CN101816739B - Chinese medicinal composition and preparation method thereof - Google Patents
Chinese medicinal composition and preparation method thereof Download PDFInfo
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Abstract
The invention relates to the field of Chinese medicine, and in particular discloses a Chinese medicinal composition for enhancing immunity or delaying senility. The medicinal composition comprise the following raw materials in part by weight: 40 to 80 parts of astragalus, 10 to 25 parts of ginseng, 10 to 30 parts of medlar, 10 to 30 parts of glossy privet fruit, 10 to 30 parts of common yam rhizome, 10 to 30 parts of Indian buead, 10 to 25 parts of epimedium herb, 10 to 25 parts of mulberry, 5 to 20 parts of yerbadetajo herb, 10 to 25 parts of lucid ganoderma, 10 to 25 parts of tangerine peel and 5 to 20 parts of liquoric root. The Chinese medicinal composition can increase weights of immune organs of mice such as thymus and spleen, enhance the cellular immunity and ensure a dose-response relationship between the effect and the dosage, and can remarkably prolong the swimming time of the mice and keep the anti-fatigue effect in the dose-response relationship. The invention also provides a method for preparing the Chinese medicinal composition. The Chinese medicinal composition is a pure Chinese preparation, can enhance the resistance and delay the senility, and has the anti-fatigue effect and good application prospect.
Description
Technical field
The present invention relates to the field of Chinese medicines, be specifically related to a kind of Chinese medicine composition and preparation method thereof with enhancing immunity and function of delaying senility.
Background technology
In the increasingly competitive modern life, the quickening of work rhythm, the rapid raising of living standard impels people to feel extraordinarily tired, in addition the appearance repeatedly of dangerous food, the physical condition that causes the modern is in continuous decline, particularly after the SARS, the propagation of influenza A H1N1, being on the increase of AIDSinfected patient quantity, bring big worried and injury to people again undoubtedly, how enhancing immunity has also just become the problem of the common concern of institute of the whole society.Increasing the weight of day by day of aging degree in addition, the antidotal problem of the focus that middle-aged and elderly people is paid close attention to is also outstanding day by day.
Chinese medicine can be regulated the human body function equilibrium on the whole, improves the internal body vigor, improves immunity, impel the whole organ of human body normal healthization, thereby reach the purpose of opposing cure diseases in the history of continuing to use that China has several thousand.Having occurred on the market is building up resistance or antidotal medicine and health product of raw material development with natural drugs such as Chinese herbal medicine a lot, but does not possess defying age, the resisting fatigue Chinese patent medicine of enhancing body resistance effect again simultaneously.
Summary of the invention
The objective of the invention is for a kind of Chinese medicine composition with enhancing immunity and slow down aging is provided.
In order to reach the foregoing invention purpose, the present invention adopts following scheme:
The Chinese medicine composition of a kind of enhancing immunity or slow down aging, its raw material comprises in weight portion: Radix Astragali 40-80 part, Radix Ginseng 10-25 part, Fructus Lycii 10-30 part, Fructus Ligustri Lucidi 10-30 part, Rhizoma Dioscoreae 10-30 part, Poria 10-30 part, Herba Epimedii 10-25 part, Fructus Mori 10-25 part, Herba Ecliptae 5-20 part, Ganoderma 10-25 part, Pericarpium Citri Reticulatae 10-25 part, Radix Glycyrrhizae 5-20 part.
Chinese medicine composition of the present invention is " monarch drug " with the Radix Astragali, Radix Ginseng supplementing QI and nourishing YIN altogether; With Fructus Lycii, Rhizoma Dioscoreae, Poria, Herba Epimedii, Fructus Ligustri Lucidi, Fructus Mori, Ganoderma, replenishing QI to invigorate the spleen, the kidney invigorating easing the affected liver, nourishing blood altogether is ministerial drug, to strengthen the effect of monarch drug; With Pericarpium Citri Reticulatae be amusing, the Radix Glycyrrhizae coordinating the actions of various ingredients in a prescription is the medicine of " help, make ", more than all medicines cooperate and can bring into play synergism better.
The Radix Astragali is the dry root of leguminous plant Radix Astagali Astragalusmembranaceus (Fisch.) Bge.var.mongholicus (Bge.) Hsiao or Radix Astragali Astragalus membranaceus (Fisch.) Bge..
Radix Ginseng is the dry root and rhizome of Araliaceae Radix Ginseng Panax ginseng C.A.Mey..
