CN111214603A - Tortoise and deer double-glue composition, preparation method and application thereof, and Gui and deer double-glue nourishing paste - Google Patents
Tortoise and deer double-glue composition, preparation method and application thereof, and Gui and deer double-glue nourishing paste Download PDFInfo
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- CN111214603A CN111214603A CN202010167463.2A CN202010167463A CN111214603A CN 111214603 A CN111214603 A CN 111214603A CN 202010167463 A CN202010167463 A CN 202010167463A CN 111214603 A CN111214603 A CN 111214603A
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Abstract
The invention discloses a tortoise-deer double glue composition, which comprises the following components: 25-35 parts of tortoise-plastron glue, 25-35 parts of deer-horn glue, 20-40 parts of astragalus root, 18-25 parts of ginseng, 15-30 parts of cyrtomium rhizome, 13-25 parts of glossy privet fruit, 15-30 parts of Chinese yam, 10-23 parts of acanthopanax root, 10-22 parts of epimedium herb, 10-18 parts of mulberry, 8-16 parts of yerbadetajo herb, 10-15 parts of hyacinth bean, 10-25 parts of dried orange peel and 5-20 parts of liquorice. The tortoise-plastron glue and the deer-horn glue are taken as monarch drugs and are supplemented with other traditional Chinese medicines, so that the resistance of a human body is further enhanced, the sleeping state can be improved after long-term taking, and people can sleep well more easily.
Description
Technical Field
The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a tortoise-deer antler glue composition and a preparation method thereof.
Technical Field
In modern life with increasingly intense competition, the work pace is accelerated, the living standard is rapidly improved, people are forced to feel tired, and unsafe foods are frequently appeared, so that the physical health condition of modern people is continuously reduced, particularly after SARS (severe acute respiratory syndrome), influenza A H1N1 and the number of AIDS infected people are continuously increased, great worry and harm are undoubtedly brought to people, and the problem of how to enhance the immunity is also a common concern of the whole society. In addition, the aging degree is getting worse, and the focus of the middle-aged and old people on aging resistance is also getting more prominent.
The traditional Chinese medicine has been used for thousands of years in China, can regulate the function balance of human bodies on the whole, improve the internal activity of the bodies, improve the immunity and promote all organs of the human bodies to be healthy, thereby achieving the aim of resisting and curing diseases. Many drugs and health care products which are developed by taking natural medicines such as Chinese herbal medicines as raw materials and can enhance the resistance appear in the market, but the effect is not good, and most of requirements can not be met.
The invention application with the application number of CN201510036126.9 discloses a preparation method of a traditional Chinese medicine composition for enhancing physique and improving human immunity, which comprises the following steps:
(1) weighing the raw materials according to the weight parts, adding water, decocting for 2 hours, and filtering to obtain filtrate, wherein the adding amount of the water is 8-10 times of the total weight of the raw materials;
(2) concentrating the filtrate at the temperature of 60-70 ℃ to obtain clear paste with the relative density of 1.2-1.4;
(3) spray drying the fluid extract, and pulverizing to powder with fineness of 100 mesh;
(4) packaging the above powder directly or making into other pharmaceutically acceptable dosage forms.
Although the raw materials such as tortoise-plastron glue are disclosed, the research of the applicant finds that the raw materials still have certain defects in the effect of enhancing the resistance.
Disclosure of Invention
The invention aims to provide a tortoise-deer-gelatin nourishing paste and a preparation method thereof, and the prepared tortoise-deer-gelatin nourishing paste has good effects of enhancing resistance and improving sub-health.
The specific scheme is as follows:
a colla Plastri Testudinis and colla Cornus Cervi composition comprises the following components: 25-35 parts of tortoise-plastron glue, 25-35 parts of deer-horn glue, 20-40 parts of astragalus root, 18-25 parts of ginseng, 15-30 parts of cyrtomium rhizome, 13-25 parts of glossy privet fruit, 15-30 parts of Chinese yam, 10-23 parts of acanthopanax root, 10-22 parts of epimedium herb, 10-18 parts of mulberry, 8-16 parts of yerbadetajo herb, 10-15 parts of hyacinth bean, 10-25 parts of dried orange peel and 5-20 parts of liquorice.
