CN106176324A - A kind of Whitening sunscreen cream containing Noni fruit quintessence oil and preparation method thereof - Google Patents
A kind of Whitening sunscreen cream containing Noni fruit quintessence oil and preparation method thereof Download PDFInfo
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- CN106176324A CN106176324A CN201610783591.3A CN201610783591A CN106176324A CN 106176324 A CN106176324 A CN 106176324A CN 201610783591 A CN201610783591 A CN 201610783591A CN 106176324 A CN106176324 A CN 106176324A
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- China
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- phase
- noni fruit
- quintessence oil
- parts
- raw material
- Prior art date
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- Granted
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- 235000017524 noni Nutrition 0.000 title claims abstract description 119
- 244000131360 Morinda citrifolia Species 0.000 title claims abstract description 118
- 235000013399 edible fruits Nutrition 0.000 title claims abstract description 113
- 230000002087 whitening effect Effects 0.000 title claims abstract description 58
- 239000006071 cream Substances 0.000 title claims abstract description 53
- 230000000475 sunscreen effect Effects 0.000 title claims abstract description 53
- 239000000516 sunscreening agent Substances 0.000 title claims abstract description 53
- 238000002360 preparation method Methods 0.000 title claims abstract description 49
- 239000002994 raw material Substances 0.000 claims abstract description 49
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims abstract description 42
- POJWUDADGALRAB-UHFFFAOYSA-N allantoin Chemical compound NC(=O)NC1NC(=O)NC1=O POJWUDADGALRAB-UHFFFAOYSA-N 0.000 claims abstract description 38
- -1 sterol ester Chemical class 0.000 claims abstract description 38
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 31
- 229930003427 Vitamin E Natural products 0.000 claims abstract description 21
- 239000008367 deionised water Substances 0.000 claims abstract description 21
- 229910021641 deionized water Inorganic materials 0.000 claims abstract description 21
- 229960001617 ethyl hydroxybenzoate Drugs 0.000 claims abstract description 21
- NUVBSKCKDOMJSU-UHFFFAOYSA-N ethylparaben Chemical compound CCOC(=O)C1=CC=C(O)C=C1 NUVBSKCKDOMJSU-UHFFFAOYSA-N 0.000 claims abstract description 21
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 claims abstract description 21
- GYCKQBWUSACYIF-UHFFFAOYSA-N o-hydroxybenzoic acid ethyl ester Natural products CCOC(=O)C1=CC=CC=C1O GYCKQBWUSACYIF-UHFFFAOYSA-N 0.000 claims abstract description 21
- 235000019165 vitamin E Nutrition 0.000 claims abstract description 21
- 229940046009 vitamin E Drugs 0.000 claims abstract description 21
- 239000011709 vitamin E Substances 0.000 claims abstract description 21
- 229940119170 jojoba wax Drugs 0.000 claims abstract description 20
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 claims abstract description 20
- POJWUDADGALRAB-PVQJCKRUSA-N Allantoin Natural products NC(=O)N[C@@H]1NC(=O)NC1=O POJWUDADGALRAB-PVQJCKRUSA-N 0.000 claims abstract description 19
- 229930182558 Sterol Natural products 0.000 claims abstract description 19
- 229960000458 allantoin Drugs 0.000 claims abstract description 19
- 150000001413 amino acids Chemical class 0.000 claims abstract description 19
- 235000003702 sterols Nutrition 0.000 claims abstract description 19
- 239000003906 humectant Substances 0.000 claims abstract description 16
- 239000003921 oil Substances 0.000 claims description 102
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 36
- 238000003756 stirring Methods 0.000 claims description 31
- 238000002156 mixing Methods 0.000 claims description 20
- 235000001014 amino acid Nutrition 0.000 claims description 17
- 238000004821 distillation Methods 0.000 claims description 17
- 239000000839 emulsion Substances 0.000 claims description 16
- WWZKQHOCKIZLMA-UHFFFAOYSA-N octanoic acid Chemical compound CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 claims description 13
- 239000004205 dimethyl polysiloxane Substances 0.000 claims description 12
- LQZZUXJYWNFBMV-UHFFFAOYSA-N dodecan-1-ol Chemical compound CCCCCCCCCCCCO LQZZUXJYWNFBMV-UHFFFAOYSA-N 0.000 claims description 12
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 claims description 12
- 230000033228 biological regulation Effects 0.000 claims description 11
- 150000002191 fatty alcohols Chemical class 0.000 claims description 11
- LADGBHLMCUINGV-UHFFFAOYSA-N tricaprin Chemical compound CCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCC)COC(=O)CCCCCCCCC LADGBHLMCUINGV-UHFFFAOYSA-N 0.000 claims description 11
- 239000007788 liquid Substances 0.000 claims description 10
- UIVPNOBLHXUKDX-UHFFFAOYSA-N 3,5,5-trimethylhexyl 3,5,5-trimethylhexanoate Chemical compound CC(C)(C)CC(C)CCOC(=O)CC(C)CC(C)(C)C UIVPNOBLHXUKDX-UHFFFAOYSA-N 0.000 claims description 9
- 229940100554 isononyl isononanoate Drugs 0.000 claims description 9
- 239000000203 mixture Substances 0.000 claims description 9
- 239000012153 distilled water Substances 0.000 claims description 8
- 239000000284 extract Substances 0.000 claims description 4
- 239000000080 wetting agent Substances 0.000 claims description 4
- 230000006837 decompression Effects 0.000 claims description 3
- 239000006228 supernatant Substances 0.000 claims description 3
- 239000000341 volatile oil Substances 0.000 claims description 3
- 150000002148 esters Chemical class 0.000 claims 2
- 241000259759 Cassida nobilis Species 0.000 claims 1
- 210000000481 breast Anatomy 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 239000000463 material Substances 0.000 claims 1
- 230000003020 moisturizing effect Effects 0.000 claims 1
- 238000010025 steaming Methods 0.000 claims 1
- XUMBMVFBXHLACL-UHFFFAOYSA-N Melanin Chemical compound O=C1C(=O)C(C2=CNC3=C(C(C(=O)C4=C32)=O)C)=C2C4=CNC2=C1C XUMBMVFBXHLACL-UHFFFAOYSA-N 0.000 abstract description 18
- 230000000694 effects Effects 0.000 abstract description 13
- 230000001629 suppression Effects 0.000 abstract description 11
- 238000010521 absorption reaction Methods 0.000 abstract description 9
- 239000002537 cosmetic Substances 0.000 abstract description 5
- 230000002292 Radical scavenging effect Effects 0.000 abstract description 4
- 206010040829 Skin discolouration Diseases 0.000 abstract description 4
- MGJZITXUQXWAKY-UHFFFAOYSA-N diphenyl-(2,4,6-trinitrophenyl)iminoazanium Chemical compound [O-][N+](=O)C1=CC([N+](=O)[O-])=CC([N+]([O-])=O)=C1N=[N+](C=1C=CC=CC=1)C1=CC=CC=C1 MGJZITXUQXWAKY-UHFFFAOYSA-N 0.000 abstract description 4