Fructus Lycii is the dry mature fruit of plant of Solanaceae lycium barbarum Lycium barbarum L..
Fructus Ligustri Lucidi is the dry mature fruit of Oleaceae plant Fructus Ligustri Lucidi Ligustrum lucidum Ait..
Rhizoma Dioscoreae is the dry rhizome of Dioscoreaceae plant Rhizoma Dioscoreae Dioscorea opposite Thunb..
Poria is the dry sclerotia of Polyporaceae fungus Poria Poria cocos (Schw.) Wolf.
Herba Epimedii is the dry aerial parts of Berberidaceae plant Herba Epimedii Epimedium brevicornum Maxim., arrow leaf Herba Epimedii Epimedium sagittatum (Sieb.etZucc.) Maxim., pubescence Herba Epimedii Epimedium pubescens Maxim., Epimedium wushanense Epimedium wushanenseT.S.Ying or Herba Epimedii Epimedium koreanum Nakai.
Fructus Mori is the dry fruit ear of moraceae plants Mulberry Morus alba L..
Herba Ecliptae is the dry aerial parts of feverfew Eclipta prostrata Eclipta prostrata L..
Ganoderma is Polyporaceae fungus Ganoderma lucidum (Leyss. Ex Fr.) Karst. Ganoderma lucidum (Leyss.ex Fr.) Karst. or Ganoderma Ganoderma sinense Zhao, the dry sporophore of Xu et zhang.
Pericarpium Citri Reticulatae is the dry mature skin of rutaceae orange Citrus reticulata Blanco and variety thereof.
Radix Glycyrrhizae is the dry root and rhizome of glycyrrhizic legume Glycyrrhiza uralensis Fisch., Glycyrrhiza inflata Bat. Glycyrrhiza inflata Bat. or Glycyrrhiza glabra L. Glycyrrhiza glabra L..
Chinese medicine composition of the present invention has supplementing QI and nourishing YIN, augments the effect of spleen kidney, can treat because of deficiency of both QI and YIN, weak breathing hard due to the spleen kidney deficiency, spontaneous sweating, dry mouth and throat, symptoms such as dizziness and tinnitus reach enhancing human body immunity power, delay body aging, simultaneously the effect of enhancing body anti-fatigue ability.
As preferably, Chinese medicine composition of the present invention, its raw material comprises in weight portion:
24 parts of 24 parts of Fructus Ligustri Lucidi of 20 parts of Fructus Lycii of 60 parts of Radix Ginsengs of the Radix Astragali
20 parts in 20 portions of Fructus Moris of 24 parts of Herba Epimedii of 24 parts of Poria of Rhizoma Dioscoreae
10 parts in 20 portions of Radix Glycyrrhizaes of 20 parts of Pericarpium Citri Reticulataes of 12 portions of Ganodermas of Herba Ecliptae.
Carrying out influence test, anti-fatigue test, the test of normal pressure anti-hypoxia that Chinese medicine composition of the present invention forms to immuning tissue's influence test, to the E-bow structure on mice finds, Chinese medicine composition of the present invention has effect of gain to mouse immune organ thymus, spleen, and have the enhancing immunization of cell, its effect and dosage are certain dose-effect relationship; Can significant prolongation mice swimming time, have antifatigue effect, and be dose-effect relationship.Institute of the present invention Chinese medicine composition is a pure Chinese medicinal preparation, can effectively build up resistance resisting fatigue, but also delaying sanility really.
Preferably, pharmaceutical composition of the present invention various regular dosage forms be can be made with pharmaceutically acceptable excipient, tablet, capsule, granule, paste nourishing agent or oral liquid comprised.
The present invention also provides the preparation method of described Chinese medicine composition, comprises following steps:
Step 1: get the fragmentation of 10-25 weight portion Radix Ginseng, decoct with water, filter and get filtrate for later use;
Step 2: get Radix Astragali 40-80 weight portion, Fructus Lycii 10-30 weight portion, Fructus Ligustri Lucidi 10-30 weight portion, Rhizoma Dioscoreae 10-30 weight portion, Poria 10-30 weight portion, Herba Epimedii 10-25 weight portion, Fructus Mori 10-25 weight portion, Herba Ecliptae 5-20 weight portion, Ganoderma 10-25 weight portion, Pericarpium Citri Reticulatae 10-25 weight portion, Radix Glycyrrhizae 5-20 weight portion and decoct with water, decoction liquor filters, and gets filtrate simmer down to clear paste;
Step 3: step 2 gained clear paste is added ethanol in stirring down, leave standstill, get supernatant and reclaim ethanol;
Step 4: step 3 is reclaimed supernatant and the merging of step 1 gained filtrate behind the ethanol, the thick paste that to be concentrated into 20～40 ℃ of relative densities be 1.28-1.36.
