CN108403703A - A kind of vitamine D3 soft capsule and preparation method thereof - Google Patents
A kind of vitamine D3 soft capsule and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a kind of vitamine D3 soft capsules, are made of content and capsule skin, and the content includes following raw material：Vitamine D3, Germinatus Phragmitis extract, cornstarch, cera alba, safflower seed oil, olive oil, soybean lecithin.The invention also discloses the preparation methods of the vitamine D3 soft capsule.Vitamine D3 soft capsule prepared by the present invention is with good stability, pass through the synergy of Germinatus Phragmitis extract and safflower seed oil, there is good antioxygenic property in the case where being not added with artificial synthesized antioxidant, it is safe and non-toxic, it is easy to carry and use without low-temperature storage, and due to being prepared into soft capsule, medical and health care cause can be more easily applied to, there is the huge social and economic benefit of foreground.
Description
Technical field
The present invention relates to medical treatment ＆ health field, specifically a kind of vitamine D3 soft capsule and preparation method thereof.
Background technology
Vitamin D is a kind of liposoluble vitamin, is also regarded as a kind of hormone precursor acting on Ca,P metabolism.Mesh
Preceding known at least 10 kinds of vitamin D, but most importantly calciferol (vitamin D2) and vitamine D3 (courage calcification
Alcohol).Wherein, vitamine D3 is the 7-DHC that is contained by the epidermis and intradermal of most of superior beings through ultraviolet light
(wavelength 265-228nm) irradiation changes, and vitamine D3 is the highest a kind of active form of biological metabolism rate in vitamin D.
Research thinks that vitamine D3 can improve absorption of the body to calcium, phosphorus, and plasma calcium and the level of blood plasma phosphorus is made to reach degree of saturation；
Promote growth and bone calcification, promotes tooth sound；Increase the absorption of phosphorus by intestinal wall, and inhaling again for phosphorus is increased by renal tubule
It receives；Maintain the normal level of citrate in blood；Prevent amino acid from being lost by kidney.
Vitamine D3 is mainly synthesized by skin under light illumination, and content is few in food, especially hinterland, therefore, dimension
Raw element D3 shortages are global common problems, it was found that the vitamine D3 deficiency and shortage of China are especially apparent, vitamin
D3 shortages can cause a variety of health problems, the international guidelines such as rickets, osteomalacia, immunity degradation, osteoporosis drop to be recommended just
Ordinary person daily suitable vitamin D magnitude of recruitment in 400-1000IU.Therefore, vitamin D 3 appropriate is very necessary.
The method of common vitamin D 3 is to take vitamin D oral preparation, currently, domestic production vitamin D oral preparation
Medicine enterprise is fewer, and the vitamin D product of production is single, mostly vitaminAD dripping pill, aqua, injection, it usually needs is stored in nitrogen
In gas, the unglazed cold environment with anacidity, there is carrying and take inconvenience, need the defects of refrigerator storage, simultaneously as being easy oxygen
Change, generally requires that artificial synthesized antioxidant is added, certain adverse effect can be caused to human body.Therefore, a kind of carrying is designed
Vitamine D3 soft capsule convenient to take, without low-temperature storage, the problem of becoming urgent need to resolve.
Invention content
The purpose of the present invention is to provide a kind of vitamine D3 soft capsules and preparation method thereof, to solve above-mentioned background technology
The problem of middle proposition.
To achieve the above object, the present invention provides the following technical solutions：
A kind of vitamine D3 soft capsule, is made of content and capsule skin, and the content includes below according to parts by weight
Raw material：25-45 parts of vitamine D3s, 1-8 parts of Germinatus Phragmitis extracts, 1-8 parts of cornstarch, 0.4-3 parts of cera albas, 4-15 parts of safflowers
Seed oil, 25-45 parts of olive oil, 0.5-4 parts of soybean lecithins.
As a further solution of the present invention：The content includes the following raw material according to parts by weight：30-40 parts of dimension lifes
Plain D3,2-6 part of Germinatus Phragmitis extract, 2-5 parts of cornstarch, 0.7-2 parts of cera albas, 7-12 parts of safflower seed oils, 30-40 portions of olives
Oil, 1-3 parts of soybean lecithins.
As further scheme of the invention：The content includes the following raw material according to parts by weight：38 parts of dimension lifes
Plain D3,4 parts of Germinatus Phragmitis extracts, 3 parts of cornstarch, 1.1 parts of cera albas, 10 parts of safflower seed oils, 35 parts of olive oil, 2 parts of soybean phosphorus
Fat.
As further scheme of the invention：The preparation method of the Germinatus Phragmitis extract is to clean asparagus, is then put
Enter in steam pressure cooker, appropriate amount of deionized water is added and carries out high temperature and pressure extraction, the pressure of the high temperature and pressure extraction is 0.5-
0.8MPa, time 30-40min, extracting solution are concentrated under reduced pressure, and the Germinatus Phragmitis extract is obtained.
