CN102397314B - Health-care product for preventing and treating renal disease of newborn Tibetan mastiff in low-altitude region - Google Patents
Health-care product for preventing and treating renal disease of newborn Tibetan mastiff in low-altitude region Download PDFInfo
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- CN102397314B CN102397314B CN 201110348119 CN201110348119A CN102397314B CN 102397314 B CN102397314 B CN 102397314B CN 201110348119 CN201110348119 CN 201110348119 CN 201110348119 A CN201110348119 A CN 201110348119A CN 102397314 B CN102397314 B CN 102397314B
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Abstract
The invention discloses application of an aqueous extract of saffron total glycoside, rhodioside, astragalus polyose, matrine, pachman, vitamin C, vitamin E, aspirin and taxus chinensis to preparation of a medicament for preventing and treating the renal disease of a newborn Tibetan mastiff in a low-altitude region.
Description
Technical field
The present invention relates to a kind of health product for the nascent Canis lupus familiaris nephropathy in control low altitude area, be specifically related to Stigma Croci total glycosides, rhodioside, astragalus polysaccharides, matrine, pachyman, vitamin C, vitamin E, aspirin, the application of Ramulus et folium taxi cuspidatae water extract in the nascent Canis lupus familiaris nephropathy in preparation control low altitude area.
Background technology
Since the eighties in last century, ground begins to feed Canis lupus familiaris in the China's Mainland, after having experienced 30 years, the body constitution of the Canis lupus familiaris on interior ground just begins slow decline, the skeleton, internal organs that shows little large fierce dog grown and above the fertility of big large fierce dog, the living environment of this and large fierce dog, raise and train, the change of diet aspect is closely-related.
In the urinary system of nascent Canis lupus familiaris the most normal ill be kidney.Are one of the main reasons that nascent Canis lupus familiaris is die when nephropathy is a lot, the main symptom that nascent Canis lupus familiaris suffers from nephropathy has in stomachache, abdominal distention and the urine and has the blood streak, and the function of kidney has begun depletion, and renal function depletion can present acute and chronic two kinds.Acute renal nonfunction, general symptom have comprised bradykinesia, vomiting, loss of appetite, dyspnea, stomachache and have not urinated.Central ill reason then may be poisoning, long-term chronic kidney problems, actute infection, consecutive infection, as uterus purulence, obstruction and cystoparalysis.More acute many of the symptom of chronic kidney nonfunction have generally to fester in extremely thirsty, hydrouria, oral cavity, anemia, lose weight and dyspnea.And the possible cause that chronic kidney nonfunction occurs has several factors, comprises tumor (optimum or pernicious) and congenital kidney disease etc.But, also there is not a kind of medicine that can treat the nascent Canis lupus familiaris nephropathy in low altitude area rapidly now, therefore, the health product that exploitation is used for the nascent Canis lupus familiaris nephropathy rehabilitation in low altitude area are targets that those skilled in the art pursue.
Technical scheme
The present invention relates to a kind of health product for the nascent Canis lupus familiaris nephropathy in control low altitude area, made by the raw material of following weight portion:
Stigma Croci total glycosides 25-50, rhodioside 25-50, astragalus polysaccharides 15-30, matrine 2-10, pachyman 2-10, Catergen-4, vitamin E2-4, aspirin 2-4, Ramulus et folium taxi cuspidatae water extract 1-3;
Above raw material is mixed, both.
Be raw material with the Stigma Croci, pulverize, 75% ethanol lixiviate, extracting solution concentrates, and last macroporous resin column is used 95% ethanol elution, and eluent is concentrated, and drying obtains the Stigma Croci total glycosides;
Be raw material with the Radix Rhodiolae, pulverize, 50% ethanol lixiviate, extracting solution concentrates, and last macroporous resin column use 75% ethanol elution, and eluent is concentrated, and last polyamide column is used 95% ethanol elution, and eluent is concentrated, and drying obtains rhodioside;
Be raw material with the Ramulus et folium taxi cuspidatae, pulverize that the water heating decocts, and filters, filtrate concentrates, and drying obtains the Ramulus et folium taxi cuspidatae water extract;
Stigma Croci, rhodioside, Ramulus et folium taxi cuspidatae water extract, its source comprise and are not restricted to above method.
Astragalus polysaccharides, matrine, pachyman adopt the conventional method of this area to prepare,
For example: a kind of method of refining astragalus polysaccharide-200610024178.5, a kind of method-200710013890.X for preparing high purity astragalus polysaccharide,
For example: the method-200510048243.3 of being produced high purity matrine oxide by Radix Sophorae Flavescentis; From Radix Sophorae Flavescentis, extract the production method-200410026189.8 of matrine,
For example: preparation method of ganoderma polysaccharide-200510014592.3, a kind of preparation method of ganoderma polysaccharide-200410067301.2.
The specific embodiment
Specific embodiment 1
Stigma Croci total glycosides 25g, rhodioside 25 g, astragalus polysaccharides 15 g, matrine 2 g, pachyman 2 g, Catergen g, vitamin E2 g, aspirin 2 g, Ramulus et folium taxi cuspidatae water extract 1 g.Above raw material is mixed, both.
Specific embodiment 2
Stigma Croci total glycosides 50 g, rhodioside 50 g, astragalus polysaccharides 30 g, matrine 10 g, pachyman 10 g, vitamin C 4 g, vitamin E g, aspirin 4 g, Ramulus et folium taxi cuspidatae water extract 3 g.Above raw material is mixed, both.