As preferably, step 1 is specially the fragmentation of 10-25 weight portion Radix Ginseng, decoct with water 3～4 times, and each 1～2 hour, filter merging filtrate, standby.
More preferably, step 1 is specially gets 20 weight portion Radix Ginsengs and is crushed to diameter and is no more than 1cm, and the decocting that adds 10 times of amounts boils 4 times, and each 1 hour, filter merging filtrate, standby.
As preferably, step 2 is specially gets Radix Astragali 40-80 weight portion, Fructus Lycii 10-30 weight portion, Fructus Ligustri Lucidi 10-30 weight portion, Rhizoma Dioscoreae 10-30 weight portion, Poria 10-30 weight portion, Herba Epimedii 10-25 weight portion, Fructus Mori 10-25 weight portion, Herba Ecliptae 5-20 weight portion, Ganoderma 10-25 weight portion, Pericarpium Citri Reticulatae 10-25 weight portion, Radix Glycyrrhizae 5-20 weight portion and decocts with water 2～4 times, each 1～2 hour, decoction liquor filters, merge the simmer down to clear paste.
More preferably, step 2 is specially gets 60 parts of the Radixs Astragali, 24 parts of Fructus Lycii, 24 parts of Fructus Ligustri Lucidi, 24 parts of Rhizoma Dioscoreaes, 24 parts in Poria, 20 parts of Herba Epimedii, 20 parts in Fructus Mori, 12 parts of Herba Ecliptaes, 20 parts of Ganodermas, 20 parts of Pericarpium Citri Reticulataes, 10 parts of decoctings that add 10 times of amounts of Radix Glycyrrhizae and boils 3 times, each 1 hour, decoction liquor filter to merge, and is concentrated into 20 ℃ of relative densities and is 1.20 clear paste.
As preferably, step 3 is specially clear paste in stirring the ethanol that adds 1～2 times of amount of clear paste volume down, leaves standstill 8-24 hour, more preferably adds the ethanol of 1.5 times of amounts of clear paste volume, leaves standstill 12 hours, gets supernatant and reclaims ethanol.
As preferably, step 4 is specially and is concentrated into 20 ℃ of relative densities is 1.35 thick paste.
Preparation method technical maturity of the present invention is reasonable, has fully taken into account the abundant extraction of various ingredients in the compositions, can make crude drug give full play to therapeutical effect and tonic effect.
The specific embodiment:
The invention discloses a kind of Chinese medicine composition that is used for enhancing immunity or slow down aging and preparation method thereof, those skilled in the art can use for reference this paper content, suitably improve technological parameter and realize.Special needs to be pointed out is that all similarly replace and change apparent to those skilled in the art, they all are regarded as being included in the present invention.Product of the present invention, method and application are described by preferred embodiment, the related personnel obviously can change or suitably change and combination methods and applications as herein described in not breaking away from content of the present invention, spirit and scope, realizes and use the present invention.
Embodiment 1: prepare Chinese medicine composition of the present invention
Described Chinese medicine composition is made by following raw medicaments in portion by weight:
Radix Astragali 40-80 part Radix Ginseng 10-25 part Fructus Lycii 10-30 part Fructus Ligustri Lucidi 10-30 part Rhizoma Dioscoreae 10-30 part Poria 10-30 part Herba Epimedii 10-25 part Fructus Mori 10-25 part Herba Ecliptae 5-20 part Ganoderma 10-25 part Pericarpium Citri Reticulatae 10-25 part Radix Glycyrrhizae 5-20 part
More than 12 flavors, get Radix Ginseng fragmentation (diameter is no more than 1cm), the water water of 12 times of amounts (add for the first time) that adds 10 times of amounts decocts 4 times, each 1 hour, filter, merging filtrate, standby.All the other ten simply, the water (water that adds 12 times of amounts for the first time) that adds 10 times of amounts decocts 3 times, each 1 hour, decoction liquor filtered, and merged, being concentrated into relative density is the clear paste of 1.20 (20 ℃), in stirring the ethanol that adds 1.5 times of amounts of clear paste volume down, staticly settled 12 hours, after getting supernatant and reclaiming ethanol, merge with the Radix Ginseng decocting liquid, being concentrated into relative density is the thick paste of 1.35 (20 ℃).
