CN103960663A - Health care food for enhancing immunologic function and preparation method of food - Google Patents
Health care food for enhancing immunologic function and preparation method of food Download PDFInfo
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Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Mycology (AREA)
- Health & Medical Sciences (AREA)
- Nutrition Science (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention relates to the field of food health care, and particularly relates to a health care food for enhancing an immunologic function and a preparation method of the food. The health care food for enhancing the immunologic function comprises the following raw materials in parts by weight of 50-100 parts of astragalus membranaceus, 50-100 parts of glossy privet fruit, 5-50 parts of American ginseng and 5-50 parts of liquorice root. The health care food for enhancing the immunologic function, provided by the embodiment of the invention has an effect of enhancing the immunologic function of a human body; all raw materials can be used in a formula of a health care food, and are high in safety, and thus a product produced according to the formula is suitable for the crowds suffering from hypoimmunity, and is capable of enhancing the immunologic function of the human body with few side effects.
Description
Technical field
The present invention relates to health care of food field, in particular to a kind of for strengthening health food of immunologic function and preparation method thereof.
Background technology
With the quickening pace of modern life, from the pressure of society, work, life each side, allow people think that immunity is much worse than in the past, add bird flu, H1N1 influenza virus and import the special germ of China from Europe into, all the time all threatening people's health, people more and more recognize that improving immunity means and have healthy physique.And the immunity of body is carried out by immune system.Immune system is born three basic functions: immune protection, immunological homeostasis, immunosurveillance.
Once immunologic dysfunction, body just there will be corresponding disease.The development that clinical and experiment immunization is learned proves, infect, allergic disease, autoimmunity disease, tumour and aids (AIDS) etc. all with function of immune system normally whether have a close relationship.
Immune system comprises immune organ, immunocyte and immune molecule.Can get rid of specifically or non-specifically the foreign matter of invading body.Immunocyte mainly comprises T and bone-marrow-derived lymphocyte, monokaryon or macrophage, BMDC, acidophilia and basophilla polymorphonuclear cell, red blood cell and blood platelet; Immune organ comprises liver, spleen, lymph node, thymus gland, marrow etc.The development condition of immunocyte and immuning tissue, organ directly has influence on the height of immunity of organisms.Immune system is more perfect for identification, activation and effector cell's interphase interaction of specific immune response obtain, and is covered with all tissues of whole body.The height of immunity of organisms directly affects its premunition.
But, in the prior art, especially, in health care of food field, yet there are no the relevant report of the health food with immune enhancing function.Therefore,, for people's immunity is provided, providing a kind of is this area technical problem urgently to be resolved hurrily for strengthening the health food of immunologic function.
Summary of the invention
The object of the present invention is to provide a kind of for strengthening the health food of immunologic function, to solve the above problems.
It is a kind of above-mentioned for strengthening the preparation method of health food of immunologic function that another object of the present invention is to provide.
Provide in an embodiment of the present invention a kind of for strengthening the health food of immunologic function, according to weighing scale, its raw material components comprises:
Radix Astragali 50-100 part, fruit of glossy privet 50-100 part, American Ginseng 5-50 part, Radix Glycyrrhizae 5-50 part.
The embodiment of the present invention provide for strengthening the health food of immunologic function, its select Radix Astragali, the fruit of glossy privet, American Ginseng, Radix Glycyrrhizae four traditional Chinese medicine material by set parts by weight forms; In traditional Chinese medical science field, the Radix Astragali (Astragali Radix) is the dry root of legume astragalus mongolicus Astragalusmembranaceus (Fisch.) Bge.var.MonghoJicus (Bge.) Hsiao and Astragalus membranacus Astragalus membranaceus (Fisch.) Bge..First appeared in the unearthed book copied on silk in tomb of Han dynasty Mawangdui " 52 Bingfang ", Shennong's Herbal is classified as top grade.Bright Compendium of Material Medica carry " over sixty years of age is long also, Radix Astragali