CN102397181B - Aging resistance cosmetic composition and periocualr skin eyeshield - Google Patents
Aging resistance cosmetic composition and periocualr skin eyeshield Download PDFInfo
- Publication number
- CN102397181B CN102397181B CN201010505194.2A CN201010505194A CN102397181B CN 102397181 B CN102397181 B CN 102397181B CN 201010505194 A CN201010505194 A CN 201010505194A CN 102397181 B CN102397181 B CN 102397181B
- Authority
- CN
- China
- Prior art keywords
- eyeshield
- wrinkle
- skin
- bulgarian rose
- cosmetic composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/0208—Tissues; Wipes; Patches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
- A61K8/606—Nucleosides; Nucleotides; Nucleic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/52—Stabilizers
- A61K2800/522—Antioxidants; Radical scavengers
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Dermatology (AREA)
- Chemical & Material Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Cosmetics (AREA)
Abstract
The present invention relates to and a kind ofly improve skin elasticity, improve wrinkle, strengthen the cosmetic composition of moisturizing power and include the periocualr skin eyeshield of this cosmetic composition.More particularly, the invention provides and a kind ofly include Bulgarian Rose extract and strengthen precollagen biosynthesis and the cosmetic composition improving wrinkle, improve elastic force, strengthen moisturizing power, a kind of eyeshield infiltrating described compositions and emphasis maintenance canthus wrinkle is provided further.
Description
Technical field
The present invention relates to one and include Bulgarian Rose extract as effective ingredient, improve skin elasticity, improve wrinkle, strengthen the cosmetic composition of moisturizing power and include the periocualr skin eyeshield of this cosmetic composition.
Background technology
Flos Rosae Rugosae, due to its abundant nutritional labeling, has become the indispensable material of cosmetics.Particularly, containing sugar, aminoacid, vitamin C, tannin, citric acid etc. in Flos Rosae Rugosae flower, skin moisture-keeping, convergence and peace and quiet effect are remarkable, and extremely contribute to deeply preserving moisture and the slow down aging of dry skin or sensitive skin.Particularly, the Flos Rosae Rugosae best results gathered the 4-5 month.Compared with rose in full bloom, alabastrum Flos Rosae Rugosae more remarkable effect.And Flos Rosae Rugosae is according to the area gathered or cultural method, and quality is also different, can in most cases, Bulgarian Rose performance optimal.
Other flower class also obtains the favor of a lot of women, can seldom as Flos Rosae Rugosae with the life of women and beauty closely related.According to Historical Data Data About, an ancient egypt epoch gram Lou Bate draws and enjoys a lot to take a shower with roseleaf, and Europe also adopts the flower of wild rose as the raw material of astringent or treats wound or scald.And, when manufacturing perfume, nearly all add Flos Rosae Rugosae.Nowadays, although be proposed the various cosmetics using natural component as raw material along with the upsurge focusing on health and pure natural, can wherein, the cosmetics still including Flos Rosae Rugosae composition that popularity is the highest.
Summary of the invention
The present inventor finds in numerous rose variety, and the antioxidation of Bulgarian Rose and moistening effect are remarkable especially, and when being in more than certain concentration, can strengthen precollagenous biosynthesis.Given this, the present inventor, used as improving wrinkle of skin, particularly, improves the compositions of wrinkle near the eyes.
Given this, the invention provides a kind of cosmetic composition that effectively can improve wrinkle of skin.
And, the present invention further provides a kind of eyeshield infiltrating the effective maintenance periocualr skin of described compositions.
Technical program of the present invention lies in:
To achieve these goals, the invention provides Bulgarian Rose extractive content in a kind of composition total weight reach 0.1-10.0 % by weight for antidotal cosmetic composition.
And, the present invention further provides the periocualr skin eyeshield that a kind of sheet type eyeshield 2 including the compositions of Bulgarian Rose extract by the thawing membranous type eyeshield 1 and infiltration that include acetylglucosamine and adenylic acid forms.