As further scheme of the invention：The capsule skin includes the following raw material according to parts by weight：11 parts of gelatin,
3 parts of glycerine, 0.01 part of sweetener, 1 part of walnut oil.
As further scheme of the invention：The sweetener is crystal diabetin, xylitol, glucose and maltitol
One or more of.
The preparation method of the vitamine D3 soft capsule, steps are as follows：
1) it is weighed in safflower seed oil merging container according to parts by weight, is heated to 40-60 DEG C while stirring, while stirring dropwise
Germinatus Phragmitis extract is added, is sent into ultrasonic cell disruptor and is ultrasonically treated after being added dropwise to complete, obtain mixture A；
2) it weighs olive oil according to parts by weight and is added into material-compound tank and be heated to 60-80 DEG C while stirring, be then added white
Beeswax continues stirring and is completely dissolved to cera alba, obtains mixture B；
3) soybean lecithin and vitamine D3 will be sequentially added in the mixture B obtained in step 2), is heated to 60-80 DEG C and stirs
10-20min is mixed, the mixture A obtained in step 1) is then slowly added into, continues to stir 10-20min, then be added while stirring
Cornstarch continues stirring until being uniformly mixed, and the filtering of 20 mesh obtains content；
4) weighing the suitable water of gelatin addition according to parts by weight makes its expansion, separately adds walnut oil after mixing with glycerine
Enter suitable water and set to be heated to 70 DEG C -80 DEG C in glue pot, the gelatin stirring of expansion is added after mixing, fusing obtains capsule
Skin；
5) capsule skin will be obtained in the content obtained in step 3) and step 4) and is pressed into soft capsule, then through washing ball, dry
It is dry, packaging to get.
As further scheme of the invention：In step 1), the supersonic frequency of the supersound process is 40-80kHz.
As further scheme of the invention：In step 1), the time of the supersound process is 20-40min.
Purposes of the vitamine D3 soft capsule in preparing health products.
Asparagus lettuce, which has effects that open, dredges gas, strong body, cancer-resisting under profit, disperse accumulation, and asparagus lettuce is suitable for urinary obstruction, urine
Blood and oedema, diabetes and obesity, nervous breakdown, hypertension, cardiac arrhythmia, insomniac are edible；Women's postpartum lack milk or
Alactation is also preferably eaten；Eating after drinking can relieve the effect of alcohol；When children and adolescents growth and development stage eat more preferably, asparagus lettuce leaf to heart disease,
Kidney trouble, neurasthenia, high blood pressure etc. have certain therapeutic effect, strong body, cancer-resisting, containing multivitamin and
Minerals have the function of adjusting nervous function, contain very abundant fluorine element, may participate in the growth of tooth and bone.
Safflower seed oil is also known as safflower oil, is the oil product using kardiseed as waste, is given birth to rich in natural dimension in safflower seed oil
Plain E is that content is highest in all plants, and vitamin E is a kind of very strong reducing agent, has extremely strong antioxidation, it
The also effect of anti-aging makes aging, the cell of aging and tissue get increasingly vigorous, and vitamin E is a kind of to improve human immunity
Power eliminates free radical, and the Fatty acid compositions of the nutriment of pre- anti-cancer, safflower seed oil are preferable, it contains abundant linoleic acid,
Serum cholesterol content is significantly reduced, the effect of prevention of cardiovascular disease, wherein also containing a large amount of vitamin E, dimension life
Plain D and abundant lecithin, it is very useful to health, in addition, human consumption's absorptivity of safflower seed oil is up to
98%.
Compared with prior art, the beneficial effects of the invention are as follows：
Vitamine D3 soft capsule prepared by the present invention is with good stability, passes through Germinatus Phragmitis extract and safflower seed oil
Synergy has good antioxygenic property in the case where being not added with artificial synthesized antioxidant, safe and non-toxic, is not necessarily to low temperature
Storage, and due to being prepared into soft capsule, it is easy to carry and use, it can more easily be applied to medical and health care cause, have
There is the huge social and economic benefit of foreground.
Specific implementation mode
Technical scheme of the present invention is described in more detail With reference to embodiment.
Embodiment 1
A kind of vitamine D3 soft capsule, is made of content and capsule skin, and the content includes below according to parts by weight
Raw material：25 parts of vitamine D3s, 1 part of Germinatus Phragmitis extract, 1 part of cornstarch, 0.4 part of cera alba, 4 parts of safflower seed oils, 25 parts of olives
Olive oil, 0.5 part of soybean lecithin.Wherein, the preparation method of the Germinatus Phragmitis extract is to clean asparagus, is then placed in steam pressure
In pot, appropriate amount of deionized water is added and carries out high temperature and pressure extraction, the pressure of high temperature and pressure extraction is 0.7MPa, and the time is
35min, extracting solution are concentrated under reduced pressure, and the Germinatus Phragmitis extract is obtained；The capsule skin includes the following raw material according to parts by weight：
11 parts of gelatin, 3 parts of glycerine, 0.01 part of sweetener, 1 part of walnut oil；The sweetener is xylitol.