The invention relates to a specific implementation mode which comprises the following components in parts by weight: 26 parts of tortoise-plastron glue, 30 parts of deer-horn glue, 25 parts of astragalus root, 20 parts of ginseng, 18 parts of cyrtomium rhizome, 17 parts of glossy privet fruit, 18 parts of Chinese yam, 15 parts of acanthopanax root, 15 parts of epimedium herb, 13 parts of mulberry, 10 parts of yerbadetajo herb, 12 parts of hyacinth bean, 15 parts of dried orange peel and 10 parts of liquorice.
The invention relates to a specific implementation mode which comprises the following components in parts by weight: 30 parts of tortoise-plastron glue, 30 parts of deer-horn glue, 35 parts of astragalus root, 20 parts of ginseng, 22 parts of cyrtomium rhizome, 21 parts of glossy privet fruit, 19 parts of Chinese yam, 20 parts of acanthopanax root, 17 parts of epimedium herb, 16 parts of mulberry, 13 parts of yerbadetajo herb, 12 parts of hyacinth bean, 25 parts of tangerine peel and 18 parts of liquorice.
In a specific embodiment of the invention, the composition further comprises pharmaceutically or food acceptable auxiliary materials.
In one embodiment of the invention, the excipient is selected from the group consisting of binders, fillers, diluents, lubricants, flavoring agents and humectants.
The invention provides an application of a tortoise-deer double glue composition, in particular to an application in preparing a medicament or a health-care product for enhancing resistance and improving sub-health.
The health care product or the medicine can be made into all the forms disclosed in the prior art, such as bags.
In a specific embodiment of the invention, the composition preparation comprises powder, granules, pills, powder, paste, pellets and suspension; the paste comprises blending paste, pounding paste, decocting paste, and pickling paste.
The composition of the present invention, its oral preparation, may contain conventional excipients such as binders, fillers, diluents, lubricants, flavoring agents and wetting agents, and the tablets may be coated if necessary.
Suitable fillers include cellulose, mannitol, lactose and other similar fillers. Suitable lubricants include, for example, magnesium stearate. Suitable pharmaceutically acceptable wetting agents include sodium lauryl sulphate. The solid oral compositions can be prepared by conventional methods of mixing, filling, tabletting and the like. Repeated mixing can distribute the active throughout those compositions that use large amounts of filler.
Oral liquid preparations may be in the form of, for example, aqueous or oily suspensions, solutions, emulsions or syrups, or may be presented as a dry product for constitution with water or other suitable vehicle before use. Such liquid preparations may contain conventional additives such as suspending agents, for example sorbitol, syrup, methyl cellulose, gelatin, hydroxyethyl cellulose, carboxymethyl cellulose, aluminium stearate gel or hydrogenated edible fats, emulsifying agents, for example lecithin, sorbitan monooleate or acacia; non-aqueous carriers (which may include edible oils), for example almond oil, fractionated coconut oil, oily esters such as esters of glycerol, propylene glycol or ethyl alcohol; preservatives, for example p-hydroxybenzyl or propyl p-hydroxybenzoate or sorbic acid, and, if desired, conventional flavouring or colouring agents.
the composition of the invention can be selectively added with a suitable pharmaceutically acceptable carrier when being prepared into a medicament, wherein the pharmaceutically acceptable carrier is selected from mannitol, sorbitol, sodium metabisulfite, sodium bisulfite, sodium thiosulfate, cysteine hydrochloride, thioglycolic acid, methionine, vitamin C, EDTA disodium, EDTA calcium sodium, carbonate, acetate, phosphate or aqueous solution thereof of monovalent alkali metals, hydrochloric acid, acetic acid, sulfuric acid, phosphoric acid, amino acid, sodium chloride, potassium chloride, sodium lactate, xylitol, maltose, glucose, fructose, dextran, glycine, starch, sucrose, lactose, mannitol, silicon derivatives, cellulose and derivatives thereof, alginate, gelatin, polyvinylpyrrolidone, glycerol, Tween 80, agar, calcium carbonate, calcium bicarbonate, surfactant, polyethylene glycol, cyclodextrin, β -cyclodextrin, phospholipid materials, kaolin, talcum powder, calcium stearate, magnesium stearate and the like.
The above-mentioned adjuvants such as carrier, excipient and the like are not limited to the use in a specific dosage form.