Embodiment 2: prepare Chinese medicine composition of the present invention
Raw material is counted with weight portion:
24 parts of 24 parts of Fructus Ligustri Lucidi of 20 parts of Fructus Lycii of 40 parts of Radix Ginsengs of the Radix Astragali
20 parts in 20 portions of Fructus Moris of 24 parts of Herba Epimedii of 24 parts of Poria of Rhizoma Dioscoreae
10 parts in 20 portions of Radix Glycyrrhizaes of 20 parts of Pericarpium Citri Reticulataes of 12 portions of Ganodermas of Herba Ecliptae.
Get the Radix Ginseng fragmentation, decoct with water 3～4 times, each 1～2 hour, filter, merging filtrate, standby.All the other ten simply, decoct with water 2～4 times, each 1～2 hour, decoction liquor filtered, and merged, be concentrated into the clear paste shape, in stirring the ethanol that adds 1～2 times of amount of clear paste volume down, staticly settled 8-24 hour, after getting supernatant and reclaiming ethanol, merge with the Radix Ginseng decocting liquid, being concentrated into relative density is the thick paste of 1.28-1.36 (20～40 ℃).
Embodiment 3: the paste nourishing agent for preparing Chinese medicine composition of the present invention
Raw material is counted with weight portion:
30 parts of 10 parts of Fructus Ligustri Lucidi of 10 parts of Fructus Lycii of 60 parts of Radix Ginsengs of the Radix Astragali
10 parts in 10 portions of Fructus Moris of 10 parts of Herba Epimedii of 10 parts of Poria of Rhizoma Dioscoreae
5 parts in 10 portions of Radix Glycyrrhizaes of 10 parts of Pericarpium Citri Reticulataes of 5 portions of Ganodermas of Herba Ecliptae.
Get Radix Ginseng fragmentation (diameter is no more than 1cm), the water (water that adds 12 times of amounts for the first time) that adds 10 times of amounts decocts 4 times, and each 1 hour, filter, merging filtrate, standby.All the other ten simply, the water (water that adds 12 times of amounts for the first time) that adds 10 times of amounts decocts 3 times, each 1 hour, decoction liquor filtered, and merged, being concentrated into relative density is the clear paste of 1.20 (20 ℃), in stirring the ethanol that adds 1.5 times of amounts of clear paste volume down, staticly settled 12 hours, after getting supernatant and reclaiming ethanol, merge with the Radix Ginseng decocting liquid, being concentrated into relative density is the thick paste of 1.35 (20 ℃).Getting sucrose adds water in right amount and refines into the syrup that relative density is 1.39 (60 ℃); It is the refined honey of 1.39 (60 ℃) that Mel refines to relative density, with syrup and refined honey mixed by 5: 2, the molasses solution for standby.Get above-mentioned thick paste, be heated to and boil, stir that to add molasses solution down an amount of, mixing, put cold, packing, promptly.
Embodiment 4: the granule for preparing Chinese medicine composition of the present invention
Raw material is counted with weight portion:
30 parts of 30 parts of Fructus Ligustri Lucidi of 25 parts of Fructus Lycii of 80 parts of Radix Ginsengs of the Radix Astragali
25 parts in 25 portions of Fructus Moris of 30 parts of Herba Epimedii of 30 parts of Poria of Rhizoma Dioscoreae
20 parts in 25 portions of Radix Glycyrrhizaes of 25 parts of Pericarpium Citri Reticulataes of 25 portions of Ganodermas of Herba Ecliptae.
Get Radix Ginseng fragmentation (diameter is no more than 1cm), the water (water that adds 12 times of amounts for the first time) that adds 10 times of amounts decocts 4 times, and each 1 hour, filter, merging filtrate, standby.All the other ten simply, the water (water that adds 12 times of amounts for the first time) that adds 10 times of amounts decocts each 1 hour 3 times, decoction liquor filters, and merges, and being concentrated into relative density is the clear paste of 1.20 (20 ℃), in stirring the ethanol that adds 1.5 times of amounts of clear paste volume down, staticly settled 12 hours, after getting supernatant and reclaiming ethanol, merge with the Radix Ginseng decocting liquid, being concentrated into relative density is the thick paste of 1.35 (20 ℃), gets thick paste, adds cane sugar powder and/or dextrin, make granule, drying; Or get thick paste, and add lactose and Aspartane, make granule, drying, promptly.