look Huang, for benefit person's length therefore named ... ".Property sweet, tepor, return lung, the spleen channel, have tonifying Qi and lifting yang, strengthening exterior and reducing sweat, inducing diuresis for removing edema, promotes the production of body fluid and nourishes blood, row stagnant logical numbness, detoxification apocenosis, the function of expelling pus and promoting granulation.In the history that reaches more than 2000 year, the Radix Astragali is used as the good medicine of enhancement ability and resist the disease in China.Modern pharmacological research shows: the Radix Astragali has sure immunological enhancement, non-specific and specific immunity are had to certain humidification, comprise and strengthen dendritic cells and cytophagous phagocytosis, raising NK cytoactive and lethal effect, adjusting cytokine content, increase T cell quantity and activity etc.In addition, there are some researches show, the Radix Astragali is observed to the impact on Turnover of Mouse Peritoneal Macrophages phagocytic activity with various dose, different approaches administration, find that there is enhancing in various degree, and can alleviate dexamethasone inhibitory action.Research is by the relatively discovery to peritoneal effluent macrophage phagocytic ability, and Radix Astragali group is apparently higher than control group.Scholar's research discovery, the Radix Astragali can raise the expression of endothelial cell surface adhesion molecule-I, strengthens the adhesion of neutrophil leucocyte and vascular endothelial cell, promotes the chemotactic of neutrophil leucocyte to areas of inflammation.After normal mouse gavages the Radix Astragali, its thymus gland significantly increases weight, and other every immune indexes all significantly improve as spleen index, phagocytic rate, phagocytic index, T cell proliferation.In addition, correlative study also shows, the Radix Astragali can promote the expression of IL-2mRNA in lymphocyte, reduce the inhibition of suppressor T lymphocyte (Ts) to lymphocyte IL-2mRNA, and induce IFN-γ, the preliminary treatment results of infant anaphylactoid purpura is shown to the Radix Astragali is improved the effect of Th1 cell factor, reduces the effect of Th2 cell factor simultaneously in addition.The researchs such as Tan Feng show, after quiet Astragalus in Treating of acute cerebral infarction patients, survey CD3, CD4+, CD4+/CD8+ level significantly increase compared with control group, CD8+ level obviously lowers, show to exist after Cerebral Infarction lymphocyte immunologic function disorder in various degree, the immunoregulation of the Radix Astragali can alleviate the pathology damage of nerve cell due to infarct acute stage immune response.The researchs such as Wang Hongmei show, astragalus injection can obviously increase T TCS and the TH cell number of tumor-bearing mice, in body, injection can also promote T lymphopoiesis and the conversion of ConA induction, and can also significantly improve IL-2, the TNF-α of immunosuppressed mice and the level that induces of IFN-γ.Cai little Yan finds under study for action, and the Radix Astragali has increased hormone and immunodepressant to a certain extent to the apoptotic inhibitory action of SLE patient, and regulate t lymphocyte subset group ratio and functional trend normal.In addition, research discovery, oral administration astragalus can obviously improve IgG1, IgG3 in IgG Subclass Deficiency infant serum.At random 80 routine infants are divided into oral group of astragalus liquid oral group (hormone+Radix Astragali) and hormone, after 6 months and 1 year, survey respectively infant serum, find that astragalus liquid group infant IgG obviously raises.In addition, cell factor has all played important regulating action in cellular immunity and humoral immunity.The Radix Astragali can make solubility IL-2 acceptor (sIL-2R) level in the cleer and peaceful urine of Children Patients with Simple Nephrotic Syndrome reduce.
The fruit of glossy privet (Ligustri Lucidi Fructus) is is the dry mature fruit of Oleaceae Ligustrum plant glossy privet Ligustrum Lucidum Ait..Begin to be loaded in Shennong's Herbal, classify as top grade, " bitter is flat, main bowl spares, five viscera settling, supports spirit, except all kinds of diseases and ailments ".Cool in nature, taste is sweet, bitter, returns liver, kidney channel.Tool is nourishing liver and kidney, black function of improving eyesight.Modern pharmacological research shows: to non-specific cell, immunity has humidification to the fruit of glossy privet, and the specific cellular immunity of normal mouse is had no significant effect.There is the phagocytic function that promotes lymphocytic propagation, strengthens macrophage; and have synergy with interleukin 2, thereby the rising of the micronuclei in mice cell number that endoxan and urethane are caused all can obviously suppress the damage of cell chromosome to play certain protective role.
