CN105456288B

CN105456288B - Health-care medicinal preparation for supplementing magnesium and resisting oxidation and preparation method thereof

Info

Publication number: CN105456288B
Application number: CN201510943741.8A
Authority: CN
Inventors: 袁广银; 裴佳; 丁文江
Original assignee: Shanghai Jiaotong University
Current assignee: Shanghai Jiaotong University
Priority date: 2015-12-15
Filing date: 2015-12-15
Publication date: 2020-07-14
Anticipated expiration: 2035-12-15
Also published as: WO2017101887A1; CN105456288A

Abstract

The invention discloses a health-care medicinal preparation with magnesium supplement and antioxidation functions and a preparation method thereof₂The micro-nano powder is prepared from the auxiliary materials which are common pharmaceutical preparation auxiliary materials. Compared with the existing magnesium-supplementing preparation, the preparation of the invention has the advantages of one-time administration, simultaneous supplement of trace element magnesium and hydrogen element with antioxidation for neutralizing oxygen free radical, convenient storage and administration, high conversion efficiency, good absorption effect, low cost and no toxic or side effect. The preparation can effectively prevent various adverse symptoms caused by magnesium deficiency, and has effects of inducing hydrogen antioxidation, relieving inflammation, strengthening body constitution, delaying aging, and preventing diseases.

Description

Health-care medicinal preparation for supplementing magnesium and resisting oxidation and preparation method thereof

Technical Field

The invention relates to the field of pharmaceutical preparations, in particular to a health-care pharmaceutical preparation with magnesium supplement and antioxidation.

Background

With the improvement of living standard, aging of population and change of life style, health care is increasingly paid attention to people. Some trace elements play a very important role in human health, such as magnesium element, which participates in the synthesis of all energy metabolism proteins in vivo, activates and catalyzes various enzyme systems, regulates the nervous system, ensures the normal contraction of cardiac muscle, enhances the immune function of the organism, protects the bone health and the like. The magnesium deficiency of human body may cause cardiovascular and cerebrovascular diseases, hypertension, diabetes, osteoporosis, migraine, anxiety, depression and other symptoms, and seriously endanger human health. Therefore, the proper amount of magnesium supplement has important significance on human health. According to the Chinese society for nutrition, about 350 mg of magnesium is required for adult men, about 300 mg for adult women, and about 450 mg for pregnant and lactating women. However, in many cases, it is difficult to sufficiently compensate for the deficiency only by diet, and a magnesium nutritional supplement is required. The magnesium health care nutriment which is most common in the market at present is magnesium salt such as magnesium oxide, magnesium gluconate, magnesium citrate, magnesium salicylate, magnesium hydroxide, magnesium chloride, magnesium sulfate and the like. There are major problems including the general lack of magnesium content; the conversion and absorption efficiency is not low (50-70%); can cause gastrointestinal discomfort and diarrhea, and can also cause side effects of chest tension, bloody stool, mouth, face and tongue swelling, abdominal cramp and the like in severe cases. However, the magnesium salt injection may cause problems of pain at the injection site, vertigo, muscle paralysis, etc. Therefore, there is a need to develop a new magnesium source-supplementing preparation which is safe, has no toxic and side effects, and has higher magnesium content and absorption and conversion efficiency.

Studies have shown that human health is also closely related to oxygen free radicals in the body. The surplus of oxygen radicals may cause cell damage or aging necrosis, eventually leading to diseases and aging of the body. Hydrogen is a colorless, tasteless, odorless and nontoxic gas, and a large number of researches show that the hydrogen has selective oxidation resistance, selectively neutralizes hydroxyl radicals and nitrite anions, and the hydroxyl radicals and the nitrite anions are the most important media of oxidative damage, so that an endogenous specific clearance path is not found in vivo at present. The hydrogen ions can be reduced into water after being combined with active oxygen and discharged out of the body, and the medicament is safe and has no toxic or side effect. And hydrogen has strong penetrability and is easy to enter any part of cells such as cell nucleus, mitochondria and the like. These establish the important features of hydrogen available for the treatment of disease. Hydrogen has protective effect on various nervous system injuries, has wide effect on cardiovascular and digestive system injury and diseases, and has therapeutic effect on human diseases such as diabetes, tumor radiotherapy, systemic lupus erythematosus skin injury, rheumatoid arthritis, etc. Therefore, the proper amount of supplemented hydrogen has certain benefits for human bodies. In recent years, hydrogen ion-rich plain water (hydrogenic water) has begun to receive wide attention in the international market. However, hydrogen rich water is limited by the low solubility of hydrogen gas, and generally contains hydrogen only about 0.1 to 1ppm, and up to about 5 ppm. The low hydrogen concentration and poor stability are the biggest problems restricting the effect of the hydrogen supplement health care product at present.

