CN102318795A - Health-care food having anti-fatigue function - Google Patents
Health-care food having anti-fatigue function Download PDFInfo
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- CN102318795A CN102318795A CN201110317080A CN201110317080A CN102318795A CN 102318795 A CN102318795 A CN 102318795A CN 201110317080 A CN201110317080 A CN 201110317080A CN 201110317080 A CN201110317080 A CN 201110317080A CN 102318795 A CN102318795 A CN 102318795A
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Abstract
The invention belongs to the technical field of health-care foods and discloses a health-care food having an anti-fatigue function. Raw materials of the health-care food comprise D-ribose, amino acid and/or vitamins. As proved by multiple years of researches, the D-ribose, amino acid and/or vitamins have anti-fatigue functions on the basis of a modern medical theory. A formula is selected preferably through an animal test, so that a new formula of the health-care food having the anti-fatigue function is determined.
Description
Technical field
The invention belongs to the health food technology field, be specifically related to the health food that a kind of raw material comprises D-ribose.
Background technology
D-ribose is a kind of pentose, is inhereditary material---the important composition material of nucleic acid in the organism.D-ribose is as the natural components that is present in the organism in all cells; With the formation of adenylate and the regeneration of ATP substantial connection is arranged; Be one of the most basic energy source of life metabolism, in heart and muscle metabolism, play a crucial role, can promote the recovery of local organization ischemic, anoxic; The speed of the synthetic ATP of the heart of human body and skeletal muscle itself is slow, and D-ribose can be accelerated synthesizing of ATP in heart and the skeletal muscle, and therefore, heart and skeletal muscle are organ and the tissues that needs most D-ribose.
D-ribose has following pharmacological action: heart ischemia is improved in (1), promotes cardiac function: heart ischemia can make heart function decline, arrhythmia cordis.Research confirms; Oral D-ribose can promote the generation of cardiac muscle cell ATP, makes cardiac muscle cell's function normal, thereby obviously improves heart function; Heart during the protection ischemic; Arrhythmia cordis to bringing out because of heart ischemia also has protective effect, make original once moving breathe heavily, often symptom nervous, uncomfortable in chest, the deficiency of vital energy is able to obvious improvement, quality of life improves greatly.(2) strengthen the human body energy, alleviate DOMS: the people feels that tired immediate cause is the ATP generation deficiency of muscle cell, makes the energy shortage of muscle activity, and the people just has sense of fatigue.D-ribose is the starting molecule of synthetic ATP, and it is the important source material of the synthetic energy matter ATP of muscle.Research confirms, replenishes the locomitivity that D-ribose can improve human body, and effectively antifatigue is alleviated DOMS.
D-ribose is through intestinal absorption, with blood by cardiac muscle cell and Skeletal Muscle Cell picked-up after, under the effect of ribokinase, add that ATP decomposes the phosphate group that the back produces and directly generates ribose 5-phosphate, generate ATP then fast.Oral D-ribose can make the ribose 5-phosphate in cardiac muscle and the Skeletal Muscle Cell synthetic fast through this reaction path, promotes the reparation of adenylic acid then, generates ATP fast.Glucose forms ribose 5-phosphate process complicacy, speed is slow, and it is simple that D-ribose forms the ribose 5-phosphate process, and speed is fast.D-ribose forms this approach of ribose 5-phosphate and has remedied cardiac muscle cell and the additional defective slowly of Skeletal Muscle Cell ATP, and when body experience anoxic, ischemic or high-intensity exercise, its effect is more outstanding.Research shows: in some meat fibers, the ATP regeneration needs 24～96 hours (1～4 day) completely, and human body could be recovered from overexercise fully.After replenishing D-ribose, can make approximately fast 3～4 times of the generating rates of ATP, that is to say that the recovery that ATP stores can reduce to 6～24 hours from 1～4 day.