The invention also provides a preparation method of the tortoise-deer-gelatin composition, which comprises the following steps:
1) drying radix astragali and Ginseng radix, pulverizing, decocting in water, and filtering to obtain filtrate;
2) decocting rhizoma Osmundae, fructus Ligustri Lucidi, rhizoma Dioscoreae, radix Acanthopanacis Senticosi, herba Epimedii, Mori fructus, Ecliptae herba, semen lablab album, pericarpium Citri Tangerinae and Glycyrrhrizae radix with water for 3-5 times, adding 5-8 times of water for each time, decocting for boiling, keeping the temperature for 30-45min, filtering after each time, mixing filtrates, standing for 3-6 hr, and concentrating the filtrate at 45-55 deg.C under reduced pressure to obtain fluid extract;
3) adding ethanol into the fluid extract obtained in the step 2) under stirring, standing, taking supernate and recovering ethanol;
4) mixing the supernatant obtained in step 3) and the filtrate obtained in step 1), adding powdered colla Plastri Testudinis and colla cornus cervi, concentrating at 20-40 deg.C under reduced pressure to obtain soft extract with relative density of 1.3-1.33, adding other adjuvants, and making into corresponding dosage forms.
The invention provides a product containing the Guilu shuangjiao composition, in particular to Guilu shuangjiao nourishing paste which can be prepared by adopting the method.
Compared with the prior art, the invention has the beneficial effects that:
the tortoise glue of the present invention contains great amount of protein, ossein, fat, calcium, phosphorus, peptide, various enzymes and various essential trace elements, and is rich in aspartic acid, threonine, serine and other amino acids and has the functions of promoting immunity, bacteriostasis, etc. It contains abundant peptides, and has effects of enhancing immunity, and resisting fungi, virus and cancer cell. The aspartic acid in the amino acids has the functions of preventing and recovering fatigue; serine can reduce capillary fragility, improve microcirculation, and enhance immunity. Further, the compound has the effect of delaying senescence of cells. The deer glue has the effect of promoting the transformation of lymphoblast of a human body, can promote the increase of the amount of red blood cells, white blood cells and platelets in peripheral blood, and can effectively improve the resistance and improve the sub-health state of the human body by particularly combining the deer glue and the tortoise-plastron glue. The tortoise-plastron glue and the deer-horn glue are taken as monarch drugs and are supplemented with other traditional Chinese medicines, so that the resistance of a human body is further enhanced, the sleeping state can be improved after long-term taking, and people can sleep well more easily.
Detailed Description
The technical solutions of the present invention will be described clearly and completely below, and it should be understood that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. The terminology used in the description of the invention herein is for the purpose of describing particular embodiments only and is not intended to be limiting of the invention. As used herein, the term "and/or" includes any and all combinations of one or more of the associated listed items.
Example 1
A preparation method of a Guilu shuangjiao composition comprises the following steps:
1) drying 20 parts of astragalus and 18 parts of ginseng, crushing, adding water, decocting for 2 times, adding 5 times of water into the decocted raw materials for each time, keeping the temperature for 30min after each time of decoction is boiled, filtering after each time of decoction, taking filtrate, combining the filtrate after the decoction is finished, and filtering to obtain the filtrate for later use;
2) decocting rhizoma Osmundae 15 parts, fructus Ligustri Lucidi 13 parts, rhizoma Dioscoreae 15 parts, radix Acanthopanacis Senticosi 10 parts, herba Epimedii 10 parts, Mori fructus 10 parts, Ecliptae herba 8 parts, semen lablab album 10 parts, pericarpium Citri Tangerinae 10 parts, and Glycyrrhrizae radix 5 parts with water for 3 times, adding 5 times of water for each time, decocting for boiling, keeping the temperature for 30min, filtering after each time, collecting filtrate, mixing filtrates after decocting, standing for 3 hr, and concentrating the filtrate at 45 deg.C under reduced pressure to obtain fluid extract;
3) adding ethanol into the fluid extract obtained in the step 2) under stirring, standing, taking supernate and recovering ethanol;
4) mixing the supernatant obtained in step 3) and the filtrate obtained in step 1), adding powdered tortoise-plastron glue 25 parts and deer-horn glue 25 parts, concentrating at 20 deg.C under reduced pressure to obtain soft extract with relative density of 1.3-1.33, adding other adjuvants, and making into powder.
