the traditional Chinese medical science is different with " virus " notion of doctor trained in Western medicine, sees from the angle of doctor trained in Western medicine, and influenza, SARS, bird flu all are to be caused a disease by virus, have stronger infectiousness; And from the angle of the traditional Chinese medical science, these diseases are main feature with " pyretic toxicity " all, belong to the epidemic febrile disease category, and by the Epidemic Febrile Disease principle, the way of treatment mainly is a heat-clearing and toxic substances removing, such as taking Radix Isatidis.The traditional Chinese medical science is thought, no matter is influenza or SARS, and the their early stage table disease interior-heat that do not eliminate is vehement, belongs to simultaneous occurrence of syndromes of both QI and WEI systems, when evacuating exopathogen, reuses the article of heat-clearing and toxic substances removing, can receive to defend that gas is ruled together, the merit of relieving exterior-interior syndrome.Chinese and western medicine is different to the treatment emphasis of infectious disease, and what doctor trained in Western medicine was directed against is pathogenic microorganism, and the traditional Chinese medical science then focuses on the raising body immunity.Healthy human body all has natural resistance to antibacterial and virus, only occurs under the situation of functional disorder at human organ, and antibacterial or virus could be invaded and caused falling ill.Therefore, attempt unrealisticly merely,, just constantly have pathogen to attack as long as the immunity of body is still low through the idea of just forever killing pathogen with a kind of biological medicine or chemical medicine.The allomeric function state of traditional Chinese medical science adjustment health, human body immunity improving power is driven away exopathogen.
Summary of the invention
One of the object of the invention be only avoid in the prior art through single type of medicine can only enhancing immunity or the deficiency of antiviral effect a kind of oral liquid that has enhancing immunity and antiviral effect concurrently is provided.
Two of the object of the invention provides the method for preparing of above-mentioned enhancing immunity and antiviral oral liquid.
The present invention realizes through following technical scheme:
A kind of enhancing immunity and antiviral oral liquid consist predominantly of Flos Lonicerae, the Radix Astragali, Fructus Lycii, Fructus Ligustri Lucidi, Radix Glycyrrhizae; Its composition of raw materials is following by ratio of weight and the number of copies:
Flos Lonicerae 10～100
The Radix Astragali 50～200
Fructus Lycii 10～100
Fructus Ligustri Lucidi 10～100
Radix Glycyrrhizae 10～80.
A kind of enhancing immunity and antiviral oral liquid, composition of raw materials are preferred by ratio of weight and the number of copies as follows:
Flos Lonicerae 25～75
The Radix Astragali 75～150
Fructus Lycii 25～75
Fructus Ligustri Lucidi 25～75
Radix Glycyrrhizae 20～30.
A kind of enhancing immunity and antiviral oral liquid, composition of raw materials are preferred by ratio of weight and the number of copies as follows:
Flos Lonicerae 50
The Radix Astragali 100
Fructus Lycii 50
Fructus Ligustri Lucidi 50
Radix Glycyrrhizae 25.
The preparation that has the following steps of the method for preparing of above-mentioned a kind of enhancing immunity and antiviral oral liquid:
A. pretreatment: selection Flos Lonicerae, the Radix Astragali, Fructus Lycii, Fructus Ligustri Lucidi and Radix Glycyrrhizae 5 flavor medical materials, wherein Fructus Ligustri Lucidi is pulverized, pack after the weighing as required, put into container then;
B. extract: be divided into extracted twice, add 10～20 times of water gagings of medical material weight for the first time and decoct 1～2h, soak 0.3～1h before wherein decocting; Add for the second time 5～12 times of water gagings of medical material weight and decoct 0.5h～2h; Again through filtering and be concentrated into 2.3～2.7 times of crude drugs (v/w);
C. precipitate with ethanol: solution to be concentrated is cooled to 40～50 ℃ behind step b, in concentrated solution, slowly adds 95% ethanol again and makes and contain the alcohol amount and reach 40%, fully stirs; Behind the 1h, stir again, leave standstill 20～40 h after-filtration then; Decompression recycling ethanol again;
D. water precipitating: behind step c, in container, add water to 80%～90% of amount of preparation, mix homogeneously, cold preservation 15～30h under 2～10 ℃ temperature filters then;
E. preparation: after steps d, in container, add sweeting agent high fructose syrup and sucralose, mix homogeneously is processed finished product through standardize solution and sterilization again.
