WO2017101887A1 - Healthcare pharmaceutical preparation having magnesium supplementation and anti-oxidation effects, and preparation method for healthcare pharmaceutical preparation - Google Patents

Abstract

A healthcare pharmaceutical preparation having magnesium supplementation and anti-oxidation effects, and a preparation method for the healthcare pharmaceutical preparation. The healthcare pharmaceutical preparation comprises a main effective component, which is a magnesium agent, and an excipient, the magnesium agent being an MgH₂ micro/nanopowder, the excipient being a commonly used pharmaceutical preparation excipient.

Description

Health medicine preparation with magnesium supplementation and antioxidation effect and preparation method thereof Technical field

The invention relates to the field of pharmaceutical preparations, in particular to a health care medicine preparation which supplements magnesium and has anti-oxidation effect.

Background technique

With the improvement of people's living standards and the aging of the population and the changes in lifestyle, health care has received increasing attention. Some trace elements play a very important role in human health, such as magnesium, which participates in the synthesis of all energy metabolism proteins in the body, activates and catalyzes various enzyme systems, regulates the nervous system, ensures normal contraction of the myocardium, enhances immune function, and protects bones. Health and other effects. Magnesium deficiency in the human body may cause symptoms such as cardiovascular and cerebrovascular diseases, hypertension, diabetes, osteoporosis, migraine, anxiety and depression, which seriously endanger human health. Therefore, proper supplementation of magnesium is of great significance to human health. According to the recommendations of the Chinese Nutrition Society, adult males need about 350 mg of magnesium per day, about 300 mg for adult women, and about 450 mg for pregnant and lactating women. However, in most cases, it is difficult to fully compensate for the deficiency by diet alone, and magnesium nutritional supplements are also needed. At present, the most common magnesium health nutrition products on the market are magnesium salts such as magnesium oxide, magnesium gluconate, magnesium citrate, magnesium salicylate, magnesium hydroxide, magnesium chloride and magnesium sulfate. There are major problems including the general low magnesium content; low conversion efficiency (50-70%); can cause stomach upset, diarrhea, severe chest tension, bloody stools, mouth, face and tongue swelling, abdominal cramps, etc. side effect. The use of magnesium salt injection may cause problems such as pain, dizziness and muscle paralysis at the injection site. Therefore, it is necessary to develop a new magnesium source preparation which has safe non-toxic side effects, high magnesium content and high absorption conversion efficiency.

Studies have shown that human health is also closely related to oxygen free radicals in the body. Excessive oxygen free radicals can cause cell damage or aging and necrosis, which can eventually lead to disease and aging in the body. Hydrogen is a colorless, odorless, odorless and non-toxic gas. A large number of studies have shown that it has selective oxidation resistance, can selectively neutralize hydroxyl radicals and nitrite anions, and the latter two are the most important media for oxidative damage. At present, no endogenous specific clearance pathway has been found in the body. Hydrogen ions combined with active oxygen can be reduced to water and excreted from the body, safe and non-toxic side effects. And hydrogen has a strong penetrability, easy to enter any part of the cell such as the nucleus and mitochondria. These lay the important features that hydrogen can be used to treat diseases. Hydrogen has protection against various types of nervous system damage, has extensive effects on organ damage and diseases such as cardiovascular and digestive system, and has some human diseases such as diabetes and tumor radiation. Treatment, systemic red pull lupus skin damage, rheumatoid arthritis and other therapeutic effects. Therefore, the right amount of hydrogen supplementation has certain benefits for the human body. In recent years, hydrogen ion-rich Hydrogen Water has received widespread attention in the international market. However, hydrogen-rich water is limited by the low solubility of hydrogen. The hydrogen content is generally only about 0.1-1 ppm, and the highest is only about 5 ppm. The low hydrogen concentration and poor stability are the biggest problems that restrict the effect of hydrogen supplement products.

Moreover, there are no preparations or health-care products that can supplement magnesium and hydrogen at the same time. Only the Dr. water-rich water-rich water bar introduced in Japan has the active ingredient of magnesium metal, but the problem is that 1) hydrogen is produced by water. Magnesium oxide, hardly soluble in water, can not be effectively used, the magnesium content into the human body is too low; 2) Hydrogen is easily escaped when it is in contact with water, unstable, must be taken immediately, inconvenient to store, and the concentration of hydrogen dissolved in water is limited. 3) The metal magnesium particles are easily oxidized to poorly soluble substances, preventing further reaction with water, so the effect is significantly reduced as the number of uses increases. Patent CN1840497A "Hydrogen-rich water production method and hydrogen-rich water generator" and the patent CN201785234U "hydrogen water generator" have the same active ingredients as above, all of which are metallic magnesium, and therefore all of the above problems exist. The patent CN102557227B "a calcium magnesium hydrogen-rich water additive and a preparation method thereof" is similar to the above-mentioned hydrogen-rich water rod principle, and the hydrogen-generating agent is a magnesium elemental substance or a calcium-magnesium alloy, except that an additional pH adjusting agent is added to improve the dissolution of magnesium. However, the above question 2) remains unresolved.