Research finds that fruit of glossy privet decoction 0.02ml can obviously increase the lymphopoiesis that suboptimal dose phytohemagglutin phytolectin (P H A), concanavalin A (C0n A) and dyers' grapes (PWM) cause in vitro, also increase significantly the rat local graft versus host reaction that xenogenesis (people) lymphocyte causes, the effect of this enhancing immunity may be due to partly by eliminating or weakening that the effect of suppressor T lymphocyte realizes.Give the lymphocyte that causes the rat intracutaneous injection process fruit of glossy privet processing of immunosuppressive condition with Cy, the reaction of result rat local immunity improves 3-4.5 times than injection without the human lymphocyte of fruit of glossy privet processing.Lumbar injection fruit of glossy privet decoction 2.5g/kg, 25g/kg, be used in conjunction 7 days, can increase the relative molecular mass of mouse immune organ thymus gland, spleen, improves Hemolysin activity, rising normal serum IgG content; Fruit of glossy privet 240mg/kg, 480mg/kg, be used in conjunction 7 days, CS7BE mouse immune organ thymus gland, spleen, lymphonodi coeliaci, adrenal relative molecular mass can be obviously increased, the activate the phagocytic capacity of cleaning up index, enhancing reticuloendothelial system of mouse to intravenous injection carbon granules can be significantly improved.The fruit of glossy privet can make total E rosette percentage (EaRFC%) increase, promote T cell replying low dosage P H A, and the rate that increases that cpm value increases rate and EaRFC% is proportionate, showing that the fruit of glossy privet promotes the activity of T cell by strengthening the activity of cell surface receptor, may be good immunomodifier for the immunologic hypofunction disease fruit of glossy privet causing because of TS hyperactivity.Fruit of glossy privet decoction has facilitation for the delayed hypersensitive reaction due to SRBC.The research of Lee's phosphorus finds that Fructus Ligustri Lucidi polysaccharide can improve tumor-bearing mice bone-marrow-derived lymphocyte, the lymphocytic multiplication capacity of T, improves the activity of its NK cell, increases the activity of tumor-bearing mice mononuclear macrophage.Ruan Hong finds that the spleen T lymphopoiesis of the deficiency of Yin mouse of Fructus Ligustri Lucidi polysaccharide to normal mouse and cortex hormone of aadrenaline moulding has remarkable facilitation.The blue or green experimental result of hippology shows that Fructus Ligustri Lucidi polysaccharide is external to the effect of stimulating proliferation of normal mouse spleen lymphocyte, the i.e. effect of mitogen sample; To athymia, also have breeder reaction without the nude mice SPL of T cell, illustrate that Fructus Ligustri Lucidi polysaccharide has to spleen B cell the effect of directly stimulating proliferation; With nylon hair post separation T, B cell, also there is breeder reaction by the cell (being wherein rich in T cell) of nylon hair post to Fructus Ligustri Lucidi polysaccharide in result, illustrates that Fructus Ligustri Lucidi polysaccharide also has certain effect of stimulating proliferation to splenic t-cell; And normal Balb/c mouse spleen lymphocyte and nude mice SPL are under the effect of same concentrations Fructus Ligustri Lucidi polysaccharide, the former proliferation function is significantly higher than the latter, illustrate that Fructus Ligustri Lucidi polysaccharide, in acting on B cell, also has effect to T cell, or promote the interaction between the two.Wu Xifeng has observed the impact that normal mouse and endoxan is caused to immunologic hypofunction immune function of mice with glossy privet fruit extract gastric infusion.Result shows, glossy privet fruit extract (ENZZ) without impact, but can obviously increase immunosuppressed mice immune organ weight to normal Mouse Weight and immune organ weight, and can suppress the reduction of its body weight, is dose dependent.Meanwhile, ENZZ has the increase Function of lymphocyte transform of dose dependent, and high dose group is more obvious to normal mouse and immunosuppressed mice increasing action, with normal and relatively P<0.05 and P<0.01 of model control group.ENZZ has significant increasing action to the macrophage phagocytic function of normal mouse and immunologic hypofunction mouse, has obvious dosage correlation.Sun Yan finds that Aqueous Extract of Ligustrum Lucidum significantly increases suboptimal dose PHA, ConA and the short human peripheral lymphocyte splitting action of PWM; Feng Zuohua finds that Aqueous Extract of Ligustrum Lucidum is without directly urging human peripheral lymphocyte mitotic activity, but can significantly increase the short lymphocytic cell division effect of suboptimal dose PHA.Its effect is to get by the fruit of glossy privet water extraction IL-1 that induces the monocyte being mingled in lymphocyte to produce to mediate.
American Ginseng (Panacis Quinquefolii Radix) is the dry root of Araliaceae American Ginseng Ranax quinque folium L., generic name precious medicinal material.Sweet, cold in nature, the micro-hardship of its taste, returns lung, the heart, kidney, the spleen channel, has the effect of " beneficial lung yin, the clear fire of deficiency type, promotes the production of body fluid to quench thirst ".American Ginseng has BA widely, and main active ingredient is compound and the trace elements such as Radix Panacis Quinquefolii polysaccharide, saponin, can act on panimmunity competent cell, promotes the secretion of some cell factor further to bring into play immunoregulation effect.For clinical enhancing immunity, antifatigue, anti-ageing, anticancer excellent tonic product.
