CN106719711A - Bactericidal composition and its application - Google Patents
Bactericidal composition and its application Download PDFInfo
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- CN106719711A CN106719711A CN201611082145.6A CN201611082145A CN106719711A CN 106719711 A CN106719711 A CN 106719711A CN 201611082145 A CN201611082145 A CN 201611082145A CN 106719711 A CN106719711 A CN 106719711A
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- bactericidal composition
- thiophene
- amine
- acid amide
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- HIEHAIZHJZLEPQ-UHFFFAOYSA-M sodium;naphthalene-1-sulfonate Chemical compound [Na+].C1=CC=C2C(S(=O)(=O)[O-])=CC=CC2=C1 HIEHAIZHJZLEPQ-UHFFFAOYSA-M 0.000 description 1
- 239000002689 soil Substances 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 229960005137 succinic acid Drugs 0.000 description 1
- 150000003460 sulfonic acids Chemical class 0.000 description 1
- 230000021918 systemic acquired resistance Effects 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 229940104261 taurate Drugs 0.000 description 1
- XOAAWQZATWQOTB-UHFFFAOYSA-N taurine Chemical compound NCCS(O)(=O)=O XOAAWQZATWQOTB-UHFFFAOYSA-N 0.000 description 1
- 150000004867 thiadiazoles Chemical class 0.000 description 1
- 230000005945 translocation Effects 0.000 description 1
- 150000003628 tricarboxylic acids Chemical class 0.000 description 1
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- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention discloses a kind of bactericidal composition and its application, belong to pesticide field, the bactericidal composition active ingredient lures amine (A) and acid amide fungicides (B) for first thiophene, and (A) is 1 with (B) weight ratio：30~40：1, preferable ratio is 1:15~20:1, more preferable ratio is 1：7~10：1.Acid amide fungicides (B) can select Boscalid, thifluzamide, furametpyr etc..Said composition allows the auxiliary element for using to be processed into any formulation in can adding other agricultural chemicals.The effect of the bactericidal composition is apparently higher than (A) and (B) single dose, with obvious synergistic effect, effectively reduce the amount of application of each single dose, preferably act on expanding fungicidal spectrum and delaying the plant resistance to the action of a drug to have, can effectively prevent and treat tobacco virus, balck shank, early blight of tomato, late blight, cucumber downy mildew, capsicum epidemic disease, damping-off etc..
Description
Technical field
The present invention relates to a kind of bactericidal composition, a kind of sterilization for luring amine and acid amide fungicides containing first thiophene is particularly related to
Composition and its application.
Background technology
In agricultural production, crops can healthy growth, in addition to being influenceed by worm, crop smothering, the preventing and treating to disease is also very heavy
Will.Reinforcement and sustainable development implementation with environmental protection ideas, efficient, low toxicity, high activity, low-residual are sent out as agricultural chemicals
The inexorable trend of exhibition.However, even efficient germicide, long-term exclusive use, also easily makes disease develop immunity to drugs, cause to use
The problems such as dose is increased, preventive effect is reduced, the lasting period shortens, is unfavorable for environment sustainable development.Therefore, how Scientific Usage of Drugs, drop
The consumption of low chemical pesticide, improves drug effect, as the problem that plant protection art is badly in need of solving.
It is a kind of thiadiazoles that Lier Chemical Co., Ltd and Nankai University develop jointly that first thiophene lures amine (SZG)
Class plant disease-proof activator, general entitled N- (5- methyl isophthalic acids, 3- the thiazol-2-yls) -4- methyl isophthalic acids of chemistry, 2,3- thiadiazoles -5-
Formamide, its structural formula is such as shown in (I).Current result of study shows that the compounds on viral disease has induction well
Disease resisting effect, mechanism of action is induction plant generation system, the anti-disease activity of wide spectrum.Plant disease-proof activator is to enjoy in recent years
The one class novelty agricultural chemicals of concern, itself has no obvious bactericidal activity, but can induce and plant as the immunoactivator of plant
Thing systemic acquired resistance, so as to reach the purpose of defending and fighting against diseases.Wherein, BTH (diazosulfide, the production of Syngenta Co., Ltd of Switzerland)
Representative Cultivars with TDL (tiadinil, Nihon Nihyaku Co., Ltd's production) is such medicament, obtain in agricultural production at present
To widely applying.But because first thiophene lures amine single dose unstable in variable rate technology, result in preventive effect and produce certain fluctuation, and it is right
The plant for having fallen ill is without good therapeutic action.
Acid amide fungicides occupy considerable status in world bactericide market, through true frequently as Peronosporales is prevented and treated
The special agent of bacterium, with significant protection, treatment and eradicant action, is widely used in the preventing and treating of plant disease.However, due to
Acid amide fungicides act on single to germ, once germ is undergone mutation, medicament can not normally play a role, and thus result in disease
Bacterium is also easy to produce the resistance to the action of a drug.The common acid amide fungicides kind of in the market is:Dimethomorph, Boscalid, thifluzamide, furan pyrrole bacterium
Amine and metalaxyl etc..
Dimethomorph, its structural formula is such as shown in (II).Be it is single-minded kill Oomycete fungal bactericide, its action character be destruction
The formation of cell envelope, has effect to each stage of the oomycetes history of life, outstanding in the formation stages of sporangiophore and egg spore
It is sensitivity, at much lower concentrations (<0.25 μ g/ml) it is to be suppressed.Exclusive use have comparing resistance risk high, so often with
Protective fungicide compounding use, with the generation of delaying drug resistance.