- 238000004519 manufacturing process Methods 0.000 abstract description 3
- 230000037072 sun protection Effects 0.000 abstract description 3
- 239000000523 sample Substances 0.000 description 12
- 238000002835 absorbance Methods 0.000 description 10
- HHEAADYXPMHMCT-UHFFFAOYSA-N dpph Chemical compound [O-][N+](=O)C1=CC([N+](=O)[O-])=CC([N+]([O-])=O)=C1[N]N(C=1C=CC=CC=1)C1=CC=CC=C1 HHEAADYXPMHMCT-UHFFFAOYSA-N 0.000 description 9
- 239000000243 solution Substances 0.000 description 9
- 230000000052 comparative effect Effects 0.000 description 8
- 241000252212 Danio rerio Species 0.000 description 7
- 206010013786 Dry skin Diseases 0.000 description 7
- 238000001035 drying Methods 0.000 description 7
- 239000000049 pigment Substances 0.000 description 7
- 239000000047 product Substances 0.000 description 7
- 210000001161 mammalian embryo Anatomy 0.000 description 6
- FBUKVWPVBMHYJY-UHFFFAOYSA-N nonanoic acid Chemical compound CCCCCCCCC(O)=O FBUKVWPVBMHYJY-UHFFFAOYSA-N 0.000 description 6
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 4
- 102000003425 Tyrosinase Human genes 0.000 description 4
- 108060008724 Tyrosinase Proteins 0.000 description 4
- 230000031700 light absorption Effects 0.000 description 4
- 238000012360 testing method Methods 0.000 description 4
- 241000196324 Embryophyta Species 0.000 description 3
- 229960000935 dehydrated alcohol Drugs 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 230000002401 inhibitory effect Effects 0.000 description 3
- 239000012488 sample solution Substances 0.000 description 3
- AZQWKYJCGOJGHM-UHFFFAOYSA-N 1,4-benzoquinone Chemical compound O=C1C=CC(=O)C=C1 AZQWKYJCGOJGHM-UHFFFAOYSA-N 0.000 description 2
- DIBAKBGYJUCGDL-UHFFFAOYSA-N 2,6-diamino-n-[1-[(2-amino-2-oxoethyl)amino]-3-(1h-imidazol-5-yl)-1-oxopropan-2-yl]hexanamide Chemical compound NCCCCC(N)C(=O)NC(C(=O)NCC(N)=O)CC1=CN=CN1 DIBAKBGYJUCGDL-UHFFFAOYSA-N 0.000 description 2
- 208000030507 AIDS Diseases 0.000 description 2
- WTDRDQBEARUVNC-LURJTMIESA-N L-DOPA Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C(O)=C1 WTDRDQBEARUVNC-LURJTMIESA-N 0.000 description 2
- WTDRDQBEARUVNC-UHFFFAOYSA-N L-Dopa Natural products OC(=O)C(N)CC1=CC=C(O)C(O)=C1 WTDRDQBEARUVNC-UHFFFAOYSA-N 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
- 241000157491 Morinda Species 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 229910021529 ammonia Inorganic materials 0.000 description 2
- 238000009835 boiling Methods 0.000 description 2
- 239000007853 buffer solution Substances 0.000 description 2
- 108010026970 bursopoietin Proteins 0.000 description 2
- 238000011161 development Methods 0.000 description 2
- 230000018109 developmental process Effects 0.000 description 2
- 235000013305 food Nutrition 0.000 description 2
- 230000007760 free radical scavenging Effects 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 210000002700 urine Anatomy 0.000 description 2
- DWNBOPVKNPVNQG-LURJTMIESA-N (2s)-4-hydroxy-2-(propylamino)butanoic acid Chemical compound CCCN[C@H](C(O)=O)CCO DWNBOPVKNPVNQG-LURJTMIESA-N 0.000 description 1
- VAJVDSVGBWFCLW-UHFFFAOYSA-N 3-Phenyl-1-propanol Chemical compound OCCCC1=CC=CC=C1 VAJVDSVGBWFCLW-UHFFFAOYSA-N 0.000 description 1
- 206010003210 Arteriosclerosis Diseases 0.000 description 1
- 102000030523 Catechol oxidase Human genes 0.000 description 1
- 108010031396 Catechol oxidase Proteins 0.000 description 1
- 241000448255 Congiopodus peruvianus Species 0.000 description 1
- AHMIDUVKSGCHAU-UHFFFAOYSA-N Dopaquinone Natural products OC(=O)C(N)CC1=CC(=O)C(=O)C=C1 AHMIDUVKSGCHAU-UHFFFAOYSA-N 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
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- 206010019233 Headaches Diseases 0.000 description 1
- 206010020772 Hypertension Diseases 0.000 description 1
- AHMIDUVKSGCHAU-LURJTMIESA-N L-dopaquinone Chemical compound [O-]C(=O)[C@@H]([NH3+])CC1=CC(=O)C(=O)C=C1 AHMIDUVKSGCHAU-LURJTMIESA-N 0.000 description 1
- 206010024453 Ligament sprain Diseases 0.000 description 1
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- 102000004316 Oxidoreductases Human genes 0.000 description 1
- 108090000854 Oxidoreductases Proteins 0.000 description 1
- DYUQAZSOFZSPHD-UHFFFAOYSA-N Phenylpropyl alcohol Natural products CCC(O)C1=CC=CC=C1 DYUQAZSOFZSPHD-UHFFFAOYSA-N 0.000 description 1
- 235000002634 Solanum Nutrition 0.000 description 1
- 241000207763 Solanum Species 0.000 description 1
- 208000010040 Sprains and Strains Diseases 0.000 description 1
- 235000021355 Stearic acid Nutrition 0.000 description 1
- GAMYVSCDDLXAQW-AOIWZFSPSA-N Thermopsosid Natural products O(C)c1c(O)ccc(C=2Oc3c(c(O)cc(O[C@H]4[C@H](O)[C@@H](O)[C@H](O)[C@H](CO)O4)c3)C(=O)C=2)c1 GAMYVSCDDLXAQW-AOIWZFSPSA-N 0.000 description 1
- 208000025865 Ulcer Diseases 0.000 description 1
- 239000002390 adhesive tape Substances 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- OBETXYAYXDNJHR-UHFFFAOYSA-N alpha-ethylcaproic acid Natural products CCCCC(CC)C(O)=O OBETXYAYXDNJHR-UHFFFAOYSA-N 0.000 description 1
- 238000010171 animal model Methods 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
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- 230000009286 beneficial effect Effects 0.000 description 1
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- 235000013351 cheese Nutrition 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
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- 229940079593 drug Drugs 0.000 description 1
- 239000000975 dye Substances 0.000 description 1
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- 230000007613 environmental effect Effects 0.000 description 1
- 239000000686 essence Substances 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000003925 fat Substances 0.000 description 1
- 230000004720 fertilization Effects 0.000 description 1
- 229930003944 flavone Natural products 0.000 description 1
- 150000002212 flavone derivatives Chemical class 0.000 description 1
- 235000011949 flavones Nutrition 0.000 description 1
- 235000012041 food component Nutrition 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- 230000002068 genetic effect Effects 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
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- 208000013465 muscle pain Diseases 0.000 description 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 229930015704 phenylpropanoid Natural products 0.000 description 1
- 125000001474 phenylpropanoid group Chemical group 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 239000013641 positive control Substances 0.000 description 1
- 239000013558 reference substance Substances 0.000 description 1