The immunological enhancement of American Ginseng, depends primarily on its contained active component.Wherein Radix Panacis Quinquefolii polysaccharide is that in American Ginseng, content is maximum, the class material that immunocompetence is stronger, and American Ginseng total reducing sugar content accounts for greatly 50%～65%.Research shows 200, under 400mg/kgBW dosage, Radix Panacis Quinquefolii polysaccharide (PPQ) can reduce by lower thymus gland, the spleen weight of antagonism endoxan (CY) effect, strengthens normally and the phagocytic function of immunocompromised mouse reticuloendothelial system.PPQ can increase nospecific immunity and the cellular immune function of mouse, and its immunological enhancement strengthens with dosage.PPQ can make the interior free calcium ions of T lymphocyte of activation increase simultaneously, thereby promotes lymphopoiesis differentiation, and 1L-2 produces, promotion cytotoxic T cell killing activity, thus bring into play its immunological enhancement.American ginseng saponin (PQS) is the another main active ingredient in American Ginseng, and it has obvious humidification to T, bone-marrow-derived lymphocyte function.The delayed allergy of American Ginseng Experiments of Chinese Herbal Compound on Mice, the antibody titer of serum hemolysin, macrophage phagocytic ability, splenic lymphocytes, serum lysozyme content has raising effect in various degree, and body is had to immunological enhancement.American ginseng root polysaccharide 100,200 for Li Yan etc., 400mg/kg3 dosage every day is to mouse stomach administration 1 time, the impact of observation American ginseng root polysaccharide on immunologic function.Result American ginseng root polysaccharide can not only resist alleviating of the minimizing of immunosuppressed mice PBL, Thymus and spleen weight, and can strengthen the phagocytic function of normal and immunosuppressed mice reticuloendothelial system; Obviously Promote immunity suppresses mouse spleen lymphocyte conversion, and improves activity of interleukin-2.Panax quinquefolium saponin for Yang Chunlong etc. (1mg～2mg/20g/ days) is given continuous seven days abdominal part hypodermics of mouse, the impact of research total panaquilon (PNS) on immune function of mice, found that PNS can work in coordination with in vivo and in vitro ConA and promote mouse boosting cell propagation; Collaborative ConA strengthens the ability of mouse splenic t-cell generation lymphokine; Obviously strengthen mice spleen NKC activity; PNS can also strengthen LPS in vivo stimulates the breeder reaction of mouse boosting cell; Strengthen the primary antibody response ability of mouse to thymus dependent antigen.
Radix Glycyrrhizae (Clycyrrhizae Radix Et Rhizoma) is the dry root root and rhizome of glycyrrhizic legume Clycyrrhiza uralensis Fisch., glycyrrhiza inflate bat Clycyrrhiza inflata Bat. or glycyrrhiza glabra Clycyrrhiza glabra L..Begin to be loaded in Shennong's Herbal, classify as top grade.Nature and flavor are sweet, flat, and the thoughts of returning home, lung, spleen, stomach warp, have and invigorate the spleen and benefit qi, moisten the lung and relieve the cough, relieving asthma, reduce phlegm and the effect of cortex hormone of aadrenaline sample, energy anti-inflammatory, anti-ageing, coordinating the drug actions of a prescription, current 12 warps.
The glycyrrhizin that Radix Glycyrrhizae contains can make mouse thymus gland obviously increase, and to total white blood cells, especially neutrophilia and monocyte number is obviously increased.Increase the activity of reticuloendothelial system; Under stress situation, can obviously strengthen the phagocytosis of Turnover of Mouse Peritoneal Macrophages.Polysaccharides LH in Radix Glycyrrhizae acts on T lymphocyte, presents immunologic enhancement.Experiment, to mouse glycyrrhizin totally 4 days, is then got its spleen and thymus gland and is weighed, and finds that the spleen of administration group mouse and the weight of thymus gland are apparently higher than control group.Show that glycyrrhizin can make murine interleukin sum, especially neutrophil leucocyte and monocyte number obviously increase simultaneously.Someone divides into groups to mouse stomach by 25mg/kg and 50mg/kg dosage with licorzinc, continuously after 28d, the antibody growing amount of finding 50mg/kg group significantly increases, also can make Aged Mice thymic weight obviously increase, show that humoral immunity and the cellular immune function of licorzinc to Aged Mice has facilitation.Zheng Yao etc. adopt gavage and intraperitoneal injection with licorice polysaccharide oral formulations, respectively establish three dosage groups, are respectively 1g/kg, 0.5g/kg, 0.25g/kg, continuous 10 days once a day, observe the impact of licorice polysaccharide on mouse nospecific immunity systemic-function.Result and Normal group comparison, oral formulations high dose group has significant difference (P < 0.05), and high, the middle dosage group of ejection preparation has significant difference (P < 0.01); With the comparison of lentinan group, high, the middle dosage group of ejection preparation has significant difference (P≤0.01).Visible licorice polysaccharide can improve mouse reticuloendothelial system function, not only specific immune function is had to facilitation, and non-specific immune function is also had to humidification.Cheng Anwei etc. carry out the culture experiment of lymphocytes in vitro, it is the nutrient solution of 10,100,200,400,600,800 μ g/ml containing GPS final concentration that administration group adds respectively 100 μ l/ holes, result interpolation licorice polysaccharide can obviously strengthen the secretory volume (P < 0.01) of lymphocytic energetic supersession level and 1L-2, show that licorice polysaccharide can induce activated lymphocyte, the secretion that improves its energetic supersession level and 1L-2, has immunoregulation effect.Min waits quietly using licorice polysaccharide 100mg.kg-1,200mg.kg-1,300mg.kg-1 dosage to mouse stomach 14d, and to DTH, reaction has certain humidification, IL-2, TNF-alpha content in the blood that can raise to result licorice polysaccharide; Show that licorice polysaccharide can obviously strengthen mouse cell immunologic function.