Technique effect of the present invention is:
The present composition can improve wrinkle and elasticity and strengthen moisturizing power, particularly, for time near the eyes, can improve periocualr skin comprehensively.And, use when including the eyeshield of said composition, can effective maintenance periocualr skin.
Accompanying drawing explanation
Fig. 1 illustrates the schematic form of eyeshield in the present invention be made up of eyeshield 1 and eyeshield 2.
Fig. 2 illustrates the antioxidant effect testing result of Bulgarian Rose extract.
Fig. 3 illustrates the hyaluronic acid synthetic effect by the Bulgarian Rose extract detected based on the elisa assay of hyaluronic acid and hyaluronic acid (HA) protein-bonded specific binding.
Fig. 4 illustrates the testing result that Bulgarian Rose extract strengthens precollagen biosynthesis usefulness.
Fig. 5 illustrates state when face's use eyeshield 1 and eyeshield 2.
Fig. 6 illustrates expert and with the naked eye assesses the result (0w: first, 0w ': after use immediately, 3w:3 week, 6w:6 week) improving wrinkle degree.
Fig. 7 illustrate artificially formed to use after wrinkle near the eyes in the present invention eyeshield maintenance near the eyes wrinkle time maintenance degree detecting result (0w: first, 0w ': after use immediately, 3w:3 week, 6w:6 week).
Fig. 8 illustrates the wrinkle degree of improvement assessment result (0w: first, 3w:3 week, 6w:6 week) using and test receiver's accreditation in the process of eyeshield in the present invention.
Fig. 9 illustrates the testing result (0w: first, 0w ': after use immediately, 3w:3 week) of periocualr skin moisture when using eyeshield in the present invention.
Figure 10 illustrates the periocualr skin wrinkle state change used in the present invention before eyeshield and afterwards.
Figure 11 illustrates and uses eyeshield in the present invention and the degree of improvement of elastic force near the eyes, near the eyes wrinkle degree of improvement and satisfaction (in 3w:3 week, 6w:6 is all) after 3 weeks and 6 weeks.
Detailed description of the invention
The invention provides and a kind ofly include Bulgarian Rose extract improves skin condition compositions as effective ingredient.Particularly, described compositions can improve skin elasticity, improves wrinkle, strengthens moisturizing power.
The present invention uses Bulgarian Rose extract, but is not limited thereto, and preferably, uses the extract extracted from calyx before blossom and the agglomerating alabastrum of floral leaf.And, the normally used extracting method in field belonging to the present invention can be adopted to extract Bulgarian Rose extract the present invention from Bulgarian Rose, preferably, use superhigh pressure technique in nonheat-treatable processing method.When adopting ultrahigh-pressure extraction method, gas or heat are not used for reagent, but apply thousands of bar pressure explosion cell membrane and extract useful component in a flash.Therefore, extraction efficiency is high and can obtain raw full-natural nutritive composition.
Bulgarian Rose extract described in cosmetic composition of the present invention is 0.1-10.0 % by weight at the content that composition total weight occupies.When content does not reach 0.1 % by weight, have little effect, when content is more than 10.0 % by weight, owing to there is the cytotoxicity for pigment synthesis cell (Melan-a cell line), should not adopt.
In the present invention, compositions is not particularly limited its dosage form according to the body part used.More particularly, such as, it can be the cosmetic composition possessing soft astringent, nutrition astringent, massage cream, nourishing cream, eye cream, facial film, gel or binding skin class State of cosmetics, also can be percutaneous absorption type dosage form, as skin care liquid, ointment, gel, frost, eyeshield or spray.
And those skilled in the art of the invention can be easy to filter out other composition in the cosmetic composition of each dosage form except described Bulgarian Rose extract of the present invention according to dosage form or application target etc. and prepare.Now, if used with other raw material simultaneously, just better usefulness can be obtained.