Example 2
A preparation method of a Guilu shuangjiao composition comprises the following steps:
1) drying 25 parts of astragalus and 20 parts of ginseng, crushing, adding water, decocting for 2 times, adding 6 times of water to the decocted raw materials for each time, keeping the temperature for 35min after each time of decoction is boiled, filtering after each time of decoction, mixing the filtrates after the decoction is finished, and filtering to obtain the filtrate for later use;
2) decocting 18 parts of cyrtomium fortunei, 17 parts of glossy privet fruit, 18 parts of Chinese yam, 15 parts of acanthopanax root, 15 parts of epimedium herb, 13 parts of mulberry, 10 parts of yerbadetajo herb, 12 parts of hyacinth bean, 15 parts of dried orange peel and 10 parts of liquorice with water for 4 times, adding 6 times of water for each time of decoction, keeping the temperature for 35min after each time of decoction is boiled, filtering after each time of decoction to obtain filtrate, merging the filtrate after the decoction is finished, standing for 4h, and concentrating the filtrate at 55 ℃ under reduced pressure to obtain clear paste;
3) adding ethanol into the fluid extract obtained in the step 2) under stirring, standing, taking supernate and recovering ethanol;
4) mixing the supernatant obtained in step 3) and the filtrate obtained in step 1), adding powdered tortoise-plastron glue 26 parts and deer-horn glue 30 parts, concentrating at 25 deg.C under reduced pressure to obtain soft extract with relative density of 1.3-1.33, and adding other adjuvants to obtain unguent.
Example 3
A preparation method of a Guilu shuangjiao composition comprises the following steps:
1) drying 35 parts of radix astragali and 20 parts of ginseng, crushing, adding water, decocting for 2-3 times, adding 5-8 times of water into the decocted raw materials for each time of decoction, keeping the temperature for 30-45min after each time of decoction is boiled, filtering to obtain filtrate, combining the filtrates after the decoction is finished, and filtering to obtain filtrate for later use;
2) decocting rhizoma Osmundae 22 parts, fructus Ligustri Lucidi 21 parts, rhizoma Dioscoreae 19 parts, radix Acanthopanacis Senticosi 20 parts, herba Epimedii 17 parts, Mori fructus 16 parts, Ecliptae herba 13 parts, semen lablab album 12 parts, pericarpium Citri Tangerinae 25 parts, and Glycyrrhrizae radix 18 parts with water for 3-5 times, adding 5-8 times of water for each time, decocting for boiling, keeping the temperature for 30-45min, filtering after each time, collecting filtrate, mixing filtrates after decocting, standing for 3-6h, and concentrating the filtrate at 45-55 deg.C under reduced pressure to obtain fluid extract;
3) adding ethanol into the fluid extract obtained in the step 2) under stirring, standing, taking supernate and recovering ethanol;
4) mixing the supernatant obtained in step 3) and the filtrate obtained in step 1), adding 30 parts of powdered tortoise-plastron glue and 30 parts of powdered deer-horn glue, concentrating at 20-40 deg.C under reduced pressure to obtain soft extract with relative density of 1.3-1.33, and adding other adjuvants to obtain unguent. .
Example 4
A preparation method of a Guilu shuangjiao composition comprises the following steps:
1) drying 40 parts of astragalus and 25 parts of ginseng, crushing, adding water, decocting for 3 times, adding 8 times of water to the decocted raw materials for each time, keeping the temperature for 45min after each time of decoction is boiled, filtering to obtain filtrate after each time of decoction, combining the filtrates after the decoction is finished, and filtering to obtain the filtrate for later use;
2) decocting rhizoma Osmundae 30 parts, fructus Ligustri Lucidi 5 parts, rhizoma Dioscoreae 30 parts, radix Acanthopanacis Senticosi 23 parts, herba Epimedii 22 parts, Mori fructus 18 parts, Ecliptae herba 16 parts, semen lablab album 15 parts, pericarpium Citri Tangerinae 25 parts, and Glycyrrhrizae radix 20 parts with water for several times, adding 8 times of water for each time, decocting for boiling, keeping the temperature for 45min, filtering after each time, collecting filtrate, mixing filtrates after decocting, standing for 6h, and concentrating the filtrate at 55 deg.C under reduced pressure to obtain fluid extract;
3) adding ethanol into the fluid extract obtained in the step 2) under stirring, standing, taking supernate and recovering ethanol;
4) mixing the supernatant obtained in step 3) and the filtrate obtained in step 1), adding powdered tortoise-plastron glue 35 parts and deer-horn glue 35 parts, concentrating at 40 deg.C under reduced pressure to obtain soft extract with relative density of 1.3-1.33, adding other adjuvants, and making into unguent.
The applicant further makes statistics on the usage of the product described in the present application.
