CN102357116B - Healthcare product for mammitis of milch goats - Google Patents
Healthcare product for mammitis of milch goats Download PDFInfo
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- CN102357116B CN102357116B CN2011103231146A CN201110323114A CN102357116B CN 102357116 B CN102357116 B CN 102357116B CN 2011103231146 A CN2011103231146 A CN 2011103231146A CN 201110323114 A CN201110323114 A CN 201110323114A CN 102357116 B CN102357116 B CN 102357116B
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- 208000004396 mastitis Diseases 0.000 title claims abstract description 28
- 241000283707 Capra Species 0.000 title abstract description 7
- 229920002678 cellulose Polymers 0.000 claims abstract description 9
- 239000001913 cellulose Substances 0.000 claims abstract description 7
- 235000013336 milk Nutrition 0.000 claims description 25
- 239000008267 milk Substances 0.000 claims description 25
- 210000004080 milk Anatomy 0.000 claims description 25
- 241001494479 Pecora Species 0.000 claims description 18
- 238000000034 method Methods 0.000 claims description 11
- 239000000843 powder Substances 0.000 claims description 11
- 239000000047 product Substances 0.000 claims description 11
- 241000628997 Flos Species 0.000 claims description 8
- 235000010980 cellulose Nutrition 0.000 claims description 8
- 239000000706 filtrate Substances 0.000 claims description 8
- 210000000582 semen Anatomy 0.000 claims description 8
- 238000001291 vacuum drying Methods 0.000 claims description 8
- 238000002360 preparation method Methods 0.000 claims description 7
- 239000000203 mixture Substances 0.000 claims description 6
- 239000003643 water by type Substances 0.000 claims description 6
- 238000001914 filtration Methods 0.000 claims description 4
- 235000017060 Arachis glabrata Nutrition 0.000 abstract description 2
- 235000010777 Arachis hypogaea Nutrition 0.000 abstract description 2
- 235000018262 Arachis monticola Nutrition 0.000 abstract description 2
- 235000020232 peanut Nutrition 0.000 abstract description 2
- 241000205585 Aquilegia canadensis Species 0.000 abstract 1
- 244000105624 Arachis hypogaea Species 0.000 abstract 1
- 244000178320 Vaccaria pyramidata Species 0.000 abstract 1
- 235000010587 Vaccaria pyramidata Nutrition 0.000 abstract 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 10
- 238000012360 testing method Methods 0.000 description 7
- 208000010693 Charcot-Marie-Tooth Disease Diseases 0.000 description 6
- 201000010099 disease Diseases 0.000 description 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 5
- 239000003153 chemical reaction reagent Substances 0.000 description 4
- 239000003814 drug Substances 0.000 description 4
- 241000894006 Bacteria Species 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 230000005764 inhibitory process Effects 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 238000001556 precipitation Methods 0.000 description 3
- 239000000243 solution Substances 0.000 description 3
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 2
- 206010059866 Drug resistance Diseases 0.000 description 2
- 206010018910 Haemolysis Diseases 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- 238000009360 aquaculture Methods 0.000 description 2
- 244000144974 aquaculture Species 0.000 description 2
- 239000007864 aqueous solution Substances 0.000 description 2
- 230000003115 biocidal effect Effects 0.000 description 2
- 239000006161 blood agar Substances 0.000 description 2
- 238000010828 elution Methods 0.000 description 2
- 239000000499 gel Substances 0.000 description 2
- 230000008588 hemolysis Effects 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 244000000010 microbial pathogen Species 0.000 description 2
- 244000052769 pathogen Species 0.000 description 2
- 230000000392 somatic effect Effects 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 229920001817 Agar Polymers 0.000 description 1
- 241001553178 Arachis glabrata Species 0.000 description 1
- 238000009641 CAMP test Methods 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 241000283898 Ovis Species 0.000 description 1
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 1
- 229930003427 Vitamin E Natural products 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 239000008272 agar Substances 0.000 description 1
- 229960003022 amoxicillin Drugs 0.000 description 1
- LSQZJLSUYDQPKJ-NJBDSQKTSA-N amoxicillin Chemical compound C1([C@@H](N)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C(O)=O)(C)C)=CC=C(O)C=C1 LSQZJLSUYDQPKJ-NJBDSQKTSA-N 0.000 description 1
- 229940042940 amoxicillin 5 mg/ml Drugs 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 238000004159 blood analysis Methods 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 230000000857 drug effect Effects 0.000 description 1
