CN102423318B - 亚氯酸盐治疗神经变性疾病 - Google Patents
亚氯酸盐治疗神经变性疾病 Download PDFInfo
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- CN102423318B CN102423318B CN201110317862.3A CN201110317862A CN102423318B CN 102423318 B CN102423318 B CN 102423318B CN 201110317862 A CN201110317862 A CN 201110317862A CN 102423318 B CN102423318 B CN 102423318B
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- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
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- A—HUMAN NECESSITIES
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- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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Landscapes
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- Chemical & Material Sciences (AREA)
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- Pharmacology & Pharmacy (AREA)
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| Application Number | Priority Date | Filing Date | Title |
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| US54157604P | 2004-02-03 | 2004-02-03 | |
| US60/541,576 | 2004-02-03 | ||
| CN2005800037236A CN101102781B (zh) | 2004-02-03 | 2005-01-25 | 亚氯酸盐治疗神经变性疾病 |
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| CN2005800037236A Division CN101102781B (zh) | 2004-02-03 | 2005-01-25 | 亚氯酸盐治疗神经变性疾病 |
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| CN102423318A CN102423318A (zh) | 2012-04-25 |
| CN102423318B true CN102423318B (zh) | 2015-09-09 |
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| CN2005800037236A Expired - Lifetime CN101102781B (zh) | 2004-02-03 | 2005-01-25 | 亚氯酸盐治疗神经变性疾病 |
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| CN2005800037236A Expired - Lifetime CN101102781B (zh) | 2004-02-03 | 2005-01-25 | 亚氯酸盐治疗神经变性疾病 |
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|---|---|
| US (5) | US7105183B2 (OSRAM) |
| EP (2) | EP1711191B1 (OSRAM) |
| JP (3) | JP5072367B2 (OSRAM) |
| CN (2) | CN102423318B (OSRAM) |
| AU (1) | AU2005213300B2 (OSRAM) |
| CA (2) | CA2554511C (OSRAM) |
| WO (1) | WO2005076819A2 (OSRAM) |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| AU2002343609B2 (en) * | 2001-11-16 | 2008-12-11 | Als Therapy Development Foundation, Inc. | Treatment of neurodegenerative disorders through the modulation of the polyamine pathway |
| US7105183B2 (en) * | 2004-02-03 | 2006-09-12 | The Regents Of The University Of California | Chlorite in the treatment of neurodegenerative disease |
| WO2006009505A1 (en) * | 2004-07-16 | 2006-01-26 | Gyros Patent Ab | Grading of immune responses |
| AU2006244617B2 (en) | 2005-05-09 | 2013-04-18 | Labrador Diagnostics Llc | Point-of-care fluidic systems and uses thereof |
| DE602006014691D1 (de) * | 2005-08-02 | 2010-07-15 | Xbiotech Inc | DIAGNOSE, BEHANDLUNG UND PRÄVENTION VON GEFÄSSERKRANKUNGEN MITTELS IL-1alpha-AUTOANTIKÖRPERN |
| US8067035B2 (en) | 2005-12-22 | 2011-11-29 | Neuraltus Pharmaceuticals, Inc. | Chlorite formulations, and methods of preparation and use thereof |
| AU2013234421B2 (en) * | 2005-12-22 | 2015-08-27 | Neuraltus Pharmaceuticals, Inc. | Chlorite formulations, and methods of preparation and use thereof |
| US8741230B2 (en) | 2006-03-24 | 2014-06-03 | Theranos, Inc. | Systems and methods of sample processing and fluid control in a fluidic system |
| US11287421B2 (en) | 2006-03-24 | 2022-03-29 | Labrador Diagnostics Llc | Systems and methods of sample processing and fluid control in a fluidic system |
| US8007999B2 (en) | 2006-05-10 | 2011-08-30 | Theranos, Inc. | Real-time detection of influenza virus |
| US20110008282A1 (en) * | 2006-05-15 | 2011-01-13 | Xbiotech, Inc. | IL-1alpha immunization induces autoantibodies protective against atherosclerosis |
| DK2109623T3 (da) * | 2006-05-22 | 2012-01-30 | Xbiotech Inc | Cancerbehandling med anti-IL-1-antistoffer |
| US20080113391A1 (en) | 2006-11-14 | 2008-05-15 | Ian Gibbons | Detection and quantification of analytes in bodily fluids |