In addition, the present invention also provides a kind of eyeshield being easy to maintenance periocualr skin.
More particularly, in the present invention, eyeshield is made up of the eyeshield 2 melting composition in membranous type eyeshield 1 and penetration enhancement eyeshield 1, and for its schematic form, Fig. 1 has made detailed diagram.
Eyeshield 1:
Eyeshield 1 is that convolution flying disk type melts film, and its application target is, improves optical fundus wrinkle and elastic force to greatest extent.In order to be contained in the composition of eyeshield 1 in effectively passing on, use described convolution flying saucer form.
Eyeshield 1 is efficiency composition, includes acetylglucosamine and adenylic acid.In the gross weight of eyeshield 1, the content of acetylglucosamine is 0.1-5.0 % by weight, and the content of adenylic acid is 0.01-5.0 % by weight.
In order to form film, in the gross weight of eyeshield 1, including the halothane of 1.0-60.0 % by weight, including 0.01-1.0 % by weight viscosifier angle glue and Chondrus crispus glue.
Eyeshield 2:
Eyeshield 2 promotes the absorption of composition in eyeshield 1, full restoration periocualr skin, improves wrinkle, elastic force and moisturizing.When eyeshield 2 is used for facial skin, become panda form.
The compositions infiltrating eyeshield 2 is efficiency composition, includes Bulgarian Rose extract.In the gross weight of compositions infiltrating eyeshield 2, the content of described Bulgarian Rose extract is 0.1-10.0 % by weight.When the content of described Bulgarian Rose extract does not reach 0.1 % by weight, have little effect, when the content of described Bulgarian Rose extract is more than 10.0 % by weight, owing to there is the cytotoxicity for pigment synthesis cell (Melan-a cell line), should not adopt.
The material being generally used for facial film can be used to produce eyeshield 2.Such as, natural material, textile class, Hydrogels, Silica hydrogel class etc. can be used.Eyeshield 2 has infiltrated water soluble cosmetics compositions, and now the composition of operable schematic water soluble cosmetics can with reference to following table 2.
Inside be contained in eyeshield 1 in periocualr skin eyeshield of the present invention different with the composition of eyeshield 2.Therefore, when using simultaneously, can more effectively maintenance periocualr skin.More particularly, when using eyeshield in the present invention, after being first close on the skin of optical fundus by eyeshield 1, again cover eyeshield 2 in the above.
In order to obtain improving effect more significantly, after fully smearing described eye cream, eyeshield 1 is close to the position, optical fundus needing emphasis maintenance, with finger beat gently massage its above and fix eyeshield 1.After 1-2 minute, with eyeshield 2 fully cover 20 minutes position near the eyes.
And the present invention obtains more outstanding improvement wrinkle effect near the eyes to make periocualr skin eyeshield, provides eye cream dosage form simultaneously.
Described eye cream and eyeshield use simultaneously, thus improve the effect improving wrinkle further.The present invention is not particularly limited composition, as long as the composition that effectively can improve wrinkle all can use, but, preferably, using EGCG or intelligent polypeptide (peptiskin) as effective ingredient.
When epicatechin (EGCG) is applied in skin, the generation of Oxidation and the peroxide caused due to active oxygen in human body can be suppressed, prevent biomembranous aging, promote the biosynthesis of collagen, it is not chafe not only, can also skin elasticity be improved, prevent and improve skin aging.Intelligence polypeptide is supercharging (boosting) material improving wrinkle, when being applied in skin, can promote the biosynthesis of collagen, suppresses the decomposition of collagen and is cross-linked.
The present invention does not limit the eye cream simultaneously used with eyeshield in the present invention, but, preferably, be grouped into according to following one-tenth, that is, in the eye cream composition total weight of described eye cream, the content of EGCG is 0.001-10 % by weight, and the content of intelligent polypeptide is 0.001-10 % by weight.
