CN102405918A - Cycloxaprid water dispersible tablets and preparation method thereof - Google Patents
Cycloxaprid water dispersible tablets and preparation method thereof Download PDFInfo
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- CN102405918A CN102405918A CN2011104410213A CN201110441021A CN102405918A CN 102405918 A CN102405918 A CN 102405918A CN 2011104410213 A CN2011104410213 A CN 2011104410213A CN 201110441021 A CN201110441021 A CN 201110441021A CN 102405918 A CN102405918 A CN 102405918A
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- aqueous dispersion
- epoxy worm
- dispersion tablets
- worm pyridine
- anionic surfactant
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Abstract
The invention belongs to the field of pesticides and discloses cycloxaprid water dispersible tablets and a preparation method thereof. The cycloxaprid water dispersible tablets are prepared by adding a wetting agent, a dispersing agent, a pH regulator and a carrier to cycloxaprid serving as an active ingredient, uniformly mixing, performing airflow smashing till the required fineness is 3-15 mu m, then tabletting and finally drying. The cycloxaprid water dispersible tablets provided by the invention are one type of cycloxaprid preparation formulations and have the advantages of high efficacy, low production cost and the like, and are convenient to meter, safe to use, simple in preparation process, easy to implement.
Description
Technical field
The present invention relates to epoxy worm pyridine formulation and preparation method thereof, particularly a kind of epoxy worm pyridine aqueous dispersion tablets and preparation method thereof.
Background technology
The pyridine of epoxy worm is a kind of high activity, the hypotoxic agricultural insecticide of East China University of Science's research invention.The pyridine of epoxy worm is efficient to homoptera pest; Lepidoptera pest also had the anti-effect of holding concurrently; Particularly great insect brown planthopper of paddy rice and exotic invasive insect Bemisia tabaci are had good control efficiency, can be used for the control of insects such as cabbage aphid, diamond-back moth, rice leaf roller in addition.Synthetic and the purposes of epoxy worm pyridine has at present been applied for Chinese invention patent and International PCT patent, and relevant epoxy worm pyridine aqueous dispersion tablets formulation and preparation method thereof is not also seen relevant report.
Summary of the invention
One of technical problem to be solved by this invention is to the deficiency of prior art a kind of epoxy worm pyridine aqueous dispersion tablets to be provided; This epoxy worm pyridine aqueous dispersion tablets is a kind of of epoxy worm pyridine formulation, and it has that drug effect height, production cost are low, the transportation metering is convenient, safe in utilization and is difficult for causing advantage such as environmental pollution.
Two of technical problem to be solved by this invention is to provide the preparation method of above-mentioned epoxy worm pyridine aqueous dispersion tablets.
Epoxy worm pyridine aqueous dispersion tablets as first aspect present invention is characterized in that, this epoxy worm pyridine aqueous dispersion tablets comprises the pyridine of active ingredient epoxy worm, and formulation is an aqueous dispersion tablets.
Described epoxy worm pyridine aqueous dispersion tablets also comprises auxiliary agent and carrier.
Described auxiliary agent is one or both and the two or more mixing in wetting agent, dispersant, the pH regulator agent.
In specific embodiment of the present invention, be 100% in the raw material total amount of epoxy worm pyridine aqueous dispersion tablets, the weight proportion of each raw material is: epoxy worm pyridine 2～90%, wetting agent 1～10%, dispersant 2～15%, pH regulator agent 1～15%, all the other are carrier.
Described wetting agent is one or both and the two or more mixing in anionic surfactant or the nonionic surface active agent.
Wherein anionic surfactant is Sulfates anionic surfactant or Sulfonates anionic surfactant.
The Sulfates anionic surfactant is specially alkyl sulfate or alkylphenol-polyethenoxy base ether formaldehyde condensation products sulphate.
The Sulfonates anionic surfactant is specially neopelex, alkylnaphthalene sulfonate, dialkyl succinylsuccinate sulfonate, monoalkyl benzene polyoxyethylene groups ether succinic acid sodium sulfonate or alkyl amide taurate.