In the present embodiment, the preparation method of the vitamine D3 soft capsule, steps are as follows：
1) it is weighed in safflower seed oil merging container according to parts by weight, is heated to 55 DEG C while stirring, adds dropwise while stirring
Enter Germinatus Phragmitis extract, is sent into ultrasonic cell disruptor after being added dropwise to complete and is ultrasonically treated with the supersonic frequency of 60kHz
30min obtains mixture A；
2) it weighs olive oil according to parts by weight and is added into material-compound tank and be heated to 70 DEG C while stirring, cera alba is then added
Continue stirring to be completely dissolved to cera alba, obtains mixture B；
3) soybean lecithin and vitamine D3 will be sequentially added in the mixture B obtained in step 2), is heated to 70 DEG C of stirrings
15min is then slowly added into the mixture A obtained in step 1), continues to stir 15min, then cornstarch is added while stirring,
Continue stirring until being uniformly mixed, the filtering of 20 mesh obtains content；
4) weighing the suitable water of gelatin addition according to parts by weight makes its expansion, separately adds walnut oil after mixing with glycerine
Enter suitable water and set to be heated to 75 DEG C in glue pot, the gelatin stirring of expansion is added after mixing, fusing obtains capsule skin；
5) capsule skin will be obtained in the content obtained in step 3) and step 4) and is pressed into soft capsule, then through washing ball, dry
It is dry, packaging to get.
Embodiment 2
A kind of vitamine D3 soft capsule, is made of content and capsule skin, and the content includes below according to parts by weight
Raw material：45 parts of vitamine D3s, 8 parts of Germinatus Phragmitis extracts, 8 parts of cornstarch, 3 parts of cera albas, 15 parts of safflower seed oils, 45 portions of olives
Oil, 4 parts of soybean lecithins.Wherein, the preparation method of the Germinatus Phragmitis extract is to clean asparagus, is then placed in steam pressure cooker
In, appropriate amount of deionized water is added and carries out high temperature and pressure extraction, the pressure of high temperature and pressure extraction is 0.7MPa, and the time is
35min, extracting solution are concentrated under reduced pressure, and the Germinatus Phragmitis extract is obtained；The capsule skin includes the following raw material according to parts by weight：
11 parts of gelatin, 3 parts of glycerine, 0.01 part of sweetener, 1 part of walnut oil；The sweetener is xylitol.
In the present embodiment, the preparation method of the vitamine D3 soft capsule, steps are as follows：
1) it is weighed in safflower seed oil merging container according to parts by weight, is heated to 55 DEG C while stirring, adds dropwise while stirring
Enter Germinatus Phragmitis extract, is sent into ultrasonic cell disruptor after being added dropwise to complete and is ultrasonically treated with the supersonic frequency of 60kHz
30min obtains mixture A；
2) it weighs olive oil according to parts by weight and is added into material-compound tank and be heated to 70 DEG C while stirring, cera alba is then added
Continue stirring to be completely dissolved to cera alba, obtains mixture B；
3) soybean lecithin and vitamine D3 will be sequentially added in the mixture B obtained in step 2), is heated to 70 DEG C of stirrings
15min is then slowly added into the mixture A obtained in step 1), continues to stir 15min, then cornstarch is added while stirring,
Continue stirring until being uniformly mixed, the filtering of 20 mesh obtains content；
4) weighing the suitable water of gelatin addition according to parts by weight makes its expansion, separately adds walnut oil after mixing with glycerine
Enter suitable water and set to be heated to 75 DEG C in glue pot, the gelatin stirring of expansion is added after mixing, fusing obtains capsule skin；
5) capsule skin will be obtained in the content obtained in step 3) and step 4) and is pressed into soft capsule, then through washing ball, dry
It is dry, packaging to get.
Embodiment 3
A kind of vitamine D3 soft capsule, is made of content and capsule skin, and the content includes below according to parts by weight
Raw material：35 parts of vitamine D3s, 4.5 parts of Germinatus Phragmitis extracts, 4.5 parts of cornstarch, 1.7 parts of cera albas, 9.5 parts of safflower seed oils,
35 parts of olive oil, 2.3 parts of soybean lecithins.Wherein, the preparation method of the Germinatus Phragmitis extract is to clean asparagus, is then placed in steaming
In steam pressure pot, appropriate amount of deionized water being added and carries out high temperature and pressure extraction, the pressure of the high temperature and pressure extraction is 0.7MPa, when
Between be 35min, extracting solution is concentrated under reduced pressure, and the Germinatus Phragmitis extract is obtained；The capsule skin includes following according to parts by weight
Raw material：11 parts of gelatin, 3 parts of glycerine, 0.01 part of sweetener, 1 part of walnut oil；The sweetener is xylitol.