And, described eye cream is the branched polymer using lipophilic alkyl group chain as side shoot, it can use acrylate/C10-30 alkyl acrylic cross linked polymer, acrylate/C12-22 alkylmethacrylate copolymer (Acrylates/C 12-22Alkyl Methacrylate Copolymer), acrylate/behenyl alcohol polyethers-25 methacrylate copolymer (Acrylates/Beheneth-25MethacrylateCopolymer) or acrylate/ceteth-20 methacrylate copolymer (Acrylates/Ceteth-20Methacrylate Copolymer), most preferably, use acrylate/C10-30 alkyl acrylate cross-linked polymer.The content manufacturing hydrocarbon-type oil of Esters oil, hydrogenated polydecene (Hydrogenated Polydecene) or the squalane (Squalane) etc. of normally used dimethyl or cyclomethicone, spermol ethylhexoate (cetyl ethyl hexanoate) or C12-15 alkyl benzoate (Alkyl Benzoate) etc. during cosmetics and composition thereof occupied in composition total weight is 2-30 % by weight, but is not limited thereto.
The present invention is further described by following examples.Following examples only to limit the scope of the invention for illustration of the present invention.
The manufacture of reference example 1 Bulgarian Rose extract
Bulgarian Rose extract is manufactured from the cultivation farm direct import Bulgarian Rose flower (Bulgarian Damascena Rose Bud) in local famous Flos Rosae Rugosae paddy Ka Zanlike (Kazanlak) area of Bulgaria.The Bulgarian Rose flower that the present invention uses be in full bloom before state, in calyx with the agglomerating form of floral leaf.
Directly the flower of Bulgarian Rose is implemented to homogenize operation by using the homogenizer of motor.Pearl beater (bead beater) is used once in a while in order to dissolve harder plant cell.Cultivate with cold water and mix (vortexing) completely afterwards and extract 1 hour water solublity fraction under room temperature environment for 24 hours.From after 15,000xg centrifugalize 1 hour under room temperature state, remove insoluble substance, and solable matter is used for the manufacture of cosmetic composition.
The manufacture of reference example 2 cosmetic composition
Use the Bulgarian Rose flower extract that the propylene glycol of 30% (v/v) obtains from described reference example 1 with appropriate concentration dilution.Then, stir 6 hours its dilutions and mix completely, and filtering with the film filter that diameter is 0.2 μm.
Test case 1 detects the antioxidant effect of Bulgarian Rose extract
It is DPPH analytic process that the resistance to oxidation of Bulgarian Rose extract detects what adopt.1,1-diphenyl-2-picryl hydrazine (1,1-Diphenyl-2-picrylhydrazyl, DPPH) itself is highly stable free radical, is the violet compound in the unique light absorption of 520nm display.Free radical is highly stable in the organic solvents such as ethanol, particularly, can fade, be easy to the antioxidant activity that detects by an unaided eye when proton free radical scavenger (proton-radicalscavenger) works in various Antioxidation Mechanism.
First, 1mM DPPH solution is prepared.Then, according to variable concentrations with after the reagent with Bulgarian Rose extract in dissolve with ethanol reference example 1, with 4: 1 ratio mixing DPPH solution and reagent.520nm is adopted to detect absorbance after mixing 30 minutes completely.In addition, use outstanding antioxidant ascorbic acid as positive contrast group.Testing result please refer to Fig. 2.
Find with reference to being not difficult during result shown in figure 2, the EC50 of Bulgarian Rose extract is about about 1.5%, and shows the antioxidant activity of the material ascorbic acid display about 90% of outstanding anti-oxidation characteristics when reaching more than 5% for concentration.It can thus be appreciated that Bulgarian Rose extract has remarkable antioxidant effect too.
Test case 2 detects the moistening effect of Bulgarian Rose extract
The moisturizing power of the hyaluronic amount assessment Bulgarian Rose extract secreted by human keratinocytes.