Summary of the invention

In view of the defects in the prior art, the object of the present invention is to provide a health care pharmaceutical preparation which has both magnesium supplementation and antioxidant activity, and is characterized in that magnesium hydride MgH ₂ micro-nano powder particles are used as main active ingredients (magnesium and hydrogen). Source), after taking into the human body, through the reaction with the body water, directly converted into magnesium ions in the body and simultaneously produce hydrogen, providing a new way for the human body to absorb magnesium and hydrogen uptake. Long-term use of this preparation can effectively prevent symptoms caused by magnesium deficiency in the body, and is also beneficial for delaying aging and preventing diseases.

The object of the invention is achieved by the following technical solutions:

The invention provides a health care medicine preparation which has both magnesium supplementation and anti-oxidation effect, and the medicine preparation comprises a main active ingredient magnesium agent and an auxiliary material, the magnesium agent is MgH ₂ micro-nano powder, and the auxiliary material is a common pharmaceutical preparation auxiliary material. .

Preferably, the MgH ₂ micro-nano powder has a size of from 100 nm to 100 μm.

MgH ₂ exists in the form of micro-nano powder. The magnesium powder of 100 nm-100 μm alone has very high oxidation activity, and it is easy to cause oxidative exothermic reaction in air and even cause dangerous accidents such as explosion. On the other hand, by combining the Mg portion and the hydrogen to form a micro-nano powder of the MgH ₂ compound, it becomes very stable and safe. At the same time, MgH ₂ is also a stable and reliable source of hydrogen. Once the MgH ₂ micro-nano powder enters the human body through the gastrointestinal tract, it passes through the following chemical reaction MgH ₂ +H ₂ O→Mg ²⁺ +2OH ^- +2H ₂ , which reacts to form human-absorbable Mg ²⁺ and hydrogen. Produces a health benefit that is beneficial to the human body.

A range of sizes from 100 nm to 100 μm is selected, which is the most economical process and is also easily absorbed by the body. The preparation cost is sharply increased with particles below 100 nm; the size exceeding 100 μm is also unfavorable for human body absorption.

Preferably, the pharmaceutical preparation has a magnesium content of 40-400 mg/dose.

Preferably, the pharmaceutical preparation produces a hydrogen content of from 72 to 720 mL per dose when administered.

Preferably, the pharmaceutical preparation is in the form of a tablet, a pill or a capsule.

The invention also provides a preparation method of a health care medicine preparation which simultaneously supplements magnesium and hydrogen, wherein the preparation method comprises: uniformly mixing a certain amount of MgH ₂ micro-nano powder with an appropriate amount of common medicinal auxiliary materials, and weighing the material by weighing , compacted, sterilized and packaged after processing.

Compared with the prior art, the present invention has the following beneficial effects:

1. This supplement of magnesium and hydrogen preparations can simultaneously supplement the essential trace element magnesium and hydrogen which neutralizes oxygen free radicals.

2. The reaction equation of the prior art is as follows:

Mg+2H ₂ O→Mg(OH) ₂ +H ₂

The reaction equation of the present invention is improved as follows:

MgH ₂ +H ₂ O→Mg ²⁺ +2OH ^- +2H ₂

As shown in the reaction formula, MgH _{2 has a} hydrogen production efficiency higher than that of metallic magnesium, which is twice as high. Moreover, the magnesium source MgH ₂ is directly converted into a soluble magnesium salt in the body after administration, instead of the magnesium hydroxide which is insoluble in the prior art. Therefore, the conversion absorption efficiency can be greatly improved.

3. Unlike hydrogen-rich water/water-based water, which is limited by the low solubility of hydrogen, the hydrogen supplemented by the preparation is produced after entering the human body, so the supplemental hydrogen concentration is greatly improved, and the hydrogen oxidation resistance can be better exerted. Health care utility.

4. The preparation reaction metabolite has no toxic side effects or adverse reactions, and is safe and reliable; at the same time, the preparation is convenient for storage and administration, and can greatly improve the convenience of use and the user's feeling.

5. The main active ingredient of the preparation, magnesium hydride MgH ₂ micro-nano powder, has low production cost and is convenient for large-scale production.

detailed description

The invention will now be described in detail in connection with specific embodiments. The following examples are intended to further understand the invention, but are not intended to limit the invention in any way. It should be noted that a number of variations and modifications may be made by those skilled in the art without departing from the inventive concept. These are all within the scope of protection of the present invention.

Example 1

The magnesium hydride is prepared into a fine powder having a scale of 100-200 nm, 250 g of the powder is taken, 500 g of pregelatinized starch, 250 g of microcrystalline cellulose are added, and uniformly mixed, and then pressed into 1000 tablets, which is obtained. Each piece weighs 1g, 2 tablets per day for adults, swallows 1-2 times a day, and children take 1 tablet once a day. After taking 1-2 weeks in a row, the muscle pain in the leg muscles caused by mountaineering or long-distance running will be effectively alleviated and disappeared due to the effective supplementation of magnesium.