Domestic have only a unique D-ribose state food that passes through through State Food and Drug Administration to be good for the word health food now: American Ginseng ribose particle is used for alleviating fatigue etc.Therefore, it is significant to carry out deep research and development to D-ribose.
Summary of the invention
For these reasons, the unexpected under study for action D-ribose and amino acid and/or vitamin found of applicant has antifatigue effect, through animal experiment prescription is carried out preferably, has confirmed a kind of prescription of health food of new antifatigue effect.
The present invention realizes through following technical proposals.
A kind of health food with antifatigue effect is characterized in that healthy food material is D-ribose, amino acid and/or vitamin.
Above-mentioned healthy food material is a D-ribose 1-10 weight portion, amino acid/11-20 weight portion, vitamin 0.05-3 weight portion.
Above-mentioned healthy food material is a D-ribose 1-10 weight portion, amino acid/11-20 weight portion.
Above-mentioned healthy food material is a D-ribose 1-10 weight portion, vitamin 0.05-3 weight portion.
Above-mentioned said amino acid be in aspartic acid, glutamic acid, cysteine, serine, glycine, threonine, alanine, valine, leucine, isoleucine, proline, phenylalanine, tyrosine, histidine and the lysine one or more; Add arginine, citrulling or taurine again.
Above-mentioned said vitamin is one or more in vitamin A, vitamin B1, vitamin B2, vitamin B6, vitamin C, vitamin E, folic acid, cobalamin, vitamin D, vitamin K, biotin, citrin, nicotinic acid, vitamin(e) M, vitamin(e) T, vitamin, biotin, water soluble vitamin, niacinamide, the pantothenic acid.Vitamin of the present invention also can be to contain mentioned component extract or concentrate.
Above-mentioned health food also comprises auxiliary material.Said auxiliary material includes but not limited to one or more in Sucralose, white granulated sugar, glucose, FOS, maltose, oligoisomaltose, rose candy, Sweet-scented Osmanthus, citric acid, blueberry, prune, acid Chinese quince, dark plum, orange, matrimony vine, Fructus Hordei Germinatus, cherry, the lemon mint.
Above-mentioned health food comprises oral formulations.
Above-mentioned health food comprises tablet, capsule, pill, granule or oral liquid.
Above-mentioned health food comprises beverage.
One, healthy food material prescription screening test
1, trial test
Test 1 group: D-ribose;
Test 2 groups: D-ribose 35mg, 2-deoxy-D-ribose 35mg, alanine 20mg, vitamin A 5mg.
Test 3 groups: 2-deoxy-D-ribose 35mg, alanine 20mg, vitamin A 5mg.
Test 4 groups: D-ribose 35mg, alanine 20mg, vitamin A 5mg.
Test method: the animal used as test mouse is divided into group, i.e. different pharmaceutical group and control group, every group of 12 mouse are adopted administration by gavage, and give mouse stomach different pharmaceutical with the 0.5g/kg dosage every day, and control group gives equivalent distilled water.1 time/d, continuous 21d.
Motion model control group and experimental group began to carry out the adaptability swimming instruction on the 15th day in irritating stomach; Swimming time is begun by 10min/d; Increased progressively 5min to the every day 20 days; Power exhausts criterion does not float for the 8s that sinks under water by mouse body weight 5% swimming with a load attached to the body to mouse, can't accomplish righting reflex after pulling out.Power exhausts swimming time: after last received reagent 30min to mouse, adopting load mode was that a quality is the lead of mouse body weight 5% in the mouse tail, and mouse is placed the swimming case of depth of water 30cm, and the temperature of water is controlled at about 30 ℃.Forced swimming to power exhausts (till the 8s that sinks under water is motionless), the record swimming time.
Table 1 power exhausts swimming time
Annotate: compare with control group
*P＜0.05,
*P＜0.01; Compare △ P＜0.05 for 1 group with test.
Annotate: above-mentioned test is on screening test basis repeatedly, to the demonstration test of technical scheme of the present invention.