In the present embodiment, the preparation method of the vitamine D3 soft capsule, steps are as follows：
1) it is weighed in safflower seed oil merging container according to parts by weight, is heated to 55 DEG C while stirring, adds dropwise while stirring
Enter Germinatus Phragmitis extract, is sent into ultrasonic cell disruptor after being added dropwise to complete and is ultrasonically treated with the supersonic frequency of 60kHz
30min obtains mixture A；
2) it weighs olive oil according to parts by weight and is added into material-compound tank and be heated to 70 DEG C while stirring, cera alba is then added
Continue stirring to be completely dissolved to cera alba, obtains mixture B；
3) soybean lecithin and vitamine D3 will be sequentially added in the mixture B obtained in step 2), is heated to 70 DEG C of stirrings
15min is then slowly added into the mixture A obtained in step 1), continues to stir 15min, then cornstarch is added while stirring,
Continue stirring until being uniformly mixed, the filtering of 20 mesh obtains content；
4) weighing the suitable water of gelatin addition according to parts by weight makes its expansion, separately adds walnut oil after mixing with glycerine
Enter suitable water and set to be heated to 75 DEG C in glue pot, the gelatin stirring of expansion is added after mixing, fusing obtains capsule skin；
5) capsule skin will be obtained in the content obtained in step 3) and step 4) and is pressed into soft capsule, then through washing ball, dry
It is dry, packaging to get.
Embodiment 4
A kind of vitamine D3 soft capsule, is made of content and capsule skin, and the content includes below according to parts by weight
Raw material：30 parts of vitamine D3s, 2 parts of Germinatus Phragmitis extracts, 2 parts of cornstarch, 0.7 part of cera alba, 7 parts of safflower seed oils, 30 parts of olives
Olive oil, 1 part of soybean lecithin.Wherein, the preparation method of the Germinatus Phragmitis extract is to clean asparagus, is then placed in steam pressure cooker
In, appropriate amount of deionized water is added and carries out high temperature and pressure extraction, the pressure of high temperature and pressure extraction is 0.7MPa, and the time is
35min, extracting solution are concentrated under reduced pressure, and the Germinatus Phragmitis extract is obtained；The capsule skin includes the following raw material according to parts by weight：
11 parts of gelatin, 3 parts of glycerine, 0.01 part of sweetener, 1 part of walnut oil；The sweetener is xylitol.
In the present embodiment, the preparation method of the vitamine D3 soft capsule, steps are as follows：
1) it is weighed in safflower seed oil merging container according to parts by weight, is heated to 55 DEG C while stirring, adds dropwise while stirring
Enter Germinatus Phragmitis extract, is sent into ultrasonic cell disruptor after being added dropwise to complete and is ultrasonically treated with the supersonic frequency of 60kHz
30min obtains mixture A；
2) it weighs olive oil according to parts by weight and is added into material-compound tank and be heated to 70 DEG C while stirring, cera alba is then added
Continue stirring to be completely dissolved to cera alba, obtains mixture B；
3) soybean lecithin and vitamine D3 will be sequentially added in the mixture B obtained in step 2), is heated to 70 DEG C of stirrings
15min is then slowly added into the mixture A obtained in step 1), continues to stir 15min, then cornstarch is added while stirring,
Continue stirring until being uniformly mixed, the filtering of 20 mesh obtains content；
4) weighing the suitable water of gelatin addition according to parts by weight makes its expansion, separately adds walnut oil after mixing with glycerine
Enter suitable water and set to be heated to 75 DEG C in glue pot, the gelatin stirring of expansion is added after mixing, fusing obtains capsule skin；
5) capsule skin will be obtained in the content obtained in step 3) and step 4) and is pressed into soft capsule, then through washing ball, dry
It is dry, packaging to get.
Embodiment 5
A kind of vitamine D3 soft capsule, is made of content and capsule skin, and the content includes below according to parts by weight
Raw material：40 parts of vitamine D3s, 6 parts of Germinatus Phragmitis extracts, 5 parts of cornstarch, 2 parts of cera albas, 12 parts of safflower seed oils, 40 portions of olives
Oil, 3 parts of soybean lecithins.Wherein, the preparation method of the Germinatus Phragmitis extract is to clean asparagus, is then placed in steam pressure cooker
In, appropriate amount of deionized water is added and carries out high temperature and pressure extraction, the pressure of high temperature and pressure extraction is 0.7MPa, and the time is
35min, extracting solution are concentrated under reduced pressure, and the Germinatus Phragmitis extract is obtained；The capsule skin includes the following raw material according to parts by weight：
11 parts of gelatin, 3 parts of glycerine, 0.01 part of sweetener, 1 part of walnut oil；The sweetener is xylitol.