In addition, a preparation or a health care nutrition product capable of simultaneously supplementing magnesium and hydrogen is not seen in China, only Dr. water element water hydrogen-rich water rods introduced in Japan have metal magnesium as an effective component, but the problems exist that 1) magnesium hydroxide is generated when meeting water and is insoluble in water, so that the magnesium cannot be effectively utilized, and the content of magnesium entering a human body is too low; 2) the hydrogen generated immediately after meeting water is easy to escape, is unstable, needs to be taken immediately, is inconvenient to store and place, and has limited concentration of hydrogen dissolved in water; 3) the metal magnesium particles are easily oxidized into insoluble matters to prevent further reaction with water, so that the effect is obviously reduced along with the increase of the use times. The above problems are also encountered in the method and apparatus for producing hydrogen-rich water of patent CN1840497A, and in the method and apparatus for producing hydrogen-rich water of patent CN201785234U, since the active ingredients are magnesium metal. However, the patent CN102557227B "a calcium-magnesium hydrogen-rich water additive and its preparation method" is similar to the principle of the above hydrogen-rich water rod, and the hydrogen production agent is magnesium simple substance or calcium-magnesium alloy, but a pH regulator is additionally added to improve the dissolution of magnesium, but the above problem 2) still remains unsolved.

Disclosure of Invention

Aiming at the defects in the prior art, the invention aims to provide a health-care medicinal preparation with magnesium supplement and antioxidation, which is characterized in that magnesium hydride MgH is used₂The micro-nano powder particles are main active ingredients (magnesium and hydrogen sources) of the preparation, and after the micro-nano powder particles are taken into a human body, the micro-nano powder particles directly convert into magnesium ions in the body through the reaction with water in the body and simultaneously generate hydrogen, thereby providing a new way for the human body to absorb magnesium elements and absorb hydrogen. The preparation can be taken for a long time, can effectively prevent symptoms caused by magnesium deficiency, and is beneficial to delaying aging and preventing diseases.

The purpose of the invention is realized by the following technical scheme:

the invention provides a health-care medicinal preparation with magnesium supplement and antioxidation functions, which comprises a main effective component magnesium agent and auxiliary materials, wherein the magnesium agent is MgH₂The micro-nano powder is prepared from the auxiliary materials which are common pharmaceutical preparation auxiliary materials.

Preferably, the MgH₂The size of the micro-nano powder is 100nm-100 mu m.

MgH₂The magnesium powder exists in the form of micro-nano powder, the oxidation activity of the single magnesium powder of 100nm-100 mu m is very high, and oxidation exothermic reaction is easy to occur in the air, even dangerous accidents such as explosion are caused. And MgH is formed by combining Mg powder and hydrogen₂The micro-nano powder of the compound becomes very stable and safe. Simultaneously MgH₂And is a stable and reliable source of hydrogen. Once MgH₂After the micro-nano powder enters the human body through the gastrointestinal tract, MgH is subjected to the following chemical reaction₂+2H₂O→Mg²⁺+2OH^-+2H₂I.e. react to form Mg absorbable by the human body²⁺And hydrogen, thereby producing a health-care effect beneficial to the human body.

The size range of 100nm-100 mu m is selected, the preparation process in the size range is most economical, and the size range is convenient to be absorbed by human bodies. Particles below 100nm, the preparation cost increases dramatically; the size of more than 100 mu m is not beneficial to the absorption of human body.