Beneficial effect of the present invention:
Traditional medicine is stressed the effect of " healthy energy " very much; Think disease generation, development and transform the growth and decline of all depending on the good and evil struggle; Thereby proposed the base therapy thinking of " strengthening vital QI to eliminate pathogenic factors ", stressed that promptly the immunity of enhancing body is to resist with disease from integral body.
The present invention chooses the Radix Astragali, Fructus Ligustri Lucidi, the Fructus Lycii that can enhancing immunity plays centralizing function, and it is primary raw material that collocation has Flos Lonicerae, the Radix Glycyrrhizae that good antiviral effect plays eliminating evil effect, allocates and obtains oral liquid through extracting back and other adjuvants.Therefore oral liquid of the present invention is with enhancing immunity and antiviral effect.
Description of drawings
Fig. 1 is a process chart of the present invention.
The specific embodiment
In conjunction with accompanying drawing and following examples the present invention is done further description.
Embodiment 1
A. pretreatment: after getting an amount of Fructus Ligustri Lucidi pulverizing earlier, take by weighing Flos Lonicerae 50g, Radix Astragali 100g, Fructus Lycii 50g, Fructus Ligustri Lucidi 50g and Radix Glycyrrhizae 25g again, Flos Lonicerae and Fructus Ligustri Lucidi pack respectively;
B. extract: carry out extracted twice, add 3300ml water for the first time, soak 0.5h earlier, decoct 1.5h again, add water 2750ml for the second time and decoct 1h; Filter, merge decoction liquor twice,, get concentrated solution 700ml through concentrating;
C. precipitate with ethanol: when solution to be concentrated is cooled to 40 ℃～50 ℃, in concentrated solution, slowly adds 95% ethanol 510ml and stir, restir once behind the 1h; Leave standstill 20h then, filter, get precipitate with ethanol filtrating 900ml; Fling to ethanol and get medicinal liquid 150ml, be precipitated as 275ml, discard;
D. water precipitating: with the 150ml medicinal liquid, add pure water to 800ml, cold preservation 15h under 7～10 ℃ of temperature filters, medicinal liquid be 790ml.
E. preparation: after 60.0g high fructose syrup and 0.20g sucralose added water 120ml and dissolve, add in the medicinal liquid, mix homogeneously filters, and adds water and is settled to 1000ml, and bottling is then at 121 ℃ of 30min that sterilize down.
Embodiment 2
A. pretreatment: after getting an amount of Fructus Ligustri Lucidi pulverizing earlier, take by weighing Flos Lonicerae 10g, Radix Astragali 50g, Fructus Lycii 10g, Fructus Ligustri Lucidi 10g and Radix Glycyrrhizae 10g again, Flos Lonicerae and Fructus Ligustri Lucidi pack respectively;
B. extract: carry out extracted twice, add 1080ml water for the first time, soak 0.5h earlier, decoct 1.5h again, add water 900ml for the second time, decoct 1h; Filter, merge decoction liquor twice,, get concentrated solution 230ml through concentrating;
C. precipitate with ethanol: when solution to be concentrated is cooled to 40 ℃～50 ℃, in concentrated solution, slowly adds 95% ethanol 167ml and stir, restir once behind the 1h; Leave standstill 24h then, filter, get precipitate with ethanol filtrating 310ml; Fling to ethanol and get medicinal liquid 100ml, be precipitated as 80ml, discard;
D. water precipitating: with medicinal liquid 100ml, add pure water to 800ml, cold preservation 15h under 7～10 ℃ of temperature filters, medicinal liquid be 795ml.
E. preparation: after 60.0g high fructose syrup and 0.20g sucralose added water 120ml and dissolve, add in the medicinal liquid, mix homogeneously filters, and adds water and is settled to 1000ml, and bottling is then at 121 ℃ of 30min that sterilize down.
Embodiment 3
A. pretreatment: after getting an amount of Fructus Ligustri Lucidi pulverizing earlier, take by weighing Flos Lonicerae 100g, Radix Astragali 200g, Fructus Lycii 100g, Fructus Ligustri Lucidi 100g and Radix Glycyrrhizae 80g again, Flos Lonicerae and Fructus Ligustri Lucidi pack respectively;
B. extract: carry out extracted twice, add 6960ml water for the first time, soak 0.5h earlier, decoct 1.5h again, add water 5800ml for the second time, decoct 1h; Filter, merge decoction liquor twice,, get concentrated solution 1400ml through concentrating;
C. precipitate with ethanol: when solution to be concentrated is cooled to 40 ℃～50 ℃, in concentrated solution, slowly adds 95% ethanol 1018ml and stir, restir once behind the 1h; Leave standstill 22h then, filter, get precipitate with ethanol filtrating 1800ml; Fling to ethanol and get medicinal liquid 600ml, be precipitated as 510ml, discard;
D. water precipitating: with medicinal liquid 600ml, add pure water to 800ml, cold preservation 15h under 7～10 ℃ of temperature filters, medicinal liquid be 785ml.