- 230000002000 scavenging effect Effects 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 239000004575 stone Substances 0.000 description 1
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- 238000006467 substitution reaction Methods 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
- 239000011573 trace mineral Substances 0.000 description 1
- 235000013619 trace mineral Nutrition 0.000 description 1
- 229940093633 tricaprin Drugs 0.000 description 1
- 231100000397 ulcer Toxicity 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
- VHBFFQKBGNRLFZ-UHFFFAOYSA-N vitamin p Natural products O1C2=CC=CC=C2C(=O)C=C1C1=CC=CC=C1 VHBFFQKBGNRLFZ-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/342—Alcohols having more than seven atoms in an unbroken chain
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/37—Esters of carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/37—Esters of carboxylic acids
- A61K8/375—Esters of carboxylic acids the alcohol moiety containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
- A61K8/4946—Imidazoles or their condensed derivatives, e.g. benzimidazoles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/63—Steroids; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/678—Tocopherol, i.e. vitamin E
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/89—Polysiloxanes
- A61K8/891—Polysiloxanes saturated, e.g. dimethicone, phenyl trimethicone, C24-C28 methicone or stearyl dimethicone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Dermatology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Chemical & Material Sciences (AREA)
- Cosmetics (AREA)
Abstract
The invention discloses a kind of Whitening sunscreen cream containing Noni fruit quintessence oil, including following raw material components: Noni fruit quintessence oil, Jojoba oil, sterol ester, vitamin E, methyl hydroxybenzoate, ethyl hydroxybenzoate, amino acid humectant, allantoin, deionized water；Wherein, Jojoba oil, sterol ester, vitamin E, methyl hydroxybenzoate, ethyl hydroxybenzoate are the raw material of A phase；Amino acid humectant, allantoin, deionized water are the raw material of B phase；Noni fruit quintessence oil is the raw material of D phase.A kind of Whitening sunscreen cream containing Noni fruit quintessence oil of the present invention, there is significant DPPH radical scavenging activity, effectively suppress the activity of tryrosinase, suppression melanin growth, effective to ultra-violet absorption, realizing the effect of whitening sun protection skin protection, its preparation method is simple to operation, and production cost is relatively low.It addition, the Noni fruit quintessence oil that the present invention proposes may be directly applied to skin protection whitening, it is also possible to be applied to prepare other skin-lightening cosmetics or skin care item product.
Description
Technical field
The present invention relates to Noni fruit and be applied to cosmetic field, particularly relate to a kind of whitening sun protection containing Noni fruit quintessence oil
Frost and preparation method thereof.
Background technology
Noni is Rubiaceae Morinda plant, has another name called Morinda Citifolia, Solanum pseudo-capsicumvar diflorum (Vell.)Bitter, India's Fructus Mori, and this plant is the most coastwise
In being grown on the bushes at seabeach, and wetland is taken up in the seashore of many stone, roadside, streams, is mainly distributed on the South Sea Islands
Small island, such as Philippine, Australia, Cambodia etc..Also there are substantial amounts of plantation, conservative estimation cultivated area in existing China Hainan, Taiwan
10000 mu of Hainan, 4000 mu of Yunnan.Noni contains 60 multiple nutritional components, including vitamin, trace element, flavone, phenylpropyl alcohol
Element, polysaccharide etc., have stronger functional characteristic, and root, stem, leaf, flower, fruit all can be used as medicine.Root can obtain the dyestuff of yellow or redness
For contaminating clothes, edible fruit use, as food and health product.Noni is used as food by the Polynesian on island, the South Pacific Ocean
Product, medicine there are about history in 2000.Noni can suppress and cure multiple disease.Such as arthritis, diabetes, hypertension, muscle
Pain, menoxenia, headache, heart disease, acquired immune deficiency syndrome (AIDS), tumor, digestive tract ulcer, various sprain, depression, aging, dyspepsia,
Arteriosclerosis, blood vessel aspect problem and be addicted to drug.Phenylpropanoids can suppress tryrosinase according to the literature
Activity, tryrosinase, also known as polyphenol oxidase, is widely present in plant, animal and microbial body, is the limit of B16 cell
Speed enzyme, controls its vigor and can control melanic growing amount.Due to the functional characteristic that noni is unique, it has been to be in great demand most in the whole world
One of health-oriented products, the demand of noni is increased by existing market with the speed of annual 50%, and government is also strengthening noni
Exploitation and development.But Noni fruit quintessence oil application on skin-lightening cosmetic or skin care item at present is also in the blank stage, is badly in need of out
Send out application.
Summary of the invention
In view of this, the invention provides a kind of Whitening sunscreen cream containing Noni fruit quintessence oil and preparation method thereof.
The technological means that the present invention uses is as follows: a kind of Whitening sunscreen cream containing Noni fruit quintessence oil, including following raw material
Component: Noni fruit quintessence oil, Jojoba oil, sterol ester, vitamin E, methyl hydroxybenzoate, ethyl hydroxybenzoate, amino acid humectant, urine
Bursin, deionized water；
Wherein, Jojoba oil, sterol ester, vitamin E, methyl hydroxybenzoate, ethyl hydroxybenzoate are the raw material of A phase；Aminoacid
Wetting agent, allantoin, deionized water are the raw material of B phase；Noni fruit quintessence oil is the raw material of D phase.
Preferably, described raw material also include lauryl alcohol, tristerin, 16/18 natural fatty alcohols, octanoic acid/
Tricaprin, isononyl isononanoate, polydimethylsiloxane, glycerol；
Wherein, tristerin, 16/18 natural fatty alcohols, caprylic/capric triglyceride, isononyl isononanoate,
Jojoba oil, polydimethylsiloxane, sterol ester, vitamin E, methyl hydroxybenzoate, ethyl hydroxybenzoate are the raw material of A phase；Glycerol,
Amino acid humectant, allantoin, deionized water are the raw material of B phase；Lauryl alcohol is the raw material of C phase；Noni fruit quintessence oil is D phase
Raw material.