Boscalid, its structural formula is such as shown in (III).It is the new nicotinamide sterilization developed by BASF Aktiengesellschaft
Agent, is mainly used in preventing and treating powdery mildew, gray mold, various rots, brown rot and root rot etc., in 2004 in Britain, moral
State and Switzerland register.Boscalid belongs to butanedioic acid ubiquinone reductase inhibitor in mitochondrial respiratory chain, and the sprouting to spore has
Very strong rejection ability, and with other bactericide no interactions resistances.
Thifluzamide, its structural formula is such as shown in (IV).It is a kind of succinate dehydrogenase inhibitor, i.e., in fungi tricarboxylic acids
Suppress the synthesis of succinate dehydrogenase in circulation.Can prevent and treat caused by multiple diseases, particularly basidiomycetes Rhizoctonia fungi
Disease, while having very strong Uptake and translocation.But to the disease caused by leaf portion pathogen, such as cercospora brown spot of peanut and black
Pinta effect is bad.
Furametpyr, its structural formula is such as shown in (V).It is the novel amide-type developed by SUMITOMO CHEMICAL chemical industrial company
Bactericide.From 1989, in laboratory and field prevent and treat the thoroughgoing and painstaking research of banded sclerotial blight, as a result show：With can
WP, pulvis foliage application basin irrigation dispenser preventing and treating sheath and culm blight of rice preventive effect brilliance with granule.But due to using all the year round,
Crop has produced the serious resistance to the action of a drug to this, causes the medicament lasting period to shorten, and formulation rate increases, prevention effect reduction.
Metalaxyl, its structural formula is such as shown in (VI).It is first bactericide with three-dimensional optically active of listing, can uses
In Seed Treatment, soil treatment and cauline leaf process.Be have protection therapeutic action systemic fungicide, can by the root of plant,
Stem, leaf absorb, and are transferred to all parts of a plant with Dynamic water transport in plant.But due to using all the year round, crop is
The serious resistance to the action of a drug is produced to this, has caused the medicament lasting period to shorten, formulation rate has increased, prevention effect reduction.
Frequently using containing single-activity component bactericide, causes most germs to generate the resistance to the action of a drug, and preventive effect is not
It is preferable.Therefore, it is badly in need of the sterilised products that a kind of novel product substitutes single-activity component, increases the resistance to the action of a drug that drug effect delays disease
Risk, reduces economic loss.
The content of the invention
For above-mentioned situation, the present invention provides a kind of bactericidal composition, to meet agricultural production the need for, institute in composition
Comprising active component there is synergistic effect to improve preventive effect and be beneficial to delay the drug-fast generation of germ mutually.
In order to solve the above technical problems, present invention offer technical scheme is as follows：
Bactericidal composition of the invention, its active ingredient lures amine and acid amide fungicides, first thiophene to lure amine and acid amides for first thiophene
The weight ratio of series bactericidal agent is 1：30~40：1, preferably weight ratio is 1：15~20：1, more preferably weight ratio is 1：7~
10：1.
The acid amide fungicides, can be fluopicolide, pyridine bacterium amine, Guardian, cyflufenamid, thiophene fluorine bacterium
In amine, zoxamide, fenhexamid, Silthiopham, dimethomorph, Boscalid, thifluzamide, furametpyr or metalaxyl
Any one.According to experiment effect, preferably dimethomorph, Boscalid, thifluzamide, furametpyr or metalaxyl enters the present invention
Row compounding.
Pesticidal preparations auxiliary element can also be contained in bactericidal composition of the present invention, be adapted to agriculturally use to be made
Formulation.
Composition of the invention can also add auxiliary addition agent includes wetting agent, dispersant, emulsifying agent, solvent and filler
Deng and other be beneficial to the known substance that active ingredient is stablized in the formulation and drug effect is played, be all to commonly use or fair in pesticidal preparations
Perhaps the various composition for using, has no specific restriction, possesses composition and consumption and is determined by simple experiment according to recipe requirements.
Bactericidal composition of the invention can be prepared into any one formulation of suitable agricultural use with known method, than
Preferable formulation is suspended emulsion (SE), wettable powder (WP), water dispersible granules (WDG), suspending agent (SC), dry suspending agent
(DF) etc..
A. the preparation of suspended emulsion (suspoemulsiob, abbreviation SE)：Solid active compound is reached into certain fineness by sand milling
Liquid active compound, surfactant, solvent is added to be mixed after being sheared using high shear dispersion machine after mixing afterwards.
B. wettable powder (WP), be can be dispersed in water solid powder preparation.Wettable powder of the present invention is removed
To in active compound plus such as outside white carbon, precipitated calcium carbonate, potter's clay, diatomite, attapulgite diluent or inert substance, also
Ionic or nonionic surface active agent (wetting agent, dispersant), wetting agent is for example, alkylbenzenesulfonate (DBS-Na), alkane
Base naphthalene sulfonate (pull open powder), alkylphenol-polyethenoxy base ether sulfate, alkylphenol-polyethenoxy base ether formaldehyde condensation products sulfuric acid
Salt, aliphatic alcohol sulfate, fatty alcohol ethylene oxide adduct sulfonate, alkyl amide taurate, aliphatic alcohol polyethenoxy base
Ether (JFC), content 0.1~30%；Dispersant such as naphthalene sulfonate, naphthalene or alkyl naphthalene formaldehyde condensate sulfonates (NO, NN0, MF),
Lignin and its derivative sulfonate (M-9, POLYFON etc.), polyoxyethylene poly-oxygen propylene aether block copolymer, alkyl phenol polyoxy
Vinyl ethers formaldehyde condensation products sulfate (SOPA), PVA, CMC content 0.1~30%；Also contain penetrating agent JFC, azone, thiophene
One or more material among ketone, penetrant t, content 0.3~30%；Stabilizer, foam inhibitor, anticaking agent can also be contained
Deng other auxiliary agents.