E. preparation: after 60.0g high fructose syrup and 0.20g sucralose added water 120ml and dissolve, add in the medicinal liquid, mix homogeneously filters, and adds water and is settled to 1000ml, and bottling is then at 121 ℃ of 30min that sterilize down.
Embodiment 4
A. pretreatment: after getting an amount of Fructus Ligustri Lucidi pulverizing earlier, take by weighing Flos Lonicerae 25g, Radix Astragali 75g, Fructus Lycii 25g, Fructus Ligustri Lucidi 25g and Radix Glycyrrhizae 20g again, Flos Lonicerae and Fructus Ligustri Lucidi pack respectively;
B. extract: carry out extracted twice, add 2040ml water for the first time, soak 0.5h earlier, decoct 1.5h again, add water 1700ml for the second time and decoct 1h; Filter, merge decoction liquor twice,, get concentrated solution 420ml through concentrating;
C. precipitate with ethanol: when solution to be concentrated is cooled to 40 ℃～50 ℃, in concentrated solution, slowly adds 95% ethanol 305ml and stir, restir once behind the 1h; Leave standstill 21h then, filter, get precipitate with ethanol filtrating 550ml; Fling to ethanol and get medicinal liquid 180ml, be precipitated as 150ml, discard;
D. water precipitating: with medicinal liquid 180ml, add pure water to 800ml, cold preservation 15h under 7～10 ℃ of temperature filters, medicinal liquid be 790ml.
E. preparation: after 60.0g high fructose syrup and 0.20g sucralose added water 120ml and dissolve, add in the medicinal liquid, mix homogeneously filters, and adds water and is settled to 1000ml, and bottling is then at 121 ℃ of 30min that sterilize down.
Embodiment 5
A. pretreatment: after getting an amount of Fructus Ligustri Lucidi pulverizing earlier, take by weighing Flos Lonicerae 75g, Radix Astragali 150g, Fructus Lycii 75g, Fructus Ligustri Lucidi 75g and Radix Glycyrrhizae 30g again, Flos Lonicerae and Fructus Ligustri Lucidi pack respectively;
B. extract: carry out extracted twice, add 4860ml water for the first time, soak 0.5h earlier, decoct 1.5h again, add water 4050ml for the second time and decoct 1h; Filter, merge decoction liquor twice,, get concentrated solution 1000ml through concentrating;
C. precipitate with ethanol: when solution to be concentrated is cooled to 40 ℃～50 ℃, in concentrated solution, slowly adds 95% ethanol 727ml and stir, restir once behind the 1h; Leave standstill 22h then, filter, get precipitate with ethanol filtrating 1350ml; Fling to ethanol and get medicinal liquid 420ml, be precipitated as 360ml, discard;
D. water precipitating: with medicinal liquid 420ml, add pure water to 800ml, cold preservation 15h under 7～10 ℃ of temperature filters, medicinal liquid be 792ml.
E. preparation: after 60.0g high fructose syrup and 0.20g sucralose added water 120ml and dissolve, add in the medicinal liquid, mix homogeneously filters, and adds water and is settled to 1000ml, and bottling is then at 121 ℃ of 30min that sterilize down.
Table 1
| ?Embodiment | ?Polysaccharide is (in glucosan, mg/100ml) | ?Chlorogenic acid (mg/100ml) |
| 1 | 52.8 | 36.0 |
| 2 | 15.4 | 7.8 |
| 3 | 110.2 | 72.3 |
| 4 | 30.5 | 18.4 |
| 5 | 80.7 | 54.3 |
Table 1 is the enhancing immunity of embodiment 1～5 preparation and the test result of antiviral oral liquid, representes its functional component with polysaccharide and chlorogenic acid respectively.
According to above-mentioned principle, the present invention can also carry out suitable change and modification to the above-mentioned specific embodiment.Therefore, the specific embodiment that discloses and describe above the present invention is not limited to also should fall in the protection domain of claim of the present invention modifications more of the present invention and change.In addition, although used some specific terms in this description, these terms are explanation for ease just, the present invention is not constituted any restriction.