Preferably, the weight part ratio of described raw material is: Noni fruit quintessence oil 0.8～1.2 parts, Jojoba oil 1～1.2 parts, steroid
Alcohol ester 0.8～1 part, vitamin E 0.5～1 part, methyl hydroxybenzoate 0.1～0.3 part, ethyl hydroxybenzoate 0.05～0.15 part, ammonia
Base acid wetting agent 2～3 parts, allantoin 0.2～0.4 part, deionized water 90～110 parts.
Preferably, the weight part ratio of described raw material is: Noni fruit quintessence oil 0.8～1.2 parts, Jojoba oil 1～1.2 parts, steroid
Alcohol ester 0.8～1 part, vitamin E 0.5～1 part, methyl hydroxybenzoate 0.1～0.3 part, ethyl hydroxybenzoate 0.05～0.15 part, ammonia
Base acid wetting agent 2～3 parts, allantoin 0.2～0.4 part, deionized water 90～110 parts, lauryl alcohol 0.7～0.9 part, stearic acid
Glyceride 1～1.5 parts, 16/18 natural fatty alcohols 0.4～0.6 part, caprylic/capric triglyceride 2～3 parts, different n-nonanoic acid are different
Nonyl ester 3～5 parts, polydimethylsiloxane 0.5～1 part, glycerol 3～5 parts.
Preferably, the weight part ratio of described raw material is: Noni fruit quintessence oil 1 part, Jojoba oil 1～1.2 parts, sterol ester 0.8
～1 part, vitamin E 0.5～1 part, methyl hydroxybenzoate 0.2 part, ethyl hydroxybenzoate 0.1 part, amino acid humectant 2～3 parts, urine
Bursin 0.3 part, deionized water 100 parts, lauryl alcohol 0.8 part, tristerin 1～1.5 parts, 16/18 natural fats
Alcohol 0.5 part, caprylic/capric triglyceride 2～3 parts, isononyl isononanoate 3～5 parts, polydimethylsiloxane 0.5～1 part, sweet
Oil 3～5 parts.
Preferably, the preparation method of described Noni fruit quintessence oil comprises the following steps: by fresh Noni fruit and the distillation of chopping
Water mix, put in distillator, connect air pump, decompression distillation 2～4h, it is thus achieved that volatile oil be Noni fruit quintessence oil.
Preferably, the preparation method of described Noni fruit quintessence oil comprises the following steps: by fresh Noni fruit and the distillation of chopping
Water mixes, and puts in distillator, air-distillation backflow 2～4h, is stood by gained backflow, extracts backflow supernatant liquid, i.e.
Obtain Noni fruit quintessence oil.
Preferably, the volume of described distilled water is that each hectogram Noni fruit adds 150ml distilled water.
The present invention also provides for the preparation method of a kind of Whitening sunscreen cream containing Noni fruit quintessence oil, comprises the following steps:
(1) A phase, B phase, the raw material of D phase are prepared；
(2) allotment A phase, B phase: preparation A phase, B phase respectively, and distinguish heated and stirred to 80～90 DEG C in homogeneously；
(3) mixing preparation: the temperature of regulation B phase higher than the temperature of A phase, and control the temperature range of A phase and B phase 80～
Between 90 DEG C, the biphase temperature difference≤5 DEG C, under stirring 800～1200 rev/min states, A phase is slowly added in B phase, to two
It is thoroughly mixed mutually, starts homogenizer, make emulsion-stabilizing and glossy；When temperature is down to 40～50 DEG C, add D phase, persistently stir
Mixing, emulsion is down to room temperature, stops stirring, stands 18～24 hours, prepares the Whitening sunscreen cream containing Noni fruit quintessence oil.
The present invention also provides for the preparation method of a kind of Whitening sunscreen cream containing Noni fruit quintessence oil, comprises the following steps:
(1) A phase, B phase, C phase, the raw material of D phase are prepared；
(2) allotment A phase, B phase: preparation A phase, B phase respectively, and distinguish heated and stirred to 80～90 DEG C in homogeneously；
(3) mixing preparation: the temperature of regulation B phase higher than the temperature of A phase, and control the temperature range of A phase and B phase 80～
Between 90 DEG C, the biphase temperature difference≤5 DEG C, under stirring 800～1200 rev/min states, A phase is slowly added in B phase, to two
It is thoroughly mixed mutually, starts homogenizer, make emulsion-stabilizing and glossy；When temperature is 60～70 DEG C, add C phase, again start
Homogenizer, until emulsion mix homogeneously；When temperature is down to 40～50 DEG C, adding D phase, continuously stirred, emulsion is down to room temperature, stops
Only stirring, stands 18～24 hours, prepares the Whitening sunscreen cream containing Noni fruit quintessence oil.
Beneficial effect: a kind of Whitening sunscreen cream containing Noni fruit quintessence oil of the present invention, has significant DPPH free radical
Scavenging activity, effectively suppresses the activity of tryrosinase, and suppression melanin grows, effective to ultra-violet absorption, it is achieved whitening is prevented
Shine the effect of skin protection.And the preparation method of Whitening sunscreen cream of the present invention is simple to operation, production cost is relatively low, Qi Zhongli
Preparing Noni fruit quintessence oil with distillation under vacuum and atmospheric distillation, it is best in quality, has preferable DPPH radical scavenging activity
Power, may be directly applied to skin protection whitening, it is also possible to be applied to prepare other skin-lightening cosmetics or skin care item product.
Accompanying drawing explanation
Fig. 1 is that sample liquid is to zebrafish embryo pigment growth inhibited situation, A: normal zebrafish embryo, B: embodiment 6 sample
The impact on pigment of the product liquid.
Detailed description of the invention
Principle and feature to the present invention are described below, and illustrated embodiment is served only for explaining the present invention, is not intended to
Limit the scope of the present invention.
Embodiment 1
A kind of Whitening sunscreen cream containing Noni fruit quintessence oil, including following raw material components:
A phase: Jojoba oil 1 part, sterol ester 0.8 part, vitamin E 0.5 part, methyl hydroxybenzoate 0.1 part, ethyl hydroxybenzoate
0.05 part；
B phase: amino acid humectant 2 parts, allantoin 0.2 part, deionized water 90 parts；
D phase: Noni fruit quintessence oil 0.8 part.