C. water dispersible granules (WDG), is that can be comparatively fast disintegrated in water, disperse to form the granule of higher suspension dispersion.
By active component, the key element such as the auxiliary agent such as wetting agent, dispersant, interleaving agent, disintegrant, stabilizer, adhesive and carrier composition.Its
Auxiliary agent and carrier, and the compound method of precursor (preformed objects before granulation) are analogous to wettable powder and suspending agent substantially.
D. dry suspending agent (Dry Flowable, abbreviation DF), is that can be comparatively fast disintegrated in water, disperse to form higher suspension dispersion
The granule of system.Preparation method：The preparation obtained by the dehydration of suspending agent.Its auxiliary agent and carrier, and precursor (are dehydrated
Preceding preformed objects) compound method it is consistent with suspending agent.
E. suspending agent (SC), is the not dispersion of water soluble solid agricultural chemicals or immiscible liquids agricultural chemicals in water or oil.By living
Property composition, auxiliary agent (wetting dispersing agent, thickener, stabilizer, pH adjusting agent, defoamer, antifreezing agent) are through soybean dietary fiber system
.Wetting dispersing agent can be naphthalene or alkyl naphthalene formaldehyde condensate sulfonates (NO, NN0, MF), lignin and its derivative sulfonic acid
Salt (M-9, POLYFON etc.), alkylphenol-polyethenoxy base ether sulfonate, polyoxyethylene polyoxypropylene base ether block copolymers, alkane
Base phenol polyethenoxy base phosphate, carboxymethylcellulose calcium (CMC), polyvinylpyrrolidone (PVP), polyethylene glycol (PEG), condensation
One or more in phosphate etc., content 0.1~12%；Thickener and stabilizer can be xanthan gum (XG), polyethylene
One or more in alcohol (PVA), Magnesiumaluminumsilicate etc., content 0.05~0.5%；PH adjusting agent and defoamer can be optionally appropriate
Addition.
Product described in the invention can be provided in finished product preparation form, i.e., each material is blended in compound, combination
The composition of thing can also be provided with unit dose form, directly directly be mixed in bucket or tank using preceding, needed for being then diluted to
Concentration.
Bactericidal composition of the invention can be used to prevent and treat plurality of plant diseases, be particularly suited for preventing and treating tobacco virus, black
The phytopathies such as shin disease, early blight of tomato, late blight, cucumber downy mildew, capsicum epidemic disease, damping-off, the cercospora brown spot of peanut, black spot
Evil.Composition of the invention can be applied by common method, such as cast, injection, spraying, dusting or spread, its amount of application with
Weather condition or crop condition change.
Compared with prior art, the beneficial effects of the present invention are：1st, compared with single dose, there is compounding obvious collaboration to increase
Effect is acted on, and improves prevention effect；2nd, composition is made up of two kinds of different active ingredients of mechanism of action, is conducive to overcoming and prolongs
The drug-fast generation of slow germ；3rd, medicament mixture reduces dosage, so as to reduce cost and alleviate the pollution to environment；
4th, it is not only effective to plant epiphyte crop disease, and anti-and treatment viral diseases of plants can be lured.The present invention is to tobacco virus, black
The virus diseases such as shin disease, early blight of tomato, late blight, cucumber downy mildew, capsicum epidemic disease, damping-off, the cercospora brown spot of peanut, black spot
There is preferable prevention effect with bacterial fungus disease.
Specific embodiment
For the technical problem, technical scheme and the advantage that to be solved embodiments of the invention are clearer, below by apparatus
Body embodiment is described in detail, but the present invention is limited to absolutely not these examples.As described below is only the present invention preferably embodiment,
Only it is used to explain the present invention, therefore can not be interpreted as the limitation to the scope of the claims of the present invention.It should be pointed out that it is all
Any modification, equivalent and improvement for being made within the spirit and principles in the present invention etc., should be included in protection of the invention
Within the scope of.Therefore, the protection domain of patent of the present invention should be determined by the appended claims.
The combination of active principles of different agricultural chemicals is made agricultural chemicals, is to develop and develop novel pesticide and preventing and treating at present agriculturally
A kind of effective and quick way of resistance germ.After the pestsides synthesis of different cultivars, a large amount of three kinds of effects classes are typically exhibited
Type：Summation action, synergistic effect and antagonism.Compound synergic is formulated well, can significantly improve actual prevention effect, drop
The usage amount of low agricultural chemicals, is the important means of integrated control disease so as to help to delay the drug-fast generation speed of germ.
The present composition lures amine (A) for a kind of active ingredient with first thiophene, acid amide fungicides (B) for it is another effectively into
Point, combined between them has obvious synergistic function to plant epiphyte class disease and virus type disease, and is not only
Two kinds of simple superposition of pharmacy effect, this can be clearly understood that from following test result.
In order to prevent and treat the cucumber downy mildew in agricultural production, inventor lures amine and acid amide fungicides-alkene acyl with first thiophene
Quinoline or metalaxyl have carried out the synergy research of mutual compounding, and specific method is：
It is test object that experiment uses downy mildew.
The test medicine that active compound is configured to need, test method reference《People's Republic of China's agricultural industry criteria》.
