CN102369016A - 用于治疗系统性病症和疾病的包含TGF-β超家族成员的蛋白质的外周施用 - Google Patents
用于治疗系统性病症和疾病的包含TGF-β超家族成员的蛋白质的外周施用 Download PDFInfo
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- CN102369016A CN102369016A CN2010800147650A CN201080014765A CN102369016A CN 102369016 A CN102369016 A CN 102369016A CN 2010800147650 A CN2010800147650 A CN 2010800147650A CN 201080014765 A CN201080014765 A CN 201080014765A CN 102369016 A CN102369016 A CN 102369016A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm rests
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1841—Transforming growth factor [TGF]
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- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1875—Bone morphogenic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
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Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Physical Education & Sports Medicine (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Epidemiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Vascular Medicine (AREA)
- Dermatology (AREA)
- Obesity (AREA)
- Anesthesiology (AREA)
- Cardiology (AREA)
- Endocrinology (AREA)
- Urology & Nephrology (AREA)
- Ophthalmology & Optometry (AREA)
- Psychology (AREA)
- Pulmonology (AREA)
- Child & Adolescent Psychology (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US15190909P | 2009-02-12 | 2009-02-12 | |
| US61/151,909 | 2009-02-12 | ||
| PCT/US2010/024106 WO2010093925A2 (en) | 2009-02-12 | 2010-02-12 | PERIPHERAL ADMINISTRATION OF PROTEINS INCLUDING TGF-β SUPERFAMILY MEMBERS FOR TREATMENT OF SYSTEMIC DISORDERS AND DISEASE |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN102369016A true CN102369016A (zh) | 2012-03-07 |
Family
ID=42105903
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2010800147650A Pending CN102369016A (zh) | 2009-02-12 | 2010-02-12 | 用于治疗系统性病症和疾病的包含TGF-β超家族成员的蛋白质的外周施用 |
Country Status (8)
| Country | Link |
|---|---|
| US (5) | US20100204123A1 (enExample) |
| EP (1) | EP2396025A2 (enExample) |
| JP (2) | JP5819733B2 (enExample) |
| CN (1) | CN102369016A (enExample) |
| AU (1) | AU2010213575B2 (enExample) |
| CA (1) | CA2752157A1 (enExample) |
| SG (2) | SG2014010680A (enExample) |
| WO (1) | WO2010093925A2 (enExample) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK2441466T3 (da) | 2004-04-13 | 2014-10-27 | St Vincents Hosp Sydney | MIC-1-inhiberende middel |
| WO2009137613A2 (en) * | 2008-05-06 | 2009-11-12 | Joslin Diabetes Center, Inc. | Methods and compositions for inducing brown adipogenesis |
| JP6254146B2 (ja) | 2012-03-27 | 2017-12-27 | エヌジーエム バイオファーマシューティカルス,インコーポレーテッド | 代謝障害を治療するための組成物および方法 |
| US8956829B2 (en) | 2013-01-25 | 2015-02-17 | Warsaw Orthopedic, Inc. | Human recombinant growth and differentiaton factor-5 (rhGDF-5) |
| US9359417B2 (en) | 2013-01-25 | 2016-06-07 | Warsaw Orthopedic, Inc. | Cell cultures and methods of human recombinant growth and differentiaton factor-5 (rhGDF-5) |
| US9051389B2 (en) | 2013-01-25 | 2015-06-09 | Warsaw Orthopedic, Inc. | Expression conditions and methods of human recombinant growth and differentiation factor-5 (rhGDF-5) |
| US9169308B2 (en) | 2013-01-25 | 2015-10-27 | Warsaw Orthopedic, Inc. | Methods and compositions of human recombinant growth and differentiation factor-5 (rhGDF-5) isolated from inclusion bodies |
| US8945872B2 (en) | 2013-01-25 | 2015-02-03 | Warsaw Orthopedic, Inc. | Methods of purifying human recombinant growth and differentiation factor-5 (rhGDF-5) protein |
| US9161966B2 (en) | 2013-01-30 | 2015-10-20 | Ngm Biopharmaceuticals, Inc. | GDF15 mutein polypeptides |
| CA2899170C (en) | 2013-01-30 | 2022-08-02 | Ngm Biopharmaceuticals, Inc. | Compositions and methods of use in treating metabolic disorders |
