CN101385772A - Effervescence tablets for increasing natural immunity - Google Patents
Effervescence tablets for increasing natural immunity Download PDFInfo
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- CN101385772A CN101385772A CNA2008100015552A CN200810001555A CN101385772A CN 101385772 A CN101385772 A CN 101385772A CN A2008100015552 A CNA2008100015552 A CN A2008100015552A CN 200810001555 A CN200810001555 A CN 200810001555A CN 101385772 A CN101385772 A CN 101385772A
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Abstract
The reasons why some people are easy to suffer from cold, flu and human avian influenza are that these people have low native immunity and lack acquired immunity, as a result, these people are repeatedly infected by virus; upon diagnosis and treatment based traditional Chinese medicine, instability of defensive Qi leads to viral invasion, while inner emptiness of defensive Qi results in rapid multiplication of viruses. A native immunity-improving effervescent tablet, which is named according to the product function, can improve native immunity and protect highly susceptible people; the effervescent tablet has rapid disintegration, can be taken in tablet form as well as in oral solution form, and is easier to carry than a preparation of liquid form. The invention belongs to the technical fields of epidemiology, viruology, immunology, respirology, and traditional Chinese medicine and pharmacy, multiple disciplines being combined with each other. Flu is difficult to prevent, and specific vaccines are difficult to be produced, for virus antigens of A strain are variable; cold is difficult to prevent, for the susceptible has low immunity but there are various guilty viruses. For the purposes of rescuing emergency patients, the effervescent tablet is developed, which improves native immunity and protects the highly susceptible, activates immunological cell molecules, induces interferon, resists viruses in broad spectrum, prevents cold, as well as flue and human avian influenza.
Description
(1) technical field
Influenza, grippal abbreviation, national Class C infectious disease.The nineties, outburst once is very popular, and 20,000,000 people are died.Bird flu outburst now, the people infects bird flu and constantly takes place, and is by on January 25th, 2006, WHO report 169 examples, dead more than half, startling.In December, 2007, Pakistani, the Chinese Jiangsu conclusive evidence human and bird fluenza 4 examples, 3 examples are dead.Why? why? exploration discovery, A type influenza virus is hidden everywhere; Stride kind of a reprovision, antigen is changeable, and escape is hidden, and seek survival (Fig. 1) evolves.Theoretically, A type influenza antigen has 135 kinds of hypotypes, and new virus occurs, the difficult one-tenth of specificity vaccine.Common cold treatment solves already, the difficult prevention of flu, because morbific viral kind type various (above 200 kinds), and the natural cover for defense, respiratory mucosa is impaired, repeated infection, the susceptible person is due to the immunocompromised.Save critical rescuing, doctor's bounden duty, wisdom works out: " improving natural immunity effervescent tablet ", and improve the natural immunity, protect high-risk susceptible person; Preventing cold, flu-prevention and the human and bird fluenza.
Affiliated technical field; Epidemiology, Molecular Virology, immunology, respiratory disease are learned and Chinese medicine and pharmacy, and be multidisciplinary warm mutually.
(2) background technology
A type influenza virus is implemented " survival of the fittest " strategy, and many places hide, and stride kind of a reprovision, and antigen is changeable, and escape is hidden, and seek survival (Fig. 1) evolves.Prevent and treat influenza, should know " flu, influenza, the human and bird fluenza, epidemiology, nosetiology, pathogenesis " (Fig. 2).Prevent and treat the human and bird fluenza, monitoring virus variation, nucleic acid vaccine research, susceptible person's prophylactic (Fig. 3).Improve natural immunity effervescent tablet preventative strategies can (Fig. 4).
(3) summary of the invention
[name] medicine name; Improve natural immunity effervescent tablet, improve the natural immunity, effervescent tablet: disintegrate fast, can tablets, can take by solution again; Carry more convenient than liquid agent.
[prescription] Radix Astragali Preparata Radix Glycyrrhizae Preparata
[pharmacology] ● Radix Astragali immune cell activated molecule, inducement interferon, broad-spectrum antiviral.