Single dose and each Mixed Pharmacy are set into 5 various concentrations gradients (on the basis of pilot study result, according to different agents first
Combination is different with proportioning, and concentration sets also different, and bacteriostasis rate sets in the range of 5%~90%).If clear water is compareed,
It is repeated 3 times.Using half live body method (plate blade method), the Pseudoperonospora cubensis spore liquid inoculation that will be prepared is everywhither in reason blade
Centre, after putting in 25 DEG C of constant temperature and humidity incubators culture four days；Lesion diameter (crossing method) is checked, each treatment is calculated and is suppressed disease
The percentage of spot growth, by the linear regression analysis between the probit value of inhibiting rate and the logarithm value of series concentration, obtains each
The EC of medicament50Value, the co-toxicity coefficient (CTC) of mixture is calculated with co-toxicity coefficient meter, and reagent agent is evaluated to germ with this
Activity.
(CTC)≤120 show as synergistic effect to the co-toxicity coefficient of complex preparation；CTC≤80 show as antagonism；80 ﹤
CTC ﹤ 120 show as summation action.
The first thiophene of table 1 lures amine to be compounded with dimethomorph and the indoor harmacological effect of cucumber downy mildew is determined
| Chemicals treatment | Virulence regression equation | EC50(mg/L) | Co-toxicity coefficient (CTC) |
| First thiophene lures amine (A) | Y=1.7344+1.9691X | 45.5450 | —— |
| Dimethomorph (B) | Y=1.7509+2.0479X | 38.6011 | —— |
| A：B=1:30 | Y=2.8009+1.5354X | 27.0529 | 143.39 |
| A：B=1:15 | Y=2.9474+1.5828X | 19.8187 | 196.65 |
| A：B=1:7 | Y=2.9509+1.6734X | 16.7708 | 234.64 |
| A：B=1:1 | Y=2.9690+1.7170X | 15.2371 | 274.24 |
| A：B=10:1 | Y=2.8132+1.6267X | 22.0934 | 202.83 |
| A：B=20:1 | Y=2.8010+1.5893X | 24.1912 | 186.67 |
| A：B=40:1 | Y=2.8009+1.5354X | 27.0529 | 167.62 |
The first thiophene of table 2 lures amine that the Toxicity Determination to cucumber downy mildew is compounded with metalaxyl
| Chemicals treatment | Virulence regression equation | EC50(mg/L) | Co-toxicity coefficient (CTC) |
| First thiophene lures amine (A) | Y=1.7344+1.9691X | 45.5450 | —— |
| Metalaxyl (F) | Y=2.2672+1.5501X | 57.9453 | —— |
| A：F=1:30 | Y=2.4845+1.5534X | 41.6248 | 137.99 |
| A：F=1:15 | Y=2.4753+1.5969X | 38.1095 | 149.51 |
| A：F=1:7 | Y=2.9400+1.5383X | 21.8358 | 256.63 |
| A：F=1:1 | Y=2.9711+1.5701X | 19.5965 | 260.26 |
| A：F=10:1 | Y=2.9794+1.4297X | 25.8997 | 179.34 |
| A：F=20:1 | Y=2.7247+1.5272X | 30.8931 | 148.95 |
| A：F=40:1 | Y=2.4394+1.6388X | 36.5165 | 125.38 |
Toxicity Determination result shows that first thiophene lures amine and dimethomorph compounding, first thiophene to lure amine and metalaxyl compounding to Huang
Melon downy mildew has obvious synergistic effect, and prevention effect is better than single dose kind.Inventor by test find, first thiophene lure amine with
Other acid amide fungicides (such as Boscalid, thifluzamide, furametpyr) are compounded, and have similar effect to cucumber downy mildew
Really.
In order to prevent and treat tomato late blight in agricultural production, inventor lures amine and acid amide fungicides-Boscalid with first thiophene
The synergy research of mutual compounding is carried out, specific method is：
It is test object that experiment uses tomato late blight.
The test medicine that active compound is configured to need, test method reference《People's Republic of China's agricultural industry criteria》.
Single dose and each Mixed Pharmacy are set into 5 various concentrations gradients (on the basis of pilot study result, according to different agents first
Combination is different with proportioning, and concentration sets also different, and bacteriostasis rate sets in the range of 5%~90%).If clear water is compareed,
It is repeated 3 times.Using pot-culture method, it is inoculated with each treatment, is placed in 28 DEG C of constant temperature and humidity incubators and cultivates 4d；Check lesion diameter
(crossing method), calculates the percentage that each treatment suppresses scab growth, by the right of the probit value of inhibiting rate and series concentration
Linear regression analysis between numerical value, obtains the EC of each medicament50Value, the co-toxicity coefficient of mixture is calculated with co-toxicity coefficient meter
(CTC) activity of the reagent agent to germ, is evaluated with this.
The first thiophene of table 3 lures amine to be compounded with Boscalid and the indoor harmacological effect of tomato late blight is determined
| Chemicals treatment | Virulence regression equation | EC50(mg/L) | Co-toxicity coefficient (CTC) |
| First thiophene lures amine (A) | Y=1.7344+1.9691X | 45.5450 | —— |
| Boscalid (C) | Y=2.6278+1.5349X | 35.1207 | —— |
| A：C=1:30 | Y=2.9480+1.7181X | 15.6444 | 226.17 |
| A：C=1:15 | Y=3.0215+1.7140X | 14.2664 | 249.75 |
| A：C=1:7 | Y=3.1129+1.7219X | 12.4706 | 289.92 |
| A：C=1:1 | Y=3.2078+1.7559X | 10.4874 | 378.16 |
| A：C=10:1 | Y=2.8305+1.7827X | 16.4803 | 269.09 |
| A：C=20:1 | Y=2.8312+1.7346X | 17.7962 | 252.36 |
| A：C=40:1 | Y=2.8451+1.6902X | 18.8316 | 240.12 |
Toxicity Determination result shows that first thiophene lures amine to be compounded with Boscalid has obvious synergy to tomato late blight
Effect, prevention effect is better than single dose kind.Inventor has found by test, and first thiophene lures amine and other acid amide fungicides (such as alkene
Morpholide, thifluzamide, furametpyr, metalaxyl etc.) compounding, there is similar effect to tomato late blight.