Preferably, the weight content of the magnesium element in the medicine preparation is 40-400 mg/dose.

Preferably, the hydrogen content produced by the pharmaceutical preparation when taken is 72-720m L per dose.

Preferably, the pharmaceutical formulation is in the form of a tablet, pill or capsule.

The invention also provides a preparation method of the health care medicine preparation for simultaneously supplementing magnesium and hydrogen, and the preparation method comprises the following steps: adding a certain amount of MgH₂The micro-nano powder is evenly mixed with a proper amount of common pharmaceutical excipients, and is prepared after weighing, material distribution, compaction, sterilization treatment and packaging processing.

Compared with the prior art, the invention has the following beneficial effects:

1. the magnesium and hydrogen supplement preparation can simultaneously supplement trace element magnesium and hydrogen for neutralizing oxygen free radical which are necessary for human bodies after being taken once.

2. The prior art reaction equation is as follows:

Mg+2H₂O→Mg(OH)₂+ H₂

the reaction equation of the present invention is improved as follows:

MgH₂+2H₂O→Mg²⁺+2OH^-+2H₂

MgH as shown in the reaction formula₂The hydrogen production efficiency is 2 times higher than that of magnesium metal. And supplement magnesium source MgH₂Is directly converted into soluble magnesium salt in vivo after being taken, and is not insoluble magnesium hydroxide in the prior art. Thus, the conversion and absorption efficiency can be improved to a large extent.

3. Different from the limit of low hydrogen solubility of hydrogen-rich water/aqueous vegetable water, the preparation replenishes hydrogen generated after entering human bodies, so that the concentration of the replenished hydrogen is greatly improved, and the antioxidant health care and treatment effects of the hydrogen can be better exerted.

4. The preparation reaction metabolite has no toxic or side effect or adverse reaction, is safe and reliable, is convenient to store and take, and can greatly improve the use convenience and the user experience.

5. The preparation contains magnesium hydride MgH as main effective component₂The production cost of the micro-nano powder is low, and the micro-nano powder is convenient for large-scale production.

Detailed Description

The present invention will be described in detail with reference to specific examples. The following examples will assist those skilled in the art in further understanding the invention, but are not intended to limit the invention in any way. It should be noted that variations and modifications can be made by persons skilled in the art without departing from the spirit of the invention. All falling within the scope of the present invention.

Example 1

Preparing the magnesium hydride into micro powder with the dimension of 100-200 nm, taking 250g of the powder, adding 500g of pregelatinized starch and 250g of microcrystalline cellulose, uniformly mixing, and pressing into 1000 tablets to obtain the tablet. Each tablet has a weight of 1g, and can be swallowed by adult in 2 tablets per day and children in 1-2 times per day, once per day. After the medicine is continuously taken for 1-2 weeks, the leg muscle soreness caused by mountain climbing or long-distance running can be effectively relieved and eliminated due to effective supplement of magnesium.

Example 2

Preparing the magnesium hydride into 600-mesh micropowder of 400 meshes, taking 150g of the micropowder, adding 150g of mannitol, 120g of superfine silica gel powder and 80g of alginic acid, grinding, sieving, mixing uniformly and then filling into capsules to obtain 1000 granules. Each capsule is 0.5g, and is swallowed by adult 2-3 capsules per day in 1-3 times, and children 1-2 capsules per day in 1-2 times. Animal experiments prove that the white mice with pneumonia continuously take the medicinal powder in the capsules for 2 weeks, 1 granule of the medicinal powder is mixed into mouse food every day for taking, the inflammation of the pneumonia of the white mice enters body fluid due to hydrogen to play an effective anti-inflammatory role, the pneumonia symptoms are effectively treated and relieved after 2 weeks, and the pneumonia is completely cured after 3 weeks of taking.

Example 3

Preparing magnesium hydride into 500 nm-1 micron micropowder, collecting powder 200g, adding lactose 150g, dextrin 100g, and CMC 50g, mixing, and making into pill to obtain 1000 granules. Each granule has a weight of 0.5g, and is administered 1-2 times daily for adults and 1-2 times daily for children. Animal experiments prove that the guinea pig suffering from hepatitis continuously takes the pills for 1 month, 1 pill of medicinal powder is mixed into mouse food for administration every day, the inflammation of the hepatitis of the guinea pig enters body fluid due to hydrogen to play an effective anti-inflammatory and anti-oxidation role, the hepatitis symptom is effectively treated and relieved in ten days, and the hepatitis is completely cured after 4 weeks of administration.

