CN102368905B - 酸性神经酰胺酶的向溶酶体抑制剂 - Google Patents

酸性神经酰胺酶的向溶酶体抑制剂 Download PDF

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Publication number
CN102368905B
CN102368905B CN200980154007.6A CN200980154007A CN102368905B CN 102368905 B CN102368905 B CN 102368905B CN 200980154007 A CN200980154007 A CN 200980154007A CN 102368905 B CN102368905 B CN 102368905B
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alkyl
cancer
cell
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CN102368905A (zh
Inventor
A·别拉夫斯基
柏爱萍
Z·M·肖尔茨
Y·A·哈努恩
J·诺里斯
柳湘
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MUSC Foundation for Research and Development
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • C07C233/17—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/18—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Vascular Medicine (AREA)
  • Oncology (AREA)
  • Urology & Nephrology (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CN200980154007.6A 2008-11-06 2009-11-06 酸性神经酰胺酶的向溶酶体抑制剂 Expired - Fee Related CN102368905B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US11185208P 2008-11-06 2008-11-06
US61/111,852 2008-11-06
PCT/US2009/063586 WO2010054223A1 (en) 2008-11-06 2009-11-06 Lysosomotropic inhibitors of acid ceramidase

Publications (2)

Publication Number Publication Date
CN102368905A CN102368905A (zh) 2012-03-07
CN102368905B true CN102368905B (zh) 2015-04-01

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Country Link
US (1) US8697379B2 (enExample)
EP (1) EP2348839B1 (enExample)
JP (1) JP5721631B2 (enExample)
CN (1) CN102368905B (enExample)
AU (1) AU2009313400A1 (enExample)
BR (1) BRPI0921278A2 (enExample)
CA (1) CA2742866C (enExample)
RU (1) RU2011117722A (enExample)
WO (1) WO2010054223A1 (enExample)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2585645C (en) * 2004-10-29 2014-10-21 Musc Foundation For Research Development Ceramides and apoptosis-signaling ligand
CA2585775C (en) 2004-10-29 2013-10-01 Musc Foundation For Research Development Cationic ceramides, and analogs thereof, and their use for preventing or treating cancer
EP2348839B1 (en) 2008-11-06 2017-04-05 MUSC Foundation For Research Development Lysosomotropic inhibitors of acid ceramidase
WO2010078247A1 (en) * 2008-12-30 2010-07-08 Musc Foundation For Research Development Sphingo-guanidines and their use as inhibitors of sphingosine kinase
DK2753346T3 (da) 2011-09-07 2020-05-25 Sinai School Medicine Ceramidase og celledifferentiering
ITMI20120921A1 (it) 2012-05-28 2013-11-29 Fond Istituto Italiano Di Tec Nologia 45 Inibitori della ceramidasi acida e loro usi come medicamenti
ITMI20120923A1 (it) 2012-05-28 2013-11-29 Fond Istituto Italiano Di Tec Nologia 45 Inibitori della ceramidasi acida e loro usi come medicamenti
EP2854910B1 (en) * 2012-06-01 2020-04-15 Icahn School of Medicine at Mount Sinai Ceramide levels in the treatment and prevention of infections
EP3659619A1 (en) 2013-03-14 2020-06-03 Icahn School of Medicine at Mount Sinai Therapeutic acid ceramidase compositions and methods of making and using them
WO2015119393A1 (ko) * 2014-02-04 2015-08-13 (주)네오팜 발모촉진용 또는 탈모방지용 조성물
KR20150091983A (ko) * 2014-02-04 2015-08-12 (주)네오팜 발모촉진용 또는 탈모방지용 조성물
EP3143009B1 (en) 2014-05-12 2019-09-18 Fondazione Istituto Italiano di Tecnologia Substituted benzoxazolone derivatives as acid ceramidase inhibitors, and their use as medicaments
WO2015173168A1 (en) 2014-05-12 2015-11-19 Fondazione Istituto Italiano Di Tecnologia Benzoxazolone derivatives as acid ceramidase inhibitors, and their use as medicaments
WO2018200931A1 (en) * 2017-04-28 2018-11-01 University Of Virginia Patent Foundation Compositions and methods for treating cancer
CN110598636B (zh) * 2019-09-09 2023-01-17 哈尔滨工业大学 一种基于特征迁移的舰船目标识别方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101027069A (zh) * 2003-11-28 2007-08-29 宝生物工程株式会社 神经酰胺酶抑制剂
US20080045470A1 (en) * 2004-10-29 2008-02-21 Alicja Bielawska Ceramides and Apoptosis-Signaling Ligand

