CA2554511C - Chlorite in the treatment of neurodegenerative disease - Google Patents

Chlorite in the treatment of neurodegenerative disease Download PDF

Info

Publication number
CA2554511C
CA2554511C CA2554511A CA2554511A CA2554511C CA 2554511 C CA2554511 C CA 2554511C CA 2554511 A CA2554511 A CA 2554511A CA 2554511 A CA2554511 A CA 2554511A CA 2554511 C CA2554511 C CA 2554511C
Authority
CA
Canada
Prior art keywords
als
disease
chlorite
cells
macrophage
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CA2554511A
Other languages
English (en)
French (fr)
Other versions
CA2554511A1 (en
Inventor
Michael S. Mcgrath
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of California San Diego UCSD
Original Assignee
University of California San Diego UCSD
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34860199&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA2554511(C) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by University of California San Diego UCSD filed Critical University of California San Diego UCSD
Priority to CA2838392A priority Critical patent/CA2838392C/en
Publication of CA2554511A1 publication Critical patent/CA2554511A1/en
Application granted granted Critical
Publication of CA2554511C publication Critical patent/CA2554511C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00Medicinal preparations containing inorganic active ingredients
    • A61K33/20Elemental chlorine; Inorganic compounds releasing chlorine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00Medicinal preparations containing inorganic active ingredients
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00Medicinal preparations containing inorganic active ingredients
    • A61K33/40Peroxides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02Inorganic compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02Muscle relaxants, e.g. for tetanus or cramps
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/18Antivirals for RNA viruses for HIV

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Inorganic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Dermatology (AREA)
  • AIDS & HIV (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychology (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
CA2554511A 2004-02-03 2005-01-25 Chlorite in the treatment of neurodegenerative disease Expired - Lifetime CA2554511C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA2838392A CA2838392C (en) 2004-02-03 2005-01-25 Chlorite in the treatment of neurodegenerative disease

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US54157604P 2004-02-03 2004-02-03
US60/541,576 2004-02-03
PCT/US2005/002469 WO2005076819A2 (en) 2004-02-03 2005-01-25 Chlorite in the treatment of neurodegenerative disease

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CA2838392A Division CA2838392C (en) 2004-02-03 2005-01-25 Chlorite in the treatment of neurodegenerative disease

Publications (2)

Publication Number Publication Date
CA2554511A1 CA2554511A1 (en) 2005-08-25
CA2554511C true CA2554511C (en) 2016-01-19

Family

ID=34860199

Family Applications (2)

Application Number Title Priority Date Filing Date
CA2554511A Expired - Lifetime CA2554511C (en) 2004-02-03 2005-01-25 Chlorite in the treatment of neurodegenerative disease
CA2838392A Expired - Lifetime CA2838392C (en) 2004-02-03 2005-01-25 Chlorite in the treatment of neurodegenerative disease

Family Applications After (1)

Application Number Title Priority Date Filing Date
CA2838392A Expired - Lifetime CA2838392C (en) 2004-02-03 2005-01-25 Chlorite in the treatment of neurodegenerative disease

Country Status (7)