In the present embodiment, the preparation method of the vitamine D3 soft capsule, steps are as follows：
1) it is weighed in safflower seed oil merging container according to parts by weight, is heated to 55 DEG C while stirring, adds dropwise while stirring
Enter Germinatus Phragmitis extract, is sent into ultrasonic cell disruptor after being added dropwise to complete and is ultrasonically treated with the supersonic frequency of 60kHz
30min obtains mixture A；
2) it weighs olive oil according to parts by weight and is added into material-compound tank and be heated to 70 DEG C while stirring, cera alba is then added
Continue stirring to be completely dissolved to cera alba, obtains mixture B；
3) soybean lecithin and vitamine D3 will be sequentially added in the mixture B obtained in step 2), is heated to 70 DEG C of stirrings
15min is then slowly added into the mixture A obtained in step 1), continues to stir 15min, then cornstarch is added while stirring,
Continue stirring until being uniformly mixed, the filtering of 20 mesh obtains content；
4) weighing the suitable water of gelatin addition according to parts by weight makes its expansion, separately adds walnut oil after mixing with glycerine
Enter suitable water and set to be heated to 75 DEG C in glue pot, the gelatin stirring of expansion is added after mixing, fusing obtains capsule skin；
5) capsule skin will be obtained in the content obtained in step 3) and step 4) and is pressed into soft capsule, then through washing ball, dry
It is dry, packaging to get.
Embodiment 6
A kind of vitamine D3 soft capsule, is made of content and capsule skin, and the content includes below according to parts by weight
Raw material：35 parts of vitamine D3s, 4 parts of Germinatus Phragmitis extracts, 3.5 parts of cornstarch, 1.35 parts of cera albas, 9.5 parts of safflower seed oils, 35
Part olive oil, 2 parts of soybean lecithins.Wherein, the preparation method of the Germinatus Phragmitis extract is to clean asparagus, is then placed in vapour pressure
In power pot, appropriate amount of deionized water is added and carries out high temperature and pressure extraction, the pressure of high temperature and pressure extraction is 0.7MPa, and the time is
35min, extracting solution are concentrated under reduced pressure, and the Germinatus Phragmitis extract is obtained；The capsule skin includes the following raw material according to parts by weight：
11 parts of gelatin, 3 parts of glycerine, 0.01 part of sweetener, 1 part of walnut oil；The sweetener is xylitol.
In the present embodiment, the preparation method of the vitamine D3 soft capsule, steps are as follows：
1) it is weighed in safflower seed oil merging container according to parts by weight, is heated to 55 DEG C while stirring, adds dropwise while stirring
Enter Germinatus Phragmitis extract, is sent into ultrasonic cell disruptor after being added dropwise to complete and is ultrasonically treated with the supersonic frequency of 60kHz
30min obtains mixture A；
2) it weighs olive oil according to parts by weight and is added into material-compound tank and be heated to 70 DEG C while stirring, cera alba is then added
Continue stirring to be completely dissolved to cera alba, obtains mixture B；
3) soybean lecithin and vitamine D3 will be sequentially added in the mixture B obtained in step 2), is heated to 70 DEG C of stirrings
15min is then slowly added into the mixture A obtained in step 1), continues to stir 15min, then cornstarch is added while stirring,
Continue stirring until being uniformly mixed, the filtering of 20 mesh obtains content；
4) weighing the suitable water of gelatin addition according to parts by weight makes its expansion, separately adds walnut oil after mixing with glycerine
Enter suitable water and set to be heated to 75 DEG C in glue pot, the gelatin stirring of expansion is added after mixing, fusing obtains capsule skin；
5) capsule skin will be obtained in the content obtained in step 3) and step 4) and is pressed into soft capsule, then through washing ball, dry
It is dry, packaging to get.
Embodiment 7
A kind of vitamine D3 soft capsule, is made of content and capsule skin, and the content includes below according to parts by weight
Raw material：38 parts of vitamine D3s, 4 parts of Germinatus Phragmitis extracts, 3 parts of cornstarch, 1.1 parts of cera albas, 10 parts of safflower seed oils, 35 parts of olives
Olive oil, 2 parts of soybean lecithins.Wherein, the preparation method of the Germinatus Phragmitis extract is to clean asparagus, is then placed in steam pressure cooker
In, appropriate amount of deionized water is added and carries out high temperature and pressure extraction, the pressure of high temperature and pressure extraction is 0.7MPa, and the time is
35min, extracting solution are concentrated under reduced pressure, and the Germinatus Phragmitis extract is obtained；The capsule skin includes the following raw material according to parts by weight：
11 parts of gelatin, 3 parts of glycerine, 0.01 part of sweetener, 1 part of walnut oil；The sweetener is xylitol.