- 239000003640 drug residue Substances 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000012173 estrus Effects 0.000 description 1
- XJRPTMORGOIMMI-UHFFFAOYSA-N ethyl 2-amino-4-(trifluoromethyl)-1,3-thiazole-5-carboxylate Chemical compound CCOC(=O)C=1SC(N)=NC=1C(F)(F)F XJRPTMORGOIMMI-UHFFFAOYSA-N 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
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- 239000000835 fiber Substances 0.000 description 1
- 230000037406 food intake Effects 0.000 description 1
- 235000012631 food intake Nutrition 0.000 description 1
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 description 1
- 238000003304 gavage Methods 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 210000005075 mammary gland Anatomy 0.000 description 1
- 235000012054 meals Nutrition 0.000 description 1
- 238000000386 microscopy Methods 0.000 description 1
- 231100000957 no side effect Toxicity 0.000 description 1
- 239000006916 nutrient agar Substances 0.000 description 1
- LSQZJLSUYDQPKJ-UHFFFAOYSA-N p-Hydroxyampicillin Natural products O=C1N2C(C(O)=O)C(C)(C)SC2C1NC(=O)C(N)C1=CC=C(O)C=C1 LSQZJLSUYDQPKJ-UHFFFAOYSA-N 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 230000007170 pathology Effects 0.000 description 1
- 239000000575 pesticide Substances 0.000 description 1
- 238000007747 plating Methods 0.000 description 1
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 1
- 229920000053 polysorbate 80 Polymers 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 238000009781 safety test method Methods 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 235000020254 sheep milk Nutrition 0.000 description 1
- 210000001082 somatic cell Anatomy 0.000 description 1
- 238000010186 staining Methods 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 238000002562 urinalysis Methods 0.000 description 1
- 229940046009 vitamin E Drugs 0.000 description 1
- 235000019165 vitamin E Nutrition 0.000 description 1
- 239000011709 vitamin E Substances 0.000 description 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
The invention discloses a healthcare product for mammitis of milch goats, which is prepared by processing the following components in parts by weight: 20-50 parts of cowherb seed, 10-50 parts of concha ostreae, 5-15 parts of spina gleditsiae, 5-15 parts of honeysuckle, 1-2 parts of saikoside and 10-40 parts of peanut shell cellulose. The healthcare product disclosed by invention can be used for preventing and treating mammitis of milch goats.
Description
Affiliated technical field
The invention belongs to the animal health-care product field, relate generally to treatment and prevention for the mastitis of milk sheep.
Background technology
The milk goat mastitis is a kind of commonly encountered diseases and the frequently-occurring disease of milk sheep.The generation of this disease and pathogenic microorganism and environment have close relationship, can be divided into clinic mastitis and Subclinical mastitis according to its form of expression.The clinic mastitis main manifestations is mammary gland swelling, hard, and grumeleuse, variable color etc. appear in milk.Subclinically cause that then milk production descends, milk composition changes and drain pathogen, the sustainable existence of subclinical stage or fast development are clinic mastitis.Affect milk yield, reduce the quality of sheep milk, also easily prolong post-partum estrus and pregnant time, even make the disease sheep lose fertility performance, cause serious economic loss, and harm humans is healthy, thereby its problem of preventing and treating is paid close attention to by people day by day.It seriously hampers the development of milk sheep aquaculture, causes very large loss to the raiser.Very common because abusing with the phenomenon of abuse of antibiotics again, cause many pathogenic microorganisms to produce drug resistance, bring difficulty for the treatment of mastitis.The high cost of the Chinese medicine for the treatment of milk goat mastitis commonly used, use inconvenient, therefore, these effects limit the use of Chinese medicine.
Summary of the invention
The object of the present invention is to provide health product and preparation method for the mastitis of milk sheep.
Technical scheme of the present invention is:
A kind of health product of the mastitis for milk sheep, it is that the raw material of following weight proportion is prepared from:
Semen Vaccariae 20-50 part, Concha Ostreae 10-50 part, Spina Gleditsiae 5-15 part, Flos Lonicerae 5-15 part, saikoside 1-2 part, Pericarppium arachidis hypogaeae cellulose 10-40 part.
