CN102335420A - Composition containing haematococcus extract and collagen peptide and preparation method for composition - Google Patents

Composition containing haematococcus extract and collagen peptide and preparation method for composition Download PDF

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Publication number
CN102335420A
CN102335420A CN2011103180163A CN201110318016A CN102335420A CN 102335420 A CN102335420 A CN 102335420A CN 2011103180163 A CN2011103180163 A CN 2011103180163A CN 201110318016 A CN201110318016 A CN 201110318016A CN 102335420 A CN102335420 A CN 102335420A
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CN
China
Prior art keywords
extract
haematococcus pluvialis
collagen peptide
haematocoocus pluvialls
preparation
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Pending
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CN2011103180163A
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Chinese (zh)
Inventor
马建
黄胜奎
陈黎明
陈苏苏
陈再亮
裴芳芳
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NINGBO HONGLONG BIO-TECHNOLOGY CO LTD
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NINGBO HONGLONG BIO-TECHNOLOGY CO LTD
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Priority to CN2011103180163A priority Critical patent/CN102335420A/en
Publication of CN102335420A publication Critical patent/CN102335420A/en
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  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

The invention discloses a composition containing a haematococcus extract and a collagen peptide. The composition is prepared from the following components in part by weight: 1 to 20 parts of haematococcus pluvialis extract, 1 to 10 parts of collagen peptide and 1 to 90 parts of safflower seed oil. The invention also discloses a preparation method for the composition. Natural astaxanthin in the haematococcus pluvialis extract has the ultrahigh oxidation resistance, ensures the normal metabolism of skin, inhibits the generation of melanin and enhances the effect of collagen; the absorption rate of the collagen peptide is between 95 and 100 percent; the collagen peptide can improve the metabolism of skin cells effectively, and can be utilized by the skin cells more easily, so that the activity of the collagen in the skin is enhanced, and the aims of preserving moisture, resisting wrinkles and nourishing the skin are fulfilled; and due to the addition of the safflower seed oil, the composition contains linoleic acid with high content and vitamin E and can prevent the oxidative deterioration of the astaxanthin, an antioxidant is not needed to be added, and the quality guarantee period can be prolonged by one time.

Description

The composition and method of making the same that contains Haematococcus Pluvialis extract and collagen peptide
Technical field
The present invention relates to cosmetic health product and preparation method thereof, particularly a kind of crease-resistant, spot-eliminating composition that is primary raw material with Haematococcus Pluvialis (claiming Haematocoocus Pluvialls again) extract (being rich in natural astaxanthin) and collagen peptide and preparation method thereof promptly contains the composition and method of making the same of Haematococcus Pluvialis extract and collagen peptide.
Background technology
The facial reason that produces wrinkle and speckle is mainly divided two big types: internal factor (natural aging) and external factor (photoaging and smoking, excessive drinking, computer radiate etc.), wherein external factor has accounted for more than 80%, becomes the human appearance maximum killer that One will never be young again.
The modern medicine biological study shows that the generation of human skin wrinkle and speckle and Skin Cell produce too much reactive oxygen free radical (ROS) has substantial connection.When skin received ultraviolet or electrical equipment radiation, skin part produced ROS, and it can destroy biomacromolecules such as the in-house collagen protein of human cell membrane, lipid, nucleic acid, caused skin photoage to take place, and finally formed little microgroove, wrinkle, speckle etc.Some bioactive substances such as antioxidant, collagen protein etc. add in the cosmetics for external use, but actual valid density is lower, and being difficult to of having is penetrated into skin corium and plays a role, and effect is not lasting, easily bounce-back.To solve skin problem at all, need inherent regulation.Become the mode that fashion beauty treatment circle is approved like administered through oral functional food or health product with the purpose that reaches skin care.A kind of skin care Flos Rosae Rugosae quintessence oil compositions is disclosed like number of patent application 200510042598.1; Number of patent application 200510040752.1 discloses a kind of beauty spot-eliminating capsule agent, and its principle is the purpose that reaches beauty treatment through ROS in the interpolation antioxidant content removing body.
Natural astaxanthin belongs to carotenoid, is the strongest antioxidant of finding at present of nature, and its oxidation resistance is 550 ~ 1000 times of vitamin E, 200 times of tea polyphenols, 17 times of procyanidin, is described as super vitamin E.In the process of skin aging, matrix metalloproteinase (NMP) is decomposes collagen albumen constantly, causes skin problems such as wrinkle generation, cutis laxa, melanin deposition.Discover that astaxanthin can significantly weaken ROS and NMP to skin corium collagen protein, the proteic destruction of elastic fibers, has guaranteed the homergy of skin; Astaxanthin has special role to paddy ammonia transaminase, can when skin receives illumination, consume putrescine, and its effect is stronger than oral vitamin A.
Collagen peptide is that the collagen protein of macromolecule is done further degraded, the polypeptide of the molecular weight that obtains about 3000D.Its property digested and assimilated is good; Can effectively replenish the synthetic amino acid needed molecule of Skin Cell; For repairing skin corium and suppressing melanic formation; The appearance of skin problem such as prevent that pachylosis, microgroove that skin is caused because of collagen protein runs off from increasing has special effect at speckle dispelling aspect crease-resistant.
 