Claims (4)
1. an enhancing immunity and antiviral oral liquid consist predominantly of Flos Lonicerae, the Radix Astragali, Fructus Lycii, Fructus Ligustri Lucidi, Radix Glycyrrhizae; It is characterized in that: composition of raw materials is following by ratio of weight and the number of copies:
Flos Lonicerae 10～100
The Radix Astragali 50～200
Fructus Lycii 10～100
Fructus Ligustri Lucidi 10～100
Radix Glycyrrhizae 10～80.
2. a kind of enhancing immunity according to claim 1 and antiviral oral liquid is characterized in that: composition of raw materials is preferred by ratio of weight and the number of copies as follows:
Flos Lonicerae 25～75
The Radix Astragali 75～150
Fructus Lycii 25～75
Fructus Ligustri Lucidi 25～75
Radix Glycyrrhizae 20～30.
3. a kind of enhancing immunity according to claim 1 and antiviral oral liquid is characterized in that: composition of raw materials is preferred by ratio of weight and the number of copies as follows:
Flos Lonicerae 50
The Radix Astragali 100
Fructus Lycii 50
Fructus Ligustri Lucidi 50
Radix Glycyrrhizae 25.
4. according to the method for preparing of described a kind of enhancing immunity of claim 1～3 and antiviral oral liquid, it is characterized in that: select the described composition of raw materials of claim 1～3 to prepare through following steps:
A. pretreatment: selection Flos Lonicerae, the Radix Astragali, Fructus Lycii, Fructus Ligustri Lucidi and Radix Glycyrrhizae 5 flavor medical materials, wherein Fructus Ligustri Lucidi is pulverized, pack after the weighing as required, put into container then;
B. extract: extract at twice, add 10～20 times of water gagings of medical material weight for the first time and decoct 1～2h, soak 0.3～1h before wherein decocting; Add for the second time 5～12 times of water gagings of medical material weight and decoct 0.5h～2h; Again through filtering and be concentrated into 2.3～2.7 times of crude drugs (v/w);
C. precipitate with ethanol: solution to be concentrated is cooled to 40～50 ℃ behind step b, in concentrated solution, slowly adds 95% ethanol again and makes and contain the alcohol amount and reach 40%, fully stirs; Behind the 1h, stir again, leave standstill 20～40 h after-filtration then; Decompression recycling ethanol again;
D. water precipitating: behind step c, in container, add water to 80%～90% of amount of preparation, cold preservation 15～30h under 2～10 ℃ temperature filters then;
E. preparation: after steps d, in container, add sweeting agent high fructose syrup and sucralose, mix homogeneously is processed finished product through standardize solution and sterilization again.
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103462123A (en) * | 2013-08-06 | 2013-12-25 | 中国热带农业科学院热带生物技术研究所 | Coconut juice composition and preparation method thereof |
| CN103960663A (en) * | 2014-05-14 | 2014-08-06 | 北京燕康科技有限公司 | Health care food for enhancing immunologic function and preparation method of food |
| CN105077473A (en) * | 2015-07-23 | 2015-11-25 | 叶芳健 | Honeysuckle concentrating beverage and preparation method thereof |
| CN112245527A (en) * | 2020-11-11 | 2021-01-22 | 广东轻工职业技术学院 | Preparation method of active polysaccharide extract, functional beverage and effervescent granule with homology of medicine and food |
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| CN1539494A (en) * | 2003-10-27 | 2004-10-27 | 朱翻身 | Chinese traditional medicine for raising immunocompetence of body for anti influenza, SARS, and preparation method |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103462123A (en) * | 2013-08-06 | 2013-12-25 | 中国热带农业科学院热带生物技术研究所 | Coconut juice composition and preparation method thereof |
| CN103462123B (en) * | 2013-08-06 | 2015-11-04 | 中国热带农业科学院热带生物技术研究所 | Coconut Juice composition and method of making the same |
| CN103960663A (en) * | 2014-05-14 | 2014-08-06 | 北京燕康科技有限公司 | Health care food for enhancing immunologic function and preparation method of food |
| CN105077473A (en) * | 2015-07-23 | 2015-11-25 | 叶芳健 | Honeysuckle concentrating beverage and preparation method thereof |
| CN105077473B (en) * | 2015-07-23 | 2017-10-31 | 湖北武当生物医药科技有限公司 | A kind of honeysuckle beverage concentrate and preparation method thereof |
| CN112245527A (en) * | 2020-11-11 | 2021-01-22 | 广东轻工职业技术学院 | Preparation method of active polysaccharide extract, functional beverage and effervescent granule with homology of medicine and food |
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