Nonionic surface active agent is aliphatic alcohol polyethenoxy base ether or alkylphenol-polyethenoxy base ether.
Described dispersant is anionic surfactant, nonionic surface active agent, water-soluble high-molecular substance, inorganic dispersant, sulfite paper slurries and does one or both and the two or more mixing in the solid natural products.
Wherein anionic surfactant is the naphthalene of Sulfonates or the alkylaryl sulfonates of alkyl naphthalene formaldehyde condensate sulfonates, fatty alcohol ethylene oxide adduct sulfonate, alkylphenol-polyethenoxy base sulfonate, lignin and derivative sulfonate or polymerization; Polycarboxylic acid salt's Sodium Polyacrylate, the fatty alcohol ethylene oxide adduct phosphate of phosphoric acid salt or alkylphenol-polyethenoxy base ether phosphate salt.
Nonionic surface active agent is polyoxyethylene polyoxyethyl propyl ether block copolymers or alkylphenol-polyethenoxy base phosphate.
Water-soluble high-molecular substance is polyvinyl alcohol, polyethylene glycol or polyvinylpyrrolidone.
Inorganic dispersant is a condensed phosphate.
Described pH regulator agent is a kind of in inorganic base, inorganic acid, organic base, the organic acid, is preferably sodium hydroxide, sodium carbonate, sodium bicarbonate, a kind of in benzoic acid, the citric acid.
Described carrier is one or both and the two or more mixing in diatomite, white carbon, bentonite, kaolin, precipitated calcium carbonate and the attapulgite.
Preparation method as the epoxy worm pyridine aqueous dispersion tablets of second aspect present invention; It is that each component is carried out just pulverizing; By weight preparing the back mixing, in airslide disintegrating mill, be crushed to required fineness 3～15 μ m, direct powder compression is epoxy worm pyridine aqueous dispersion tablets.
Epoxy worm pyridine aqueous dispersion tablets controlling object of the present invention comprises brown planthopper, insects such as small brown rice planthopper, white-backed planthopper, aphid, leafhopper, thrips, little amber stinkbug, Bemisia tabaci, rice leaf roller.
Embodiment
In order to make the object of the invention, technical scheme and advantage clearer and more definite, below in conjunction with instance the present invention is done to describe in further detail, describe only limiting to better explain the present invention here, and be not used in qualification the present invention.Embodiment provides the prescription of part epoxy worm pyridine aqueous dispersion tablets for the technical staff, and the technical staff can prepare with reference to these prescriptions.
Embodiment 1
By weight percentage epoxy worm pyridine 25%, calcium lignosulfonate 5%, lauryl sodium sulfate 2%, sodium carbonate 2%, white carbon 6%, kaolin are complemented to 100%; Calcium lignosulfonate carries out coarse crushing earlier; Each component is by weight preparing the back mixing; In airslide disintegrating mill, be crushed to 3～15 μ m, with the 25% epoxy worm pyridine aqueous dispersion tablets that is of direct powder compression gained.
Embodiment 2
By weight percentage epoxy worm pyridine 50%, calcium lignosulfonate 4%, Negel 3%, sodium bicarbonate 4%, white carbon 8%, kaolin are complemented to 100%; Calcium lignosulfonate carries out coarse crushing earlier; Each component is by weight preparing the back mixing; In airslide disintegrating mill, be crushed to 3～15 μ m, with the 50% epoxy worm pyridine aqueous dispersion tablets that is of direct powder compression gained.