Country Link
US (5) US7105183B2 (OSRAM)
EP (2) EP1711191B1 (OSRAM)
JP (3) JP5072367B2 (OSRAM)
CN (2) CN102423318B (OSRAM)
AU (1) AU2005213300B2 (OSRAM)
CA (2) CA2554511C (OSRAM)
WO (1) WO2005076819A2 (OSRAM)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2002343609B2 (en) * 2001-11-16 2008-12-11 Als Therapy Development Foundation, Inc. Treatment of neurodegenerative disorders through the modulation of the polyamine pathway
US7105183B2 (en) * 2004-02-03 2006-09-12 The Regents Of The University Of California Chlorite in the treatment of neurodegenerative disease
WO2006009505A1 (en) * 2004-07-16 2006-01-26 Gyros Patent Ab Grading of immune responses
AU2006244617B2 (en) 2005-05-09 2013-04-18 Labrador Diagnostics Llc Point-of-care fluidic systems and uses thereof
DE602006014691D1 (de) * 2005-08-02 2010-07-15 Xbiotech Inc DIAGNOSE, BEHANDLUNG UND PRÄVENTION VON GEFÄSSERKRANKUNGEN MITTELS IL-1alpha-AUTOANTIKÖRPERN
US8067035B2 (en) 2005-12-22 2011-11-29 Neuraltus Pharmaceuticals, Inc. Chlorite formulations, and methods of preparation and use thereof
AU2013234421B2 (en) * 2005-12-22 2015-08-27 Neuraltus Pharmaceuticals, Inc. Chlorite formulations, and methods of preparation and use thereof
US8741230B2 (en) 2006-03-24 2014-06-03 Theranos, Inc. Systems and methods of sample processing and fluid control in a fluidic system
US11287421B2 (en) 2006-03-24 2022-03-29 Labrador Diagnostics Llc Systems and methods of sample processing and fluid control in a fluidic system
US8007999B2 (en) 2006-05-10 2011-08-30 Theranos, Inc. Real-time detection of influenza virus
US20110008282A1 (en) * 2006-05-15 2011-01-13 Xbiotech, Inc. IL-1alpha immunization induces autoantibodies protective against atherosclerosis
DK2109623T3 (da) * 2006-05-22 2012-01-30 Xbiotech Inc Cancerbehandling med anti-IL-1-antistoffer
US20080113391A1 (en) 2006-11-14 2008-05-15 Ian Gibbons Detection and quantification of analytes in bodily fluids
FR2910811B1 (fr) * 2007-01-03 2009-07-10 Ass Pour Le Dev De La Biothera Utilisation du riluzole et de ses derives pour fabriquer de nouveaux medicaments
US8158430B1 (en) 2007-08-06 2012-04-17 Theranos, Inc. Systems and methods of fluidic sample processing
US8034337B2 (en) * 2008-05-30 2011-10-11 Xbiotech, Inc. Interleukin-1α antibodies
AU2009291536B2 (en) * 2008-09-12 2012-08-16 Xbiotech Inc. Targeting pathogenic monocytes
AU2010281524A1 (en) * 2009-08-06 2012-02-23 Neuraltus Pharmaceuticals, Inc. Treatment of macrophage-related disorders
EP4535370A3 (en) 2009-10-19 2025-06-25 Labrador Diagnostics LLC Integrated health data capture and analysis system
CA2792471A1 (en) * 2010-03-10 2011-09-15 Yeda Research And Development Co. Ltd Cellular blood markers for early diagnosis of als and for als progression
WO2011159976A2 (en) 2010-06-18 2011-12-22 Xbiotech, Inc. Arthritis treatment
SI2605771T1 (sl) * 2010-08-16 2018-09-28 Allergan, Inc. Metoda aktivacije regulatornih celic t z agonisti adrenergičnih receptorjev alfa-2b
CN103153340A (zh) 2010-08-23 2013-06-12 埃克斯生物科技公司 对肿瘤疾病的治疗
US9724409B2 (en) 2011-04-01 2017-08-08 Xbiotech, Inc. Treatment of inflammatory skin disease
ES2695102T3 (es) 2011-09-23 2019-01-02 Xbiotech Inc Tratamiento para la caquexia
CN104125826A (zh) 2011-12-22 2014-10-29 努沃研究有限责任公司 亚氯酸盐或氯酸盐脂质体组合物
SG10201906328RA (en) * 2012-08-31 2019-08-27 Five Prime Therapeutics Inc Methods of treating conditions with antibodies that bind colony stimulating factor 1 receptor (csf1r)
US9545441B2 (en) 2012-09-18 2017-01-17 Xbiotech, Inc. Treatment of diabetes
AU2015258892A1 (en) * 2014-05-16 2016-11-17 Neuraltus Pharmaceuticals, Inc. Methods and compositions for treatment of macrophage-related disorders
EP3072513A1 (en) * 2015-03-26 2016-09-28 Medday Biotin for treating Amyotrophic lateral sclerosis
WO2017079161A2 (en) * 2015-11-02 2017-05-11 Neuraltus Pharmaceuticals, Inc. Treatment of neurodegenerative disease with sodium chlorite
CN110382001A (zh) 2017-02-16 2019-10-25 埃克斯生物科技公司 化脓性汗腺炎的治疗
CA3233863A1 (en) 2021-10-04 2023-04-13 Arasteh AZHIR Treatment methods for als patients
JP2025518546A (ja) * 2022-05-19 2025-06-17 ニューヴィヴォ, インコーポレイテッド 神経変性疾患のバイオマーカー
WO2025014800A2 (en) * 2023-07-07 2025-01-16 The Regents Of The University Of California Chlorite uses for stem cells