Example 2

The magnesium hydride was prepared into a fine powder of 400-600 mesh, 150 g of the powder was taken, 150 g of mannitol, 120 g of micro-silica gel, and 80 g of alginic acid were added, and the mixture was finely sieved, uniformly mixed, and then placed in a capsule to obtain 1,000 tablets. Each capsule weighs 0.5g, 2-3 capsules per day for adults, and is swallowed 1-3 times a day. Children take 1-2 capsules a day, taking 1-2 times. It was confirmed by animal experiments that the mice with pneumonia continuously took the above-mentioned capsule powder for 2 weeks, and one powder was mixed into the rat diet every day. The pneumonia inflammation of the mice played an effective anti-inflammatory effect due to hydrogen entering the body fluid, and the pneumonia symptoms. It was effectively treated and alleviated at 2 weeks, and pneumonia completely healed after 3 weeks.

Example 3

The magnesium hydride was prepared into a fine powder of 500 nm to 1 μm, 200 g of the powder was taken, 150 g of lactose, 100 g of dextrin, and 50 g of CMC were added, and the mixture was uniformly mixed and processed into pellets, and a total of 1000 particles were obtained. Each weight is 0.5g, 1-2 adults per day, 1-2 children per day, swallowed 1-2 times. It has been confirmed by animal experiments that guinea pigs with hepatitis continuously take the above pills for one month, and one pill dose of powder per day is mixed into the rat diet. The inflammatory inflammation of guinea pigs has an effective anti-inflammatory and anti-oxidative effect due to hydrogen entering the body fluid. Symptoms were effectively treated and alleviated in ten days, and hepatitis completely healed after 4 weeks.

Example 4

The magnesium hydride was prepared into a fine powder of 1-10 micrometers, 350 g of the powder was taken, 300 g of mannitol and 150 g of microcrystalline cellulose were added, mixed uniformly, and then compressed into tablets, and the surface was coated with sugar, and 1000 pieces of sugar-coated tablets were obtained. Each piece weighs 0.8g and is swallowed by 1 tablet per day for adults. After 2 weeks of continuous use, the insomnia caused by neurological disorders can be effectively alleviated and disappeared due to the effective supplementation of magnesium.

Example 5

The magnesium hydride is prepared into a fine powder of 1000-1500 mesh, and 40 g of the powder is obtained, which is commercially available as a trace element additive. 100 pieces of folic acid tablets, finely mixed and then pressed into tablets, a total of 100 tablets. Pregnant women swallow 1 tablet daily. It can help pregnant women supplement the essential element magnesium while supplementing folic acid. Continuous taking for 1-2 months, some middle-aged and elderly people due to neurological disorders caused by abdominal fullness, bowel, sigh, eating less, vomiting, diarrhea or constipation and other symptoms of gastrointestinal abnormalities due to regular supplementation of magnesium ions and hydrogen The antioxidant effect is effectively relieved and disappeared.

Example 6

The magnesium hydride was prepared into a micro powder of 1000-1500 mesh, 30 g of the powder was taken, and 100 pieces of commercially available calcium tablets were added as a trace element additive, and the mixture was finely mixed and then re-compressed into tablets, and a total of 100 tablets were obtained. 1 swallow per day for adults. At the same time, supplementation with magnesium can help patients with osteoporosis to enhance the absorption and utilization of calcium. After taking 1-3 months in a row, the symptoms of fatigue, fatigue, cramps, backache, allergies, and flu caused by calcium deficiency and magnesium deficiency in adults can be effectively supplemented by magnesium and calcium and anti-inflammatory and anti-oxidation of hydrogen. The effect is effectively relieved and cured.

The specific embodiments of the present invention have been described in detail above. It will be appreciated that many modifications and variations can be made in the present invention without departing from the scope of the invention. Therefore, any technical solution that can be obtained by a person skilled in the art based on the prior art based on the prior art by logic analysis, reasoning or limited experimentation should be within the scope of protection determined by the claims.

Claims (6)

1. A health care pharmaceutical preparation supplementing magnesium and having an antioxidant effect, characterized in that the pharmaceutical preparation comprises a main active ingredient magnesium agent and an auxiliary material, the magnesium agent is a MgH ₂ micro-nano powder, and the auxiliary material is a commonly used pharmaceutical preparation auxiliary material. .
2. The health care pharmaceutical preparation according to claim 1, wherein the MgH ₂ micro/nano powder has a size of from 100 nm to 100 μm.
3. The health care pharmaceutical preparation according to claim 1, wherein the magnesium content of the pharmaceutical preparation is 40-400 mg/dose.
4. The health care pharmaceutical preparation according to claim 1, which has an antioxidant effect, wherein the pharmaceutical preparation has a hydrogen content of 72 to 720 mL per dose.
5. The health care pharmaceutical preparation according to claim 1, which has both an antioxidant effect and an antioxidant composition, wherein the pharmaceutical preparation is in the form of a tablet, a pill or a capsule.
6. A method for preparing a health care pharmaceutical preparation containing magnesium supplementation and antioxidant activity according to any one of claims 1 to 5, wherein the preparation method comprises the following steps: using MgH ₂ micro-nano powder and common pharmaceutical excipients It is uniformly mixed and prepared by weighing, compacting, sterilizing and packaging.