To sum up, by 4 above-mentioned taste food and medicament dual-purpose medicinal materials according to after set weight proportion, when different component has drug effect concurrently, also other components are had to complementary effect, the organic cooperation of each component, supports mutually, fruit of glossy privet tonifying liver kidney yin, bowl spares gas in the Radix Astragali, above two tastes are main ingredient.American Ginseng boosting qi and nourishing yin, wants supplement and not dry, is ministerial drug in side; Its performance emergency of Radix Glycyrrhizae; All medicines share, and energy boosting qi and nourishing yin is deficient for prolonged illness, deficiency of both vital energy and Yin, and particularly suitable is deficient and should not complete benefit person.This formula has the effect that improves body immunity, in side, each raw material all can be used for the formula of health food, has very high security, and the product of producing according to this formula is applicable to the crowd of hypoimmunity, can strengthen body immunity function, and almost be free from side effects.
Optionally, the formulation of described health food is powder.
A preparation method for above-mentioned health food, comprises the following steps:
After the Radix Astragali of set parts by weight, the fruit of glossy privet, American Ginseng, Radix Glycyrrhizae are mixed, pulverize, obtain mixed powder;
After described mixed powder adds water, decoct the scheduled time, obtain solid-liquid admixing medical solutions;
By described solid-liquid admixing medical solutions Separation of Solid and Liquid, obtain liquid;
Described liquid, successively by concentrated, dry, is obtained to health food.
Optionally, described, the Radix Astragali of set parts by weight, the fruit of glossy privet, American Ginseng, Radix Glycyrrhizae are mixed to rear pulverizing, obtain in the step of mixed powder:
The particle diameter of described mixed powder is 1.5-3 centimetre.
Optionally, after described mixed powder adds water, decoct the scheduled time, obtain, in the step of solid-liquid admixing medical solutions, specifically comprising:
In described mixed powder, adding weight is described mixed powder 6-12 water doubly, decocts 1-2 hour, and Separation of Solid and Liquid, obtains the first decoction liquor and the dregs of a decoction;
In the described dregs of a decoction, adding weight is described dregs of a decoction 5-10 water doubly, again decocts 0.4-1.5 hour, and Separation of Solid and Liquid, obtains the second decoction liquor;
Decoct liquid and described second by described first and decoct liquid mixing, obtain solid-liquid admixing medical solutions.
Optionally,, obtain in the step of liquid: described Separation of Solid and Liquid is specially filtration described solid-liquid admixing medical solutions Separation of Solid and Liquid described.
Optionally,, obtain in the step of liquid: described Separation of Solid and Liquid is specially centrifugal described solid-liquid admixing medical solutions Separation of Solid and Liquid described.
Optionally, in the process of described filtration, the order number of filter screen used is 200-300 order.
Optionally, described, described liquid is passed through to concentrate, be dried successively, obtain in the step of health food;
Described be dried as spraying dry.
Brief description of the drawings
Fig. 1 show that the embodiment of the present invention six provides for strengthening the preparation flow figure of health food of immunologic function.
Detailed description of the invention
Provide in the present invention for strengthening the health food of immunologic function, according to parts by weight meter, its material component comprises:
Radix Astragali 50-100 part, fruit of glossy privet 50-100 part, American Ginseng 5-50 part, Radix Glycyrrhizae 5-50 part; In addition, for the type of health food, it is preferably powder.
Below by specific embodiment, the present invention is described in further detail.
Embodiment mono-
The embodiment of the present invention provide for strengthening the health food of immunologic function, according to parts by weight meter, its material component comprises:
50 parts of the Radixs Astragali, 50 parts of the fruit of glossy privets, 5 parts of American Ginsengs, 5 parts, Radix Glycyrrhizae.
Embodiment bis-
The embodiment of the present invention provide for strengthening the health food of immunologic function, according to parts by weight meter, its material component comprises:
75 parts of the Radixs Astragali, 75 parts of the fruit of glossy privets, 25 parts of American Ginsengs, 25 parts, Radix Glycyrrhizae.
Embodiment tri-
The embodiment of the present invention provide for strengthening the health food of immunologic function, according to parts by weight meter, its material component comprises:
100 parts of the Radixs Astragali, 100 parts of the fruit of glossy privets, 50 parts of American Ginsengs, 50 parts, Radix Glycyrrhizae.