More particularly, by human keratinocytes with 1*10
4cells/well is inoculated into 48 porocyte culture plates and after cultivating, executes agent treated with reference to Bulgarian Rose extract in example 1 with 0.0%, 0.1%, 0.5%, 1.0% at sample interior-excess.After cultivating 72 hours, elisa assay method is adopted to detect the hyaluronic amount of enhancing moisturizing power material being secreted into culture medium.Testing result please refer to Fig. 3.
As shown in Figure 3, Bulgarian Rose extract makes the hyaluronic biosynthesis being present in culture supernatant strengthen about 20% under the concentration environment of 1%.It can thus be appreciated that, contribute to when Bulgarian Rose extract is applied in skin improving moisturizing power.
Test case 3 detects the enhancing precollagen biosynthesis effect of Bulgarian Rose extract
The enhancing skin elasticity effect of the precollagenous amount assessment Bulgarian Rose extract secreted by human fibroblast.
More particularly, by human fibroblast HDF cell with 1*10
4cells/well is inoculated into 48 porocyte culture plates and after cultivating, executes agent treated with reference to Bulgarian Rose extract in example 1 with 0.01%, 0.1%, 1.0% at sample interior-excess.After cultivating 72 hours, elisa assay method is adopted to detect the precollagenous amount being secreted into culture medium.Testing result please refer to Fig. 4.
As shown in Figure 4, Bulgarian Rose extract significantly strengthens precollagen biosynthesis under concentration environment more than 1%, effectively can improve wrinkle of skin.
Reference example 3 manufacture is used for eyeshield near the eyes
The manufacture of eyeshield 1
Eyeshield 1 is manufactured by following table 1 ingredients listed.
Table 1 eyeshield 1
| Composition (content, % by weight) | Embodiment |
| Halothane | 52 |
| Trehalose | 17 |
| Jojoba seed oil | 13 |
| Propylene glycol | 1.6 |
| Glycerol | 1.3 |
| Polysorbate60 | 1.1 |
| Hydrogenated starch hydrolysate | 0.9 |
| Acetylglucosamine | 0.53 |
| Essence | 0.3 |
| Sorbitan stearate | 0.3 |
| Algaroba glue | 0.2 |
| Chondrus crispus | 0.2 |
| Hydrolytic collagen | 0.2 |
| Xanthan gum | 0.1 |
| Adenylic acid | 0.04 |
| Water | To 100 |
The concrete manufacture method of eyeshield 1 is as follows:
Under normal temperature environment, composition various in upper table 1 is contained in stir in heating container and mixes.First, add halothane in ionized water and after being heated to more than 55 DEG C, while making the temperature of its solution keep more than 55 DEG C, add all the other materials, finally adding viscosifier and efficiency material, thus produce eyeshield 1 in the present invention.
The manufacture of eyeshield 2
According to following table 2 ingredients listed, produced the compositions be about to for eyeshield 2 by common cosmetic composition manufacture method.
Table 2 eyeshield 2
| Composition (content, % by weight) | Embodiment |
| Water | To 100 |
| Betanin | 2.0 |
| Glycerol | 3.0 |
| Cellulose gum | 0.1 |
| Bulgarian Rose extract (reference example 2) | 1.0 |
| PEG.PPG-17.6 copolymer | 1.0 |
| Antiseptic | 0.05-0.3 |
| Essence | 0.005 |
Infiltrate non-woven fabrics shown in Fig. 1 by described compositions and produce eyeshield 2.
Reference example 4 manufactures eye cream
Eye cream is produced according to following table 3 ingredients listed.
Table 3
Manufacture method is as follows:
1) oily composition is heated to 70 DEG C.
2) mix watery composition with general artificial intelligence's agitator and be heated to 75 DEG C and dissolve.
3) above-mentioned 2) watery composition in add 1) oily composition and under 8000rpm state, run 5 minutes homogenizers manufacture protective skin cream.