Embodiment 5: Chinese medicine composition of the present invention is to the effect of gain of immune organ
Laboratory animal: healthy Kunming mouse, the male and female dual-purpose, body weight 17-19g, institute for drug control, Yunnan Province laboratory animal room provides.
Experimental drug: the Chinese medicine composition and the preparation thereof of embodiment 1-4 preparation are provided by Kunming Chinese Medicine Factory Co., Ltd..
Anti-senility oral liquid: Zhengda Qingchunbao Pharmaceutical Co., Ltd, market is bought.
Experimental technique:
Chinese medicine composition solution preparation of the present invention: Chinese medicine composition of the present invention or its dosage form (being equivalent to crude drug in whole 40g) adding distil water stirs evenly and promptly gets test liquid to 50ml.
Experiment grouping and step: 40 of healthy mices are divided into four groups, gastric infusion, every day 1 time, administration 10 days at random.Chinese medicine composition of the present invention is established high and low dose, and high dose is 40g (crude drug in whole)/kg/ days, and low dosage is 20g (crude drug in whole)/kg/ days, and the blank group is given ordinary water, and 50ml/kg/ days, positive control QINGCHUN BAO group dosage was pressed 50ml/kg/ days.After administration in the 10th day, with etherization till death, thymus is got in dissection, the spleen degrease claims weight in wet base, calculates with every 10g body weight milligram.
Experimental result:
Mouse thymus, spleen weight are calculated, and the result is through the t check or proofread and correct the t check, sees Table 1:
Table 1 Chinese medicine composition of the present invention is to the effect of gain of mouse immune organ (n=10x ± SD)
| Group | One daily dose | Thymus heavy (mg/10g) | The P value | Spleen heavy (mg/10g) | The P value |
| Blank (water) | 50ml/kg | 4.4±1.3 | - | 35.2±8.6 | - |
| QINGCHUN BAO | 50ml/kg | 7.8±2.7 | ＜0.01 | 62.2±23.8 | ＜0.001 |
| High dose | 40g/kg | 6.8±1.8 | ＜0.05 | 53.2±16.5 | ＜0.01 |
| Low dosage | 20g/kg | 5.4±1.0 | ＞0.05 | 49.3±12.5 | ＜0.05 |
Table 1 result shows: QINGCHUN BAO group and blank group compare, and the spleen weightening finish is extremely significantly meaning (P＜0.001), and thymus is highly significant meaning (P＜0.01).Chinese medicine composition high dose group of the present invention and blank group are relatively, the weightening finish of thymus, spleen is highly significant meaning (P＜0.01), Chinese medicine composition low dosage of the present invention and blank are relatively, the weightening finish of spleen is significance meaning (P＜0.01), and thymus is significance meaning (P＜0.05).Experiment shows that Chinese medicine composition of the present invention has effect of gain to mouse immune organ thymus, spleen, and is certain dose-effect relationship.
Embodiment 6: the influence that Chinese medicine composition of the present invention forms the E-bow structure
Experiment material: injection liquid of thymic peptide alpha 1, Kunming Golden Temple pharmaceutical factory product.
Calf thymus: take from Chengdu institute of section of army of army.
Sheep red blood cell: take from Chengdu institute of section of army of army.
The Chinese medicine composition of the present invention and the preparation thereof of embodiment 1-4 preparation
Experimental technique:
The preparation of Chinese medicine composition solution of the present invention: get Chinese medicine composition of the present invention or its dosage form (being equivalent to crude drug in whole 640mg), add normal saline to 4ml (160mg/ml), gently stir well even, filter, get filtrate, be diluted to: 80mg (crude drug in whole)/ml, 40mg (crude drug in whole)/ml with physiologic dose brine, 8mg (crude drug in whole)/ml, standby.
Get 30 of small test tubes, 5 test tubes of negative control group respectively add 0.1ml Han Shi liquid, 5 test tubes of positive controls respectively add injection liquid of thymic peptide alpha 1 (1mg/ml) 0.1ml, paste nourishing agent is established 4 dosage groups, be respectively 160mg (crude drug in whole)/ml, 80 (crude drug in whole) mg/ml, 40mg (crude drug in whole)/ml, 8mg (crude drug in whole)/ml, 5 test tubes of each dosage group, add the Chinese medicine composition solution 0.1ml of the present invention of respective concentration, every pipe adds deactivation and takes off E thymocyte cell 0.2ml, mixing, 37 ℃ of waters bath with thermostatic control are incubated 1 hour, centrifugal (1500 rev/mins) 3 minutes remove supernatant, and reuse Han Shi liquid is given a baby a bath on the third day after its birth inferior.The sheep red blood cell 0.2ml that adds new preparation, mixing, centrifugal (1500 rev/mins) 3 minutes put 4 ℃ of refrigerator overnight.Take out next day, and abandoning supernatant is stayed a little, and each pipe adds 1 of fixative, shake up gently, and static 10 minutes, add 1 of dyeing liquor again, begin counting after static 15 minutes.Pale blue is lymphocyte (being thymocyte cell) than maxicell in the microscopically visual field, and every several 200, statistics E rosette forming cell number (in conjunction with the lymphocyte of 3 above sheep red blood cells) wherein calculates and forms percentage rate.The results are shown in Table 2.