Be used for the health product preparation method of the mastitis of milk sheep, the method is following steps:
Semen Vaccariae 20-50 part, Concha Ostreae 10-50 part, Spina Gleditsiae 5-15 part, Flos Lonicerae 5-15 part are mixed, and water decocts, and filters, and gets filtrate and mixes with saikoside 1-2 part, Pericarppium arachidis hypogaeae cellulose 10-40 part, and vacuum drying obtains powder.
The preparation method of saikoside includes but not limited to following steps:
Radix Bupleuri is crushed to 80 orders, adds the soak with ethanol of 75 % by weight, add the Tween 80 of mixture weight 0.5%, ultrasonic 30 minutes, get filtrate, filter, concentrated, cross macroporous resin D101, the ethanol elution with 85% is collected ethanol elution, Recycled ethanol, get concentrated solution, vacuum drying obtains saikoside.
The cellulosic preparation method of Pericarppium arachidis hypogaeae includes but not limited to following steps:
Peanut hull meal is broken to 80 orders, through 20 % by weight hydrochloric acid heating extraction, the extracting solution sucking filtration, sucking filtration liquid is concentrated, and concentrated solution adds 95% soak with ethanol, and is centrifugal, and the precipitation drying obtains the Pericarppium arachidis hypogaeae fiber.
Advantage of the present invention and beneficial effect are: can prevent and treat the mastitis of milk sheep, have the drug effect height, have no side effect, the characteristics of noresidue.
The specific embodiment
The below describes the present invention for example.
Embodiment 1:
Semen Vaccariae 20 weight portions, Concha Ostreae 10 weight portions, Spina Gleditsiae 5 weight portions, Flos Lonicerae 5 weight portions are mixed, decoct with 200 weight parts waters, filter, get filtrate and mix with saikoside 1 weight portion, Pericarppium arachidis hypogaeae cellulose 10 weight portions, vacuum drying obtains powder.
Embodiment 2:
Semen Vaccariae 50 weight portions, Concha Ostreae 50 weight portions, Spina Gleditsiae 15 weight portions, Flos Lonicerae 15 weight portions are mixed, decoct with 600 weight parts waters, filter, get filtrate and mix with saikoside 2 weight portions, Pericarppium arachidis hypogaeae cellulose 40 weight portions, vacuum drying obtains powder.
Embodiment 3:
Semen Vaccariae 30 weight portions, Concha Ostreae 20 weight portions, Spina Gleditsiae 10 weight portions, Flos Lonicerae 10 weight portions are mixed, decoct with 400 weight parts waters, filtration is got 20 parts of filtrate and 1.5 parts of saikosides, Pericarppium arachidis hypogaeae celluloses and is mixed, and vacuum drying obtains powder.
Embodiment 4:
Safety testing
The powder 20g/kg of mouse gavaging embodiment 3 is equivalent to 300 times of the positive usual amounts of milk sheep, and nothing is dead in 96 hours; Gavage 10g/kg every day, be equivalent to 300 times of the positive usual amounts of milk sheep, continuous 3 months, body weight, food-intake, blood, routine urinalysis and pathology blood examination were looked into all no abnormal.
Embodiment 5:
The control milk goat mastitis test of pesticide effectiveness
Choose 100 of milk sheeps that suffer from mastitis, be divided into test group and matched group, every group each 50, the same feedstuff of feeding two groups of every days:
Test group, feedstuff add the powder 10g/ day/head of feeding embodiment 3,2 times/days, are used in conjunction 7;
Test group, feedstuff add feeds vitamin E 10g/ day/head, 2 times/days, is used in conjunction 7;
Matched group, 30 bellwethers turn negative, and 20 there are no improvement;
Test group, 45 bellwethers turn negative, and 5 there are no improvement.
Negative determination methods is with reference to California mastitis detection method (CMT)
CMT is the method for diagnosing mastitis by indirect determination Ruzhong somatic number (SCC).Its principle is that the Ruzhong somatic cell is destroyed, discharges DNA under surfactant and alkalescent medicine effect, and further effect makes milk produce precipitation or formation gel.Somatic number is more, and the precipitation of generation or gel are also more, thereby indirectly diagnoses the degree of mastitis and inflammation.
1. reagent and method
Reagent and method that CMT uses in detecting are as follows: dodecyl sodium sulfate 30g is dissolved in the 1000mL distilled water, regulate PH with the sodium hydroxide of 2M and equal 6.4, add bromocresol purple 0.1g, the CMT test liquid, get 1 on mastitis diagnosis dish, drip tested newborn 2mL, diagnosticum 2mL slowly makes the concentric circles pendulum.The finished product reagent of commercially available finished product CMT diagnostic reagent or additive method is according to description operation.