The preparation method of the above-mentioned Whitening sunscreen cream containing Noni fruit quintessence oil, comprises the following steps:
(1) Noni fruit quintessence oil is prepared (distillation under vacuum): takes the fresh Noni fruit chopping of 200g, mixes 300mL distilled water,
It is positioned in clean 500mL alembic, extracts volatile oil, i.e. with air pump by heating mantle heats to boiling, decompression distillation 2h
Obtain Noni fruit quintessence oil, for the raw material of D phase；
(2) A phase, the raw material of B phase are prepared；
(3) allotment A phase, B phase: take the 150ml beaker after two sterilizing-dryings, respectively preparation A phase, B phase, and heat respectively
Stir to 80～90 DEG C in homogeneously；
(4) mixing preparation: the temperature of regulation B phase higher than the temperature of A phase, and control the temperature range of A phase and B phase 80～
Between 90 DEG C, the biphase temperature difference≤5 DEG C, stirring 800 rev/min states under, A phase is slowly added in B phase, to the most biphase completely
Mixing, starts homogenizer, makes emulsion-stabilizing and glossy；When temperature is down to 40 DEG C, adding D phase, continuously stirred, emulsion is down to
Room temperature, closes agitator, stops stirring, bottles after standing 18 hours, prepares the Whitening sunscreen cream containing Noni fruit quintessence oil.
Embodiment 2
A kind of Whitening sunscreen cream containing Noni fruit quintessence oil, including following raw material components:
A phase: Jojoba oil 1.2 parts, sterol ester 1 part, vitamin E 1 part, methyl hydroxybenzoate 0.3 part, ethyl hydroxybenzoate
0.15 part；
B phase: amino acid humectant 3 parts, allantoin 0.4 part, deionized water 110 parts；
D phase: Noni fruit quintessence oil 1.2 parts.
The preparation method of the above-mentioned Whitening sunscreen cream containing Noni fruit quintessence oil, comprises the following steps:
(1) Noni fruit quintessence oil is prepared (atmospheric distillation): takes the fresh Noni fruit chopping of 300g, mixes 500mL distilled water,
Being positioned in clean 1L alembic, be heated to boiling, air-distillation backflow 4h by electric jacket, gained backflow stands and extracts
Layer liquid obtains quintessence oil, i.e. obtains Noni fruit quintessence oil, for the raw material of D phase；
(2) A phase, the raw material of B phase are prepared；
(3) allotment A phase, B phase: take the 150ml beaker after two sterilizing-dryings, respectively preparation A phase, B phase, and heat respectively
Stir to 80～90 DEG C in homogeneously；
(4) mixing preparation: the temperature of regulation B phase higher than the temperature of A phase, and control the temperature range of A phase and B phase 80～
Between 90 DEG C, the biphase temperature difference≤5 DEG C, under stirring 1200 rev/min states, A phase is slowly added in B phase, to biphase complete
Full mixing, starts homogenizer, makes emulsion-stabilizing and glossy；When temperature is down to 50 DEG C, adding D phase, continuously stirred, emulsion drops
To room temperature, close agitator, stop stirring, bottle after standing 24 hours, prepare the Whitening sunscreen cream containing Noni fruit quintessence oil.
Embodiment 3
A kind of Whitening sunscreen cream containing Noni fruit quintessence oil, including following raw material components:
A phase: Jojoba oil 1.2 parts, sterol ester 1 part, vitamin E 1 part, methyl hydroxybenzoate 0.2 part, ethyl hydroxybenzoate 0.1
Part；
B phase: amino acid humectant 3 parts, allantoin 0.3 part, deionized water 100 parts；
D phase: Noni fruit quintessence oil 1.0 parts.
The preparation method of the above-mentioned Whitening sunscreen cream containing Noni fruit quintessence oil, comprises the following steps:
(1) prepared by Noni fruit quintessence oil: use the preparation method of Noni fruit quintessence oil in embodiment 1, it is thus achieved that the raw material of D phase；
(2) A phase, the raw material of B phase are prepared；
(3) allotment A phase, B phase: take the 150ml beaker after two sterilizing-dryings, respectively preparation A phase, B phase, and heat respectively
Stir to 80～90 DEG C in homogeneously；
(4) mixing preparation: the temperature of regulation B phase higher than the temperature of A phase, and control the temperature range of A phase and B phase 80～
Between 90 DEG C, the biphase temperature difference≤5 DEG C, under stirring 1000 rev/min states, A phase is slowly added in B phase, to biphase complete
Full mixing, starts homogenizer, makes emulsion-stabilizing and glossy；When temperature is down to 45 DEG C, adding D phase, continuously stirred, emulsion drops
To room temperature, close agitator, stop stirring, bottle after standing 24 hours, prepare the Whitening sunscreen cream containing Noni fruit quintessence oil.
Embodiment 4
A kind of Whitening sunscreen cream containing Noni fruit quintessence oil, including following raw material components:
A phase: Jojoba oil 1 part, sterol ester 0.8 part, vitamin E 0.5 part, methyl hydroxybenzoate 0.1 part, ethyl hydroxybenzoate
0.05 part, tristerin 1 part, 16/18 natural fatty alcohol 0.4 part, caprylic/capric triglyceride 2 parts, different n-nonanoic acid different
Nonyl ester 3 parts, polydimethylsiloxane 0.5 part；
B phase: amino acid humectant 2 parts, allantoin 0.2 part, deionized water 90 parts, glycerol 3 parts；
C phase: lauryl alcohol 0.7 part；
D phase: Noni fruit quintessence oil 0.8 part.
The preparation method of the above-mentioned Whitening sunscreen cream containing Noni fruit quintessence oil, comprises the following steps:
(1) prepared by Noni fruit quintessence oil: use the preparation method of Noni fruit quintessence oil in embodiment 2, it is thus achieved that the raw material of D phase；
(2) A phase, B phase, the raw material of C phase are prepared；
(3) allotment A phase, B phase: take the 150ml beaker after two sterilizing-dryings, respectively preparation A phase, B phase, and heat respectively
Stir to 80～90 DEG C in homogeneously；
(4) mixing preparation: the temperature of regulation B phase higher than the temperature of A phase, and control the temperature range of A phase and B phase 80～
Between 90 DEG C, the biphase temperature difference≤5 DEG C, stirring 800 rev/min states under, A phase is slowly added in B phase, to the most biphase completely
Mixing, starts homogenizer, makes emulsion-stabilizing and glossy；When temperature is 60～70 DEG C, add C phase, again start homogenizer,
Until emulsion mix homogeneously；When temperature is down to 40 DEG C, adding D phase, continuously stirred, emulsion is down to room temperature, closes agitator, stops
Only stirring, bottles after standing 18 hours, prepares the Whitening sunscreen cream containing Noni fruit quintessence oil.