| FR2910811B1 (fr) * | 2007-01-03 | 2009-07-10 | Ass Pour Le Dev De La Biothera | Utilisation du riluzole et de ses derives pour fabriquer de nouveaux medicaments |
| US8158430B1 (en) | 2007-08-06 | 2012-04-17 | Theranos, Inc. | Systems and methods of fluidic sample processing |
| US8034337B2 (en) * | 2008-05-30 | 2011-10-11 | Xbiotech, Inc. | Interleukin-1α antibodies |
| AU2009291536B2 (en) * | 2008-09-12 | 2012-08-16 | Xbiotech Inc. | Targeting pathogenic monocytes |
| AU2010281524A1 (en) * | 2009-08-06 | 2012-02-23 | Neuraltus Pharmaceuticals, Inc. | Treatment of macrophage-related disorders |
| EP4535370A3 (en) | 2009-10-19 | 2025-06-25 | Labrador Diagnostics LLC | Integrated health data capture and analysis system |
| CA2792471A1 (en) * | 2010-03-10 | 2011-09-15 | Yeda Research And Development Co. Ltd | Cellular blood markers for early diagnosis of als and for als progression |
| WO2011159976A2 (en) | 2010-06-18 | 2011-12-22 | Xbiotech, Inc. | Arthritis treatment |
| SI2605771T1 (sl) * | 2010-08-16 | 2018-09-28 | Allergan, Inc. | Metoda aktivacije regulatornih celic t z agonisti adrenergičnih receptorjev alfa-2b |
| CN103153340A (zh) | 2010-08-23 | 2013-06-12 | 埃克斯生物科技公司 | 对肿瘤疾病的治疗 |
| US9724409B2 (en) | 2011-04-01 | 2017-08-08 | Xbiotech, Inc. | Treatment of inflammatory skin disease |
| ES2695102T3 (es) | 2011-09-23 | 2019-01-02 | Xbiotech Inc | Tratamiento para la caquexia |
| CN104125826A (zh) | 2011-12-22 | 2014-10-29 | 努沃研究有限责任公司 | 亚氯酸盐或氯酸盐脂质体组合物 |
| SG10201906328RA (en) * | 2012-08-31 | 2019-08-27 | Five Prime Therapeutics Inc | Methods of treating conditions with antibodies that bind colony stimulating factor 1 receptor (csf1r) |
| US9545441B2 (en) | 2012-09-18 | 2017-01-17 | Xbiotech, Inc. | Treatment of diabetes |
| AU2015258892A1 (en) * | 2014-05-16 | 2016-11-17 | Neuraltus Pharmaceuticals, Inc. | Methods and compositions for treatment of macrophage-related disorders |
| EP3072513A1 (en) * | 2015-03-26 | 2016-09-28 | Medday | Biotin for treating Amyotrophic lateral sclerosis |
| WO2017079161A2 (en) * | 2015-11-02 | 2017-05-11 | Neuraltus Pharmaceuticals, Inc. | Treatment of neurodegenerative disease with sodium chlorite |
| CN110382001A (zh) | 2017-02-16 | 2019-10-25 | 埃克斯生物科技公司 | 化脓性汗腺炎的治疗 |
| CA3233863A1 (en) | 2021-10-04 | 2023-04-13 | Arasteh AZHIR | Treatment methods for als patients |
| JP2025518546A (ja) * | 2022-05-19 | 2025-06-17 | ニューヴィヴォ， インコーポレイテッド | 神経変性疾患のバイオマーカー |
| WO2025014800A2 (en) * | 2023-07-07 | 2025-01-16 | The Regents Of The University Of California | Chlorite uses for stem cells |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4507285A (en) * | 1982-04-10 | 1985-03-26 | Kuehne Friedrich Wilhelm | Stabilized activated oxygen and pharmaceutical compositions containing said stabilized activated oxygen |
| CN1433481A (zh) * | 1999-11-30 | 2003-07-30 | 奥克索化学有限公司 | 通过基因表达分析评价和预测临术预后 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4576945A (en) * | 1982-10-26 | 1986-03-18 | Sanders Mark E | Hexaalkylmelamine-amino-oxy compounds |
| DE3515745A1 (de) | 1985-05-02 | 1986-11-06 | Oxo Chemie GmbH, 6900 Heidelberg | Waessrige chloritmatrix-loesung |
| US5051414A (en) * | 1989-08-03 | 1991-09-24 | Dupont Merck Pharmaceutical Company | Inhibition of HIV and other retroviruses by polyoxoanions |
| DE4208828A1 (de) | 1992-03-19 | 1993-09-23 | Oxo Chemie Gmbh | Verwendung einer chemisch stabilisierten chloritmatrix zur herstellung von arzneimitteln zur behandlung von hiv-infektionen |
| US6099855A (en) * | 1992-06-25 | 2000-08-08 | Bioxy, Inc. | Therapeutic, production and immunostimulatory uses of biocidal compositions |
| US5855922A (en) * | 1995-12-07 | 1999-01-05 | Bio-Cide International, Inc. | Antiseptic composition and process for prophylaxis and therapeutic treatment of dermal disorders |
| US5877222A (en) | 1996-07-19 | 1999-03-02 | The Regents Of The University Of California | Method for treating aids-associated dementia |