Embodiment tetra-
The embodiment of the present invention provide for strengthening the health food of immunologic function, according to parts by weight meter, its material component comprises:
100 parts of the Radixs Astragali, 100 parts of the fruit of glossy privets, 15 parts of American Ginsengs, 15 parts, Radix Glycyrrhizae.
Embodiment five
80 parts of the Radixs Astragali, 80 parts of the fruit of glossy privets, 15 parts of American Ginsengs, 15 parts, Radix Glycyrrhizae.
The above embodiment of the present invention provide for strengthening the health food of immunologic function, its Radix Astragali by set parts by weight, the fruit of glossy privet, American Ginseng and Radix Glycyrrhizae form; 4 above-mentioned taste food and medicament dual-purpose medicinal materials, according to after set weight proportion, when different component has drug effect concurrently, are also had to complementary effect to other components.The organic cooperation of each component, supports mutually; Fruit of glossy privet tonifying liver kidney yin, bowl spares gas in the Radix Astragali, above two tastes are main ingredient; American Ginseng boosting qi and nourishing yin, wants supplement and not dry, is ministerial drug in side; Its performance emergency of Radix Glycyrrhizae; All medicines share, and energy boosting qi and nourishing yin is deficient for prolonged illness, deficiency of both vital energy and Yin, and particularly suitable is deficient and should not complete benefit person.This formula has the effect that improves body immunity, in side, each raw material all can be used for the formula of health food, has very high security, and the product of producing according to this formula is applicable to the crowd of hypoimmunity, can strengthen body immunity function, and almost be free from side effects.
For the health food for strengthening immunologic function that makes the above embodiment of the present invention is better applied, more effectively apply in the field of health food, the present invention also provides the preparation method of health food on the basis of above-described embodiment, is now described in detail and explains:
Embodiment six
The preparation method that the embodiment of the present invention provides comprises the following steps:
Step 101: pulverize after the Radix Astragali of set parts by weight, the fruit of glossy privet, American Ginseng, Radix Glycyrrhizae are mixed, obtain mixed powder;
In step 101, in the process of pulverizing after the Radix Astragali, the fruit of glossy privet, American Ginseng, Radix Glycyrrhizae are mixed, preferably its pulverizing is obtained to thinner particle (making the active ingredient of health food obtain discharging comparatively completely), preferred, the particle diameter of described mixed powder is 1.5-3 centimetre.
Step 102: decoct the scheduled time after described mixed powder adds water, obtain solid-liquid admixing medical solutions;
Concrete, decocting sufficient effect in order to realize, above-mentioned steps is carried out according to following operation: in described mixed powder, adding weight is described mixed powder 6-12 water doubly, decocts 1-2 hour, and Separation of Solid and Liquid, obtains the first decoction liquor and the dregs of a decoction;
In the described dregs of a decoction, adding weight is described dregs of a decoction 5-10 water doubly, again decocts 0.4-1.5 hour, and Separation of Solid and Liquid, obtains the second decoction liquor;
Decoct liquid and described second by described first and decoct liquid mixing, obtain solid-liquid admixing medical solutions.
By adding after the water of set weight carries out twice decoction, obtain solid-liquid admixing medical solutions, its drug effect extracts active ingredients is complete, the drug effect of the health food made to help raising.
Step 103: by described solid-liquid admixing medical solutions Separation of Solid and Liquid, obtain liquid;
Concrete, the mode of Separation of Solid and Liquid can be taked mode centrifugal or that filter, and in the time adopting filter operation, preferred, the order number of filter screen used is 200-300 order.
Step 104: described liquid, successively by concentrated, dry, is obtained to health food.
In dry process, preferably make the liquid pulverize powder health food after concentrated by spray-dired mode.
In addition, the health food that the present invention also provides for embodiment tetra-and five has provided concrete preparation example (being designated as respectively preparation example one and preparation example two)
Preparation example one
A kind of for strengthening the health food of immunologic function, according to listed as parts by weight, made by 15 parts of 100 parts of the Radixs Astragali, 100 parts of the fruit of glossy privets, 15 parts of American Ginsengs, Radix Glycyrrhizae, production method comprises the steps: first to select that the Radix Astragali, the fruit of glossy privet, American Ginseng, the Radix Glycyrrhizae of dried and clean pulverize, and makes material particular diameter after pulverizing in 2cm left and right; After weighing, mix, subsequently mixed material is mixed with the weight ratio of 1: 10 with water, boil, then keeping micro-boils 1 hour, then filter and obtain the first decoction liquor, will expect that slag mixes with the weight ratio of 1: 8 with water, boils subsequently, then keep micro-and boil 40 minutes, subsequently after filtration or centrifugal second decoction liquor that obtains; By after the first decoction liquor and the merging of the second decoction liquor, be condensed into medicinal extract, be dried successively, pulverize, obtain Powdered health food.