Family Cites Families (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB630712A (en) 1946-03-22 1949-10-19 Merck & Co Inc Process of preparing intermediates useful in the preparation of penicill amine
US2515465A (en) 1946-03-22 1950-07-18 Merck & Co Inc Preparation of 2-alkyl-4-isopropylidene-5(4)-oxazolones
GB844431A (en) * 1957-12-07 1960-08-10 Boehringer & Soehne Gmbh Injectable aqueous solutions of chloramphenicol
US3466292A (en) 1966-05-13 1969-09-09 Upjohn Co Diazatricyclododecanediones and diazatricyclododecadiendiones
GB1307539A (en) * 1970-06-25 1973-02-21 Smith Kline French Lab Thiourea derivatives
US4016287A (en) 1972-07-17 1977-04-05 Boehringer Ingelheim Gmbh Dermatological compositions containing an acylamino-carboxylic acid or an alkyl ester thereof
DE2408813A1 (de) 1974-02-23 1975-09-04 Agfa Gevaert Ag N-carbamoyloxypyridiniumsalze und verfahren zur herstellung derselben
US4481203A (en) 1977-04-05 1984-11-06 Taiho Pharmaceutical Company, Limited Composition containing 1-(n-hexylcarbamoyl)-5-fluorouracil and uracil
DE2817494A1 (de) 1977-05-03 1978-11-09 Continental Pharma Aminoalkohol-derivat
US4151198A (en) 1978-06-02 1979-04-24 American Cyanamid Company Resolution of N-acyl-DL (+)-phenylalanines
US4283541A (en) 1980-05-27 1981-08-11 Usv Pharmaceutical Corporation Pyridylacyl-hydroxamates
US4544670A (en) 1982-08-24 1985-10-01 William H. Rorer, Inc. Method of treating coccidiosis with acyl guanidines
US4897355A (en) 1985-01-07 1990-01-30 Syntex (U.S.A.) Inc. N[ω,(ω-1)-dialkyloxy]- and N-[ω,(ω-1)-dialkenyloxy]-alk-1-yl-N,N,N-tetrasubstituted ammonium lipids and uses therefor
US4937232A (en) 1986-09-15 1990-06-26 Duke University Inhibition of protein kinase C by long-chain bases
EP0310545A3 (de) 1987-09-02 1989-07-26 Ciba-Geigy Ag Cyanoguanidine als Härter für Epoxidharze
US5262568A (en) 1990-03-02 1993-11-16 State Of Oregon Tri- and tetra-substituted guanidines and their use as excitatory amino acid antagonists
US5679350A (en) 1992-05-28 1997-10-21 The University Of Toledo Method of delivery of a medicament to a cancer cell using a pathway of plasminogen activator material
US5369030A (en) 1992-09-11 1994-11-29 Duke University Method of inducing cellular differentiations and altering cell phenotype using ceramide analogs
AU7823894A (en) * 1993-08-27 1995-03-21 Vrije Universiteit New imidazole derivatives having agonistic or antagonistic activity on the histamine h3 receptor
US5916911A (en) 1995-09-20 1999-06-29 The Regents Of The University Of Michigan Amino ceramide--like compounds and therapeutic methods of use
US5830916A (en) 1996-05-23 1998-11-03 Duke University Inhibitor of ceramidase
DE19621038A1 (de) 1996-05-24 1997-11-27 Boehringer Ingelheim Kg Aminoguanidine, Verfahren zu ihrer Herstellung und Arzneimittel, die diese Verbindungen enthalten
US6649362B2 (en) 1997-09-08 2003-11-18 Medvet Science Pty. Ltd. Screening method for an agent having an effect on a sphingosine kinase signaling pathway
US6610835B1 (en) 1998-02-12 2003-08-26 Emory University Sphingolipid derivatives and their methods of use
CA2347847A1 (en) 1998-11-06 2000-05-18 Musc Foundation For Research Development A method of treating tumors using fas-induced apoptosis
AU2001252506A1 (en) 2000-04-19 2001-10-30 Yissum Research Development Company Of The Hebrew University Of Jerusalem Sphingolipids
US6756504B2 (en) 2000-04-19 2004-06-29 Yissum Research Development Company Of The Hebrew University Of Jerusalem Sphingolipids
US6696081B2 (en) 2000-06-09 2004-02-24 Duke University Carbohydrate based lipid compositions and supramolecular structures comprising same
EP1317288A2 (en) 2000-09-11 2003-06-11 MUSC Foundation For Research Development Method and composition for treating tumors by selective induction of apoptosis
WO2003005965A2 (en) 2001-07-11 2003-01-23 Musc Foundation For Research Development Modulators of ceramidase and methods of use based thereon
JP2004210733A (ja) * 2003-01-07 2004-07-29 Kyowa Hakko Kogyo Co Ltd アリールスルファマート誘導体
WO2004067530A1 (en) * 2003-01-27 2004-08-12 Pfizer Products Inc. Isothiazole derivatives
WO2004074247A2 (en) 2003-02-19 2004-09-02 Endacea, Inc. A1 adenosine receptor antagonists
DK1725540T5 (da) 2004-03-05 2012-10-22 Hoffmann La Roche Diaminopyrimidiner som p2x3- og p2x2/3-antagonister
JP2005336174A (ja) * 2004-04-27 2005-12-08 Santen Pharmaceut Co Ltd 変形性関節症治療剤
CA2585775C (en) 2004-10-29 2013-10-01 Musc Foundation For Research Development Cationic ceramides, and analogs thereof, and their use for preventing or treating cancer
JP2006298807A (ja) * 2005-04-19 2006-11-02 Lead Chemical Co Ltd 新規化合物及びその用途
CN101248041B (zh) 2005-06-17 2013-11-20 艾宝奇生物工艺有限公司 鞘氨醇激酶抑制剂
WO2007117400A2 (en) * 2006-03-31 2007-10-18 Janssen Pharmaceutica N.V. Benzoimidazol-2-yl pyridines as modulators of the histamine h4 receptor
EP2102154A1 (en) * 2006-12-13 2009-09-23 Schering-Plough Ltd. Water-soluble prodrugs of chloramphenicol, thiamphenicol, and analogs thereof
EP2348839B1 (en) 2008-11-06 2017-04-05 MUSC Foundation For Research Development Lysosomotropic inhibitors of acid ceramidase
WO2010078247A1 (en) 2008-12-30 2010-07-08 Musc Foundation For Research Development Sphingo-guanidines and their use as inhibitors of sphingosine kinase