Death due to the quiet notes of the Radix Astragali mice, minimizing influenza viruse attack, the protection mice is to influenza infection, and protective rate is more than 50%.5%～10% Radix Astragali is protected cell effectively, suppresses the vesicular stomatitis virus cytopathogenic effect.Inducement interferon in the body: the quiet notes of Radix Astragali mice, 0.4ml/, after 2 hours, serum interferon is 40U/ml, can reach 160U/ml in 6 hours, can not survey in 24 hours.Strengthen macrophage phagocytic function: Radix Astragali injection mice, 18～24 hours, the macrophage index significantly increased (P＜0,01), reduced to normal in 72 hours. and phagocytic function strengthens consistent with the antiviral peak period.Use the macrophage inhibitor, the blocking-up phagocytic function does not influence Radix Astragali inducement interferon, but reduces mice is protected.Show that Radix Astragali antiviral is relevant with activating macrophage.Strengthening resisiting influenza virus antibody generates: Radix Astragali injection mice (0.4ml/ only), between 2～3 weeks in the mice serum resisiting influenza virus antibody titer be equating in 4 times (P＜0.05) the 4th week of matched group
[1]
28 experiments of 1299 mices, the Radix Astragali infects I type parainfluenza virus protective effect.To 1000 people, with Radix Astragali oral liquid or spray nose, flu-prevention, epidemiologic observation has preventive effect.The flu susceptible person takes the Radix Astragali after two weeks, and blood leukocytes inducement interferon ability is more preceding for high than taking medicine on every side.Took the Radix Astragali two months, and improved SIgA and IgG content in susceptible person's nose juice significantly, and between SIgA changes of contents and the flu parallel relation is arranged.The Radix Astragali promotes that SIgA raises in the nose juice, effectively anti-ly cures cold, the various respiratory road infects
[2]
Radix Astragali endogenous inducement interferon has extensive antiviral effect.Viral infection is early stage, and interferon-induced host cell produces antiviral protein, and blocking-up nucleic acid and protein synthesis suppress virus replication; Interferon wakes up and closes on cell resistance virus, and activated macrophage, NK cell, cytotoxic cell are killed infection cell; The item during natural immunity, interferon suppresses virus replication, prevents diffusion, removes virus, plays decisive role.
● Radix Glycyrrhizae immune cell activated molecule, inducement interferon, broad-spectrum antiviral.
Give the mouse inoculation influenza virus, observe and injected the glycyrrhizin therapeutic effect, the experimental mice survival rate is apparently higher than matched group as a result, and pathological observation finds that the experimental mice pulmonary lesion obviously is lighter than matched group.Also the experimental mice splenocyte is transferred to normal mouse, it is exposed infect environment, found that mice 100% existence, and the inoculator does not all infect after the influenza dead, but experiment in vitro is found glycyrrhizin influenza virus is not had inhibitory action, its mechanism of action is relevant with T lymphocyte generation gamma interferon in the glycyrrhizin inductor
[3]Experiment shows, glycyrrhizin can improve concanavalin A, Con A goes into splenocyte and produce the gamma interferon level, and the generation optimum concentration is 200ug/ml, the most suitablely induces 48 hours time, and cell concentration is with 1 * 10
7/ ml is advisable, and the interferon of inducing generation is based on the gamma interferon type
[4]
Angelica Polysaccharide has obvious anti-vesicular stomatitis virus, adenovirus, simple herpes virus, vaccinia virus activity
[5]Angelica Polysaccharide can induce human whole blood cell and mononuclearcell gamma interferon separately, and tiring to reach 4168IU/ml
[6]Laboratory observation, Angelica Polysaccharide have the mouse lymphocyte of activation propagation, can think that Angelica Polysaccharide is a kind of new mitogen
[7]
Easily catch a cold a little less than [side separate] old germling, influenza; the traditional Chinese medical science is thought failure of defensive QI to protect the body against pathogen; can not resist the exopathogen invasion; easily catch a cold, influenza, " defending gas " is human body defence exopathogen barrier, protects the healthy energy of oneself; through cloud: " healthy energy internal memory; heresy can not be done ", in medical QI invigorating set upright, Gu Wei heals preventing cold, influenza.Immunology and virusology progress studies show that, high-risk susceptible person, and the natural immunity is low, the acquired immunity disappearance, the breeding of new virus quick copy causes severe complications or death.Merge multiple subject, QI invigorating is set upright, and Gu Wei heals; Improve the natural immunity, protect high-risk susceptible person.