In the present embodiment, the preparation method of the vitamine D3 soft capsule, steps are as follows：
1) it is weighed in safflower seed oil merging container according to parts by weight, is heated to 55 DEG C while stirring, adds dropwise while stirring
Enter Germinatus Phragmitis extract, is sent into ultrasonic cell disruptor after being added dropwise to complete and is ultrasonically treated with the supersonic frequency of 60kHz
30min obtains mixture A；
2) it weighs olive oil according to parts by weight and is added into material-compound tank and be heated to 70 DEG C while stirring, cera alba is then added
Continue stirring to be completely dissolved to cera alba, obtains mixture B；
3) soybean lecithin and vitamine D3 will be sequentially added in the mixture B obtained in step 2), is heated to 70 DEG C of stirrings
15min is then slowly added into the mixture A obtained in step 1), continues to stir 15min, then cornstarch is added while stirring,
Continue stirring until being uniformly mixed, the filtering of 20 mesh obtains content；
4) weighing the suitable water of gelatin addition according to parts by weight makes its expansion, separately adds walnut oil after mixing with glycerine
Enter suitable water and set to be heated to 75 DEG C in glue pot, the gelatin stirring of expansion is added after mixing, fusing obtains capsule skin；
5) capsule skin will be obtained in the content obtained in step 3) and step 4) and is pressed into soft capsule, then through washing ball, dry
It is dry, packaging to get.
Embodiment 8
A kind of vitamine D3 soft capsule, is made of content and capsule skin, and the content includes below according to parts by weight
Raw material：38 parts of vitamine D3s, 4 parts of Germinatus Phragmitis extracts, 3 parts of cornstarch, 1.1 parts of cera albas, 10 parts of safflower seed oils, 35 parts of olives
Olive oil, 2 parts of soybean lecithins.Wherein, the preparation method of the Germinatus Phragmitis extract is to clean asparagus, is then placed in steam pressure cooker
In, appropriate amount of deionized water is added and carries out high temperature and pressure extraction, the pressure of high temperature and pressure extraction is 0.7MPa, and the time is
35min, extracting solution are concentrated under reduced pressure, and the Germinatus Phragmitis extract is obtained；The capsule skin includes the following raw material according to parts by weight：
11 parts of gelatin, 3 parts of glycerine, 0.01 part of sweetener, 1 part of walnut oil；The sweetener is xylitol.
In the present embodiment, the preparation method of the vitamine D3 soft capsule, steps are as follows：
1) it is weighed in safflower seed oil merging container according to parts by weight, is heated to 55 DEG C while stirring, adds dropwise while stirring
Enter Germinatus Phragmitis extract, is sent into ultrasonic cell disruptor after being added dropwise to complete and is ultrasonically treated with the supersonic frequency of 60kHz
30min obtains mixture A；
2) it weighs olive oil according to parts by weight and is added into material-compound tank and be heated to 70 DEG C while stirring, cera alba is then added
Continue stirring to be completely dissolved to cera alba, obtains mixture B；
3) soybean lecithin and vitamine D3 will be sequentially added in the mixture B obtained in step 2), is heated to 70 DEG C of stirrings
15min is then slowly added into the mixture A obtained in step 1), continues to stir 15min, then cornstarch is added while stirring,
Continue stirring until being uniformly mixed, the filtering of 20 mesh obtains content；
4) weighing the suitable water of gelatin addition according to parts by weight makes its expansion, separately adds walnut oil after mixing with glycerine
Enter suitable water and set to be heated to 75 DEG C in glue pot, the gelatin stirring of expansion is added after mixing, fusing obtains capsule skin；
5) capsule skin will be obtained in the content obtained in step 3) and step 4) and is pressed into soft capsule, then through washing ball, dry
Dry, packaging is to get vitamine D3 soft capsule, wherein every vitamin d3 levels point can be made in the vitamine D3 soft capsule
Not Wei 1000IU, the capsule of 2000IU, 5000IU reaches the requirement of On Vitamin Supplement D, makes up domestic vitamine D3 preparation
Formula defect, fill up every vitamin d3 levels respectively in 1000IU, the technological gap of 2000IU, 5000IU meet different
The demand of crowd's vitamin D reaches the requirement of On Vitamin Supplement D, and then improves the health of broad masses of the people, subtracts
The generation of few obesity, diabetes, metabolic syndrome, osteoporosis, tumour caused by vitamin D deficiency.
Comparative example 1
A kind of vitamine D3 soft capsule, is made of content and capsule skin, and the content includes below according to parts by weight
Raw material：38 parts of vitamine D3s, 3 parts of cornstarch, 1.1 parts of cera albas, 10 parts of safflower seed oils, 35 parts of olive oil, 2 parts of soybean phosphorus
Fat.Wherein, the capsule skin includes the following raw material according to parts by weight：11 parts of gelatin, 3 parts of glycerine, 0.01 part of sweetener, walnut
1 part of oil；The sweetener is xylitol.