| WO1999017787A2 (en) * | 1997-10-06 | 1999-04-15 | Oxo Chemie Ag | Use of a chemically-stabilized chlorite solution for inhibiting an antigen-specific immune response |
| US7087648B1 (en) | 1997-10-27 | 2006-08-08 | The Regents Of The University Of California | Methods for modulating macrophage proliferation using polyamine analogs |
| JP2001078775A (ja) * | 1999-09-14 | 2001-03-27 | Kokuritsu Seishin Shinkei Center | マクロファージ機能調節剤 |
| US6685754B2 (en) | 2001-03-06 | 2004-02-03 | Alchemix Corporation | Method for the production of hydrogen-containing gaseous mixtures |
| AU2002343609B2 (en) | 2001-11-16 | 2008-12-11 | Als Therapy Development Foundation, Inc. | Treatment of neurodegenerative disorders through the modulation of the polyamine pathway |
| US7105183B2 (en) | 2004-02-03 | 2006-09-12 | The Regents Of The University Of California | Chlorite in the treatment of neurodegenerative disease |
-
2005
- 2005-01-24 US US11/042,816 patent/US7105183B2/en not_active Expired - Lifetime
- 2005-01-25 CN CN201110317862.3A patent/CN102423318B/zh not_active Expired - Lifetime
- 2005-01-25 CA CA2554511A patent/CA2554511C/en not_active Expired - Lifetime
- 2005-01-25 CN CN2005800037236A patent/CN101102781B/zh not_active Expired - Lifetime
- 2005-01-25 WO PCT/US2005/002469 patent/WO2005076819A2/en not_active Ceased
- 2005-01-25 EP EP05722556.7A patent/EP1711191B1/en not_active Expired - Lifetime
- 2005-01-25 CA CA2838392A patent/CA2838392C/en not_active Expired - Lifetime
- 2005-01-25 AU AU2005213300A patent/AU2005213300B2/en not_active Expired
- 2005-01-25 EP EP12192303.1A patent/EP2574342B1/en not_active Expired - Lifetime
- 2005-01-25 JP JP2006552151A patent/JP5072367B2/ja not_active Expired - Lifetime
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2006
- 2006-03-17 US US11/378,987 patent/US8029826B2/en active Active
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2010
- 2010-10-07 US US12/900,361 patent/US20110053186A1/en not_active Abandoned
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2011
- 2011-10-25 JP JP2011233850A patent/JP5797083B2/ja not_active Expired - Lifetime
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2012
- 2012-04-27 US US13/458,954 patent/US9364501B2/en not_active Expired - Lifetime
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2015
- 2015-06-12 JP JP2015118841A patent/JP2015205901A/ja active Pending
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2016
- 2016-09-12 US US15/262,981 patent/US20170065634A1/en not_active Abandoned
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4507285A (en) * | 1982-04-10 | 1985-03-26 | Kuehne Friedrich Wilhelm | Stabilized activated oxygen and pharmaceutical compositions containing said stabilized activated oxygen |
| CN1433481A (zh) * | 1999-11-30 | 2003-07-30 | 奥克索化学有限公司 | 通过基因表达分析评价和预测临术预后 |
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| Publication number | Publication date |
|---|---|
| AU2005213300A1 (en) | 2005-08-25 |
| CA2838392A1 (en) | 2005-08-25 |
| US20060159775A1 (en) | 2006-07-20 |
| US20170065634A1 (en) | 2017-03-09 |
| US20110053186A1 (en) | 2011-03-03 |
| CN102423318A (zh) | 2012-04-25 |
| US8029826B2 (en) | 2011-10-04 |
| US20050181068A1 (en) | 2005-08-18 |
| AU2005213300B2 (en) | 2011-06-16 |
| CA2554511C (en) | 2016-01-19 |
| CA2554511A1 (en) | 2005-08-25 |
| US20120295296A1 (en) | 2012-11-22 |
| EP2574342B1 (en) | 2018-03-07 |
| EP1711191A2 (en) | 2006-10-18 |
| EP2574342A1 (en) | 2013-04-03 |
| US7105183B2 (en) | 2006-09-12 |
| JP2012067110A (ja) | 2012-04-05 |
| CN101102781A (zh) | 2008-01-09 |
| EP1711191A4 (en) | 2008-12-17 |
| CN101102781B (zh) | 2012-06-20 |
| JP5797083B2 (ja) | 2015-10-21 |
| WO2005076819A3 (en) | 2006-04-13 |
| CA2838392C (en) | 2017-04-04 |
| JP2015205901A (ja) | 2015-11-19 |
| US9364501B2 (en) | 2016-06-14 |
| EP1711191B1 (en) | 2014-03-19 |
| WO2005076819A2 (en) | 2005-08-25 |
| JP5072367B2 (ja) | 2012-11-14 |
| JP2007520554A (ja) | 2007-07-26 |
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