In order to prevent and treat rice sheath blight disease in agricultural production, inventor lures amine and acid amide fungicides-furametpyr with first thiophene
The synergy research of mutual compounding is carried out, specific method is：
It is test object that experiment uses banded sclerotial blight.
The test medicine that active compound is configured to need, test method reference《People's Republic of China's agricultural industry criteria》.
Single dose and each Mixed Pharmacy are set into 5 various concentrations gradients (on the basis of pilot study result, according to different agents first
Combination is different with proportioning, and concentration sets also different, and bacteriostasis rate sets in the range of 5%~90%).If clear water is compareed,
It is repeated 3 times.Using pot-culture method, it is inoculated with each treatment, is placed in 28 DEG C~30 DEG C constant temperature and humidity incubators and cultivates 2d；Check disease
Spot length, calculates the percentage that each treatment suppresses scab growth, by the logarithm value of the probit value of inhibiting rate and series concentration it
Between linear regression analysis, obtain the EC of each medicament50Value, the co-toxicity coefficient (CTC) of mixture is calculated with co-toxicity coefficient meter, with this
To evaluate activity of the reagent agent to germ.
The first thiophene of table 4 lures amine to be compounded with furametpyr and the indoor harmacological effect of rice sheath blight disease is determined
| Chemicals treatment | Virulence regression equation | EC50(mg/L) | Co-toxicity coefficient (CTC) |
| First thiophene lures amine (A) | Y=1.7344+1.9691X | 45.5450 | —— |
| Furametpyr (E) | Y=4.0225+0.6603X | 30.2333 | —— |
| A：E=1:30 | Y=4.1857+0.6617X | 17.0025 | 179.77 |
| A：E=1:15 | Y=4.2189+0.6590X | 15.3213 | 201.56 |
| A：E=1:7 | Y=4.2531+0.6699X | 13.0309 | 242.19 |
| A：E=1:1 | Y=4.2618+0.6771X | 12.3084 | 295.26 |
| A：E=10:1 | Y=4.2123+0.6684X | 15.0811 | 288.69 |
| A：E=20:1 | Y=4.0622+0.7110X | 20.8401 | 213.40 |
| A：E=40:1 | Y=3.9927+0.7084X | 26.4243 | 170.26 |
Toxicity Determination result shows that first thiophene lures amine to be compounded with furametpyr has obvious synergy to rice sheath blight disease
Effect, prevention effect is better than single dose kind.Inventor has found by test, and first thiophene lures amine and other acid amide fungicides (such as alkene
Morpholide, Boscalid, thifluzamide, metalaxyl etc.) compounding, there is similar effect to rice sheath blight disease.
In order to prevent and treat tobacco virus in agricultural production, inventor lures amine and acid amide fungicides-thifluzamide with first thiophene
The synergy research of mutual compounding is carried out, specific method is：
It is test object that experiment uses tobacco virus.
The test medicine that active compound is configured to need, test method reference《People's Republic of China's agricultural industry criteria》.
Single dose and each Mixed Pharmacy are set into 5 various concentrations gradients (on the basis of pilot study result, according to different agents first
Combination is different with proportioning, and concentration sets also different, and bacteriostasis rate sets in the range of 5%~90%).If clear water is compareed,
It is repeated 3 times.Using pot-culture method, to tobacco virus is inoculated with each treatment, it is placed in 28 DEG C~30 DEG C constant temperature and humidity incubators and cultivates
5d；The morbidity scab number on each treatment inoculation blade is checked, the percentage that each treatment suppresses scab growth is calculated, by inhibiting rate
Probit value and the logarithm value of series concentration between linear regression analysis, obtain the EC of each medicament50Value, uses co-toxicity coefficient meter
The co-toxicity coefficient (CTC) of mixture is calculated, activity of the reagent agent to germ is evaluated with this.
The first thiophene of table 5 lures amine to be compounded with thiophene fluorine bacterium amine and the indoor harmacological effect of virosis is determined
Toxicity Determination result shows that first thiophene lures amine to be compounded with thiophene fluorine bacterium amine has obvious synergy to tobacco virus
Effect, prevention effect is better than single dose kind.Inventor has found by test, and first thiophene lures amine and other acid amide fungicides (such as alkene
Morpholide, Boscalid, furametpyr, metalaxyl etc.) compounding, there is similar effect to tobacco virus.
Bactericidal composition of the invention can be prepared into any one formulation of suitable agricultural use with known method, than
Preferable formulation is wettable powder, aqueous suspension agent, oil-suspending agent, suspended emulsion, water dispersible granules.It is right with reference to embodiments
Present invention is described further, and percentage is weight percentage in all formulas.The various formulations of the present composition
Processing technology is prior art, can be varied from according to different situations.
Embodiment 1：32% first thiophene lures amine furametpyr suspending agent
2% first thiophene is weighed respectively lures amine, 30% furametpyr, 4% polycarboxylic acids sodium, 3% AEO, 6%
Ethylene glycol, 0.35%XG, 0.6% organic silicon defoamer, 0.4% Sodium Benzoate, deionized water adds to 100% weight portion.Will be each
Component mixes, well mixed through high speed shear, then is sanded 2-3 hours by sand mill, reaches fineness 1-5 microns, obtains final product 32%
First thiophene lures amine furametpyr suspending agent.