Preparation example two
A kind of for strengthening the health food of immunologic function, according to weight portion meter, be made up of 15 parts of 80 parts of the Radixs Astragali, 80 parts of the fruit of glossy privets, 15 parts of American Ginsengs, Radix Glycyrrhizae, production method comprises the steps: first to select the Radix Astragali, the fruit of glossy privet, American Ginseng, the Radix Glycyrrhizae four taste health foods of dried and clean; After weighing, mix, subsequently mixed material is mixed with the weight ratio of 1: 8 with water, boil, then keeping micro-boils 1.5 hours, then filter and obtain the first decoction liquor, will expect that slag mixes with the weight ratio of 1: 6 with water, boils subsequently, then keep micro-and boil 1 hour, subsequently after filtration or centrifugal second decoction liquor that obtains; The first decoction liquor and the second decoction liquor are merged to rear concentrating, then be spray dried to powder.
In addition, the present invention also provides the animal immune experiment research that above-described embodiment provides five health food:
Animal used as test and grouping: the healthy Male Kunming strain mice of SPF level, body weight 18～22g.Every 40 mouse are one group, totally 6 groups.Immunity I group, the mouse spleen lymphocyte transformation experiment that carries out ConA induction; Immunity II group, carries out delayed allergy experiment; Immunity III group, carries out dirty/body ratio measurement, and serum hemolysin is measured and antibody-producting cell number is measured; Immunity IV～VI group, carries out respectively that carbon is cleaned up experiment, peritoneal macrophage is engulfed chicken red blood cell and tested and NK cytoactive detection.If a negative control group, 10 every group.
Dosage is selected to give mode with tested material: according to the oral recommendation consumption of people, establish that basic, normal, high dosage group is respectively 2.7,5.4,10.8mg/kg BW.Powdered health food dissolves with pure water, gives respectively corresponding dosage treated animal gavage.Negative control group gives isopyknic pure water.Every day gavage 1 time, continuously gavage 30 days.
Experimental technique and result:
1, the impact of sample on Mouse Weight
Table 1 Mouse Weight
Note: the experiment of each dosage group is initial, the weightening finish of Mice Body restatement and control group comparison in mid-term and latter stage, and there are no significant for difference (P>0.05).
From table 1, oral administration gives the sample 30 days of mouse various dose, Mouse Weight and duration of test weight of mice value and the negative control group comparison of experiment initial stage, experiment mid-term, test sample in latter stage each dosage group, no significant difference (P>0.05), shows that this sample has no significant effect the body weight gain of mouse.
2, the impact of sample on mouse immune organ internal organs/body weight ratio:
Table 2 mouse immune organ internal organs/body weight ratio
From table 2, thymus gland/body weight of the each dosage group of sample mouse and spleen/body weight ratio and negative control group comparison, difference that there are no significant (P>0.05), shows that sample has no significant effect the immune organ weight of mouse.
3, the impact (mtt assay) of the mouse spleen lymphocyte conversion capability of sample on ConA induction
Table 3 mouse lymphocyte transformation experiment result
From table 3, the lymphocyte proliferation ability of the each dosage group of sample mouse is higher than negative control group, and the difference of high dose group and negative control group has conspicuousness (P<0.05), show that sample has the lymphocyte proliferation of promotion mouse, the effect of conversion capability.
4, the impact (ear swelling method) of sample on mouse delayed allergy DTH
Table 4 mouse delayed allergy DTH experimental result
From table 4, the left and right auricle weight difference of the each dosage group of sample mouse is higher than negative control group, and the difference of height, middle dosage group and negative control group has very significant (P<0.01), show that sample has the effect of the delayed allergy that promotes mouse.
5, the impact of the antibody-producting cell number of sample on mouse (Jerne improves slide method)
Table 5 mouse antibodies cellulation test experience result
From table 5, the antibody-producting cell number of the each dosage group of sample mouse is higher than negative control group, and the difference of high dose group and negative control group has very significant (P<0.01), show that sample has the value-added effect of antibody-producting cell that promotes mouse.
6, the impact (Hemagglutination Method) of sample on mice serum hemolysin
Table 6 mouse hemolysin test result
From table 6, the antibody product of the each dosage group of sample mouse is higher than negative control group, and the difference of high dose group and negative control group has conspicuousness (P<0.05), show that sample has the effect of the serum hemolysin that improves mouse.
7, the impact (carbon is cleaned up experiment) that sample is cleaned up the monocytes/macrophages carbon of mouse
Table 7 mouse monokaryon-macrophage carbon is cleaned up experimental result
From table 7, phagocytic index and the negative control group comparison of the monocytes/macrophages of the each dosage group of sample mouse, there was no significant difference tool (P>0.05), shows that sample cleans up function without obvious facilitation to the monocytes/macrophages carbon of mouse.