4) then, stir supplementary elements such as adding viscosifier, and use homogenizer to stir 3 minutes under 8000rpm state.
5) under 45 DEG C of temperature environments, EGCG, intelligent polypeptide and essence is added further.
6), after stirring completely, take out from homogenizer and be cooled to 30 DEG C.
Test case 4 detects and improves wrinkle effect near the eyes
Detect the improvement wrinkle effect near the eyes using eyeshield near the eyes that above-mentioned reference example 3 manufactures.Selected 25-39 year Chinese women 30 detect.Biweekly, within 6 weeks, use this to use eyeshield near the eyes totally, and there is degree, elastic force degree and moisture in the time period wrinkle detected respectively near the eyes after being divided into use immediately, after 3 weeks and after 6 weeks.
Use described eyeshield as follows.In the above-mentioned reference example 4 of abundant film after eye cream, eyeshield 1 is pasted onto the position, optical fundus needing emphasis maintenance, and fixes eyeshield with pointing to beat gently above massage eye-shield.Then, 20 minutes canthus are covered with eyeshield 2.When use eyeshield 1 and eyeshield 2, state please refer to Fig. 5.
1. expert with the naked eye assesses wrinkle
2 experts observe first (0w), use after make assessment after (0w '), 3 weeks (3w) and 6 weeks (6w) visit immediately the canthus of test receiver.The yardstick of assessment mark is 5 points, can assess into 1 point, 3 points and 5 points.Mark from 1 point more close to, illustrate that wrinkle is also fewer.
As shown in Figure 6, the wrinkle improvement rate presented immediately after using this product reaches 2%, and the improvement rate after 3 weeks and 6 weeks reaches 12% and 19% respectively.It can thus be appreciated that after using this product, wrinkle reduces gradually, and effect improving wrinkles is remarkable.
2. people is the later evaluation restoring force forming canthus wrinkle
After the wrinkle making canthus skin appearance darker artificially, assessed the elastic force degree of skin by assessment recovery extent.Make to send out after wrinkle blend compounds band is pasted with the canthus skin be as the criterion within upper and lower 1.5cm scope to wait for 5 minutes, thus make canthus skin occur wrinkle artificially.Then, remove adhesive tape and detect restoring degree and the length of wrinkle.Make overall length reach 3cm to detect the restoring force used after this product, and the length detected is considered as skin elasticity degree.Now, length is longer, and restoring force is also more outstanding.When length reaches 3cm, illustrate that skin has returned to original state.
As shown in Figure 7, with before use eyeshield time state compared with, after using eyeshield 3,6 weeks, the skin length at canthus is significantly increased to 2.85cm and 2.86cm respectively.It can thus be appreciated that, because this product strengthens the elastic force degree of canthus skin, effectively improve the artificial wrinkle formed.
3. test receiver's self assessment wrinkle
Use in the process of eyeshield in the present invention in 6 weeks, the wrinkle degree of improvement of assessment test receiver accreditation.Make by testing receiver directly to examine the change after this product of use and assess and submit the effect approved to.Test receiver is divided into yardstick to assess with 5.
As shown in Figure 8, the wrinkle improvement rate after 6 weeks is used to reach 19%, higher than the wrinkle improvement rate 12% after use 3 weeks.It can thus be appreciated that, use eyeshield in the present invention can improve wrinkle gradually.
4. the moisture of evaluate ocular cuticle skin
For when detecting moisture before and after this product of use, use
(CM825, C+K, Germany) carries out detecting and assesses the increase degree of moisture.Detect after 3 weeks with use before the use, and make with relative value and representing, unit is AU.
As shown in Figure 9, after using this product, moisture rises to about about 30% immediately, and thus, we can examine water supply effect immediately.After using 3 weeks, even if skin does not have this product of film, moisture also significantly increases by 10%.It can thus be appreciated that, when using this product, the moisturizing power of canthus skin can be strengthened.