Furametpyr in the present embodiment can be replaced other acid amide fungicides (such as dimethomorph, Boscalid, thiophene fluorine
Acid amides, metalaxyl etc.), to form new embodiment.
Embodiment 2：30% first thiophene lures amine furametpyr suspending agent
15% first thiophene is weighed respectively lures amine, 15% furametpyr, 4% sodium naphthalene sulfonate, 2% Nonyl pheno phosphoric acid
Ester, 6% ethylene glycol, 0.30%XG, 0.6% organic silicon defoamer, 0.4% Sodium Benzoate, deionized water adds to 100% weight
Part.Each component is mixed, it is well mixed through high speed shear, then be sanded 2-3 hours by sand mill, fineness 1-5 microns is reached, i.e.,
Obtain 30% first thiophene and lure amine furametpyr suspending agent.
Furametpyr in the present embodiment can be replaced other acid amide fungicides (such as dimethomorph, Boscalid, thiophene fluorine
Acid amides, metalaxyl etc.), to form new embodiment.
Embodiment 3：22% first thiophene lures amine furametpyr suspended emulsion
Weigh 2% furametpyr, 3% phosphoric acid ester APEO, 2% NPE, 10% C9 aromatic
Solvent, mixing and stirring is standby, weighs 20% first thiophene and lures amine, 2% phosphoric acid ester APEO, 6% ethylene glycol, 0.25%
XG, 0.6% organic silicon defoamer, 0.4% Sodium Benzoate, deionized water adds to 100% weight portion.Fineness 1- is reached by being sanded
Add the furametpyr solution for preparing that 22% first is can be prepared by using mixing after high shear dispersion machine shearing 30min after 4 microns
Thiophene lures amine furametpyr suspended emulsion.
Furametpyr in the present embodiment can be replaced other acid amide fungicides (such as dimethomorph, Boscalid, thiophene fluorine
Acid amides, metalaxyl etc.), to form new embodiment.
Embodiment 4：46.5% first thiophene lures amine furametpyr suspending agent
1.5% first thiophene is weighed respectively lures amine, 45% furametpyr, 4% polycarboxylic acids sodium, 3% AEO,
6% ethylene glycol, 0.35%XG, 0.6% organic silicon defoamer, 0.4% Sodium Benzoate, deionized water adds to 100% weight portion.Will
Each component mixes, well mixed through high speed shear, then is sanded 2-3 hours by sand mill, reaches fineness 1-5 microns, obtains final product
46.5% first thiophene lures amine furametpyr suspending agent.
Furametpyr in the present embodiment can be replaced other acid amide fungicides (such as dimethomorph, Boscalid, thiophene fluorine
Acid amides, metalaxyl etc.), to form new embodiment.
Embodiment 5：24% first thiophene lures amine dimethomorph water dispersion granula
Weigh 3% first thiophene and lure amine, 21% dimethomorph, 5% lauryl sodium sulfate, 5% dodecyl sodium sulfate, 2%
Modified lignin resin, 2% calcium chloride, kaolin complements to 100% weight portion.Each component is mixed, through mechanical crushing, then through air-flow
Crush, be well mixed, then through wet granulation and dry, obtain final product 24% first thiophene and lure amine dimethomorph water dispersion granula.
Dimethomorph in the present embodiment can be replaced other acid amide fungicides (such as furametpyr, Boscalid, thiophene fluorine
Acid amides, metalaxyl etc.), to form new embodiment.
Embodiment 6：31.5% first thiophene lures amine dimethomorph suspended emulsion
Weigh 1.5% dimethomorph, 3% phosphoric acid ester APEO, 2% NPE, 8% C9 aromatic
Solvent, mixing and stirring is standby, weighs 30% first thiophene and lures amine, 3% phosphoric acid ester APEO, 6% ethylene glycol, 0.25%
XG, 0.6% organic silicon defoamer, 0.4% Sodium Benzoate, deionized water adds to 100% weight portion.Fineness 1- is reached by being sanded
Mixing can be prepared by 31.5% after adding the dimethomorph solution for preparing to shear 30min using high shear dispersion machine after 4 microns
First thiophene lures amine dimethomorph suspended emulsion.
Dimethomorph in the present embodiment can be replaced other acid amide fungicides (such as furametpyr, Boscalid, thiophene fluorine
Acid amides, metalaxyl etc.), to form new embodiment.
Embodiment 7：30% first thiophene lures amine dimethomorph wettable powder
Weigh 15% first thiophene and lure amine, 15% dimethomorph, 7% modified lignin resin, 3% APEO formaldehyde condensation products,
5% white carbon, kaolin complement to 100% weight portion；Each component is mixed, through mechanical crushing, then through air-flow crushing, mixing is equal
It is even, obtain final product 30% first thiophene and lure amine dimethomorph wettable powder.
Dimethomorph in the present embodiment can be replaced other acid amide fungicides (such as furametpyr, Boscalid, thiophene fluorine
Acid amides, metalaxyl etc.), to form new embodiment.
Embodiment 8：41% first thiophene lures amine thifluzamide water dispersible granules
Weigh 1% first thiophene and lure amine, 40% thifluzamide, 5% lauryl sodium sulfate, 5% dodecyl sodium sulfate, 2%
Modified lignin resin, 2% calcium chloride, kaolin complements to 100% weight portion.Each component is mixed, through mechanical crushing, then through air-flow
Crush, be well mixed, then through wet granulation and dry, obtain final product 41% first thiophene and lure amine thifluzamide water dispersible granules.