Experimental result:
Table 2 Chinese medicine composition of the present invention influences n=5 (X ± SD) to what the E-bow structure formed
| Group | Dosage | The percentage rate (%) that the E-bow structure forms |
| Blank | - | 8.5±1.3 |
| Thymosin | 1.0mg/ml 0.1ml | 25.5±1.7 |
| Chinese medicine composition | 8.0mg/ml 0.1ml | 17.9±2.2 |
| Chinese medicine composition | 40.0mg/ml 0.1ml | 25.6±1.7 |
| Chinese medicine composition | 80.0mg/ml 0.1ml | 30.8±1.0 |
| Chinese medicine composition | 160.0mg/ml 0.1ml | 33.4±2.0 |
Thymosin group, each dosage group of Chinese medicine composition of the present invention deduct the knot flower rate 10% above person behind the blank group bow structure percentage rate, and thinking has the enhance immunity effect.Experimental result shows that Chinese medicine composition of the present invention and thymosin have the enhancing immunization of cell, and the enhancing immunization of cell and the dosage of Chinese medicine composition of the present invention are certain dose-effect relationship.Low dose group does not have effect.
Embodiment 7: Chinese medicine composition of the present invention is to the antifatigue effect of mice
(1) laboratory animal: healthy Kunming mouse, male, body weight 18-20g, institute for drug control, Yunnan Province laboratory animal room provides.
(2) experimental drug: embodiment 1-4 prepares Chinese medicine composition of the present invention and preparation thereof
The power of giving birth to capsule: Yunnan Long Run-Pharmaceutical Co, market is bought.
Experimental technique:
Chinese medicine composition solution preparation of the present invention: get Chinese medicine composition of the present invention or its dosage form (being equivalent to crude drug in whole 40g) adding distil water to 50ml, stir evenly and promptly get test liquid.
The preparation of the refreshing capsule suspension of the power of giving birth to: get this product 20g porphyrize in mortar, add 1%CMC (liquid), edged mill in limit supplies on probation to 100ml.
Experiment grouping and step: 40 of healthy mices, male, be divided into four groups at random, gastric infusion, every day 1 time, administration 4 days.Chinese medicine composition of the present invention is established high and low dose, and high dose is 20ml/kg/ days, and low dosage is 4ml/kg/ days, and the blank group is given ordinary water, and 50ml/kg/ days, positive control was given birth to the refreshing Capsules group dosage of power and pressed 10ml/kg/ days.Water is fed in fasting in the 4th day, irritates behind the stomach 1 hour, puts into 29 ℃ of waters bath with thermostatic control and carries out swimming test, and mice bears a heavy burden and is equivalent to 10% of mice body weight, record mice sinking time.The results are shown in Table 3.
Experimental result:
Table 3 Chinese medicine composition of the present invention influences n=10 (X ± SD) to the mice swimming time
| Group | One daily dose | Swimming time (S) (second) | The P value |
| Blank group (water) | 50ml/kg | 149.4±67.8 | - |
| The refreshing group of the power of giving birth to | 10ml/kg | 197.4±64.4 | ＜0.05 |
| The Chinese medicine composition high dose group | 20ml/kg | 185.1±46.2 | ＜0.05 |
| The Chinese medicine composition low dose group | 4ml/kg | 151.2±55.7 | ＞0.05 |
The refreshing group of the high low dose group of Chinese medicine composition of the present invention and the power of giving birth to compares with the blank group, swimming time prolongs, check through T, Chinese medicine composition high dose group of the present invention is significance meaning (P＜0.05) with the power of giving birth to god, and Chinese medicine composition low dose group of the present invention is no significance meaning (P＞0.05).Experiment shows, Chinese medicine composition tool antifatigue effect of the present invention, and be dose-effect relationship.