And how natural astaxanthin is organically combined with collagen peptide, preparing a kind of fully defying age again can be effectively by the product of skin absorbs, and prior art is not appeared in the newspapers.
Summary of the invention
The present invention is directed to the above-mentioned deficiency of prior art, providing a kind of can increase the compositions that contains Haematococcus Pluvialis extract and collagen peptide that forms with speckle from root alleviation facial wrinkles.
In order to solve the problems of the technologies described above, the technical scheme that the present invention adopts is: a kind of compositions that contains Haematococcus Pluvialis extract and collagen peptide, and said composition is prepared by each component of following parts by weight:
1~20 part of Haematocoocus Pluvialls extract;
1~10 part of collagen peptide;
1~90 part of safflower oil.
The above-mentioned Haematocoocus Pluvialls extract of the present invention is a natural astaxanthin content at 1~10% grease.
The above-mentioned Haematocoocus Pluvialls extract of the present invention is that Haematococcus Pluvialis is through CO 2Supercritical technology extraction or alcoholic extract gained.
CO 2The supercritical extraction process: Haematocoocus Pluvialls (Haematococcus Pluvialis) behind drying, pulverizing, breaking cellular wall, obtain the Haematococcus Pluvialis powder (with Haematococcus Pluvialis through dried to moisture<5%, being ground into granularity then is 60~120 purpose powders; Be that 60~120 purpose powders pass through the further broken wall treatment of wall-breaking machine with granularity then, obtaining granularity is that 1000~3000 orders, sporoderm-broken rate are 75%~95% Haematococcus Pluvialis powder), the Haematococcus Pluvialis powder is feeded in supercritical equipment extraction kettle CO 2Flow is 50~100L/h, and temperature is 45~65 ℃, and extracting pressure is to extract 3~5 hours under the operating condition of 35~47MPa, obtains content astaxanthin and be 1~10% Haematococcus Pluvialis extract.
The alcoholic extract process: Haematococcus Pluvialis obtains the Haematococcus Pluvialis powder behind drying, pulverizing and breaking cellular wall (< 5%, being ground into granularity then is 60~120 purpose powders through dried to moisture with Haematococcus Pluvialis; Be that 60~120 purpose powders pass through the further broken wall treatment of wall-breaking machine with granularity then, obtaining granularity is that 1000~3000 orders, sporoderm-broken rate are 75%~95% Haematococcus Pluvialis powder), the Haematococcus Pluvialis powder is placed extraction vessel; The edible ethanol lixiviate 4~7h of adding 95% repeats 1~2 time, collects extracting solution; Centrifugal through ultrahigh speed; After the filtration, lixiviating solution is rotated evaporation and concentration, obtains content astaxanthin and be 1~10% Haematococcus Pluvialis extract.
The above-mentioned collagen peptide of the present invention is to be the collagen peptide (of the present invention collagen peptide be commercial product) of raw material through degrading and extracting with the animal collagen.
The above-mentioned safflower oil of the present invention is that linoleic acid content is the safflower oil more than 67.8%.
Another technical problem that the present invention will solve provides a kind of above-mentioned Haematococcus Pluvialis extract and collagen peptide preparation of compositions method of containing, and preparation process comprises:
(1) takes by weighing each raw material by recipe ingredient, earlier safflower oil is heated to 40~50 ℃ then, slowly add the stirring of Haematocoocus Pluvialls extract and obtained miscella in 1~2 hour;
(2) microgranule and the antibacterial in employing membrane ultrafiltration device elimination step (1) miscella mixed the collagen peptide powder then, obtains compound through stirring 0.5~2h, homogenizing.
The above-mentioned homogenizing process of the present invention is that 30~40 ℃, pressure are that 20~40Mpa carries out homogenizing for the control temperature.
The present invention is above-mentioned contains Haematococcus Pluvialis extract and collagen peptide preparation of compositions method; Preparation process also comprises: the step that the compound of gained is prepared into soft capsule: by Automatic Combined thing granulator the compound of step (2) preparation is processed compositions (adopting enteric-coating material is capsule shell as the shell of compositions), last fill becomes bottle.
The concrete addition of the above-mentioned Haematocoocus Pluvialls extract of the present invention will confirm that content astaxanthin is controlled at 3~8mg/ in the above-mentioned soft capsule according to the percentage composition of the astaxanthin that is contained in the extract.
Advantage of the present invention and beneficial effect:
1. compositions of the present invention; Natural astaxanthin composition in the Haematocoocus Pluvialls extract wherein has superpower oxidation resistance; Can significantly weaken ROS and NMP to skin corium collagen protein, the proteic destruction of elastic fibers; Guaranteed the homergy of skin, suppressed melanic generation, the effect of strengthened collagen; The metabolism of Skin Cell can effectively participated in and improve to the absorbance of collagen peptide between 95%~100%, more be prone to by the Skin Cell utilization, makes active reinforcement of collagen protein in the skin, reach preserve moisture, the purpose of wrinkle resistant and skin nutrition; Effect crease-resistant, speckle dispelling that the synergism of two kinds of effective ingredient can reach.And the adding of safflower oil, because it not only contains the linoleic acid of high level, also rich in vitamin E prevents the oxidation deterioration of astaxanthin composition, so needn't add antioxidant in the product that the shelf-life can prolong one times time.
2. simple, the suitable suitability for industrialized production of preparation of compositions technology of the present invention.
The specific embodiment
Through embodiment the present invention is described in further detail below, but the present invention not only is confined to following examples.
Embodiment 1:
Earlier safflower oil is added in the reaction vessel for 80 parts and be warming up to 45 ℃; Slowly add content astaxanthin then and be 10 parts of 5% Haematocoocus Pluvialls extracts; Stir 1.5h, after ultrafiltration, mix 10 parts of collagen peptides, stir 1.5h; Adopt automatic filling machine to prepare liquid capsule after under 35 ℃, the condition of 40Mpa, carrying out homogenizing, and the packing bottling.
Above-mentioned content astaxanthin is that 5% Haematocoocus Pluvialls extract prepares process and is: with Haematococcus Pluvialis through dried to moisture<5%, being ground into granularity then is 120 purpose powders; Be that 120 purpose powders pass through the further broken wall treatment of wall-breaking machine with granularity then, obtaining granularity is that 3000 orders, sporoderm-broken rate are 90% Haematococcus Pluvialis powder, the Haematococcus Pluvialis powder is feeded in supercritical equipment extraction kettle CO 2Flow is 80L/h, and temperature is 60 ℃, and extracting pressure is extraction 4 hours under the operating condition of 42MPa, obtains content astaxanthin and be 5% Haematococcus Pluvialis extract.
Embodiment 2:
Earlier safflower oil is added in the reaction vessel for 85 parts and be warming up to 45 ℃; Slowly add content astaxanthin and be 10 parts of 3.5% Haematococcus Pluvialis extracts; Stir 1.5 h, after ultrafiltration, mix 5 parts of collagen protein peptide powders, stir 1h; Adopt automatic filling machine to prepare liquid capsule after under 30 ℃, the condition of 32Mpa, carrying out homogenizing, and the packing bottling.
Above-mentioned content astaxanthin is that 3.5% Haematocoocus Pluvialls extract prepares process and is: with Haematococcus Pluvialis through dried to moisture<5%, being ground into granularity then is 100 purpose powders; Be that 100 purpose powders pass through the further broken wall treatment of wall-breaking machine with granularity then, obtaining granularity is that 2500 orders, sporoderm-broken rate are 85% Haematococcus Pluvialis powder, the Haematococcus Pluvialis powder is feeded in supercritical equipment extraction kettle CO 2Flow is 90L/h, and temperature is 62 ℃, and extracting pressure is extraction 4.5 hours under the operating condition of 40MPa, obtains content astaxanthin and be 3.5% Haematococcus Pluvialis extract.
Embodiment 3:
Earlier safflower oil is added in the reaction vessel for 88 parts and be warming up to 45 ℃; Slowly add content astaxanthin and be 8 parts of 4.5% Haematococcus Pluvialis extracts; Stir 1h, after ultrafiltration, mix 4 parts of collagen protein peptide powders, stir 45min; Adopt automatic filling machine to prepare liquid capsule after under 37 ℃, the condition of 22Mpa, carrying out homogenizing, and the packing bottling.
Above-mentioned content astaxanthin is that 4.5% Haematocoocus Pluvialls extract prepares process and is: < 5%, being ground into granularity then is 70 purpose powders through dried to moisture with Haematocoocus Pluvialls; Be that 70 purpose powders pass through the further broken wall treatment of wall-breaking machine with granularity then, obtaining granularity is that 2600 orders, sporoderm-broken rate are 95% Haematococcus Pluvialis powder, and the Haematococcus Pluvialis powder is placed extraction vessel; The edible ethanol lixiviate 6h of adding 95% repeats 2 times, collects extracting solution; Centrifugal through ultrahigh speed; After the filtration, lixiviating solution is rotated evaporation and concentration, obtains content astaxanthin and be 4.5% Haematococcus Pluvialis extract.