Conclusion (of pressure testing): above-mentioned result of the test shows; Use D-ribose antifatigue effect effect separately; After D-ribose and 2-deoxy-D-ribose, amino acid, vitamin combination; The antifatigue effect has also descended, and this has explained that D-ribose and 2-deoxy-D-ribose structure are similar, and the two might have antagonism; And after D-ribose and amino acid, vitamin combination, have the extremely significantly effect of antifatigue effect, explain that tentatively D-ribose and amino acid, vitamin make up the prescription that can become new antifatigue effect.
2, screening test
Test 1 group: D-ribose 5g, amino acid/11 5g (each 1g of aspartic acid, glutamic acid, cysteine, serine, glycine, threonine, alanine, valine, leucine, isoleucine, proline, phenylalanine, tyrosine, histidine and lysine);
Test 2 groups: D-ribose 5g, vitamin 1g (vitamin A 0.1g, vitaminB10 .1g, vitamin B2 0.05g, vitamin B6 0.05g, vitamin C 0.1g, vitamin E 0.1g, folic acid 0.1g, cobalamin 0.1g, vitamin D 0.1g, vitamin K 0.1g, biotin 0.1g).
Test 3 groups: D-ribose 5g; Amino acid/11 5g (each 1g of aspartic acid, glutamic acid, cysteine, serine, glycine, threonine, alanine, valine, leucine, isoleucine, proline, phenylalanine, tyrosine, histidine and lysine), vitamin 1g (vitamin A 0.1g, vitaminB10 .1g, vitamin B2 0.05g, vitamin B6 0.05g, vitamin C 0.1g, vitamin E 0.1g, folic acid 0.1g, cobalamin 0.1g, vitamin D 0.1g, vitamin K 0.1g, biotin 0.1g).
Test method: the animal used as test mouse is divided into group, i.e. different pharmaceutical group and control group, every group of 12 mouse are adopted administration by gavage, and give mouse stomach different pharmaceutical with the 0.5g/kg dosage every day, and control group gives equivalent distilled water.1 time/d, continuous 21d.
The mensuration of serum urea nitrogen: the 1. preparation of serum: after last receives reagent 30min to mouse; With the swimming case that mouse does not bear a heavy burden and places depth of water 30cm, the temperature of water is controlled at about 30 ℃, swimming 90min; Afterbody blood sampling at once behind the rest 30min, about 0.5ml that takes a blood sample (not adding anti-coagulants).Put 4 ℃ of about 3h of refrigerator, the centrifugal 15min of 2500r/min after the blood clotting gets serum and measures the serum urea nitrogen value.2. determination of urea nitrogen method: press document [Wei Xudong.The comparison of 3 kinds of serum urea nitrogen determination methods [J].Chongqing medical science.1997，26(4)：246。] method mensuration.The mensuration of hepatic glycogen: the 1. extraction of hepatic glycogen: after last receives reagent 30min to mouse, take off neck at once and put to death, get liver, inhale the blood of attachment removal rapidly with filter paper.Take by weighing about 1g, put in the mortar, add and clean fine sand a little and 10% trichloroacetic acid 1ml and grind.Add 5% trichloroacetic acid 2ml again and continue to grind, fully worn into the meat gruel shape to liver organization till.Then with the centrifugal 10min of 2500r/min.Supernatant is changed over to another centrifuge tube and measures volume, add 95% ethanol, after the mixing, leave standstill 10min with volume.This moment, glycogen became flocculent deposit to separate out.Precipitation solution is with the centrifugal 10min of 2500r/min.Abandoning supernatant, and centrifuge tube is inverted in 2min on the filter paper.Add distilled water 1ml in the deposition and be precipitated to dissolving with the glass bar stirring.The mensuration of hepatic glycogen: press literature method anthrone-concentrated sulfuric acid method and measure hepatic glycogen content, every group is repeated 3 times, averages.
Result of the test: see table 2 and table 3.