Embodiment 8: Chinese medicine composition of the present invention is to mice normal pressure oxygen lack resistant function
(1) laboratory animal: healthy Kunming mouse, male and female half and half, body weight 19-20g, institute for drug control, Yunnan Province laboratory animal room provides.
(2) experimental drug: embodiment 1-4 prepares Chinese medicine composition of the present invention and preparation thereof
Anti-senility oral liquid: Zhengda Qingchunbao Pharmaceutical Co., Ltd, market is bought.
Experimental technique:
Chinese medicine composition solution preparation of the present invention: get Chinese medicine composition of the present invention or its dosage form (being equivalent to crude drug in whole 40g) adding distil water to 50ml, stir evenly and promptly get test liquid.
Experiment grouping and step: get 40 of healthy mices, male and female half and half are divided into four groups at random, gastric infusion, every day 1 time, administration 5 days.Chinese medicine composition of the present invention is established high and low dose, and high dose is 50ml/kg/ days, and low dosage is 30ml/kg/ days, and the blank group is given ordinary water, and 50ml/kg/ days, positive control QINGCHUN BAO group dosage was pressed 50ml/kg/ days.Water is fed in fasting in the 4th day, irritates behind the stomach 1 hour, puts into 29 ℃ of waters bath with thermostatic control and carries out swimming test, and mice bears a heavy burden and is equivalent to 10% of mice body weight, record mice sinking time.The results are shown in Table 4.
Experimental result:
Table 4 Chinese medicine composition of the present invention influences n=10 (X ± SD) to the mice swimming time
| Group | One daily dose | Swimming time (S) (second) | The P value |
| Blank group (water) | 50ml/kg | 149.4±67.8 | - |
| The refreshing group of the power of giving birth to | 10ml/kg | 197.4±64.4 | ＜0.05 |
| The Chinese medicine composition high dose group | 20ml/kg | 185.1±46.2 | ＜0.05 |
| The Chinese medicine composition low dose group | 4ml/kg | 151.2±55.7 | ＞0.05 |
The refreshing group of the high low dose group of Chinese medicine composition of the present invention and the power of giving birth to compares with the blank group, swimming time prolongs, check through T, Chinese medicine composition high dose group of the present invention is significance meaning (P＜0.05) with the power of giving birth to god, and Chinese medicine composition low dose group of the present invention is no significance meaning (P＞0.05).Experiment shows, Chinese medicine composition tool antifatigue effect of the present invention, and be dose-effect relationship.
The above only is a preferred implementation of the present invention; should be pointed out that for those skilled in the art, under the prerequisite that does not break away from the principle of the invention; can also make some improvements and modifications, these improvements and modifications also should be considered as protection scope of the present invention.
Claims (11)
1. the Chinese medicine composition of an enhancing immunity, its raw material comprises in weight portion:
Radix Astragali 40-80 part Radix Ginseng 10-25 part Fructus Lycii 10-30 part Fructus Ligustri Lucidi 10-30 part
Rhizoma Dioscoreae 10-30 part Poria 10-30 part Herba Epimedii 10-25 part Fructus Mori 10-25 part
Herba Ecliptae 5-20 part Ganoderma 10-25 part Pericarpium Citri Reticulatae 10-25 part Radix Glycyrrhizae 5-20 part.
2. Chinese medicine composition according to claim 1 is characterized in that, its raw material comprises in weight portion:
24 parts of 24 parts of Fructus Ligustri Lucidi of 20 parts of Fructus Lycii of 60 parts of Radix Ginsengs of the Radix Astragali
20 parts in 20 portions of Fructus Moris of 24 parts of Herba Epimedii of 24 parts of Poria of Rhizoma Dioscoreae
10 parts in 20 portions of Radix Glycyrrhizaes of 20 parts of Pericarpium Citri Reticulataes of 12 portions of Ganodermas of Herba Ecliptae.
3. comprise the dosage form that described Chinese medicine composition of claim 1 and pharmaceutically acceptable excipient are made.
4. the preparation method of the described Chinese medicine composition of claim 1 comprises following steps:
Step 1: get the fragmentation of 10-25 weight portion Radix Ginseng, decoct with water, filter and get filtrate for later use;
Step 2: get Radix Astragali 40-80 weight portion, Fructus Lycii 10-30 weight portion, Fructus Ligustri Lucidi 10-30 weight portion, Rhizoma Dioscoreae 10-30 weight portion, Poria 10-30 weight portion, Herba Epimedii 10-25 weight portion, Fructus Mori 10-25 weight portion, Herba Ecliptae 5-20 weight portion, Ganoderma 10-25 weight portion, Pericarpium Citri Reticulatae 10-25 weight portion, Radix Glycyrrhizae 5-20 weight portion and decoct with water, decoction liquor filters, and gets filtrate simmer down to clear paste;
Step 3: step 2 gained clear paste is added ethanol in stirring down, leave standstill, get supernatant and reclaim ethanol;
Step 4: with the filtrate merging that step 3 reclaims supernatant and step 1 gained behind the ethanol, the thick paste that to be concentrated into 20～40 ℃ of relative densities be 1.28-1.36.