Embodiment 5
A kind of Whitening sunscreen cream containing Noni fruit quintessence oil, including following raw material components:
A phase: Jojoba oil 1.2 parts, sterol ester 1 part, vitamin E 1 part, methyl hydroxybenzoate 0.3 part, ethyl hydroxybenzoate
0.15 part, tristerin 1.5 parts, 16/18 natural fatty alcohol 0.6 part, caprylic/capric triglyceride 3 parts, different n-nonanoic acid
Different nonyl ester 5 parts, polydimethylsiloxane 1 part；
B phase: amino acid humectant 3 parts, allantoin 0.4 part, deionized water 110 parts, glycerol 5 parts；
C phase: lauryl alcohol 0.9 part；
D phase: Noni fruit quintessence oil 1.2 parts.
The preparation method of the above-mentioned Whitening sunscreen cream containing Noni fruit quintessence oil, comprises the following steps:
(1) prepared by Noni fruit quintessence oil: use the preparation method of Noni fruit quintessence oil in embodiment 1, it is thus achieved that the raw material of D phase；
(2) A phase, B phase, the raw material of C phase are prepared；
(3) allotment A phase, B phase: take the 150ml beaker after two sterilizing-dryings, respectively preparation A phase, B phase, and heat respectively
Stir to 80～90 DEG C in homogeneously；
(4) mixing preparation: the temperature of regulation B phase higher than the temperature of A phase, and control the temperature range of A phase and B phase 80～
Between 90 DEG C, the biphase temperature difference≤5 DEG C, under stirring 1200 rev/min states, A phase is slowly added in B phase, to biphase complete
Full mixing, starts homogenizer, makes emulsion-stabilizing and glossy；When temperature is 60～70 DEG C, add C phase, again start homogenizing
Machine, until emulsion mix homogeneously；When temperature is down to 50 DEG C, adding D phase, continuously stirred, emulsion is down to room temperature, closes stirring
Device, stops stirring, bottles after standing 24 hours, prepares the Whitening sunscreen cream containing Noni fruit quintessence oil.
Embodiment 6
A kind of Whitening sunscreen cream containing Noni fruit quintessence oil, including following raw material components:
A phase: Jojoba oil 1 part, sterol ester 1 part, vitamin E 1 part, methyl hydroxybenzoate 0.2 part, ethyl hydroxybenzoate 0.1
Part, tristerin 1 part, 16/18 natural fatty alcohol 0.5 part, caprylic/capric triglyceride 2 parts, isononyl isononanoate
3 parts, polydimethylsiloxane 1 part；
B phase: amino acid humectant 2 parts, allantoin 0.3 part, deionized water 100 parts, glycerol 4 parts；
C phase: lauryl alcohol 0.8 part；
D phase: Noni fruit quintessence oil 1 part.
The preparation method of the above-mentioned Whitening sunscreen cream containing Noni fruit quintessence oil, comprises the following steps:
(1) prepared by Noni fruit quintessence oil: use the preparation method of Noni fruit quintessence oil in embodiment 2, it is thus achieved that the raw material of D phase；
(2) A phase, B phase, C phase are prepared；
(3) allotment A phase, B phase: take the 150ml beaker after two sterilizing-dryings, respectively preparation A phase, B phase, and heat respectively
Stir to 80～90 DEG C in homogeneously；
(4) mixing preparation: the temperature of regulation B phase higher than the temperature of A phase, and control the temperature range of A phase and B phase 80～
Between 90 DEG C, the biphase temperature difference≤5 DEG C, under stirring 1000 rev/min states, A phase is slowly added in B phase, to biphase complete
Full mixing, starts homogenizer, makes emulsion-stabilizing and glossy；When temperature is 60～70 DEG C, add C phase, again start homogenizing
Machine, until emulsion mix homogeneously；When temperature is down to 45 DEG C, adding D phase, continuously stirred, emulsion is down to room temperature, closes stirring
Device, stops stirring, bottles after standing 24 hours, prepares the Whitening sunscreen cream containing Noni fruit quintessence oil.
Comparative example 1
A kind of frost without Noni fruit quintessence oil, including following raw material components:
A phase: Jojoba oil 1 part, sterol ester 1 part, vitamin E 1 part, methyl hydroxybenzoate 0.2 part, ethyl hydroxybenzoate 0.1
Part, tristerin 1 part, 16/18 natural fatty alcohol 0.5 part, caprylic/capric triglyceride 2 parts, isononyl isononanoate
3 parts, polydimethylsiloxane 1 part；
B phase: amino acid humectant 2 parts, allantoin 0.3 part, deionized water 100 parts, glycerol 4 parts；
C phase: lauryl alcohol 0.8 part.
Its preparation method: allotment A phase, B phase: take the 150ml beaker after two sterilizing-dryings, respectively preparation A phase, B phase, and
Distinguish heated and stirred to 80～90 DEG C in homogeneously；Mixing preparation: the temperature of regulation B phase is higher than the temperature of A phase, and controls A phase and B
The temperature range of phase is between 80～90 DEG C, and the biphase temperature difference≤5 DEG C, under stirring 1000 rev/min states, by slow for A phase
Add in B phase, be thoroughly mixed to the most biphase, start homogenizer, make emulsion-stabilizing and glossy；When temperature is 60～70 DEG C, add
Entering C phase, again start homogenizer, until emulsion mix homogeneously, emulsion is down to room temperature, is closed agitator, stop stirring, stands 24
Bottle after hour, prepare the frost without Noni fruit quintessence oil.
One, the antioxidant activity test of Noni fruit quintessence oil
1. the mensuration of scavenging ability of DPPH free radical
Weigh a certain amount of DPPH, be configured to the DPPH solution of 0.04mg/mL with dehydrated alcohol.Take 2mL difference respectively dense
Quintessence oil that the embodiment 1～2 of degree prepares (2,4,6,8mg/mL) solution, add 2mL DPPH solution, mix homogeneously, room temperature is put
After putting 30min, 5000r/min is centrifuged 10min.Take supernatant at 517nm, survey light absorption value.With Vc as positive control.Sample
The clearance rate below equation of DPPH free radical is calculated:
A0: the light absorption value of 2mL dehydrated alcohol+2mL DPPH solution；
A1: the light absorption value of 2mL sample solution+2mL DPPH solution；
A2: the light absorption value of 2mL sample solution+2mL dehydrated alcohol；
The test result of the DPPH clearance rate that two kinds of methods prepare Noni fruit quintessence oil is as shown in table 1:
| Embodiment | Embodiment 1 (distillation under vacuum) | Embodiment 2 (atmospheric distillation) |
| DPPH clearance rate (%) | 89.76 | 90.93 |
Being shown by the result of table 1, quintessence oil prepared by the distillation under vacuum of the present invention and atmospheric distillation all has preferably
DPPH radical scavenging activity.
Two, ultraviolet experiment is absorbed
The respectively Whitening sunscreen cream containing Noni fruit quintessence oil of precise 0.06g embodiment 1～6 and comparative example 1
White uniform application without Noni fruit quintessence oil in on the microscope slide of medical adhesive tape, with do not smear sunscreen cream microscope slide as sky
In vain, after timebase, scanning sample and reference substance uv absorption meansigma methods in UVA, UVB, UVC wave band, compare the present invention
The Whitening sunscreen cream containing Noni fruit quintessence oil and comparative example 1, blank to ultra-violet absorption situation.