Table 2 serum urea nitrogen content
Annotate: compare with control group
*P＜0.05,
*P＜0.01; Compare △ P＜0.05 for 1 group with test.
Table 3 hepatic glycogen content
Annotate: compare with control group
*P＜0.05,
*P＜0.01.
Conclusion (of pressure testing): above-mentioned result of the test shows behind D-ribose and amino acid or vitamin compatibility, antifatigue effect to be had good effect, and after D-ribose and amino acid, vitamin make up simultaneously, has better pharmacological effect.
Two, preparation embodiment
Embodiment 1
Healthy food material is: D-ribose 1g, amino acid/11 g (isoleucine 0.3g, proline 0.7g), vitamin C 3g.
Add pharmaceutic adjuvant and be prepared into tablet, capsule, granule, pill or oral liquid.
In adding Sucralose, white granulated sugar, glucose, FOS, maltose, oligoisomaltose, rose candy, Sweet-scented Osmanthus, citric acid, blueberry, prune, acid Chinese quince, dark plum, orange, matrimony vine, Fructus Hordei Germinatus, cherry, the lemon mint one or more are prepared into beverage.
Embodiment 2
Healthy food material is: D-ribose 10g, amino acid 2g (serine), vitamin E 0.05g.
Add pharmaceutic adjuvant and be prepared into tablet, capsule, granule, pill or oral liquid.
In adding Sucralose, white granulated sugar, glucose, FOS, maltose, oligoisomaltose, rose candy, Sweet-scented Osmanthus, citric acid, blueberry, prune, acid Chinese quince, dark plum, orange, matrimony vine, Fructus Hordei Germinatus, cherry, the lemon mint one or more are prepared into beverage.
Embodiment 3
Healthy food material is: D-ribose 5g, amino acid/11 5g (each 1g of aspartic acid, glutamic acid, cysteine, serine, glycine, threonine, alanine, valine, leucine, isoleucine, proline, phenylalanine, tyrosine, histidine and lysine).
Add pharmaceutic adjuvant and be prepared into tablet, capsule, granule, pill or oral liquid.
In adding Sucralose, white granulated sugar, glucose, FOS, maltose, oligoisomaltose, rose candy, Sweet-scented Osmanthus, citric acid, blueberry, prune, acid Chinese quince, dark plum, orange, matrimony vine, Fructus Hordei Germinatus, cherry, the lemon mint one or more are prepared into beverage.
Embodiment 4
Healthy food material is: D-ribose 5g, vitamin 1g (vitamin A 0.1g, vitaminB10 .1g, vitamin B2 0.05g, vitamin B6 0.05g, vitamin C 0.1g, vitamin E 0.1g, folic acid 0.1g, cobalamin 0.1g, vitamin D 0.1g, vitamin K 0.1g, biotin 0.1g).
Add pharmaceutic adjuvant and be prepared into tablet, capsule, granule, pill or oral liquid.
In adding Sucralose, white granulated sugar, glucose, FOS, maltose, oligoisomaltose, rose candy, Sweet-scented Osmanthus, citric acid, blueberry, prune, acid Chinese quince, dark plum, orange, matrimony vine, Fructus Hordei Germinatus, cherry, the lemon mint one or more are prepared into beverage.
Embodiment 5
Healthy food material is: D-ribose 5g; Amino acid/11 5g (each 1g of aspartic acid, glutamic acid, cysteine, serine, glycine, threonine, alanine, valine, leucine, isoleucine, proline, phenylalanine, tyrosine, histidine and lysine), vitamin 1g (vitamin A 0.1g, vitaminB10 .1g, vitamin B2 0.05g, vitamin B6 0.05g, vitamin C 0.1g, vitamin E 0.1g, folic acid 0.1g, cobalamin 0.1g, vitamin D 0.1g, vitamin K 0.1g, biotin 0.1g).
Add pharmaceutic adjuvant and be prepared into tablet, capsule, granule, pill or oral liquid.