5. preparation method according to claim 4 is characterized in that, step 1 is specially the fragmentation of 10-25 weight portion Radix Ginseng, decoct with water 3～4 times, and each 1～2 hour, filter merging filtrate, standby.
6. preparation method according to claim 4 is characterized in that, step 1 is specially gets 20 parts of Radix Ginsengs and be crushed to diameter and be no more than 1cm, and the decocting that adds 10 times of amounts boils 4 times, each 1 hour, filter merging filtrate, and standby.
7. preparation method according to claim 4, it is characterized in that, step 2 is specially gets Radix Astragali 40-80 weight portion, Fructus Lycii 10-30 weight portion, Fructus Ligustri Lucidi 10-30 weight portion, Rhizoma Dioscoreae 10-30 weight portion, Poria 10-30 weight portion, Herba Epimedii 10-25 weight portion, Fructus Mori 10-25 weight portion, Herba Ecliptae 5-20 weight portion, Ganoderma 10-25 weight portion, Pericarpium Citri Reticulatae 10-25 weight portion, Radix Glycyrrhizae 5-20 weight portion and decocts with water 2～4 times, each 1～2 hour, decoction liquor filters, merge the simmer down to clear paste.
8. preparation method according to claim 4, it is characterized in that, step 2 is specially gets 60 parts of the Radixs Astragali, 24 parts of Fructus Lycii, 24 parts of Fructus Ligustri Lucidi, 24 parts of Rhizoma Dioscoreaes, 24 parts in Poria, 20 parts of Herba Epimedii, 20 parts in Fructus Mori, 12 parts of Herba Ecliptaes, 20 parts of Ganodermas, 20 parts of Pericarpium Citri Reticulataes, 10 parts of decoctings that add 10 times of amounts of Radix Glycyrrhizae and boils 3 times, each 1 hour, decoction liquor filter to merge, and is concentrated into 20 ℃ of relative densities and is 1.20 clear paste.
9. preparation method according to claim 4 is characterized in that, step 3 is specially the ethanol that clear paste is added 1～2 times of amount of clear paste volume under stirring, and leaves standstill 8-24 hour.
10. preparation method according to claim 9 is characterized in that, step 3 is specially the ethanol that clear paste is added 1.5 times of amounts of clear paste volume under stirring, and leaves standstill 12 hours, gets supernatant and reclaims ethanol.
11. preparation method according to claim 4 is characterized in that, the described thick paste of step 4 is that 20 ℃ of relative densities are 1.35 thick paste.
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| CN104415132A (en) * | 2013-08-21 | 2015-03-18 | 上海圣赐康生物医药科技有限公司 | Compound formula for preparing soft capsule by pro-liposomes of ganoderma spore and freshwater mussel and preparation method thereof |
| CN104705634A (en) * | 2013-12-11 | 2015-06-17 | 余邦 | Lucid ganoderma healthcare product for protecting health |
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| CN104998002A (en) * | 2015-07-07 | 2015-10-28 | 柳州草子吉生物科技有限公司 | Traditional Chinese medicine composition for defying aging, stopping hair loss and promoting hair growth and preparation method thereof |
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Date of cancellation: 20170519 Granted publication date: 20110928 Pledgee: China Merchants Bank, Limited by Share Ltd, Kunming branch Pledgor: Kunming Chinese Medicine Factory Co., Ltd. Registration number: 2016990000339 |
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Denomination of invention: Chinese medicine composition and its preparing method Effective date of registration: 20170519 Granted publication date: 20110928 Pledgee: China Merchants Bank, Limited by Share Ltd, Kunming branch Pledgor: Kunming Chinese Medicine Factory Co., Ltd. Registration number: 2017990000427 |
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Date of cancellation: 20190716 Granted publication date: 20110928 Pledgee: China Merchants Bank, Limited by Share Ltd, Kunming branch Pledgor: Kunming Chinese Medicine Factory Co., Ltd. Registration number: 2017990000427 |