Trial statistics were randomly performed on 50 elderly, 50 middle aged (office workers) and the results are given in table 1 below:
the season in which the ointment prepared in example 2 is tried is spring, which is a season in which a cold is easily produced, and testers are tracked, about 35% of old people and about 15% of middle-aged people can catch a cold in the past in the season, but after the ointment prepared in the application is tried, none of the testers catch a cold.
The foregoing is illustrative of the preferred embodiments of this invention, and it is to be understood that the invention is not limited to the precise form disclosed herein and that various other combinations, modifications, and environments may be resorted to, falling within the scope of the concept as disclosed herein, either as described above or as apparent to those skilled in the relevant art. And that modifications and variations may be effected by those skilled in the art without departing from the spirit and scope of the invention as defined by the appended claims.
Claims (9)
1. The tortoise-deer-gelatin composition is characterized by comprising the following components: 25-35 parts of tortoise-plastron glue, 25-35 parts of deer-horn glue, 20-40 parts of astragalus root, 18-25 parts of ginseng, 15-30 parts of cyrtomium rhizome, 13-25 parts of glossy privet fruit, 15-30 parts of Chinese yam, 10-23 parts of acanthopanax root, 10-22 parts of epimedium herb, 10-18 parts of mulberry, 8-16 parts of yerbadetajo herb, 10-15 parts of hyacinth bean, 10-25 parts of dried orange peel and 5-20 parts of liquorice.
2. The tortoise-deer-gelatin composition of claim 1, which comprises the following components in parts by weight: 26 parts of tortoise-plastron glue, 30 parts of deer-horn glue, 25 parts of astragalus root, 20 parts of ginseng, 18 parts of cyrtomium rhizome, 17 parts of glossy privet fruit, 18 parts of Chinese yam, 15 parts of acanthopanax root, 15 parts of epimedium herb, 13 parts of mulberry, 10 parts of yerbadetajo herb, 12 parts of hyacinth bean, 15 parts of dried orange peel and 10 parts of liquorice.
3. The colla Plastri Testudinis and colla Cornus Cervi composition of claim 1, wherein: the paint comprises the following components in parts by weight: 30 parts of tortoise-plastron glue, 30 parts of deer-horn glue, 35 parts of astragalus root, 20 parts of ginseng, 22 parts of cyrtomium rhizome, 21 parts of glossy privet fruit, 19 parts of Chinese yam, 20 parts of acanthopanax root, 17 parts of epimedium herb, 16 parts of mulberry, 13 parts of yerbadetajo herb, 12 parts of hyacinth bean, 25 parts of tangerine peel and 18 parts of liquorice.
4. The colla Plastri Testudinis composition of any one of claims 1-3, wherein: also comprises auxiliary materials acceptable in medicines or foods.
5. The colla Plastri Testudinis and colla Cornus Cervi composition of claim 4, wherein: the adjuvants are selected from binders, fillers, diluents, lubricants, flavoring agents and humectants.
6. Use of the colla Plastri Testudinis and colla Cornus Cervi composition of any one of claims 1-5 in preparing medicine or health product for enhancing resistance and improving sub-health.
7. Use according to claim 6, characterized in that: the preparation of the medicine comprises powder, granules, pills, powder, paste, pellets and suspension; the paste comprises blending paste, pounding paste, decocting paste, and pickling paste.
8. The preparation method of the Guilu shuangjiao composition is characterized by comprising the following steps:
1) drying radix astragali and Ginseng radix, pulverizing, decocting in water, and filtering to obtain filtrate;
2) decocting rhizoma Osmundae, fructus Ligustri Lucidi, rhizoma Dioscoreae, radix Acanthopanacis Senticosi, herba Epimedii, Mori fructus, Ecliptae herba, semen lablab album, pericarpium Citri Tangerinae and Glycyrrhrizae radix with water for 3-5 times, adding 5-8 times of water for each time, decocting for boiling, keeping the temperature for 30-45min, filtering after each time, mixing filtrates, standing for 3-6 hr, and concentrating the filtrate at 45-55 deg.C under reduced pressure to obtain fluid extract;
3) adding ethanol into the fluid extract obtained in the step 2) under stirring, standing, taking supernate and recovering ethanol;
4) mixing the supernatant obtained in step 3) and the filtrate obtained in step 1), adding powdered colla Plastri Testudinis and colla cornus cervi, concentrating at 20-40 deg.C under reduced pressure to obtain soft extract with relative density of 1.3-1.33, adding other adjuvants, and making into corresponding dosage forms.
9. The Guilu shuangjiao nourishing paste is characterized in that: prepared by the method of claim 8.
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