In adding Sucralose, white granulated sugar, glucose, FOS, maltose, oligoisomaltose, rose candy, Sweet-scented Osmanthus, citric acid, blueberry, prune, acid Chinese quince, dark plum, orange, matrimony vine, Fructus Hordei Germinatus, cherry, the lemon mint one or more are prepared into beverage.
Embodiment 6
Healthy food material is: D-ribose 35mg, alanine 20mg, vitamin A 5mg.
Add pharmaceutic adjuvant and be prepared into tablet, capsule, granule, pill or oral liquid.
In adding Sucralose, white granulated sugar, glucose, FOS, maltose, oligoisomaltose, rose candy, Sweet-scented Osmanthus, citric acid, blueberry, prune, acid Chinese quince, dark plum, orange, matrimony vine, Fructus Hordei Germinatus, cherry, the lemon mint one or more are prepared into beverage.
Claims (10)
1. the health food with antifatigue effect is characterized in that healthy food material is D-ribose, amino acid and/or vitamin.
2. a kind of health food with antifatigue effect according to claim 1, wherein healthy food material is a D-ribose 1-10 weight portion, amino acid/11-20 weight portion, vitamin 0.05-3 weight portion.
3. a kind of health food with antifatigue effect according to claim 1, wherein healthy food material is a D-ribose 1-10 weight portion, amino acid/11-20 weight portion.
4. a kind of health food with antifatigue effect according to claim 1, wherein healthy food material is a D-ribose 1-10 weight portion, vitamin 0.05-3 weight portion.
5. according to each described a kind of health food of claim 1-3 with antifatigue effect, wherein amino acid be in aspartic acid, glutamic acid, cysteine, serine, glycine, threonine, alanine, valine, leucine, isoleucine, proline, phenylalanine, tyrosine, histidine and the lysine one or more; Add arginine, citrulling or taurine again.
6. according to claim 1,2 or 4 described a kind of health foods with antifatigue effect; Wherein vitamin is one or more in vitamin A, vitamin B1, vitamin B2, vitamin B6, vitamin C, vitamin E, folic acid, cobalamin, vitamin D, vitamin K, biotin, citrin, nicotinic acid, vitamin(e) M, vitamin(e) T, vitamin, biotin, water soluble vitamin, niacinamide, the pantothenic acid, and perhaps vitamin is to contain mentioned component extract or concentrate.
7. according to each described a kind of health food with antifatigue effect of claim 1-4, wherein health food also comprises auxiliary material.
8. the health food of a kind of concrete antifatigue effect according to claim 7, wherein auxiliary material comprises one or more in Sucralose, white granulated sugar, glucose, FOS, maltose, oligoisomaltose, rose candy, Sweet-scented Osmanthus, citric acid, blueberry, prune, acid Chinese quince, dark plum, orange, matrimony vine, Fructus Hordei Germinatus, cherry, the lemon mint.
9. according to each described a kind of health food with antifatigue effect of claim 1-4, wherein feedstock production becomes oral formulations, and oral formulations comprises tablet, capsule, pill, granule or oral liquid.
10. according to claim 1-4,7 each described a kind of health foods with antifatigue effect, wherein feedstock production becomes beverage.