Example 4

Preparing magnesium hydride into 1-10 micron micropowder, collecting powder 350g, adding mannitol 300g and microcrystalline cellulose 150g, mixing, making into tablet, and coating sugar coat on the surface to obtain 1000 tablets. Each tablet weighs 0.8g, and is swallowed by 1 tablet per day for adults. After being continuously taken for 2 weeks, the insomnia phenomenon caused by the nerve dysfunction can be effectively relieved and disappeared due to the effective supplement of magnesium.

Example 5

Preparing magnesium hydride into 1000-fold 1500-mesh micro powder, taking 40g of powder as a trace element additive, adding 100 commercially available folic acid tablets, grinding, uniformly mixing, and pressing into tablets again to obtain 100 tablets. The pregnant woman can take 1 tablet daily. Can help pregnant women supplement folic acid and essential element magnesium. After being continuously taken for 1-2 months, gastrointestinal dysfunction symptoms such as abdominal fullness, borborborygmus, sigh, anorexia, vomit, diarrhea or constipation caused by nerve dysfunction of some middle-aged and elderly people can be effectively relieved and eliminated due to the regular supplement of magnesium ions and the antioxidation of hydrogen.

Example 6

Preparing magnesium hydride into 1000-plus 1500-mesh micro powder, taking 30g of powder as a trace element additive, adding 100 commercially available calcium supplement tablets, grinding, uniformly mixing, and pressing into tablets again to obtain 100 tablets. The tablet is taken by adult 1 tablet per day. Meanwhile, magnesium supplement can help osteoporosis patients to enhance the absorption and utilization of calcium. After the medicine is continuously taken for 1-3 months, the symptoms of lassitude, hypodynamia, cramp, soreness of waist and back pain, easy allergy, easy cold and the like of adult men caused by calcium deficiency and magnesium deficiency can be effectively relieved and cured due to the effective supplement of magnesium and calcium and the anti-inflammatory and anti-oxidation effects of hydrogen.

The specific embodiments of the present invention have been described above in detail. It should be understood that numerous modifications and variations could be devised by those skilled in the art in light of the present teachings without departing from the inventive concepts. Therefore, the technical solutions available to those skilled in the art through logic analysis, reasoning and limited experiments based on the prior art according to the concept of the present invention should be within the scope of protection defined by the claims.

Claims

1. The application of a medicinal preparation in preparing a health-care medicinal preparation with the functions of supplementing magnesium and resisting oxidation is characterized in that the medicinal preparation comprises a main effective component magnesium agent and auxiliary materials, wherein the magnesium agent is MgH₂Micro-nano powder, wherein the auxiliary material is a common pharmaceutical preparation auxiliary material; the MgH₂The size of the micro-nano powder is 100nm-600 meshes; the weight content of the magnesium element in the medicine preparation is 40-400 mg/dose; the MgH₂After the micro-nano powder enters a human body through the gastrointestinal tract, MgH is chemically reacted₂+2H₂O→Mg²⁺+2OH^-+2H₂I.e. react to form Mg absorbable by the human body²⁺And hydrogen, wherein the content of hydrogen generated by the medicine preparation when the medicine preparation is taken is 72-720m L per dose.

2. Use of a pharmaceutical preparation according to claim 1 for the preparation of a health care pharmaceutical preparation for magnesium supplementation with an antioxidant effect, wherein the pharmaceutical preparation is in the form of a tablet, a pill or a capsule.

3. The use of the pharmaceutical preparation according to claim 1 for the preparation of a health-care pharmaceutical preparation for magnesium supplementation and antioxidation, wherein the preparation method comprises the following steps: MgH is added₂Mixing the micro-nano powder with common medicinal adjuvants, weighing, separating, compacting, sterilizing, and packaging.