Embodiment 3
25% epoxy worm pyridine aqueous dispersion tablets toxicity test:
With the 25% epoxy worm pyridine aqueous dispersion tablets agar of embodiment 1 leaf dipping method of preserving moisture, measure insecticidal effect to the Type B Bemisia tabaci.Mensuration result shows that the pyridine of epoxy worm has good insecticidal effect to the Type B Bemisia tabaci, is 3.49mg/L to the LC50 of Type B Bemisia tabaci sensitive strain, and the virulence LC50 of contrast medicament thiophene worm piperazine commonly used is 18.06mg/L.The pyridine of antagonism strain epoxy worm has also showed stronger effect, and the LC50 of epoxy worm pyridine antagonism Type B Bemisia tabaci is 12.33mg/L, and the LC50 of thiophene worm piperazine antagonism Type B Bemisia tabaci is 1386.6mg/L.
Embodiment 4
Different dosage form relatively
25% epoxy worm pyridine aqueous dispersion tablets, 25% epoxy worm pyridine wetting powder, the experiment of sub-district, 10% epoxy worm pyridine suspending agent field experiment control cabbage aphid with embodiment 1; The experimental result of 7 days and 14 days behind the investigation medicine; The result shows that drug effect does not have evident difference between different dosage form, and to supplying to study thing wild cabbage safety.Experimental result sees the following form:
| Medicament | Dosage (ai.g/ mu) | Preventive effect after 7 days, % | Preventive effect after 14 days, % |
| 25% epoxy worm pyridine aqueous dispersion tablets | 2 | 91.3 | 89.9 |
| 25% epoxy worm pyridine wetting powder | 2 | 90.6 | 89.3 |
| 10% epoxy worm pyridine suspending agent | 2 | 89.7 | 89.5 |
Claims (9)
1. epoxy worm pyridine aqueous dispersion tablets is characterized in that, this epoxy worm pyridine aqueous dispersion tablets comprises the pyridine of active ingredient epoxy worm, and formulation is an aqueous dispersion tablets.
2. epoxy worm pyridine aqueous dispersion tablets as claimed in claim 1 is characterized in that, also comprises auxiliary agent and carrier.
3. epoxy worm pyridine aqueous dispersion tablets as claimed in claim 2 is characterized in that, described auxiliary agent is one or both and the two or more mixing in wetting agent, dispersant, the pH regulator agent.
4. epoxy worm pyridine aqueous dispersion tablets as claimed in claim 3; It is characterized in that, be 100% in the raw material total amount of epoxy worm pyridine aqueous dispersion tablets, and the weight proportion of each raw material is: epoxy worm pyridine 2～90%; Wetting agent 1～10%; Dispersant 2～15%, pH regulator agent 1～15%, all the other are carrier.
5. epoxy worm pyridine aqueous dispersion tablets as claimed in claim 4 is characterized in that, described wetting agent is one or both and the two or more mixing in anionic surfactant or the nonionic surface active agent; Wherein anionic surfactant is Sulfates anionic surfactant or Sulfonates anionic surfactant; The Sulfates anionic surfactant is specially alkyl sulfate or alkylphenol-polyethenoxy base ether formaldehyde condensation products sulphate; The Sulfonates anionic surfactant is specially neopelex, alkylnaphthalene sulfonate, dialkyl succinylsuccinate sulfonate, monoalkyl benzene polyoxyethylene groups ether succinic acid sodium sulfonate or alkyl amide taurate; Nonionic surface active agent is aliphatic alcohol polyethenoxy base ether or alkylphenol-polyethenoxy base ether.
6. epoxy worm pyridine aqueous dispersion tablets as claimed in claim 4; It is characterized in that described dispersant is anionic surfactant, nonionic surface active agent, water-soluble high-molecular substance, inorganic dispersant, sulfite paper slurries and does one or both and the two or more mixing in the solid natural products; Wherein anionic surfactant is the naphthalene of Sulfonates or the alkylaryl sulfonates of alkyl naphthalene formaldehyde condensate sulfonates, fatty alcohol ethylene oxide adduct sulfonate, alkylphenol-polyethenoxy base sulfonate, lignin and derivative sulfonate or polymerization; Polycarboxylic acid salt's Sodium Polyacrylate, the fatty alcohol ethylene oxide adduct phosphate of phosphoric acid salt or alkylphenol-polyethenoxy base ether phosphate salt; Nonionic surface active agent is polyoxyethylene polyoxyethyl propyl ether block copolymers or alkylphenol-polyethenoxy base phosphate; Water-soluble high-molecular substance is polyvinyl alcohol, polyethylene glycol or polyvinylpyrrolidone; Inorganic dispersant is a condensed phosphate.