Claims (10)

1. compositions that contains Haematococcus Pluvialis extract and collagen peptide is characterized in that: said composition is by each component preparation of following parts by weight:
1~20 part of Haematocoocus Pluvialls extract;
1~10 part of collagen peptide;
1~90 part of safflower oil.
2. the compositions that contains Haematococcus Pluvialis extract and collagen peptide according to claim 1 is characterized in that: described Haematocoocus Pluvialls extract is a natural astaxanthin content at 1~10% grease.
3. the compositions that contains Haematococcus Pluvialis extract and collagen peptide according to claim 1 is characterized in that: described Haematocoocus Pluvialls extract is that Haematococcus Pluvialis is through CO 2Supercritical extraction or alcoholic extract gained.
4. the compositions that contains Haematococcus Pluvialis extract and collagen peptide according to claim 3 is characterized in that: described CO 2The supercritical extraction process is: Haematocoocus Pluvialls obtains the Haematococcus Pluvialis powder behind drying, pulverizing, breaking cellular wall, and the Haematococcus Pluvialis powder is loaded in the supercritical equipment extraction kettle, at CO 2Flow is that 50~100L/h, temperature are that 45~65 ℃, extracting pressure are to extract 3~5 hours under the operating condition of 35~47MPa, obtains content astaxanthin and be 1~10% Haematococcus Pluvialis extract;
Described alcoholic extract process is: Haematocoocus Pluvialls obtains the Haematococcus Pluvialis powder behind drying, pulverizing and breaking cellular wall, the Haematococcus Pluvialis powder is placed extraction vessel, adds edible ethanol lixiviate 4~7h of 95%; Repeat 1~2 time; Collect extracting solution, centrifugal through ultrahigh speed, after the filtration; Be rotated evaporation and concentration, obtain content astaxanthin and be 1~10% Haematococcus Pluvialis extract.
5. the compositions that contains Haematococcus Pluvialis extract and collagen peptide according to claim 1 is characterized in that: described safflower oil is that linoleic acid content is the safflower oil more than 67.8%.
6. one kind contains Haematococcus Pluvialis extract and collagen peptide preparation of compositions method, and it is characterized in that: preparation process comprises:
(1) takes by weighing each raw material by recipe ingredient, earlier safflower oil is heated to 40~50 ℃ then, add the stirring of Haematocoocus Pluvialls extract again and obtained miscella in 1~2 hour;
(2) microgranule and the antibacterial in employing membrane ultrafiltration device elimination step (1) miscella mixed collagen peptide then, obtains compound through stirring 0.5~2h, homogenizing.
7. Haematococcus Pluvialis extract and the collagen peptide preparation of compositions method of containing according to claim 6 is characterized in that: described homogenizing process is that 30~40 ℃, pressure are that 20~40Mpa carries out homogenizing for the control temperature.
8. Haematococcus Pluvialis extract and the collagen peptide preparation of compositions method of containing according to claim 7; It is characterized in that: also comprise the step that compound is prepared soft capsule: by Automatic Combined thing granulator the compound of step (2) preparation is processed soft capsule, fill becomes bottle then.
9. Haematococcus Pluvialis extract and the collagen peptide preparation of compositions method of containing according to claim 8, it is characterized in that: content astaxanthin is controlled at 3~8mg/ in the said soft capsule.
10. Haematococcus Pluvialis extract and the collagen peptide preparation of compositions method of containing according to claim 6 is characterized in that: described Haematocoocus Pluvialls extract is through CO 2The supercritical extraction gained: Haematocoocus Pluvialls obtains the Haematococcus Pluvialis powder behind drying, pulverizing, breaking cellular wall, and the Haematococcus Pluvialis powder is loaded in the supercritical equipment extraction kettle, at CO 2Flow is that 50~100L/h, temperature are that 45~65 ℃, extracting pressure are to extract 3~5 hours under the operating condition of 35~47MPa, obtains content astaxanthin and be 1~10% Haematococcus Pluvialis extract; Or described Haematocoocus Pluvialls extract is through the alcoholic extract gained: Haematocoocus Pluvialls obtains the Haematococcus Pluvialis powder behind drying, pulverizing and breaking cellular wall; The Haematococcus Pluvialis powder is placed extraction vessel, add edible ethanol lixiviate 4~7h of 95%, repeat 1~2 time; Collect extracting solution; Centrifugal through ultrahigh speed, filter after, be rotated evaporation and concentration, obtain content astaxanthin and be 1~10% Haematococcus Pluvialis extract.
CN2011103180163A 2011-10-19 2011-10-19 Composition containing haematococcus extract and collagen peptide and preparation method for composition Pending CN102335420A (en)