Dimethomorph in the present embodiment can be replaced other acid amide fungicides, and (such as furametpyr, Boscalid, first are white
Spirit etc.), to form new embodiment.
Embodiment 9：31% first thiophene lures amine thifluzamide suspended emulsion
1% thifluzamide is weighed, 3% phosphoric acid ester APEO, 2% NPE, 8% C9 aromatic is molten
Agent, mixing and stirring is standby, weighs 30% first thiophene and lures amine, 3% phosphoric acid ester APEO, 6% ethylene glycol, 0.25%XG,
0.6% organic silicon defoamer, 0.4% Sodium Benzoate, deionized water adds to 100% weight portion.Fineness 1-4 is reached by sand milling micro-
The dimethomorph solution for preparing is added to be lured using the first thiophene that mixing after high shear dispersion machine shearing 30min can be prepared by 31% after rice
Amine thifluzamide suspended emulsion.
Dimethomorph in the present embodiment can be replaced other acid amide fungicides, and (such as furametpyr, Boscalid, first are white
Spirit etc.), to form new embodiment.
Rice sheath blight disease is prevented and treated with pesticidal preparations obtained in above-described embodiment to test：
1st, test process：Experiment is carried out with reference to People's Republic of China's standard (pesticide field efficacy medicine test criterion).This examination
Test dosing and three concentration for the treatment of are set according to the difference of each composition respectively.Comparison medicament is respectively the first thiophene of commercially available agricultural chemicals 25%
Lure amine and 15% furametpyr WP and blank clean water experiment.
2nd, test method：Each plot area is 50m2, it is repeated 4 times, the inspection drug effect side after being investigated before dispenser and being prevented and treated
Method is：Taken a little per cell diagonal, every is extracted 10 clumps of investigation.Result of the test see the table below 6：
The first thiophene of table 6 lures amine and furametpyr to compound the prevention effect to rice sheath blight disease
Field efficacy result shows that first thiophene lures amine and furametpyr to compound, and there is excellent preventing and treating to imitate to rice sheath blight disease
Really, prevention effect is better than single dose kind.
Tobacco black shank is prevented and treated with pesticidal preparations obtained in above-described embodiment to test：
1st, test process：Experiment is carried out with reference to People's Republic of China's standard (pesticide field efficacy medicine test criterion).This examination
Test dosing and three concentration for the treatment of are set according to the difference of each composition respectively, comparison medicament is respectively the first thiophene of commercially available agricultural chemicals 25%
Lure amine and 50% dimethomorph WG and blank clean water experiment.
2nd, test method：Each plot area is 50m2, it is repeated 4 times, the inspection drug effect side after being investigated before dispenser and being prevented and treated
Method is：Per the sampling of cell diagonal, 10 plants are often clicked.The percentage of whole stem area is accounted for the lesion area on every plant of whole strain stem
To be classified, result of the test see the table below 7：
The first thiophene of table 7 lures amine and dimethomorph to compound the prevention effect to tobacco black shank
Field efficacy result shows that first thiophene lures amine and dimethomorph compounding that tobacco black shank is also imitated with excellent preventing and treating
Really, prevention effect is better than single dose kind.
Cucumber downy mildew is prevented and treated with pesticidal preparations obtained in above-described embodiment to test：
1st, test process：Experiment is carried out with reference to People's Republic of China's standard (pesticide field efficacy medicine test criterion).This examination
Test dosing and three concentration for the treatment of are set according to the difference of each composition respectively, comparison medicament is respectively the first thiophene of commercially available agricultural chemicals 25%
Lure amine and 50% dimethomorph WG and blank clean water experiment.
2nd, test method：Each plot area is 50m2, it is repeated 4 times, the inspection drug effect side after being investigated before dispenser and being prevented and treated
Method is：Per the sampling of cell diagonal, 10 plants are often clicked.The percentage of whole leaf area is accounted for the lesion area on every plant of one-piece blade
To be classified, result of the test see the table below 8：
The first thiophene of table 8 lures amine and dimethomorph to compound the prevention effect to cucumber downy mildew
Field efficacy result shows that first thiophene lures amine and dimethomorph compounding that cucumber downy mildew is also imitated with excellent preventing and treating
Really, prevention effect is better than single dose kind.
Tobacco virus are prevented and treated with pesticidal preparations obtained in above-described embodiment to test：
1st, test process：Experiment is carried out with reference to People's Republic of China's standard (pesticide field efficacy medicine test criterion).This examination
Test dosing and three concentration for the treatment of are set according to the difference of each composition respectively, comparison medicament is respectively the first thiophene of commercially available agricultural chemicals 25%
Lure amine and 24% thifluzamide SC and blank clean water experiment.
2nd, test method：Each plot area is 50m2, it is repeated 4 times, the inspection drug effect side after being investigated before dispenser and being prevented and treated
Method is：Per the sampling of cell diagonal, 10 plants are often clicked.The percentage of whole stem area is accounted for the lesion area on every plant of whole strain stem
To be classified, result of the test see the table below 7：
The first thiophene of table 9 lures amine and thifluzamide to compound the prevention effect to tobacco virus
Field efficacy result shows that first thiophene lures amine and thifluzamide compounding that tobacco virus are also imitated with excellent preventing and treating
Really, prevention effect is better than single dose kind.
Claims (8)
1. a kind of bactericidal composition, it is characterised in that：Amine and acid amide fungicides are lured to constitute by first thiophene, the acid amide fungicides
It is Boscalid, thifluzamide or furametpyr, it is 1 that the first thiophene lures the weight ratio of amine and acid amide fungicides：30~40：1.