Each embodiment and comparative example 1, blank are shown in Table 2 to ultra-violet absorption experimental result:
| Title | UVA (320～420nm) | UVB (275～320nm) | UVC (200～275nm) |
| Embodiment 1 | 2.1628 | 2.4583 | 2.4368 |
| Embodiment 2 | 2.2308 | 2.5613 | 2.5482 |
| Embodiment 3 | 2.4981 | 2.7419 | 2.7602 |
| Embodiment 4 | 2.2849 | 2.5537 | 2.5481 |
| Embodiment 5 | 2.3164 | 2.6105 | 2.6138 |
| Embodiment 6 | 2.5497 | 2.8988 | 2.8825 |
| Comparative example 1 | 0.8731 | 0.9528 | 0.9951 |
| Blank product (0g) | 0.000 | 0.000 | 0.000 |
Being shown by the result of table 2, ultraviolet is inhaled by the Whitening sunscreen cream that embodiment 1～6 prepares containing Noni fruit quintessence oil
Receive effective, possess preferable sun-proof function.Wherein, embodiment 6 and embodiment 3 are preferable to ultra-violet absorption effect, and promise is described
When beautiful fruit quintessence oil weight part ratio is 1 part, Whitening sunscreen cream is to ultra-violet absorption best results.And comparative example 1 does not contains Noni fruit
The frost of quintessence oil is poor to ultra-violet absorption.
Three, tyrosinase inhibitory activity measures
Tryrosinase is a kind of oxidoreductase, and tryrosinase oxidation can promote that TYR generates melanin, at cheese
Propylhomoserin formed melanic during, tryrosinase can promote TYR produce L-3,4 dihydroxyphenylalanine and further effect make L-3,4 dihydroxyphenylalanine shape
Becoming bar quinone, DOPA quinone ultimately generates melanin.
The computing formula of suppression ratio: [1-(T2-T1)/(C2-C1)] * 100%
C1 is buffer solution and the absorbance of tryrosinase extracting solution, and C2 represents the melanic absorbance of generation,
Being C2-C1 with the absorbance that C1 surveys C2 for reference, it is black that expression generates after the absorbance of deduction tryrosinase extracting solution
The absorbance of pigment.T1 is to add sample, tryrosinase extracting solution and the absorbance of buffer solution, and T2 is to press down through sample
The melanic absorbance generated after system, same obtains T2-T1 with the absorbance that T1 is reference survey T2, represents and deducting
Under the influence of sample and tryrosinase extracting solution absorbance, the melanic absorbance after the suppression of sample.Embodiment 1
The sample solution obtained to embodiment 6 and comparative example 1 suppression ratio result such as table 3 institute in tyrosinase inhibitory activity measures
Show:
Shown by the test result of above-mentioned suppression ratio, U.S. containing Noni fruit quintessence oil that embodiment 1 to embodiment 6 obtains
White sunscreen cream is strong to tryrosinase rejection ability, may be used for skin-whitening.Especially, the suppression ratio of embodiment 6 is the highest, implements
Example 3 is taken second place.Illustrate that, when Noni fruit quintessence oil weight part ratio is 1 part, Whitening sunscreen cream is to the strongest to tryrosinase rejection ability.And it is real
Execute example 6 to compare the component of embodiment more than 3 tyrosinase inhibitory action plays collaborative effect, and comparative example 1 does not contains Noni fruit
The frost of quintessence oil is poor to tryrosinase suppression.Show that Noni fruit quintessence oil has preferable tyrosinase activity rejection ability, noni
Really quintessence oil has whitening sun protection effect and may be used for preparing Whitening sunscreen cream.
Four, the animal model test of suppression melanin growth
Brachydanio rerio is the model animal of a kind of external fertilization, blastoprolepsis, has been widely used in genetic development,
Multiple field such as environmental monitoring.This model is also widely used for assessing the impact that melanin is grown by compound at present.Collect speckle
Horse fish embryo puts in 96 orifice plates, 4 pieces of every hole embryo, adds the sample liquid of embodiment 6 preparation when 6hpf, and 72h observes zebra
Fish pigment growing state.Fig. 1 be sample liquid to zebrafish embryo pigment growth inhibited situation, wherein A is normal zebrafish embryo,
B is the impact on pigment of embodiment 6 sample liquid.Finding from Fig. 1, relative to the situation of the normal Brachydanio rerio of A, the pigment of B subtracts significantly
Few, show that the effect of embodiment 6 sample liquid suppression melanin growth is the best, U.S. containing Noni fruit quintessence oil of the present invention is described
White sunscreen cream can suppress melanin to grow, and plays white-skinned face function.
In sum, a kind of Whitening sunscreen cream containing Noni fruit quintessence oil of the present invention, there is significant DPPH free radical
Scavenging activity, effectively suppresses the activity of tryrosinase, and suppression melanin grows, effective to ultra-violet absorption, it is achieved whitening is prevented
Shine the effect of skin protection.And the preparation method of Whitening sunscreen cream of the present invention is simple to operation, production cost is relatively low, Qi Zhongli
Preparing Noni fruit quintessence oil with distillation under vacuum and atmospheric distillation, it is best in quality, has preferable DPPH radical scavenging activity
Power, may be directly applied to skin protection whitening, it is also possible to be applied to prepare other skin-lightening cosmetics or skin care item product.
The foregoing is only presently preferred embodiments of the present invention, not in order to limit the present invention, all essences in the present invention
Within god and principle, any modification, equivalent substitution and improvement etc. done, within should be included in the scope of protection of the invention.
Claims (10)
1. the Whitening sunscreen cream containing Noni fruit quintessence oil, it is characterised in that include following raw material components: Noni fruit quintessence oil,
Jojoba oil, sterol ester, vitamin E, methyl hydroxybenzoate, ethyl hydroxybenzoate, amino acid humectant, allantoin, deionized water；
Wherein, Jojoba oil, sterol ester, vitamin E, methyl hydroxybenzoate, ethyl hydroxybenzoate are the raw material of A phase；Aminoacid moisturizing
Agent, allantoin, deionized water are the raw material of B phase；Noni fruit quintessence oil is the raw material of D phase.