| JP6704358B2 (ja) | 2014-07-30 | 2020-06-03 | エヌジーエム バイオファーマシューティカルズ インコーポレイテッド | 代謝障害を治療するための組成物および使用方法 |
| CN106687128B (zh) | 2014-10-31 | 2022-05-10 | Ngm生物制药有限公司 | 用于治疗代谢病症的组合物和方法 |
| CN117986363A (zh) | 2016-03-31 | 2024-05-07 | 恩格姆生物制药公司 | 结合蛋白及其使用方法 |
| BR112021002703A2 (pt) | 2018-08-31 | 2021-05-11 | Timothy A. Bertram | composições compreendendo vesículas derivadas de células e usos das mesmas |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030022830A1 (en) * | 1996-03-22 | 2003-01-30 | Charette Marc F. | Methods for enhancing functional recovery following central nervous system ischemia or trauma |
Family Cites Families (64)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL83003A (en) | 1986-07-01 | 1995-07-31 | Genetics Inst | Osteoinductive factors |
| US5266683A (en) | 1988-04-08 | 1993-11-30 | Stryker Corporation | Osteogenic proteins |
| US5011691A (en) | 1988-08-15 | 1991-04-30 | Stryker Corporation | Osteogenic devices |
| US5702716A (en) | 1988-10-03 | 1997-12-30 | Atrix Laboratories, Inc. | Polymeric compositions useful as controlled release implants |
| AU666291B2 (en) | 1990-06-15 | 1996-02-08 | Carnegie Institution Of Washington | Gdf-1 |
| US5849686A (en) | 1991-03-11 | 1998-12-15 | Creative Biomolecules, Inc. | Morphogen-induced liver regeneration |
| US6800603B2 (en) | 1991-03-11 | 2004-10-05 | Curis, Inc. | Morphogen-induced neural cell adhesion |
| US5674844A (en) | 1991-03-11 | 1997-10-07 | Creative Biomolecules, Inc. | Treatment to prevent loss of and/or increase bone mass in metabolic bone diseases |
| US6949505B1 (en) | 1991-03-11 | 2005-09-27 | Curis, Inc. | Morphogen-induced dendritic growth |
| US5656593A (en) | 1991-03-11 | 1997-08-12 | Creative Biomolecules, Inc. | Morphogen induced periodontal tissue regeneration |
| US6506729B1 (en) | 1991-03-11 | 2003-01-14 | Curis, Inc. | Methods and compositions for the treatment and prevention of Parkinson's disease |
| CZ282231B6 (cs) * | 1991-06-05 | 1997-06-11 | The Procter And Gamble Company | Prostředek na generování nového růstu kosti v savci |
| US5693615A (en) * | 1991-06-05 | 1997-12-02 | The Procter & Gamble Company | Therapeutic compositions for osteoinduction |
| US6287816B1 (en) | 1991-06-25 | 2001-09-11 | Genetics Institute, Inc. | BMP-9 compositions |
| KR100259827B1 (ko) | 1991-11-04 | 2000-06-15 | 브루스 엠. 에이센, 토마스 제이 데스로저 | 재조합 골형태 형성 단백질 헤테로다이머, 그 조성물 및 사용방법 |
| CA2129820C (en) | 1992-02-12 | 2003-06-17 | Helge Neidhardt | Dna sequences encoding novel growth/differentiation factors |
| WO1994010203A2 (en) | 1992-11-03 | 1994-05-11 | Creative Biomolecules, Inc. | Op-3-induced morphogenesis |
| WO1994015966A1 (en) | 1993-01-12 | 1994-07-21 | Johns Hopkins University School Of Medicine | Growth differentiation factor-9 |
| EP0690871A4 (en) | 1993-01-12 | 1999-10-20 | Univ Johns Hopkins Med | GROWTH DIFFERENTIATION FACTOR-5 |
| CA2157577C (en) | 1993-03-19 | 2009-11-17 | Se-Jin Lee | Growth differentiation factor-8 |
| EP0698094B1 (en) | 1993-05-12 | 2004-02-04 | Genetics Institute, LLC | Bmp-11 compositions |
| ATE265529T1 (de) | 1993-05-12 | 2004-05-15 | Inst Genetics Llc | Bmp-10 zusammensetzungen |
| US5447725A (en) | 1993-06-11 | 1995-09-05 | The Procter & Gamble Company | Methods for aiding periodontal tissue regeneration |
| JPH09503903A (ja) | 1993-07-09 | 1997-04-22 | ザ ジョーンズ ホプキンス ユニバーシティー スクール オブ メディシン | 増殖分化因子−6 |
| EP0725796A4 (en) | 1993-10-08 | 1999-12-01 | Univ Johns Hopkins | Growth differentiation factor-10 |
| JP3300500B2 (ja) | 1993-10-12 | 2002-07-08 | 新日本製鐵株式会社 | 疲労強度、降伏強度および被削性に優れる熱間鍛造用鋼の製造方法 |