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Cited By (24)

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CN102783653A (en) * 2012-09-04 2012-11-21 郭威 Collagen peptide nutritional supplement containing astaxanthin and processing method thereof
CN102793186A (en) * 2012-09-04 2012-11-28 郭威 Collagen peptide nutritional supplement containing astaxanthin and processing method of same
CN103271258A (en) * 2013-05-15 2013-09-04 上海莱博生物科技有限公司 Health product and application thereof
CN103271950A (en) * 2013-05-15 2013-09-04 上海莱博生物科技有限公司 Application of haematococcus pluvialis microcapsule powder
CN105055482A (en) * 2015-09-14 2015-11-18 王衍斌 Nutritional supplement and preparation method of soft capsule thereof
CN105055250A (en) * 2015-08-29 2015-11-18 云南蓝钻生物科技股份有限公司 Cosmetic containing phycocyanin and preparation method
CN105055251A (en) * 2015-08-29 2015-11-18 云南蓝钻生物科技股份有限公司 Anti-aging cosmetic and preparation method thereof
CN105725184A (en) * 2016-02-02 2016-07-06 北京同仁堂健康药业股份有限公司 Composition containing haematococcus pluvialis and collagen and preparing method thereof
CN106036916A (en) * 2016-06-02 2016-10-26 王斐芬 Postoperative repairing nutriment
CN106668842A (en) * 2017-03-06 2017-05-17 李树森 Anti-aging medicine and preparation method thereof
CN106692955A (en) * 2016-12-30 2017-05-24 浙江海洋大学 Seaweed extract healthcare product having anti-aging effect and preparation method of seaweed extract healthcare product
CN107281253A (en) * 2017-07-04 2017-10-24 云南德彩堂生物医药科技有限公司 A kind of composition for significantly improving anti-decrepit beauty function, preparation method and use
CN107549812A (en) * 2017-10-16 2018-01-09 海南三元星生物科技股份有限公司 It is a kind of using acerola concentrate extract, haematococcus pluvialis and Isin glue collagen peptide as beautifying and anti-aging food of raw material and preparation method thereof
CN108403703A (en) * 2018-06-04 2018-08-17 桑艳红 A kind of vitamine D3 soft capsule and preparation method thereof
CN108635324A (en) * 2018-05-14 2018-10-12 深圳市仙迪化妆品有限公司 Antioxidant and the preparation method and application thereof, antioxidant and preparation method thereof
CN108719541A (en) * 2017-04-19 2018-11-02 邢金华 A kind of tea of the U.S. breast of chest enlarge
CN108902958A (en) * 2018-07-20 2018-11-30 深圳市博奥生物科技有限公司 A kind of astaxanthin soft capsule and preparation method thereof
CN108904687A (en) * 2018-07-16 2018-11-30 何利均 Saussurea involucrata haematococcus cream
CN110743004A (en) * 2019-11-27 2020-02-04 天津活力达生物科技有限公司 Astaxanthin direct drinking powder composition with whitening function and preparation method and application thereof
CN111165578A (en) * 2018-11-09 2020-05-19 内蒙古伊利实业集团股份有限公司 Functional lactobacillus beverage and preparation method thereof
CN111248269A (en) * 2018-11-30 2020-06-09 内蒙古伊利实业集团股份有限公司 Lactobacillus rhamnosus-containing probiotic fermented milk and preparation method thereof
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Cited By (26)