A kind of Whitening sunscreen cream containing Noni fruit quintessence oil the most according to claim 1, it is characterised in that described raw material is also
Including lauryl alcohol, tristerin, 16/18 natural fatty alcohols, caprylic/capric triglyceride, isononyl isononanoate,
Polydimethylsiloxane, glycerol；
Wherein, tristerin, 16/18 natural fatty alcohols, caprylic/capric triglyceride, isononyl isononanoate, flash
Bar oil, polydimethylsiloxane, sterol ester, vitamin E, methyl hydroxybenzoate, ethyl hydroxybenzoate are the raw material of A phase；Glycerol, amino
Acid wetting agent, allantoin, deionized water are the raw material of B phase；Lauryl alcohol is the raw material of C phase；Noni fruit quintessence oil is the former of D phase
Material.
A kind of Whitening sunscreen cream containing Noni fruit quintessence oil the most according to claim 1, it is characterised in that described raw material
Weight part ratio is: Noni fruit quintessence oil 0.8～1.2 parts, Jojoba oil 1～1.2 parts, sterol ester 0.8～1 part, vitamin E 0.5～
1 part, methyl hydroxybenzoate 0.1～0.3 part, ethyl hydroxybenzoate 0.05～0.15 part, amino acid humectant 2～3 parts, allantoin 0.2
～0.4 part, deionized water 90～110 parts.
A kind of Whitening sunscreen cream containing Noni fruit quintessence oil the most according to claim 2, it is characterised in that described raw material
Weight part ratio is: Noni fruit quintessence oil 0.8～1.2 parts, Jojoba oil 1～1.2 parts, sterol ester 0.8～1 part, vitamin E 0.5～
1 part, methyl hydroxybenzoate 0.1～0.3 part, ethyl hydroxybenzoate 0.05～0.15 part, amino acid humectant 2～3 parts, allantoin 0.2
～0.4 part, deionized water 90～110 parts, lauryl alcohol 0.7～0.9 part, tristerin 1～1.5 parts, 16/18 days
So fatty alcohol 0.4～0.6 part, caprylic/capric triglyceride 2～3 parts, isononyl isononanoate 3～5 parts, polydimethylsiloxane
0.5～1 part, glycerol 3～5 parts.
A kind of Whitening sunscreen cream containing Noni fruit quintessence oil the most according to claim 2, it is characterised in that described raw material
Weight part ratio is: Noni fruit quintessence oil 1 part, Jojoba oil 1～1.2 parts, sterol ester 0.8～1 part, vitamin E 0.5～1 part, Buddhist nun
Pool tortoise beetle ester 0.2 part, ethyl hydroxybenzoate 0.1 part, amino acid humectant 2～3 parts, allantoin 0.3 part, deionized water 90～110
Part, lauryl alcohol 0.8 part, tristerin 1～1.5 parts, 16/18 natural fatty alcohol 0.5 part, caprylic/capric glycerol
Three esters 2～3 parts, isononyl isononanoate 3～5 parts, polydimethylsiloxane 0.5～1 part, glycerol 3～5 parts.
A kind of Whitening sunscreen cream containing Noni fruit quintessence oil the most according to claim 1, it is characterised in that described Noni fruit
The preparation method of quintessence oil comprises the following steps: the fresh Noni fruit of chopping being mixed with distilled water, put in distillator, connection is taken out
Air pump, decompression distillation 2～4h, it is thus achieved that volatile oil be Noni fruit quintessence oil.
A kind of Whitening sunscreen cream containing Noni fruit quintessence oil the most according to claim 1, it is characterised in that described Noni fruit
The preparation method of quintessence oil comprises the following steps: the fresh Noni fruit of chopping is mixed with distilled water, puts in distillator, and normal pressure steams
Evaporate backflow 2～4h, gained backflow is stood, extract backflow supernatant liquid, obtain Noni fruit quintessence oil.
8. according to a kind of Whitening sunscreen cream containing Noni fruit quintessence oil described in claim 6 or 7, it is characterised in that described steaming
The volume of distilled water is that each hectogram Noni fruit adds 150ml distilled water.
9., according to the preparation method of a kind of Whitening sunscreen cream containing Noni fruit quintessence oil described in claim 1 or 3, its feature exists
In, comprise the following steps:
(1) A phase, B phase, the raw material of D phase are prepared；
(2) allotment A phase, B phase: preparation A phase, B phase respectively, and distinguish heated and stirred to 80～90 DEG C in homogeneously；
(3) mixing preparation: the temperature of regulation B phase is higher than the temperature of A phase, and controls the temperature range of A phase and B phase at 80～90 DEG C
Between, the biphase temperature difference≤5 DEG C, under stirring 800～1200 rev/min states, A phase is slowly added in B phase, to biphase complete
Full mixing, starts homogenizer, makes emulsion-stabilizing and glossy；When temperature is down to 40～50 DEG C, add D phase, continuously stirred, breast
Liquid is down to room temperature, stops stirring, stands 18～24 hours, prepares the Whitening sunscreen cream containing Noni fruit quintessence oil.
10. according to the preparation method of a kind of Whitening sunscreen cream containing Noni fruit quintessence oil described in any one of claim 2,4,5,
It is characterized in that, comprise the following steps:
(1) A phase, B phase, C phase, the raw material of D phase are prepared；
(2) allotment A phase, B phase: preparation A phase, B phase respectively, and distinguish heated and stirred to 80～90 DEG C in homogeneously；
(3) mixing preparation: the temperature of regulation B phase is higher than the temperature of A phase, and controls the temperature range of A phase and B phase at 80～90 DEG C
Between, the biphase temperature difference≤5 DEG C, under stirring 800～1200 rev/min states, A phase is slowly added in B phase, to biphase complete
Full mixing, starts homogenizer, makes emulsion-stabilizing and glossy；When temperature is 60～70 DEG C, add C phase, again start homogenizing
Machine, until emulsion mix homogeneously；When temperature is down to 40～50 DEG C, adding D phase, continuously stirred, emulsion is down to room temperature, stops stirring
Mix, stand 18～24 hours, prepare the Whitening sunscreen cream containing Noni fruit quintessence oil.
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| CN108096115A (en) * | 2018-01-18 | 2018-06-01 | 张健 | A kind of plant essence suncream and preparation method thereof |
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| CN113974039A (en) * | 2021-07-30 | 2022-01-28 | 海南师范大学 | Noni fruit enzyme without peculiar smell and preparation method thereof |
| CN114632038A (en) * | 2022-02-17 | 2022-06-17 | 广州丸美生物科技有限公司 | Whitening sunscreen skin care matrix and preparation method thereof, and cosmetic and preparation method thereof |
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| CN114632038A (en) * | 2022-02-17 | 2022-06-17 | 广州丸美生物科技有限公司 | Whitening sunscreen skin care matrix and preparation method thereof, and cosmetic and preparation method thereof |
| CN114632038B (en) * | 2022-02-17 | 2023-12-29 | 广州丸美生物科技有限公司 | Whitening sun-screening skin care matrix and preparation method thereof, and cosmetics and preparation method thereof |
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|---|---|
| CN106176324B (en) | 2019-01-29 |
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