| DE4334646C1 (de) | 1993-10-12 | 1994-09-29 | Quinting Friedhelm | Durchsichtige Analog-Zeituhr |
| EP0733109B9 (en) | 1993-12-07 | 2006-07-05 | Genetics Institute, LLC | Bmp-12, bmp-13 and tendon-inducing compositions thereof |
| US5399677A (en) | 1993-12-07 | 1995-03-21 | Genetics Institute, Inc. | Mutants of bone morphogenetic proteins |
| IL114397A0 (en) | 1994-07-01 | 1995-10-31 | Bioph Biotech Entw Pharm Gmbh | Growth/differentiation factor of the TGF-beta-family |
| DE69534468T2 (de) | 1994-07-08 | 2006-07-13 | The Johns Hopkins University School Of Medicine | Wachstums-differenzierungsfaktor-11 |
| WO1996014335A1 (en) | 1994-11-07 | 1996-05-17 | The Government Of The United States Of America, Asrepresented By The Secretary, Department Of Health And Human Services | Cartilage-derived morphogenetic proteins |
| US5635372A (en) | 1995-05-18 | 1997-06-03 | Genetics Institute, Inc. | BMP-15 compositions |
| US6498142B1 (en) | 1996-05-06 | 2002-12-24 | Curis, Inc. | Morphogen treatment for chronic renal failure |
| WO1999015191A2 (en) * | 1997-09-19 | 1999-04-01 | Biopharm Gesellschaft Zur Biotechnologischen Entwicklung Von Pharmaka Mbh | Cytokines having neurotrophic activity |
| US20030170213A1 (en) * | 1998-01-23 | 2003-09-11 | Marc F. Charette | Methods and compositions for enhancing cognitive function using morphogenic proteins |
| US7147839B2 (en) * | 1998-05-29 | 2006-12-12 | Curis, Inc. | Methods for evaluating tissue morphogenesis and activity |
| JP3762222B2 (ja) | 1998-10-07 | 2006-04-05 | ストライカー・コーポレーション | 改変型TGF−βスーパーファミリータンパク質 |
| US6846906B1 (en) | 1998-10-07 | 2005-01-25 | Stryker Corporation | Modified proteins of the TGF-β superfamily, including morphogenic proteins |
| US6677432B1 (en) | 1998-10-07 | 2004-01-13 | Stryker Corporation | Mutations of the C-terminal portion of TGF-β superfamily proteins |
| US20030104977A1 (en) * | 2000-03-31 | 2003-06-05 | Ugo Ripamonti | Methods for inducing angiogenesis using morphogenic proteins and stimulatory factors |
| BR0209198A (pt) * | 2001-04-26 | 2004-06-08 | Control Delivery Sys Inc | Métodos de sìntese de compostos contendo fenol |
| US8154581B2 (en) | 2002-10-15 | 2012-04-10 | Revolutionary Concepts, Inc. | Audio-video communication system for receiving person at entrance |
| DK1677735T3 (da) * | 2003-10-17 | 2014-10-27 | Joslin Diabetes Center Inc | Fremgangsmåder og sammensætninger til modulering af adipocytfunktion |
| CA2561809A1 (en) | 2004-03-31 | 2005-10-20 | Xencor, Inc. | Bmp-7 variants with improved properties |
| EP1750743A4 (en) * | 2004-04-29 | 2009-07-08 | Glaxosmithkline Zagreb | ORAL PREPARATIONS CONTAINING BONE MORPHOGENETIC PROTEINS FOR THE TREATMENT OF METABOLIC BONE DISEASES |
| US20090042780A1 (en) | 2004-05-20 | 2009-02-12 | Acceleron Pharma Inc | Modified TGF-Beta Superfamily Polypeptides and Related Methods |
| AU2005251741B2 (en) * | 2004-06-03 | 2009-09-24 | Genera Istrazivanja D.O.O. | Insulin-independent, bone morphogenetic protein (BMP)-mediated uptake of blood glucose by peripheral cells and tissues |
| US7901395B2 (en) * | 2005-08-16 | 2011-03-08 | Borden Jonathan R | Catheter having staggered lumens and method |
| ATE543833T1 (de) | 2005-12-22 | 2012-02-15 | Janssen Biotech Inc | Bmp-7-varianten-zusammensetzungen, verfahren und verwendungen |
| EP2144624A1 (en) * | 2007-05-15 | 2010-01-20 | Stryker Corporation | Concentrated protein preparations of bone morphogenetic proteins and methods of use thereof |
| WO2010117047A1 (ja) | 2009-04-10 | 2010-10-14 | 株式会社ニコン | 光学材料、光学素子、及びその製造方法 |
| JP2011211450A (ja) | 2010-03-30 | 2011-10-20 | Victor Co Of Japan Ltd | 立体映像表示装置、立体映像撮像装置および立体映像表示方法 |