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101027069A (zh) * 2003-11-28 2007-08-29 宝生物工程株式会社 神经酰胺酶抑制剂
US20080045470A1 (en) * 2004-10-29 2008-02-21 Alicja Bielawska Ceramides and Apoptosis-Signaling Ligand

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Novel analogs of d-e-MAPP and B13. Part 1: Synthesis and evaluation as potential anticancer agents;Zdzislaw M. Szulc等;《Bioorganic & Medicinal Chemistry》;20080115;第16卷(第2期);第1015-1031页 *

Also Published As

Publication number Publication date
US20110251197A1 (en) 2011-10-13
EP2348839A1 (en) 2011-08-03
US8697379B2 (en) 2014-04-15
AU2009313400A1 (en) 2010-05-14
JP2012508249A (ja) 2012-04-05
CN102368905A (zh) 2012-03-07
WO2010054223A1 (en) 2010-05-14
BRPI0921278A2 (pt) 2015-08-25
EP2348839A4 (en) 2012-04-04
EP2348839B1 (en) 2017-04-05
JP5721631B2 (ja) 2015-05-20
CA2742866C (en) 2017-10-24
HK1167999A1 (en) 2012-12-21
RU2011117722A (ru) 2012-12-20
CA2742866A1 (en) 2010-05-14

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