7. epoxy worm pyridine aqueous dispersion tablets as claimed in claim 4 is characterized in that, described pH regulator agent is a kind of in inorganic base, inorganic acid, organic base, the organic acid.
8. epoxy worm pyridine aqueous dispersion tablets as claimed in claim 4 is characterized in that, described carrier is one or both and the two or more mixing in diatomite, white carbon, bentonite, kaolin, precipitated calcium carbonate and the attapulgite.
9. the preparation method of an epoxy worm pyridine aqueous dispersion tablets as claimed in claim 4; It is characterized in that each component is carried out just pulverizing; By weight preparing the back mixing, in airslide disintegrating mill, be crushed to required fineness 3～15 μ m, the direct powder compression gained be epoxy worm pyridine aqueous dispersion tablets.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011104410213A CN102405918A (en) | 2011-12-25 | 2011-12-25 | Cycloxaprid water dispersible tablets and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011104410213A CN102405918A (en) | 2011-12-25 | 2011-12-25 | Cycloxaprid water dispersible tablets and preparation method thereof |
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| Publication Number | Publication Date |
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| CN102405918A true CN102405918A (en) | 2012-04-11 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN2011104410213A Pending CN102405918A (en) | 2011-12-25 | 2011-12-25 | Cycloxaprid water dispersible tablets and preparation method thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103493830A (en) * | 2013-10-11 | 2014-01-08 | 江苏龙灯化学有限公司 | Pesticide composition containing cycloxaprid and chlorfenapyr |
| CN107433167A (en) * | 2017-09-18 | 2017-12-05 | 盐城方正医药科技有限公司 | It is a kind of to be pulverized and mixed the high Azithromycin dispersible tablet preparation facilities of quality |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102197807A (en) * | 2011-03-31 | 2011-09-28 | 上海生农生化制品有限公司 | Cycloxaprid wettable powder and preparation method thereof |
| CN102197808A (en) * | 2011-03-31 | 2011-09-28 | 上海生农生化制品有限公司 | Cycloxaprid water dispersible granule and preparation method thereof |
-
2011
- 2011-12-25 CN CN2011104410213A patent/CN102405918A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102197807A (en) * | 2011-03-31 | 2011-09-28 | 上海生农生化制品有限公司 | Cycloxaprid wettable powder and preparation method thereof |
| CN102197808A (en) * | 2011-03-31 | 2011-09-28 | 上海生农生化制品有限公司 | Cycloxaprid water dispersible granule and preparation method thereof |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103493830A (en) * | 2013-10-11 | 2014-01-08 | 江苏龙灯化学有限公司 | Pesticide composition containing cycloxaprid and chlorfenapyr |
| CN107433167A (en) * | 2017-09-18 | 2017-12-05 | 盐城方正医药科技有限公司 | It is a kind of to be pulverized and mixed the high Azithromycin dispersible tablet preparation facilities of quality |
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| C53 | Correction of patent of invention or patent application | ||
| CB03 | Change of inventor or designer information |
Inventor after: Shen Jianzhong Inventor after: Li Zhong Inventor after: Xu Xiaoyong Inventor after: Ye Zhenhui Inventor after: Xu Zhiping Inventor after: Zhang Zhiping Inventor after: Qian Xuhong Inventor before: Shen Jianzhong Inventor before: Li Zhong Inventor before: Xu Xiaoyong Inventor before: Ye Zhenhui Inventor before: Xu Zhiping Inventor before: Zhang Zhiping Inventor before: Qian Xuhong |
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Application publication date: 20120411 |