2. criterion: can be with reference to following table
Decision method and the standard of table CMT method
Embodiment 5:
Get the serious milk Lac caprae seu ovis sample 10mL of mastitis clinical symptoms, add respectively in the sterilization centrifuge tube with centrifugal 15 min of 3000 r/min, discard and manage at the middle and upper levels liquid, leave and take precipitate, be inoculated in sheep blood Agar Plating, put 37 ℃ of calorstats and cultivate 24 h, observe colonial morphology and haemolysis situation, and bacterium colony carried out Gram’s staining, microscopy.Bacterium colony forms light gray, protuberance, flash of light, sticky petite at blood agar plate, and can produce completely β haemolysis, and CAMP test is positive; In serum broth the initial stage evenly muddy, after can form flocculent deposit at the pipe end; Undergrowth on Nutrient agar can not be grown on maconkey agar.
Carry out the inhibition zone test of mastitis bacterium colony with the aqueous solution 2,4,8 of the powder of embodiment 3,16mg/ mL, take amoxicillin 5mg/ mL as contrast, detect with disk diffusion method, the diameter of the inhibition zone of the aqueous solution of the powder of embodiment 3 increases with concentration, is respectively 0.5,1.5,3,5cm.The diameter of the inhibition zone of amoxicillin is 2 cm.
Therefore, product of the present invention has good action to the milk goat mastitis, and sick sheep has been turned out cloudy or alleviated in various degree disease, the present invention uses Chinese medicine extract, can be antibiotic, the Drug resistance of having avoided using antibiotic to bring, drug residue, etc. shortcoming, be of value to the development to the milk sheep aquaculture.
Claims (3)
1. health product preparation method that is used for the mastitis of milk sheep is characterized in that the method is following steps:
Semen Vaccariae 30 weight portions, Concha Ostreae 20 weight portions, Spina Gleditsiae 10 weight portions, Flos Lonicerae 10 weight portions are mixed, decoct with 400 weight parts waters, filtration is got 20 parts of filtrate and 1.5 parts of saikosides, Pericarppium arachidis hypogaeae celluloses and is mixed, and vacuum drying obtains powder.
2. health product preparation method that is used for the mastitis of milk sheep is characterized in that the method is following steps:
Semen Vaccariae 20 weight portions, Concha Ostreae 10 weight portions, Spina Gleditsiae 5 weight portions, Flos Lonicerae 5 weight portions are mixed, decoct with 200 weight parts waters, filter, get filtrate and mix with saikoside 1 weight portion, Pericarppium arachidis hypogaeae cellulose 10 weight portions, vacuum drying obtains powder.
3. health product preparation method that is used for the mastitis of milk sheep is characterized in that the method is following steps:
Semen Vaccariae 50 weight portions, Concha Ostreae 50 weight portions, Spina Gleditsiae 15 weight portions, Flos Lonicerae 15 weight portions are mixed, decoct with 600 weight parts waters, filter, get filtrate and mix with saikoside 2 weight portions, Pericarppium arachidis hypogaeae cellulose 40 weight portions, vacuum drying obtains powder.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011103231146A CN102357116B (en) | 2011-10-22 | 2011-10-22 | Healthcare product for mammitis of milch goats |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011103231146A CN102357116B (en) | 2011-10-22 | 2011-10-22 | Healthcare product for mammitis of milch goats |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102357116A CN102357116A (en) | 2012-02-22 |
| CN102357116B true CN102357116B (en) | 2013-05-01 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN2011103231146A Expired - Fee Related CN102357116B (en) | 2011-10-22 | 2011-10-22 | Healthcare product for mammitis of milch goats |
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Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103751360B (en) * | 2014-02-19 | 2015-05-27 | 崔新明 | Pharmaceutical composition for treating breast distention and application thereof |
| CN109464528A (en) * | 2018-12-30 | 2019-03-15 | 广西武鸣绿世界生态农业投资有限公司 | The pharmaceutical composition and preparation method thereof for treating Black Hills goat mastitis |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN100509014C (en) * | 2006-11-30 | 2009-07-08 | 灵宝市商业医院 | Medicament for treating mammitis |
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| Publication number | Publication date |
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