In the present embodiment, the preparation method of the vitamine D3 soft capsule, steps are as follows：
1) it is weighed in safflower seed oil merging container according to parts by weight, is heated to 55 DEG C while stirring, is then fed into ultrasonic wave
Supersound process 30min is carried out with the supersonic frequency of 60kHz in cell disruptor, obtains mixture A；
2) it weighs olive oil according to parts by weight and is added into material-compound tank and be heated to 70 DEG C while stirring, cera alba is then added
Continue stirring to be completely dissolved to cera alba, obtains mixture B；
3) soybean lecithin and vitamine D3 will be sequentially added in the mixture B obtained in step 2), is heated to 70 DEG C of stirrings
15min is then slowly added into the mixture A obtained in step 1), continues to stir 15min, then cornstarch is added while stirring,
Continue stirring until being uniformly mixed, the filtering of 20 mesh obtains content；
4) weighing the suitable water of gelatin addition according to parts by weight makes its expansion, separately adds walnut oil after mixing with glycerine
Enter suitable water and set to be heated to 75 DEG C in glue pot, the gelatin stirring of expansion is added after mixing, fusing obtains capsule skin；
5) capsule skin will be obtained in the content obtained in step 3) and step 4) and is pressed into soft capsule, then through washing ball, dry
It is dry, packaging to get.
Comparative example 2
Compared with Example 7, safflower seed oil is free of, other are same as Example 7.
Comparative example 3
Compared with Example 7, Germinatus Phragmitis extract and safflower seed oil are free of, other are same as Example 7.
Performance test
Detection of Stability is carried out to the vitamine D3 soft capsule of the preparation of embodiment 7 and comparative example 1-3, passes through strong illumination
The stability of vitamine D3 soft capsule is measured, specific method is the vitamine D3 for randomly selecting embodiment 7 and comparative example 1-3 preparations
Each 100 of soft capsule, is accordingly divided into four groups, is irradiated under 4000 lux fluorescent lamps 10 days, and the 4th, 7,10 day is separately sampled,
Using the front and back vitamine D3 survival rate of high performance liquid chromatograph detection experiment, every group of testing result is averaged, and testing result is such as
Shown in table 1.
It, can from can be seen that the present invention in the data comparison of embodiment 7 and comparative example 1 by adding Germinatus Phragmitis extract
Effectively improve the VD after vitamine D3 soft capsule strong illumination3Survival rate, and then improve its stability；From embodiment 7 with it is right
As can be seen that present invention addition safflower seed oil, can effectively improve vitamine D3 soft capsule intense light irradiation in the data comparison of ratio 2
VD after penetrating3Survival rate, and then improve its stability；In addition, can be with from the data comparison of embodiment 7 and comparative example 1-3
Find out, the present invention is cooperated by Germinatus Phragmitis extract and safflower seed oil, plays synergistic effect, can further have
Effect improves the VD after vitamine D3 soft capsule strong illumination3Survival rate, and then its stability is improved, be conducive to carry out room temperature storage
It deposits.
1 vitamine D3 Stability of Soft Capsules testing result of table
Asparagus lettuce, which has effects that open, dredges gas, strong body, cancer-resisting under profit, disperse accumulation, and asparagus lettuce is suitable for urinary obstruction, urine
Blood and oedema, diabetes and obesity, nervous breakdown, hypertension, cardiac arrhythmia, insomniac are edible；Women's postpartum lack milk or
Alactation is also preferably eaten；Eating after drinking can relieve the effect of alcohol；When children and adolescents growth and development stage eat more preferably, asparagus lettuce leaf to heart disease,
Kidney trouble, neurasthenia, high blood pressure etc. have certain therapeutic effect, strong body, cancer-resisting, containing multivitamin and
Minerals have the function of adjusting nervous function, contain very abundant fluorine element, may participate in the growth of tooth and bone.
Safflower seed oil is also known as safflower oil, is the oil product using kardiseed as waste, is given birth to rich in natural dimension in safflower seed oil
Plain E is that content is highest in all plants, and vitamin E is a kind of very strong reducing agent, has extremely strong antioxidation, it
The also effect of anti-aging makes aging, the cell of aging and tissue get increasingly vigorous, and vitamin E is a kind of to improve human immunity
Power eliminates free radical, and the Fatty acid compositions of the nutriment of pre- anti-cancer, safflower seed oil are preferable, it contains abundant linoleic acid,
Serum cholesterol content is significantly reduced, the effect of prevention of cardiovascular disease, wherein also containing a large amount of vitamin E, dimension life
Plain D and abundant lecithin, it is very useful to health, in addition, human consumption's absorptivity of safflower seed oil is up to
98%.