2. bactericidal composition according to claim 1, it is characterised in that：The first thiophene lures the weight of amine and acid amide fungicides
Amount is than being 1：15~20：1.
3. bactericidal composition according to claim 1, it is characterised in that：The first thiophene lures the weight of amine and acid amide fungicides
Amount is than being 1：7~10：1.
4. according to any described bactericidal composition in claims 1 to 3, it is characterised in that：Also contain in the bactericidal composition
There is pesticidal preparations auxiliary element, to be made the formulation for being adapted to agriculturally use.
5. bactericidal composition according to claim 4, it is characterised in that：The pesticidal preparations auxiliary element is solvent, breast
One or more in agent, dispersant, stabilizer, antifreezing agent or wetting agent.
6. bactericidal composition according to claim 5, it is characterised in that：The formulation of the bactericidal composition is wettable powder
Agent, suspended emulsion, water dispersion granule, suspending agent or dry suspending agent.
7. the application of the bactericidal composition described in claim 1, it is characterised in that：For controlling plant diseases.
8. the application of bactericidal composition according to claim 7, it is characterised in that：For preventing and treating tobacco virus, black shin
Disease, early blight of tomato, late blight, cucumber downy mildew, capsicum epidemic disease, damping-off, the cercospora brown spot of peanut, black spot.
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| CN201611082145.6A Expired - Fee Related CN106719711B (en) | 2014-04-17 | 2014-04-17 | Bactericidal composition and application thereof |
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| CN105191950B (en) * | 2014-05-30 | 2017-07-14 | 四川利尔作物科学有限公司 | Bactericidal composition and its application |
| CN106614642B (en) * | 2015-11-02 | 2020-04-21 | 四川利尔作物科学有限公司 | Seed treatment agent composition and application thereof |
| CN107801721A (en) * | 2016-09-08 | 2018-03-16 | 四川利尔作物科学有限公司 | Bactericidal composition and its application |
| CN107801724A (en) * | 2016-09-08 | 2018-03-16 | 四川利尔作物科学有限公司 | Bactericidal composition and its application |
| CN108094431A (en) * | 2016-11-24 | 2018-06-01 | 四川利尔作物科学有限公司 | Bactericidal composition and its application |
| CN109122701A (en) * | 2017-06-16 | 2019-01-04 | 四川利尔作物科学有限公司 | Bactericidal composition and its application |
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| CN1810808A (en) * | 2006-02-20 | 2006-08-02 | 南开大学 | New [1,2,3]-thiobiazole derivative and its synthesis and use |
| CN101091490A (en) * | 2007-01-12 | 2007-12-26 | 南开大学 | New type heterocycle bactericide and composition |
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| DE102004049761A1 (en) * | 2004-10-12 | 2006-04-13 | Bayer Cropscience Ag | Fungicidal drug combinations |
| CN101544633B (en) * | 2008-03-28 | 2011-04-20 | 南开大学 | Synthesis technology for methyl thiadiazole formamide |
| CN101265241B (en) * | 2008-05-12 | 2010-06-02 | 南开大学 | Method for preventing and curing plant disease by increasing plant immunity and use thereof |
| CN101265240B (en) * | 2008-05-12 | 2010-09-08 | 南开大学 | Method for preventing and curing plant disease by increasing plant immunity and use thereof |
| JP2010037311A (en) * | 2008-08-08 | 2010-02-18 | Bayer Cropscience Ag | Novel insecticidal acylaminobenzamide derivative |
| TWI584732B (en) * | 2008-12-19 | 2017-06-01 | 拜耳作物科學股份有限公司 | Active compound combinations |
| JP2010222256A (en) * | 2009-03-19 | 2010-10-07 | Sumitomo Chemical Co Ltd | Method for effectively controlling disease of jatropha |
| AR077432A1 (en) * | 2009-07-30 | 2011-08-24 | Marrone Bio Innovations | INHIBITOR COMBINATIONS OF PLANT PATHOGENS AND METHODS OF USE |
| JP2012036142A (en) * | 2010-08-10 | 2012-02-23 | Sumitomo Chemical Co Ltd | Plant disease control composition, and application for same |
| JP2014511705A (en) * | 2011-04-15 | 2014-05-19 | ビーエーエスエフ ソシエタス・ヨーロピア | How to grow sugarcane |
| CN102422839B (en) * | 2011-11-04 | 2013-05-29 | 利尔化学股份有限公司 | Plant disease-controlling composition and disease-controlling pesticides |
| CN102524269B (en) * | 2012-01-17 | 2013-10-30 | 利尔化学股份有限公司 | Bactericidal composition, pesticide and application thereof |
| CN102657185B (en) * | 2012-04-20 | 2014-04-23 | 杭州宇龙化工有限公司 | Sterilization combination containing thifluzamide and tetraconazole |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1810808A (en) * | 2006-02-20 | 2006-08-02 | 南开大学 | New [1,2,3]-thiobiazole derivative and its synthesis and use |
| CN101091490A (en) * | 2007-01-12 | 2007-12-26 | 南开大学 | New type heterocycle bactericide and composition |
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| CN109287643B (en) | 2021-04-16 |
| CN109452292A (en) | 2019-03-12 |
| CN106719711B (en) | 2020-07-10 |
| CN105010358B (en) | 2017-05-17 |
| CN105010358A (en) | 2015-11-04 |
| CN109452292B (en) | 2021-04-16 |
| CN109287643A (en) | 2019-02-01 |
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