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CN102783653A (en) * 2012-09-04 2012-11-21 郭威 Collagen peptide nutritional supplement containing astaxanthin and processing method thereof
CN102793186A (en) * 2012-09-04 2012-11-28 郭威 Collagen peptide nutritional supplement containing astaxanthin and processing method of same
CN103271258A (en) * 2013-05-15 2013-09-04 上海莱博生物科技有限公司 Health product and application thereof
CN103271950A (en) * 2013-05-15 2013-09-04 上海莱博生物科技有限公司 Application of haematococcus pluvialis microcapsule powder
CN105055251A (en) * 2015-08-29 2015-11-18 云南蓝钻生物科技股份有限公司 Anti-aging cosmetic and preparation method thereof
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CN105725184A (en) * 2016-02-02 2016-07-06 北京同仁堂健康药业股份有限公司 Composition containing haematococcus pluvialis and collagen and preparing method thereof
CN106036916A (en) * 2016-06-02 2016-10-26 王斐芬 Postoperative repairing nutriment
CN106692955A (en) * 2016-12-30 2017-05-24 浙江海洋大学 Seaweed extract healthcare product having anti-aging effect and preparation method of seaweed extract healthcare product
CN106668842A (en) * 2017-03-06 2017-05-17 李树森 Anti-aging medicine and preparation method thereof
CN108719541A (en) * 2017-04-19 2018-11-02 邢金华 A kind of tea of the U.S. breast of chest enlarge
CN107281253A (en) * 2017-07-04 2017-10-24 云南德彩堂生物医药科技有限公司 A kind of composition for significantly improving anti-decrepit beauty function, preparation method and use
CN107549812A (en) * 2017-10-16 2018-01-09 海南三元星生物科技股份有限公司 It is a kind of using acerola concentrate extract, haematococcus pluvialis and Isin glue collagen peptide as beautifying and anti-aging food of raw material and preparation method thereof
CN108635324A (en) * 2018-05-14 2018-10-12 深圳市仙迪化妆品有限公司 Antioxidant and the preparation method and application thereof, antioxidant and preparation method thereof
CN108403703A (en) * 2018-06-04 2018-08-17 桑艳红 A kind of vitamine D3 soft capsule and preparation method thereof
CN108904687A (en) * 2018-07-16 2018-11-30 何利均 Saussurea involucrata haematococcus cream
CN108902958A (en) * 2018-07-20 2018-11-30 深圳市博奥生物科技有限公司 A kind of astaxanthin soft capsule and preparation method thereof
CN111165578A (en) * 2018-11-09 2020-05-19 内蒙古伊利实业集团股份有限公司 Functional lactobacillus beverage and preparation method thereof
CN111248269A (en) * 2018-11-30 2020-06-09 内蒙古伊利实业集团股份有限公司 Lactobacillus rhamnosus-containing probiotic fermented milk and preparation method thereof
CN110743004A (en) * 2019-11-27 2020-02-04 天津活力达生物科技有限公司 Astaxanthin direct drinking powder composition with whitening function and preparation method and application thereof
CN112616991A (en) * 2020-08-24 2021-04-09 河南工业大学 Method for extracting protein in chlorella and application of protein in sweet potato chlorella meal replacement powder
CN112772919A (en) * 2021-03-08 2021-05-11 郭宝叶 Food composition for improving body instinct, resisting oxidation and resisting aging and preparation method thereof
WO2023273206A1 (en) * 2021-07-01 2023-01-05 海南三元星生物科技股份有限公司 Astaxanthin-collagen peptide oral liquid and preparation method therefor

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Application publication date: 20120201