As can be seen that vitamine D3 soft capsule prepared by the present invention, has inoxidizability by addition from result above
Germinatus Phragmitis extract and safflower seed oil, have good inoxidizability, it is safe and non-toxic without adding artificial antioxidant, meanwhile,
By the synergy of Germinatus Phragmitis extract and safflower seed oil, have in the case where being not added with artificial synthesized antioxidant good steady
It is qualitative, it is not necessarily to low-temperature storage, and due to being prepared into soft capsule, it is easy to carry and use, it can more easily be applied to medical treatment
And public health work, there is the huge social and economic benefit of foreground, have a vast market foreground.
The better embodiment of the present invention is explained in detail above, but the present invention is not limited to above-mentioned embodiment party
Formula, one skilled in the relevant art within the scope of knowledge, can also be without departing from the purpose of the present invention
Various changes can be made.There is no necessity and possibility to exhaust all the enbodiments.And it thus amplifies out apparent
Variation or variation be still in the protection scope of this invention.
Claims (10)
1. a kind of vitamine D3 soft capsule, is made of content and capsule skin, which is characterized in that the content includes pressing below
According to the raw material of parts by weight：25-45 parts of vitamine D3s, 1-8 parts of Germinatus Phragmitis extracts, 1-8 parts of cornstarch, 0.4-3 parts of cera albas, 4-
15 parts of safflower seed oils, 25-45 parts of olive oil, 0.5-4 parts of soybean lecithins.
2. vitamine D3 soft capsule according to claim 1, which is characterized in that the content includes below according to weight
The raw material of part：30-40 parts of vitamine D3s, 2-6 parts of Germinatus Phragmitis extracts, 2-5 parts of cornstarch, 0.7-2 parts of cera albas, 7-12 parts it is red
Flower seed oil, 30-40 part olive oil, 1-3 parts of soybean lecithins.
3. vitamine D3 soft capsule according to claim 2, which is characterized in that the content includes below according to weight
The raw material of part：38 parts of vitamine D3s, 4 parts of Germinatus Phragmitis extracts, 3 parts of cornstarch, 1.1 parts of cera albas, 10 parts of safflower seed oils, 35 parts
Olive oil, 2 parts of soybean lecithins.
4. vitamine D3 soft capsule according to claim 1 or 2 or 3, which is characterized in that the preparation of the Germinatus Phragmitis extract
Method is to clean asparagus, is then placed in steam pressure cooker, and appropriate amount of deionized water is added and carries out high temperature and pressure extraction, the height
The pressure of warm high pressure extraction is 0.5-0.8MPa, time 30-40min, and extracting solution is concentrated under reduced pressure, and obtains the asparagus extraction
Object.
5. vitamine D3 soft capsule according to claim 1, which is characterized in that the capsule skin includes below according to weight
The raw material of part：11 parts of gelatin, 3 parts of glycerine, 0.01 part of sweetener, 1 part of walnut oil.
6. vitamine D3 soft capsule according to claim 5, which is characterized in that the sweetener is crystal diabetin, xylose
One or more of alcohol, glucose and maltitol.
7. a kind of preparation method of vitamine D3 soft capsule as described in claim 1-6 is any, which is characterized in that step is such as
Under：
1）It is weighed in safflower seed oil merging container according to parts by weight, is heated to 40-60 DEG C while stirring, is added dropwise while stirring
Germinatus Phragmitis extract is sent into ultrasonic cell disruptor after being added dropwise to complete and is ultrasonically treated, obtains mixture A；
2）Olive oil is weighed according to parts by weight being added into material-compound tank and be heated to 60-80 DEG C while stirring, cera alba is then added
Continue stirring to be completely dissolved to cera alba, obtains mixture B；
3）By step 2）In sequentially add soybean lecithin and vitamine D3 in obtained mixture B, be heated to 60-80 DEG C of stirring
10-20min is then slowly added into step 1）In obtained mixture A, continue to stir 10-20min, then be added while stirring beautiful
Rice starch continues stirring until being uniformly mixed, and the filtering of 20 mesh obtains content；
4）Weighing the suitable water of gelatin addition according to parts by weight makes its expansion, separately walnut oil and glycerine is added after mixing suitable
The water of amount, which is set, is heated to 70 DEG C -80 DEG C in glue pot, the gelatin stirring of expansion is added after mixing, and fusing obtains capsule skin；
5）By step 3）In obtained content and step 4）In obtain capsule skin and be pressed into soft capsule, then through washing ball, drying, packet
Dress to get.
8. the preparation method of vitamine D3 soft capsule according to claim 7, which is characterized in that step 1）In, it is described super
The supersonic frequency of sonication is 40-80kHz.
9. the preparation method of vitamine D3 soft capsule according to claim 8, which is characterized in that step 1）In, it is described super
The time of sonication is 20-40min.
10. a kind of purposes of vitamine D3 soft capsule as described in claim 1-6 is any in preparing health products.
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| CN112075625A (en) * | 2020-09-11 | 2020-12-15 | 深圳太太药业有限公司 | Composition for improving memory, soft capsule thereof and preparation method thereof |
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Application publication date: 20180817 |