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3213389A1 (de) * 1982-04-10 1983-10-20 Friedrich-Wilhelm Dr. 7107 Neckarsulm Kühne Stabilisierter aktivierter sauerstoff und arzneimittel, die diesen stabilisierten aktivierten sauerstoff enthalten
US4576945A (en) * 1982-10-26 1986-03-18 Sanders Mark E Hexaalkylmelamine-amino-oxy compounds
DE3515745A1 (de) 1985-05-02 1986-11-06 Oxo Chemie GmbH, 6900 Heidelberg Waessrige chloritmatrix-loesung
US5051414A (en) * 1989-08-03 1991-09-24 Dupont Merck Pharmaceutical Company Inhibition of HIV and other retroviruses by polyoxoanions
DE4208828A1 (de) 1992-03-19 1993-09-23 Oxo Chemie Gmbh Verwendung einer chemisch stabilisierten chloritmatrix zur herstellung von arzneimitteln zur behandlung von hiv-infektionen
US6099855A (en) * 1992-06-25 2000-08-08 Bioxy, Inc. Therapeutic, production and immunostimulatory uses of biocidal compositions
US5855922A (en) * 1995-12-07 1999-01-05 Bio-Cide International, Inc. Antiseptic composition and process for prophylaxis and therapeutic treatment of dermal disorders
US5877222A (en) 1996-07-19 1999-03-02 The Regents Of The University Of California Method for treating aids-associated dementia
WO1999017787A2 (en) * 1997-10-06 1999-04-15 Oxo Chemie Ag Use of a chemically-stabilized chlorite solution for inhibiting an antigen-specific immune response
US7087648B1 (en) 1997-10-27 2006-08-08 The Regents Of The University Of California Methods for modulating macrophage proliferation using polyamine analogs
JP2001078775A (ja) * 1999-09-14 2001-03-27 Kokuritsu Seishin Shinkei Center マクロファージ機能調節剤
US20040224306A1 (en) * 1999-11-30 2004-11-11 Frederich-Wilhelm Kuhne Evaluating and predicting clinical outcomes by gene expression analysis
US6685754B2 (en) 2001-03-06 2004-02-03 Alchemix Corporation Method for the production of hydrogen-containing gaseous mixtures
AU2002343609B2 (en) 2001-11-16 2008-12-11 Als Therapy Development Foundation, Inc. Treatment of neurodegenerative disorders through the modulation of the polyamine pathway
US7105183B2 (en) 2004-02-03 2006-09-12 The Regents Of The University Of California Chlorite in the treatment of neurodegenerative disease

Also Published As

Publication number Publication date
AU2005213300A1 (en) 2005-08-25
CA2838392A1 (en) 2005-08-25
US20060159775A1 (en) 2006-07-20
US20170065634A1 (en) 2017-03-09
US20110053186A1 (en) 2011-03-03
CN102423318A (zh) 2012-04-25
US8029826B2 (en) 2011-10-04
US20050181068A1 (en) 2005-08-18
AU2005213300B2 (en) 2011-06-16
CA2554511A1 (en) 2005-08-25
US20120295296A1 (en) 2012-11-22
EP2574342B1 (en) 2018-03-07
CN102423318B (zh) 2015-09-09
EP1711191A2 (en) 2006-10-18
EP2574342A1 (en) 2013-04-03
US7105183B2 (en) 2006-09-12
JP2012067110A (ja) 2012-04-05
CN101102781A (zh) 2008-01-09
EP1711191A4 (en) 2008-12-17
CN101102781B (zh) 2012-06-20
JP5797083B2 (ja) 2015-10-21
WO2005076819A3 (en) 2006-04-13
CA2838392C (en) 2017-04-04
JP2015205901A (ja) 2015-11-19
US9364501B2 (en) 2016-06-14
EP1711191B1 (en) 2014-03-19
WO2005076819A2 (en) 2005-08-25
JP5072367B2 (ja) 2012-11-14
JP2007520554A (ja) 2007-07-26

Similar Documents

Publication Publication Date Title
CA2554511C (en) Chlorite in the treatment of neurodegenerative disease
Zhang et al. Evidence for systemic immune system alterations in sporadic amyotrophic lateral sclerosis (sALS)
Holmgren et al. Biochemical effect of liver transplantation in two Swedish patients with familial amyloidotic polyneuropathy (FAP‐met30)
Mayeux et al. Genetic susceptibility and head injury as risk factors for Alzheimer's disease among community‐dwelling elderly persons and their first‐degree relatives
Bennett et al. A comparison of cyclobenzaprine and placebo in the management of fibrositis
AU2014203207B2 (en) Chlorite in the treatment of neurodegenerative disease
US20170106017A1 (en) Methods and compositions for treatment of macrophage-related disorders
Dominguez et al. Long term outcomes in patients with anti-DPPX autoimmunity
Hartard et al. Wilson's disease with cerebral manifestation: monitoring therapy by CSF copper concentration
Dore et al. Prospective analysis of seizures occurring in human immunodeficiency virus type-1 infection
Ellis et al. Cerebrospinal fluid tau protein is not elevated in HIV-associated neurologic disease in humans
Golden Tourette syndrome: Recent advances
DE69732114T2 (de) Verfahren zum nachweis von autoimmunkrankheiten
Thevos et al. A comparison of psychopathology in cocaine and alcohol dependence
DOBKIN et al. Familial progressive bulbar and spinal muscular atrophy: Juvenile onset and late morbidity with ragged‐red fibers
Haupt et al. Severity of symptoms and rate of progression in Alzheimer's disease: a comparison of cases with early and late onset
Klose 3.2 Publikation II: CSF oligoclonal IgG bands are not associated with ALS progression and prognosis
Briggs et al. Screening depressives for causative medical illness; the example of thyroid function testing: II. Hypothesis testing in ambulatory depressives
Hall Predicting cognitive decline and dementia in elderly twins from indicators of early life oral health
Finkel Steps toward optimal use of Alzheimer-specific drugs

Legal Events

Date Code Title Description
EEER Examination request