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Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102813265A (en) * | 2012-08-08 | 2012-12-12 | 刘东升 | Functional beverage with ribose and L-carnitine and preparation method thereof |
| CN103211259A (en) * | 2013-04-22 | 2013-07-24 | 河南省淼雨饮品股份有限公司 | Anti-fatigue vitamin health care beverage and preparation method thereof |
| CN104026563A (en) * | 2013-03-07 | 2014-09-10 | 山东明仁福瑞达制药股份有限公司 | Composition having muscle power fatigue alleviating and anoxic tolerance improving effects, and preparation method thereof |
| CN104041803A (en) * | 2013-03-14 | 2014-09-17 | 叶宁 | Anti-senility plant stem cell lozenge and preparation method thereof |
| CN104509902A (en) * | 2013-09-29 | 2015-04-15 | 桂林中族中药股份有限公司 | Function beverage |
| CN105611926A (en) * | 2013-10-09 | 2016-05-25 | 味之素株式会社 | Anti-fatigue composition |
| CN109170888A (en) * | 2018-09-18 | 2019-01-11 | 广东时代食品与生命健康研究有限公司 | A kind of anti-oxidant, anti-Fatigue Composition and preparation method thereof |
| CN109567211A (en) * | 2018-12-21 | 2019-04-05 | 江西正和大健康产业有限公司 | A kind of functional food composite and food prepared therefrom containing D-ribose |
| CN114158669A (en) * | 2021-12-10 | 2022-03-11 | 河北氨健喜生物科技有限公司 | Solid beverage formula for improving exercise endurance and preparation method thereof |
| CN114868924A (en) * | 2022-05-13 | 2022-08-09 | 武汉工程大学 | Composition based on D-ribose and amino acid and application thereof |
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Cited By (17)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102813265A (en) * | 2012-08-08 | 2012-12-12 | 刘东升 | Functional beverage with ribose and L-carnitine and preparation method thereof |
| CN104026563A (en) * | 2013-03-07 | 2014-09-10 | 山东明仁福瑞达制药股份有限公司 | Composition having muscle power fatigue alleviating and anoxic tolerance improving effects, and preparation method thereof |
| CN104041803A (en) * | 2013-03-14 | 2014-09-17 | 叶宁 | Anti-senility plant stem cell lozenge and preparation method thereof |
| CN104041803B (en) * | 2013-03-14 | 2015-12-02 | 叶宁 | A kind of anti-ageing plant stem cell lozenge and preparation method thereof |
| CN103211259A (en) * | 2013-04-22 | 2013-07-24 | 河南省淼雨饮品股份有限公司 | Anti-fatigue vitamin health care beverage and preparation method thereof |
| CN103211259B (en) * | 2013-04-22 | 2014-11-26 | 河南省淼雨饮品股份有限公司 | Anti-fatigue vitamin health care beverage and preparation method thereof |
| CN104509902A (en) * | 2013-09-29 | 2015-04-15 | 桂林中族中药股份有限公司 | Function beverage |
| EP3078375A1 (en) * | 2013-10-09 | 2016-10-12 | Ajinomoto Co., Inc. | Anti-fatigue composition |
| CN105611926A (en) * | 2013-10-09 | 2016-05-25 | 味之素株式会社 | Anti-fatigue composition |
| EP3078375A4 (en) * | 2013-10-09 | 2017-04-05 | Ajinomoto Co., Inc. | Anti-fatigue composition |
| US10369163B2 (en) | 2013-10-09 | 2019-08-06 | Ajinomoto Co., Inc. | Anti-fatigue composition |
| CN111743999A (en) * | 2013-10-09 | 2020-10-09 | 味之素株式会社 | Anti-fatigue composition |
| EP3078375B1 (en) | 2013-10-09 | 2021-05-12 | Ajinomoto Co., Inc. | Anti-fatigue composition |
| CN109170888A (en) * | 2018-09-18 | 2019-01-11 | 广东时代食品与生命健康研究有限公司 | A kind of anti-oxidant, anti-Fatigue Composition and preparation method thereof |
| CN109567211A (en) * | 2018-12-21 | 2019-04-05 | 江西正和大健康产业有限公司 | A kind of functional food composite and food prepared therefrom containing D-ribose |
| CN114158669A (en) * | 2021-12-10 | 2022-03-11 | 河北氨健喜生物科技有限公司 | Solid beverage formula for improving exercise endurance and preparation method thereof |
| CN114868924A (en) * | 2022-05-13 | 2022-08-09 | 武汉工程大学 | Composition based on D-ribose and amino acid and application thereof |
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Application publication date: 20120118 |