[toxicity] Radix Astragali toxicity, mouse peritoneal injection LD
50Be 40 ± 5g crude drug/kg
[8]The Radix Glycyrrhizae extractum acute toxicity, LD
506.68g/kg
[9]
(4) specific embodiment
[prescription] Radix Astragali Preparata 1998g Radix Glycyrrhizae Preparata 333g
[method for making] above two hidden, and decocts with water twice, and 2 hours for the first time, 1 hour for the second time, collecting decoction filtered, and filtrate is concentrated into the clear paste that relative density is 1.15～1.20 (50～60 ℃), spray drying; Be divided into two parts, add organic acid and adjuvant in the portion, make acid particles, drying; Add sodium bicarbonate and adjuvant in another part, make alkali grain, drying.Two kinds of granules are shaken up, granulate is pressed into 1000, promptly again.
[function with cure mainly] QI invigorating is set upright, and Gu Wei heals; Improve the natural immunity, immune cell activated molecule, inducement interferon, broad-spectrum antiviral; Preventing cold, flu-prevention and the human and bird fluenza.Be fit to easy catching a cold child, old people, immunocompromised person and epidemic disease fowl contactee repeatedly.
[usage and consumption] is oral.One time 5,3 times on the one.Child cut down according to the circumstance (2～1, put into warm water, quicken to take after disintegrate becomes liquid).
[specification] a slice is equivalent to crude drug 2.3g.
[storage] sealing.
(5) description of drawings
Fig. 1 .A type influenza virus " survival of the fittest " strategy.Fig. 2. flu, influenza, the human and bird fluenza, epidemiology, nosetiology and pathogenesis.Fig. 3. prevention and control people high pathogenic avian influenza emergency measure.Fig. 4. improve natural immunity effervescent tablet preventative strategies can.
[list of references]
[1] Zhang Xingquan, etc. effect of Radix Astragali resisiting influenza virus and inducement interferon promote the research of immunologic function, Chinese microbiology and Journal of Immunology .1984,4 (2), 94～97
[2] Chinese Academy of Medical Sciences's epidemic diseases dispensary: the preliminary observation and the Radix Astragali Principle Discussion of the Radix Astragali and people's umbilical blood interferon use in conjunction preventing cold epidemiological effect, medical research communication .1978,4 (4), 4～6
[3] UtsunomiyaT, etal.Gleyrrhizin, an active component oflicoricerools, reduces morbidity and morbidity of mice infected with lethaldose of influenza virus.Antimicrob Agenfs Chenother, 1997,41 (3): 551～556 is attached: 10 pages of the Chinese manuscripts of a translation
[4] Feng Yongshan. the influence that glycyrrhizin produces gamma interferon to the human splenocyte cell, China's biology and Journal of Immunology, 1986,6 (2): 99～102
[5] Chang Yaping, etc. the research of Angelica Polysaccharide antivirus action, CHINA JOURNAL OF CHINESE MATERIA MEDICA 1989,14 (4): 44～46
[6] Chang Yaping, etc. several Chinese medicine extract induce human interferon, Chinese experimental clinical immunology magazine, 1992,4 (6), 37～40
[7] history is brave, etc. Angelica Polysaccharide to mouse lymphocyte activationa and proliferation effect, Chinese Journal of Immunology, 1986,2 (5), 295～229
[8] Huang Houpin, etc. the diuresis of the Radix Astragali and hypotensive effect, Acta Pharmaceutica Sinica, 1965,12 (5): 319～324
[9] Cen Qinbo in building chief editor. arrangement of conventional Chinese medicine material kind and quality research, second 490～493 in combined publication society of China Concord Medical Science University of Beijing Medical University
Claims (1)
- Improve natural immunity effervescent tablet, changeable according to A type virus antigen, the difficult one-tenth of specificity vaccine; The susceptible person, immunocompromised, repeated infection virus; Due to the card genus, traditional Chinese medical science healthy energy interior-deficiency, failure of defensive QI to protect the body against pathogen, differential diagnosis of diseases combines with dialectical, development prescription: Radix Astragali Preparata, Radix Glycyrrhizae Preparata.Has the raising natural immunity, immune cell activated molecule, inducement interferon, broad-spectrum antiviral.