8, sample is engulfed the impact (half intracorporal method) of chicken red blood cell ability on the peritoneal macrophage of mouse
Table 8 Turnover of Mouse Peritoneal Macrophages is engulfed chicken red blood cell experimental result
From table 8, the phagocytic rate of the peritoneal macrophage of the each dosage group of sample mouse to chicken red blood cell and phagocytic index are higher than negative control group, wherein the phagocytic rate of high dose group and the difference of negative control group have very significant (P<0.01), the phagocytic index of high, middle dosage group and the difference of negative control group have conspicuousness (P<0.01 and P<0.05 respectively), show that sample has the effect of the phagocytic function of the peritoneal macrophage that promotes mouse.
9, the impact (LDH determination method) of the NK cytoactive of sample on mouse
Table 9 NK cells in mice determination of activity result
From table 9, the NK cytoactive of the each dosage group of sample mouse is higher than negative control group, but there are no significant (P>0.05) for the difference of each dosage group and negative control group, show that sample obviously affects the NK cytoactive thing of mouse.
Known by the above-mentioned experiment for mouse, what the embodiment of the present invention provided is this for strengthening the health food of immunologic function, there is the effect that improves people's immunity, in side, each raw material all can be used for the formula of health food, there is very high security, the product of producing according to this formula is applicable to the crowd of hypoimmunity, can strengthen body immunity function.
Finally, it is pointed out that this health food that the above-mentioned all embodiment of the present invention provide, it can not eaten or be taken as final products.For example, it can be used as that raw material mixes with other auxiliary materials and for making health food or the medicine etc. with immunoenhancement result of other types the health food that above-mentioned all embodiment provide.
The foregoing is only the preferred embodiments of the present invention, be not limited to the present invention, for a person skilled in the art, the present invention can have various modifications and variations.Within the spirit and principles in the present invention all, any amendment of doing, be equal to replacement, improvement etc., within all should being included in protection scope of the present invention.
Claims (9)
1. for strengthening a health food for immunologic function, it is characterized in that, according to weighing scale, its raw material components comprises:
Radix Astragali 50-100 part, fruit of glossy privet 50-100 part, American Ginseng 5-50 part, Radix Glycyrrhizae 5-50 part.
2. health food according to claim 1 and 2, is characterized in that, the formulation of described health food is powder.
3. a preparation method for health food according to claim 1, is characterized in that, comprises the following steps:
After the Radix Astragali of set parts by weight, the fruit of glossy privet, American Ginseng, Radix Glycyrrhizae are mixed, pulverize, obtain mixed powder;
After described mixed powder adds water, decoct the scheduled time, obtain solid-liquid admixing medical solutions;
By described solid-liquid admixing medical solutions Separation of Solid and Liquid, obtain liquid;
Described liquid, successively by concentrated, dry, is obtained to health food.
4. the preparation method of health food according to claim 3, is characterized in that, described, the Radix Astragali of set parts by weight, the fruit of glossy privet, American Ginseng, Radix Glycyrrhizae is mixed to rear pulverizing, obtains in the step of mixed powder:
The particle diameter of described mixed powder is 1.5-3 centimetre.
5. the preparation method of health food according to claim 3, is characterized in that, after described mixed powder adds water, decocts the scheduled time, obtains, in the step of solid-liquid admixing medical solutions, specifically comprising:
In described mixed powder, adding weight is described mixed powder 6-12 water doubly, decocts 1-2 hour, and Separation of Solid and Liquid, obtains the first decoction liquor and the dregs of a decoction;
In the described dregs of a decoction, adding weight is described dregs of a decoction 5-10 water doubly, again decocts 0.4-1.5 hour, and Separation of Solid and Liquid, obtains the second decoction liquor;
Decoct liquid and described second by described first and decoct liquid mixing, obtain solid-liquid admixing medical solutions.
6. the preparation method of health food according to claim 3, is characterized in that,, obtains in the step of liquid: described Separation of Solid and Liquid is specially filtration described solid-liquid admixing medical solutions Separation of Solid and Liquid described.
7. the preparation method of health food according to claim 3, is characterized in that,, obtains in the step of liquid: described Separation of Solid and Liquid is specially centrifugal described solid-liquid admixing medical solutions Separation of Solid and Liquid described.
8. the preparation method of health food according to claim 6, is characterized in that, in the process of described filtration, the order number of filter screen used is 200-300 order.
9. the preparation method of health food according to claim 3, is characterized in that, described, described liquid is passed through to concentrate, be dried successively, obtains in the step of health food;
Described be dried as spraying dry.
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Application publication date: 20140806 |