| US9507084B2 (en) | 2010-12-03 | 2016-11-29 | Ofs Fitel, Llc | Single-mode, bend-compensated, large-mode-area optical fibers designed to accomodate simplified fabrication and tighter bends |
| US8886307B2 (en) | 2012-01-30 | 2014-11-11 | Medtronic, Inc. | Adaptive cardiac resynchronization therapy |
| KR101851912B1 (ko) | 2012-06-07 | 2018-04-24 | 아사히 가세이 일렉트로닉스 가부시끼가이샤 | 위치 검출 장치 |
| US9298469B2 (en) | 2012-06-15 | 2016-03-29 | International Business Machines Corporation | Management of multiple nested transactions |
| US9405290B1 (en) | 2013-01-17 | 2016-08-02 | Kla-Tencor Corporation | Model for optical dispersion of high-K dielectrics including defects |
| JP6154215B2 (ja) | 2013-06-28 | 2017-06-28 | 株式会社日立国際電気 | 半導体装置の製造方法、基板処理装置およびプログラム |
| US9170581B2 (en) | 2013-09-30 | 2015-10-27 | Crown Equipment Limited | Industrial vehicles with overhead light based localization |
| JP6541301B2 (ja) | 2014-03-28 | 2019-07-10 | キヤノン株式会社 | ロボット装置、ロボット装置の制御方法、ロボット制御プログラム、及び記録媒体 |
| US9411440B2 (en) | 2014-08-22 | 2016-08-09 | Qualcomm Incorporated | Digital ultrasonic emitting base station |
| US9407762B2 (en) | 2014-10-10 | 2016-08-02 | Bank Of America Corporation | Providing enhanced user authentication functionalities |
| US9412814B2 (en) | 2014-12-24 | 2016-08-09 | Taiwan Semiconductor Manufacturing Co., Ltd. | Structure and formation method of FinFET device |
-
2010
- 2010-02-12 US US12/705,259 patent/US20100204123A1/en not_active Abandoned
- 2010-02-12 SG SG2014010680A patent/SG2014010680A/en unknown
- 2010-02-12 WO PCT/US2010/024106 patent/WO2010093925A2/en not_active Ceased
- 2010-02-12 CA CA2752157A patent/CA2752157A1/en not_active Abandoned
- 2010-02-12 EP EP10705489A patent/EP2396025A2/en not_active Withdrawn
- 2010-02-12 CN CN2010800147650A patent/CN102369016A/zh active Pending
- 2010-02-12 JP JP2011550274A patent/JP5819733B2/ja not_active Expired - Fee Related
- 2010-02-12 AU AU2010213575A patent/AU2010213575B2/en not_active Ceased
- 2010-02-12 SG SG2011057668A patent/SG173632A1/en unknown
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2012
- 2012-04-11 US US13/444,282 patent/US20120258917A1/en not_active Abandoned
- 2012-11-19 US US13/680,381 patent/US20130288966A1/en not_active Abandoned
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2013
- 2013-07-18 US US13/945,317 patent/US20140187486A1/en not_active Abandoned
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2014
- 2014-02-21 US US14/186,545 patent/US20140336595A1/en not_active Abandoned
- 2014-06-24 JP JP2014128940A patent/JP2014169336A/ja active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030022830A1 (en) * | 1996-03-22 | 2003-01-30 | Charette Marc F. | Methods for enhancing functional recovery following central nervous system ischemia or trauma |
Non-Patent Citations (2)
| Title |
|---|
| 温纪林 等: "骨形态发生蛋白治疗骨缺损研究进展", 《中华创伤骨科杂志》, vol. 6, no. 3, 31 March 2004 (2004-03-31), pages 333 - 336 * |
| 王敏 等: "骨形态发生蛋白与骨肿瘤", 《肿瘤防治杂志》, vol. 10, no. 5, 31 May 2003 (2003-05-31), pages 545 - 548 * |
Also Published As
| Publication number | Publication date |
|---|---|
| SG2014010680A (en) | 2014-04-28 |
| US20120258917A1 (en) | 2012-10-11 |
| US20100204123A1 (en) | 2010-08-12 |
| JP2012517482A (ja) | 2012-08-02 |
| US20140187486A1 (en) | 2014-07-03 |
| WO2010093925A3 (en) | 2010-10-28 |
| US20130288966A1 (en) | 2013-10-31 |
| EP2396025A2 (en) | 2011-12-21 |
| SG173632A1 (en) | 2011-09-29 |
| JP5819733B2 (ja) | 2015-11-24 |
| WO2010093925A2 (en) | 2010-08-19 |
| AU2010213575A1 (en) | 2011-08-18 |
| JP2014169336A (ja) | 2014-09-18 |
| AU2010213575B2 (en) | 2013-11-14 |
| US20140336595A1 (en) | 2014-11-13 |
| CA2752157A1 (en) | 2010-08-19 |
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