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| CNA2008100015552A CN101385772A (en) | 2008-01-09 | 2008-01-09 | Effervescence tablets for increasing natural immunity |
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103960663A (en) * | 2014-05-14 | 2014-08-06 | 北京燕康科技有限公司 | Health care food for enhancing immunologic function and preparation method of food |
| CN103990021A (en) * | 2014-04-22 | 2014-08-20 | 安徽省太湖山中药饮片有限公司 | Soybean-containing madder effervescent tablet and preparation method thereof |
| CN104083427A (en) * | 2014-07-30 | 2014-10-08 | 河南中医学院 | Compound astragalus polysaccharide particle for preventing and treating avian influenza |
| CN107198710A (en) * | 2016-03-18 | 2017-09-26 | 兰州大学 | A kind of pharmaceutical composition and its application in anti-infectives are prepared |
| CN108567854A (en) * | 2017-10-11 | 2018-09-25 | 山西中医药大学 | Join Ling oral liquid and preparation method thereof |
| CN112451557A (en) * | 2021-01-13 | 2021-03-09 | 兰州大学第一医院 | A Chinese medicinal composition for treating upper respiratory infection with heat and toxic materials clearing away, sore-throat relieving, and antiinflammatory effects, and its preparation method |
| CN112915136A (en) * | 2021-04-06 | 2021-06-08 | 广州百奥格林生物科技有限公司 | Pharmaceutical composition with anti-inflammatory and immune effects, and preparation method and application thereof |
-
2008
- 2008-01-09 CN CNA2008100015552A patent/CN101385772A/en active Pending
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103990021A (en) * | 2014-04-22 | 2014-08-20 | 安徽省太湖山中药饮片有限公司 | Soybean-containing madder effervescent tablet and preparation method thereof |
| CN103960663A (en) * | 2014-05-14 | 2014-08-06 | 北京燕康科技有限公司 | Health care food for enhancing immunologic function and preparation method of food |
| CN104083427A (en) * | 2014-07-30 | 2014-10-08 | 河南中医学院 | Compound astragalus polysaccharide particle for preventing and treating avian influenza |
| CN104083427B (en) * | 2014-07-30 | 2017-06-27 | 河南中医学院 | Prevent and treat the compound Radix Astragali polysaccharide particle of bird flu |
| CN107198710A (en) * | 2016-03-18 | 2017-09-26 | 兰州大学 | A kind of pharmaceutical composition and its application in anti-infectives are prepared |
| CN108567854A (en) * | 2017-10-11 | 2018-09-25 | 山西中医药大学 | Join Ling oral liquid and preparation method thereof |
| CN112451557A (en) * | 2021-01-13 | 2021-03-09 | 兰州大学第一医院 | A Chinese medicinal composition for treating upper respiratory infection with heat and toxic materials clearing away, sore-throat relieving, and antiinflammatory effects, and its preparation method |
| CN112915136A (en) * | 2021-04-06 | 2021-06-08 | 广州百奥格林生物科技有限公司 | Pharmaceutical composition with anti-inflammatory and immune effects, and preparation method and application thereof |
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Application publication date: 20090318 |