Specific embodiment 3
Shanghai Canis lupus familiaris plant, in July, 2010,20 the little Canis lupus familiaris of being born, wherein 8 because urinary tract infection causes nephritis, wherein 4 the mixing embodiment of the invention 2 treatments in feedstuff, 0.5g medicine/time, 3 times/day, wherein 4 are used penicillin+diuretic thiazine pyrimidine treatment, 0.25g penicillin+0.5g diuretic thiazine pyrimidine/time, 1 time/day, injection.Continue 10 days, detect protein content in the urine
Its result is as follows:
| Group (protein quantification, milligram) | n | 3 days | 6 days | 9 days |
| Normal group | 4 | 35.22±9.56 | 45.12±9.12 | 39.89±9.89 |
| Penicillin+diuretic | 4 | 298.35±18.25 * | 86.36±23.78 * | 236.78±29.36 * |
| The embodiment of the invention 2 | 4 | 167.27±15.56 ** | 123.56±17.36 ** | 100.89±49.23 ** |
*p<0.05,
**p<0.01
Specific embodiment 4
Continue to detect blood urea nitrogen in the blood, creatinine, total protein after 10 days, all the other are with embodiment 3,
Its result is as follows:
| Group | n | Blood urea nitrogen | Creatinine | Total protein |
| (ρ/mmol.l -1 ) | (ρ/μmol.l -1 ) | (ρ/gl -1 ) | ||
| Normal group | 4 | 3.96±1.23 | 68.31±6.21 | 54.96±2.12 |
| Penicillin+diuretic | 4 | 32.26±7.32 * | 243.27±45.23 * | 78.21±1.39 * |
| The embodiment of the invention 2 | 4 | 23.52±5.78 ** | 171.35±31.29 ** | 66.58±6.89 ** |
*p<0.05,
**p<0.01
Specific embodiment 5, rehabilitation duration
Continue after 20 days,
| Group | Rehabilitation in the 20th day | Rehabilitation in the 30th day | Rehabilitation in the 40th day | Death in the 50th day |
| Total number | Total number | Total number | Total number | |
| Normal group | 0 | 0 | 0 | 0 |
| Penicillin+diuretic | 1 | 2 | 2 | 2 |
| The embodiment of the invention 2 | 1 | 3 | 4 | 0 |
Therefore, the embodiment of the invention 2 can reduce blood urea nitrogen, creatinine, total protein content, improves the survival rate of the nascent Canis lupus familiaris nephropathy in control low altitude area.
Claims (1)
1. health product that are used for the nascent Canis lupus familiaris nephropathy in control low altitude area is characterized in that being made by the raw material of following weight portion:
Stigma Croci total glycosides 25-50, rhodioside 25-50, astragalus polysaccharides 15-30, matrine 2-10, pachyman 2-10, Catergen-4, vitamin E2-4, aspirin 2-4, Ramulus et folium taxi cuspidatae water extract 1-3;
Above raw material is mixed, namely;
Be raw material with the Stigma Croci, pulverize, 75% ethanol lixiviate, extracting solution concentrates, and last macroporous resin column is used 95% ethanol elution, and eluent is concentrated, and drying obtains the Stigma Croci total glycosides;
Be raw material with the Radix Rhodiolae, pulverize, 50% ethanol lixiviate, extracting solution concentrates, and last macroporous resin column use 75% ethanol elution, and eluent is concentrated, and last polyamide column is used 95% ethanol elution, and eluent is concentrated, and drying obtains rhodioside;
Be raw material with the Ramulus et folium taxi cuspidatae, pulverize that the water heating decocts, and filters, filtrate concentrates, and drying obtains the Ramulus et folium taxi cuspidatae water extract.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201110348119 CN102397314B (en) | 2011-11-07 | 2011-11-07 | Health-care product for preventing and treating renal disease of newborn Tibetan mastiff in low-altitude region |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201110348119 CN102397314B (en) | 2011-11-07 | 2011-11-07 | Health-care product for preventing and treating renal disease of newborn Tibetan mastiff in low-altitude region |
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| Publication Number | Publication Date |
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| CN102397314A CN102397314A (en) | 2012-04-04 |
| CN102397314B true CN102397314B (en) | 2013-08-21 |
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| CN 201110348119 Expired - Fee Related CN102397314B (en) | 2011-11-07 | 2011-11-07 | Health-care product for preventing and treating renal disease of newborn Tibetan mastiff in low-altitude region |
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Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108586628A (en) * | 2018-05-07 | 2018-09-28 | 武汉紫杉红技术开发有限公司 | A kind of preparation method and applications with the yew amylose for dropping high lithemia effect |
| CN109846895A (en) * | 2019-02-20 | 2019-06-07 | 吉林大学 | Rhodioside is as the protectant new application of oral administration furans renal toxicity |
| CN113956303B (en) * | 2021-09-30 | 2023-03-21 | 湖南绿蔓生物科技股份有限公司 | Method for simultaneously extracting salidroside, rosavin and polysaccharide from rhodiola rosea |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101085169A (en) * | 2007-06-26 | 2007-12-12 | 北京艺信堂医药研究所 | Traditional Chinese medicine for treating uric acid nephritis |
| CN102078485A (en) * | 2011-01-03 | 2011-06-01 | 山东大学威海分校 | Preparation method and application of compound dogwood preparation |
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2011
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101085169A (en) * | 2007-06-26 | 2007-12-12 | 北京艺信堂医药研究所 | Traditional Chinese medicine for treating uric acid nephritis |
| CN102078485A (en) * | 2011-01-03 | 2011-06-01 | 山东大学威海分校 | Preparation method and application of compound dogwood preparation |
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