5. assess extent of wrinkle improvement by photo
Figure 10 illustrates the periocualr skin wrinkle state used in the present invention before eyeshield and afterwards.During according to this state, be easy to assess canthus wrinkle of the present invention and improve degree.
As shown in Figure 10, with the naked eye examine after using before this product and using and to be appreciated that use 6 weeks during the state after this product 6 weeks, quantity and the length of the numerous fan-shaped wrinkle on eye tail place and optical fundus significantly reduce, and its degree of depth significantly shoals.
6. carry out the questionnaire survey about result of use and quality for test receiver
Carry out in the process of above-mentioned test, carry out following questionnaire survey for the test receiver taken one's test.
Questionnaire survey content
Does canthus elastic force improve after using 3 weeks and 6 weeks?
Does canthus wrinkle improve after using 3 weeks and 6 weeks?
Do are you how many to the satisfaction of eyeshield 1 and eyeshield 2 after using 3 weeks and 6 weeks?
Test receiver think, after using the present invention 3 weeks and 6 weeks, the improvement rate of canthus elastic force reaches 77% and 93% respectively, and the improvement rate of canthus wrinkle reaches 87% and 90% respectively.After test receiver uses eyeshield product 8 weeks, satisfaction is unexpectedly up to 93%.
Claims (5)
1. the canthus skin eyeshield that the sheet type eyeshield 2 including the compositions of Bulgarian Rose extract by the thawing membranous type eyeshield 1 and infiltration that include acetylglucosamine and adenylic acid forms, it is characterized in that: in the gross weight of compositions, the content of described Bulgarian Rose extract is 0.1-10.0 % by weight, wherein, described Bulgarian Rose extract extracts from the alabastrum of Bulgarian Rose.
2. eyeshield according to claim 1, is characterized in that: in the gross weight of eyeshield 1, and the content of described acetylglucosamine is 0.1-5.0 % by weight, and the content of adenylic acid is 0.01-5.0%.
3. eyeshield according to claim 1, is characterized in that: described eyeshield is for improving canthus wrinkle.
4. eyeshield according to claim 1, is characterized in that: described eyeshield is for improving canthus skin elasticity.
5. eyeshield according to claim 1, is characterized in that: described eyeshield is for improving canthus skin moisture-keeping power.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR10-2010-0091159 | 2010-09-16 | ||
| KR1020100091159A KR101831756B1 (en) | 2010-09-16 | 2010-09-16 | Cosmetic composition for improving wrinkles and the patch for the skin around eyes using the same |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102397181A CN102397181A (en) | 2012-04-04 |
| CN102397181B true CN102397181B (en) | 2015-09-16 |
Family
ID=45880081
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201010505194.2A Active CN102397181B (en) | 2010-09-16 | 2010-09-30 | Aging resistance cosmetic composition and periocualr skin eyeshield |
Country Status (2)
| Country | Link |
|---|---|
| KR (1) | KR101831756B1 (en) |
| CN (1) | CN102397181B (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3990124A1 (en) * | 2019-06-28 | 2022-05-04 | L'Oréal | Anti-aging compositions and skin masks containing anti-aging compositions |
| KR102182857B1 (en) | 2020-06-23 | 2020-11-25 | 이정음 | Preparing method of patch containing hydrogel nanoised active ingredients |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1280859A (en) * | 1998-08-04 | 2001-01-24 | 株式会社资生堂 | Method of cosmetology |
| CN1688595A (en) * | 2002-10-09 | 2005-10-26 | 株式会社钟纺化妆品 | N-acetylglucosamine derivatives and use thereof |
| CN101068601A (en) * | 2004-11-05 | 2007-11-07 | 拜尔福斯克宁科学院 | Polyamine compositions |
-
2010
- 2010-09-16 KR KR1020100091159A patent/KR101831756B1/en active IP Right Grant
- 2010-09-30 CN CN201010505194.2A patent/CN102397181B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1280859A (en) * | 1998-08-04 | 2001-01-24 | 株式会社资生堂 | Method of cosmetology |
| CN1688595A (en) * | 2002-10-09 | 2005-10-26 | 株式会社钟纺化妆品 | N-acetylglucosamine derivatives and use thereof |
| CN101068601A (en) * | 2004-11-05 | 2007-11-07 | 拜尔福斯克宁科学院 | Polyamine compositions |
Non-Patent Citations (2)
| Title |
|---|
| 核苷酸类物质的应用研究进展;应国清等;《广州食品工业科技》;20041231;第20卷(第2期);125-128 * |
| 玫瑰精油提取工艺研究;马希汉等;《林产化学与工业》;20040831;第24卷;80-84 * |
Also Published As
| Publication number | Publication date |
|---|---|
| KR101831756B1 (en) | 2018-02-26 |
| KR20120029204A (en) | 2012-03-26 |
| CN102397181A (en) | 2012-04-04 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN103648479B (en) | Comprise the topical skin care preparation of plant extract | |
| CN108143702A (en) | A kind of efficient whitening and moisturizing facial mask liquid, facial mask and preparation method thereof | |
| CN107961211A (en) | Cosmetic composition | |
| KR101723526B1 (en) | Cosmetic composition containing the extract of Camellia japonica flower, Prunus serrulata flower, Jasminum officinale flower, Chamomilla recutita flower and Nelumbo nucifera flower | |
| CN104367537A (en) | Moistening and beautifying facial mask and preparation method thereof | |
| CN105168054A (en) | Mask capable of supplementing water, whitening and removing wrinkles and preparation method of mask | |
| CN105168038A (en) | Aurea helianthus flower mud facial mask and preparation method therefor | |
| CN109350579B (en) | Whitening cosmetic additive, whitening skin-refreshing lotion and preparation method thereof | |
| CN109330954B (en) | Whitening skin brightening lotion, preparation method thereof and tyrosinase inhibitor | |
| CN108567641A (en) | The tender factor of vegetation water and the skin care compositions for including the tender factor of vegetation water | |
| CN106176324A (en) | A kind of Whitening sunscreen cream containing Noni fruit quintessence oil and preparation method thereof | |
| CN108601797A (en) | Skin care compositions and methods | |
| CN102397181B (en) | Aging resistance cosmetic composition and periocualr skin eyeshield | |
| CN102949328B (en) | Toning lotion with functions of anti-senile, wrinkle-dispelling and moisturizing and preparation method thereof | |
| CN107802545A (en) | A kind of anti-oxidant and lightening compositions and the skin care item containing said composition | |
| CN111358710A (en) | Moisture-preserving and soothing donkey-hide gelatin face cream and preparation method thereof | |
| CN107213099B (en) | One kind containing Margarita extract cosmetic material | |
| JP2001233727A (en) | Cosmetic | |
| KR20110032715A (en) | Antiaging cosmetic compositions and method for producing thereof | |
| CN108158960A (en) | With the lip care lipstick for alleviating pigmentation | |
| KR20190067287A (en) | Anti-aging and anti-allergic cosmetic compositon comprising the extract of the flower, root, callus and seed of Hibiscus syriacus L. as an active ingredient and preparation method of the same | |
| CN113876671A (en) | Anti-aging composition containing rape bud extract and preparation method thereof | |
| JP2006241130A (en) | Function of ameliorating collagen fiber formation and wrinkle and flabbiness of human body skin to enhance lifting effect through using polymer component of water-soluble polysaccharide in bracket fungus of the genus fomes | |
| KR101710142B1 (en) | Functional food composition comprising complex ferment consisting of soybean and barley | |
| KR100563442B1 (en) | Organic farming natural extract having moisture-protection and stimulus-relief activities, and cosmetic composition comprising the same |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant |