CN105853826A - Tumor preventing and treating medicine and application of medicine - Google Patents
Tumor preventing and treating medicine and application of medicine Download PDFInfo
- Publication number
- CN105853826A CN105853826A CN201610338818.3A CN201610338818A CN105853826A CN 105853826 A CN105853826 A CN 105853826A CN 201610338818 A CN201610338818 A CN 201610338818A CN 105853826 A CN105853826 A CN 105853826A
- Authority
- CN
- China
- Prior art keywords
- ethanol
- twice
- medicine
- tank
- filter
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000003814 drug Substances 0.000 title claims abstract description 27
- 206010028980 Neoplasm Diseases 0.000 title claims abstract description 22
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 58
- 241000208340 Araliaceae Species 0.000 claims abstract description 25
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 claims abstract description 25
- 235000003140 Panax quinquefolius Nutrition 0.000 claims abstract description 25
- 235000008434 ginseng Nutrition 0.000 claims abstract description 25
- 238000000605 extraction Methods 0.000 claims abstract description 18
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 18
- 239000008213 purified water Substances 0.000 claims abstract description 15
- 108090000790 Enzymes Proteins 0.000 claims abstract description 13
- 102000004190 Enzymes Human genes 0.000 claims abstract description 13
- 210000000582 semen Anatomy 0.000 claims abstract description 12
- 238000002156 mixing Methods 0.000 claims abstract description 8
- 238000002360 preparation method Methods 0.000 claims abstract description 8
- 239000000284 extract Substances 0.000 claims abstract description 7
- 239000000843 powder Substances 0.000 claims abstract description 6
- 239000007902 hard capsule Substances 0.000 claims abstract description 3
- 239000000243 solution Substances 0.000 claims description 24
- 239000006071 cream Substances 0.000 claims description 15
- 229920005989 resin Polymers 0.000 claims description 15
- 239000011347 resin Substances 0.000 claims description 15
- 239000007788 liquid Substances 0.000 claims description 13
- 238000003860 storage Methods 0.000 claims description 12
- 229940088598 enzyme Drugs 0.000 claims description 11
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 9
- 239000003480 eluent Substances 0.000 claims description 9
- 239000000047 product Substances 0.000 claims description 8
- 230000033228 biological regulation Effects 0.000 claims description 7
- 239000000706 filtrate Substances 0.000 claims description 7
- 239000000376 reactant Substances 0.000 claims description 7
- 238000003809 water extraction Methods 0.000 claims description 7
- 238000002481 ethanol extraction Methods 0.000 claims description 6
- 238000001914 filtration Methods 0.000 claims description 6
- 239000000463 material Substances 0.000 claims description 6
- 229910001220 stainless steel Inorganic materials 0.000 claims description 6
- 239000010935 stainless steel Substances 0.000 claims description 6
- 108010059892 Cellulase Proteins 0.000 claims description 4
- 102000004139 alpha-Amylases Human genes 0.000 claims description 4
- 108090000637 alpha-Amylases Proteins 0.000 claims description 4
- 229940024171 alpha-amylase Drugs 0.000 claims description 4
- 238000013459 approach Methods 0.000 claims description 4
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 claims description 4
- 229940106157 cellulase Drugs 0.000 claims description 4
- 230000002265 prevention Effects 0.000 claims description 4
- 238000010521 absorption reaction Methods 0.000 claims description 3
- 238000006243 chemical reaction Methods 0.000 claims description 3
- 239000012141 concentrate Substances 0.000 claims description 3
- 230000005484 gravity Effects 0.000 claims description 3
- 230000007935 neutral effect Effects 0.000 claims description 3
- 238000012856 packing Methods 0.000 claims description 3
- 238000001179 sorption measurement Methods 0.000 claims description 3
- 238000005538 encapsulation Methods 0.000 claims description 2
- 239000007974 sodium acetate buffer Substances 0.000 claims description 2
- BHZOKUMUHVTPBX-UHFFFAOYSA-M sodium acetic acid acetate Chemical compound [Na+].CC(O)=O.CC([O-])=O BHZOKUMUHVTPBX-UHFFFAOYSA-M 0.000 claims description 2
- 239000002994 raw material Substances 0.000 abstract description 4
- 244000241838 Lycium barbarum Species 0.000 abstract 2
- 235000015459 Lycium barbarum Nutrition 0.000 abstract 2
- 235000015468 Lycium chinense Nutrition 0.000 abstract 2
- 235000013399 edible fruits Nutrition 0.000 abstract 2
- 230000006837 decompression Effects 0.000 abstract 1
- 238000000227 grinding Methods 0.000 abstract 1
- 230000000694 effects Effects 0.000 description 9
- RWXIFXNRCLMQCD-JBVRGBGGSA-N (20S)-ginsenoside Rg3 Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@H]1CC[C@]2(C)[C@H]3C[C@@H](O)[C@H]4[C@@]([C@@]3(CC[C@H]2C1(C)C)C)(C)CC[C@@H]4[C@@](C)(O)CCC=C(C)C)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O RWXIFXNRCLMQCD-JBVRGBGGSA-N 0.000 description 6
- 230000000259 anti-tumor effect Effects 0.000 description 6
- 238000002512 chemotherapy Methods 0.000 description 6
- 230000036039 immunity Effects 0.000 description 6
- CKUVNOCSBYYHIS-UHFFFAOYSA-N (20R)-ginsenoside Rg3 Natural products CC(C)=CCCC(C)(O)C1CCC(C2(CCC3C4(C)C)C)(C)C1C(O)CC2C3(C)CCC4OC1OC(CO)C(O)C(O)C1O CKUVNOCSBYYHIS-UHFFFAOYSA-N 0.000 description 5
- CKUVNOCSBYYHIS-IRFFNABBSA-N (20S)-ginsenoside Rh2 Chemical compound O([C@H]1CC[C@]2(C)[C@H]3C[C@@H](O)[C@H]4[C@@]([C@@]3(CC[C@H]2C1(C)C)C)(C)CC[C@@H]4[C@@](C)(O)CCC=C(C)C)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O CKUVNOCSBYYHIS-IRFFNABBSA-N 0.000 description 5
- CKUVNOCSBYYHIS-LGYUXIIVSA-N 20(R)-Ginsenoside Rh2 Natural products O([C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1)[C@@H]1C(C)(C)[C@H]2[C@@](C)([C@H]3[C@](C)([C@@]4(C)[C@H]([C@H](O)C3)[C@@H]([C@](O)(CC/C=C(\C)/C)C)CC4)CC2)CC1 CKUVNOCSBYYHIS-LGYUXIIVSA-N 0.000 description 5
- XIRZPICFRDZXPF-UHFFFAOYSA-N Ginsenoside Rg3 Natural products CC(C)=CCCC(C)(O)C1CCC(C2(CC(O)C3C4(C)C)C)(C)C1C(O)CC2C3(C)CCC4OC1OC(CO)C(O)C(O)C1OC1OC(CO)C(O)C(O)C1O XIRZPICFRDZXPF-UHFFFAOYSA-N 0.000 description 5
- 210000004369 blood Anatomy 0.000 description 4
- 239000008280 blood Substances 0.000 description 4
- 210000004027 cell Anatomy 0.000 description 4
- 235000009508 confectionery Nutrition 0.000 description 4
- 230000002708 enhancing effect Effects 0.000 description 4
- 210000004881 tumor cell Anatomy 0.000 description 4
- 206010027476 Metastases Diseases 0.000 description 3
- 230000006870 function Effects 0.000 description 3
- 210000004185 liver Anatomy 0.000 description 3
- 230000009401 metastasis Effects 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 239000001397 quillaja saponaria molina bark Substances 0.000 description 3
- 229930182490 saponin Natural products 0.000 description 3
- 150000007949 saponins Chemical class 0.000 description 3
- 210000000952 spleen Anatomy 0.000 description 3
- 206010058467 Lung neoplasm malignant Diseases 0.000 description 2
- 230000001093 anti-cancer Effects 0.000 description 2
- 230000006907 apoptotic process Effects 0.000 description 2
- 239000006286 aqueous extract Substances 0.000 description 2
- 210000004204 blood vessel Anatomy 0.000 description 2
- 239000002775 capsule Substances 0.000 description 2
- 206010017758 gastric cancer Diseases 0.000 description 2
- 230000036541 health Effects 0.000 description 2
- 230000006698 induction Effects 0.000 description 2
- 230000001939 inductive effect Effects 0.000 description 2
- 238000001764 infiltration Methods 0.000 description 2
- 238000007689 inspection Methods 0.000 description 2
- 210000004072 lung Anatomy 0.000 description 2
- 231100000957 no side effect Toxicity 0.000 description 2
- 230000001629 suppression Effects 0.000 description 2
- 208000024891 symptom Diseases 0.000 description 2
- 206010006187 Breast cancer Diseases 0.000 description 1
- 208000026310 Breast neoplasm Diseases 0.000 description 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- 229920001875 Ebonite Polymers 0.000 description 1
- 206010019663 Hepatic failure Diseases 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 208000005016 Intestinal Neoplasms Diseases 0.000 description 1
- RRHGJUQNOFWUDK-UHFFFAOYSA-N Isoprene Chemical compound CC(=C)C=C RRHGJUQNOFWUDK-UHFFFAOYSA-N 0.000 description 1
- 241000699670 Mus sp. Species 0.000 description 1
- 208000002193 Pain Diseases 0.000 description 1
- 208000004880 Polyuria Diseases 0.000 description 1
- 206010039897 Sedation Diseases 0.000 description 1
- 208000005718 Stomach Neoplasms Diseases 0.000 description 1
- 210000001015 abdomen Anatomy 0.000 description 1
- 230000003187 abdominal effect Effects 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 230000036592 analgesia Effects 0.000 description 1
- 230000001142 anti-diarrhea Effects 0.000 description 1
- 230000000118 anti-neoplastic effect Effects 0.000 description 1
- 230000003064 anti-oxidating effect Effects 0.000 description 1
- 230000000702 anti-platelet effect Effects 0.000 description 1
- 230000001754 anti-pyretic effect Effects 0.000 description 1
- 230000000840 anti-viral effect Effects 0.000 description 1
- 239000003146 anticoagulant agent Substances 0.000 description 1
- 239000002221 antipyretic Substances 0.000 description 1
- 230000001640 apoptogenic effect Effects 0.000 description 1
- 235000019789 appetite Nutrition 0.000 description 1
- 230000036528 appetite Effects 0.000 description 1
- 210000001367 artery Anatomy 0.000 description 1
- 210000002469 basement membrane Anatomy 0.000 description 1
- -1 be dried Substances 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 210000000013 bile duct Anatomy 0.000 description 1
- 230000036772 blood pressure Effects 0.000 description 1
- 239000007853 buffer solution Substances 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 230000000711 cancerogenic effect Effects 0.000 description 1
- 231100000357 carcinogen Toxicity 0.000 description 1
- 239000003183 carcinogenic agent Substances 0.000 description 1
- 210000002318 cardia Anatomy 0.000 description 1
- 230000009084 cardiovascular function Effects 0.000 description 1
- 230000024245 cell differentiation Effects 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 210000003792 cranial nerve Anatomy 0.000 description 1
- 231100000433 cytotoxic Toxicity 0.000 description 1
- 230000001472 cytotoxic effect Effects 0.000 description 1
- 206010061428 decreased appetite Diseases 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 230000004069 differentiation Effects 0.000 description 1
- 229940079919 digestives enzyme preparation Drugs 0.000 description 1
- 230000035619 diuresis Effects 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 239000000469 ethanolic extract Substances 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 230000004438 eyesight Effects 0.000 description 1
- 235000021050 feed intake Nutrition 0.000 description 1
- 208000010749 gastric carcinoma Diseases 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- 229930182494 ginsenoside Natural products 0.000 description 1
- 229940089161 ginsenoside Drugs 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 235000013402 health food Nutrition 0.000 description 1
- 230000002519 immonomodulatory effect Effects 0.000 description 1
- 230000036737 immune function Effects 0.000 description 1
- 238000002513 implantation Methods 0.000 description 1
- 230000008595 infiltration Effects 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 201000002313 intestinal cancer Diseases 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 208000007903 liver failure Diseases 0.000 description 1
- 231100000835 liver failure Toxicity 0.000 description 1
- 201000005202 lung cancer Diseases 0.000 description 1
- 208000020816 lung neoplasm Diseases 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000003340 mental effect Effects 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 239000000178 monomer Substances 0.000 description 1
- 230000010016 myocardial function Effects 0.000 description 1
- 210000005036 nerve Anatomy 0.000 description 1
- 238000004806 packaging method and process Methods 0.000 description 1
- 230000036407 pain Effects 0.000 description 1
- 230000000505 pernicious effect Effects 0.000 description 1
- 230000002980 postoperative effect Effects 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 238000001959 radiotherapy Methods 0.000 description 1
- 238000002271 resection Methods 0.000 description 1
- 230000036280 sedation Effects 0.000 description 1
- 230000005586 smoking cessation Effects 0.000 description 1
- 208000010110 spontaneous platelet aggregation Diseases 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 201000011549 stomach cancer Diseases 0.000 description 1
- 201000000498 stomach carcinoma Diseases 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 230000001256 tonic effect Effects 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 229930182493 triterpene saponin Natural products 0.000 description 1
- 238000001291 vacuum drying Methods 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
- 210000001835 viscera Anatomy 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
- A61K36/815—Lycium (desert-thorn)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
- A61K36/8994—Coix (Job's tears)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/19—Preparation or pretreatment of starting material involving fermentation using yeast, bacteria or both; enzymatic treatment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/55—Liquid-liquid separation; Phase separation
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a tumor preventing and treating medicine and application of the medicine. The preparation method comprises the following steps: preparing a mixed enzyme, adding ginseng into an extraction tank, extracting twice with 75% ethanol, and merging the alcohol extracting solution twice for later use; adding barbary wolfberry fruit and semen coicis into the extraction tank filled with ginseng extracted by ethanol, wherein the mass ratio of ginseng raw materials to barbary wolfberry fruit to semen coicis is 3:2:1; extracting twice by using purified water, merging the extracting solution for later use, performing vacuum concentration on the purified water extracting solution twice to form dry extract, and grinding; performing vacuum decompression concentration on the alcohol extracting solution, adding the mixed enzyme, adsorbing, eluting, preparing dried powder, merging the extracted powder twice, uniformly mixing, preparing hard capsules or tablets, so as to obtain the tumor preventing and treating medicine.
Description
Technical field
The present invention relates to the preparation method and applications of a kind of medicine, the medicine of a kind of anti-curing oncoma and
The application of this medicine.
Background technology
Treatment to tumor at present follows the treatment route of operation, radiotherapy, chemotherapy or Comprehensive Treatment always,
Big to the wound of patient, clearly, treatment cost is high in side effect.In terms of the prevention of tumor, mainly
By smoking cessation limit wine, moderate exercise, reasonable diet, selection health food and shut out at all kinds of production links as far as possible
The modes such as the discharge of exhausted carcinogen reduce the chance suffering from tumor.Above-mentioned prevention and therapeutic modality are also paid no attention to
Think.
Summary of the invention
It is an object of the invention to provide that a kind of tumor effect is good, have no side effect, hurtless measure, treat in preventing and treating
The preparation method of this low preventing and treating tumour medicine and the application of this medicine, overcome the deficiencies in the prior art.
The medicine of the anti-curing oncoma of the present invention, preparation method is as follows:
(1), mixed enzyme is prepared, by β-glucose enzyme, α-amylase, cellulase in mass ratio 1: 1
: the ratio mixing of 1, make mixed enzyme, standby after encapsulation；
(2), Radix Ginseng is put in extraction pot, with dense cross 75% ethanol extraction twice；
Wherein ethanol addition is for the first time: 8 liters/1 kilogram Radix Ginseng, heats with jacket steam, at 45 minutes
In inside making extraction pot, temperature rises to 80 DEG C, then keeps 80 DEG C of constant temperature 2 hours, whole extraction process every 30
Minute return stream 10 minutes, homogeneous temperature upper and lower in making tank, the extracted tank bottoms 120 mesh sieve plate mistakes of extracting solution
Filter, then filter through filter 140 eye mesh screen, it is transported to storage tank with stainless steel pump stand-by；
Ethanol addition is for the second time: 6 liters/1 kilogram Radix Ginseng, operational approach is the same for the previous；
Twice alcohol extract is merged stand-by.
(3), in the extraction pot equipped with the Radix Ginseng after ethanol extraction, Fructus Lycii and Semen Coicis, ginseng raw are put into
Expect that the mass ratio with Fructus Lycii and Semen Coicis is: 3: 2: 1, then use purified water extraction twice；
Wherein purified water addition is for the first time: material in 8 liters/1 kilogram tank, heats with jacket steam, 1
In making tank in hour, temperature rises to 95 DEG C, then keeps 95 DEG C of constant temperature 3 hours, whole extraction process every 30
Minute return stream 10 minutes, homogeneous temperature upper and lower in making tank, the extracted tank bottoms 120 mesh sieve plate mistakes of extracting solution
Filter, then filter through filter 140 eye mesh screen, it is transported to storage tank with stainless steel pump stand-by；
Second time is extracted, and the interpolation quality of purified water is: material in 6 liters/1 kilogram tank, operational approach is with front
The most identical；
Twice purified water extraction liquid is merged stand-by；
(4), twice purified water extraction liquid being carried out concentrating under reduced pressure, being concentrated into density is 1.1g/cm3, use plate
Frame filter filters, and discards filtering residue, filtrate is transported to storage tank stand-by；
(5) filtrate, to (4th) step obtained carries out concentrating under reduced pressure, and being concentrated into density is 1.15g/cm3,
Forming paste, releasing condensed cream carries out vacuum crawler and is dried, is dried to dry cream moisture ＜ 5%, collects dry cream, powder
Broken, packed for standby use；
(6), twice alcohol extract is carried out vacuum-concentrcted, be concentrated into without alcohol, concentrated solution feed pump
It is delivered to reactor, in a kettle. by concentrated solution constant temperature to 50 DEG C and keep constant temperature, uses Acetic acid-sodium acetate
Buffer solution regulation concentrated solution, makes PH=5.0, and in reactor, addition Radix Ginseng puts into the mixed of the 1/1000 of quality
Synthase, with NaOH regulation pH value to neutral after reacting 4 hours, terminates reaction；
(7) squeeze into D101 resin column high position storage tank after the reacting liquid filtering, by (6) obtained, adsorb,
Reactant liquor enters resin column by gravity tank and adsorbs；Adsorption flow rate: 0.5-1.0BV/H；
(8), after reactant liquor absorption completely, with pure water, D101 resin column is carried out eluting, washes flow velocity:
2.0-4.0BV/H, washes 6 times of volumes, then with the dense ethanol solution crossing 40%, resin column is carried out desorbing,
Ethanol consumption is 4.0BV, stripping liquid flow velocity: 1.5-2.0BV/H, collect eluent, concentrate, be dried, powder
Broken otherwise utilized；
(9), by the resin column after (8th) step 40% ethanol desorbing again with the dense ethanol solution of 75% of crossing to tree
Fat post carries out desorbing, and ethanol consumption is 6.0BV, stripping liquid flow velocity: 1.5-2.0BV/H, collects eluent and treats
With；
(10), (9th) step is obtained eluent carrying out concentrating under reduced pressure, being concentrated into density is 1.2g/cm3,
Condensed cream being vacuum dried, is dried to dry cream moisture ＜ 5%, crushing packing is stand-by；
(11), the product that (5th) step and (10th) step are obtained is carried out in 45: 0.8～1.5 ratios
Mixing, makes hard capsule or tablet, obtains the medicine of anti-curing oncoma.
The application in terms of prevention and treatment tumor of the medicine of the anti-curing oncoma of the present invention.
The traditional Chinese medical science thinks that tumor is caused by patient's body yin and yang imbalance, regulates QI and blood, internal organs, meridians merit
The balance of energy, enhancing human body immunity power can reach antineoplastic effect.
Radix Ginseng sweet in the mouth, micro-hardship, warm in nature, flat.Return spleen, lung meridian, heart channel.There is strongly invigorating primordial QI, Gu de-raw
Tianjin, the effect calmed the nerves.Modern medicine study proves have regulation nervus centralis, improve myocardial function, enhancing
The functions such as immunity of organism, antioxidation, antitumor, are a kind of conventional tonic.
Fructus Lycii sweet in the mouth, property is put down.Sweet filling-in and, matter moisten many liquid, there is the merit of nourishing the liver and kidney, replenishing vital essence to improve eyesight,
It also has the effects such as blood fat reducing, defying age, antitumor.
Semen Coicis is sweet, light, cool, returns spleen, stomach, lung meridian, has spleen invigorating eliminating dampness by diuresis, eliminating impediment antidiarrheal, heat clearing away row
Effect of pus, have antipyretic, analgesia, sedation.Modern medicine study show Semen Coicis have antitumor,
The pharmacologically active of the aspects such as immunomodulating, blood sugar lowering blood calcium, blood pressure lowering, antiviral.
Ginsenoside Rg3 is a kind of panoxadiol's class tetracyclic triterpene saponin, has anticancer, Anticancer metastasis action.
Ginsenoside Rg3 can significantly improve the immunologic function of tumor-bearing mice；Suppression intra-tumor new vessels is formed；Resistance
Anti-avulsion falls the cancerous cell implantation in blood vessel wall；The suppression tumor cell infiltration to blood vessel wall basement membrane, has notable
Anti-infiltration, metastasis effect.Clinical experiment confirms that ginsenoside Rg3 can effectively suppress pulmonary carcinoma, hepatocarcinoma, stomach
Cancer, intestinal cancer, growth of breast cancers, hence it is evident that improve clinical symptoms, improve life quality, prevent and treat cancer,
Improve cardiovascular function, anti-platelet aggregation, protection cranial nerve cell, improve immunity of organisms.
Ginsenoside Rh2 is protopanaxadiol-type's low sugar chain saponin monomer, has anti-tumor activity, and aligns
Often cytotoxic side effect.Ginsenoside Rh2 has modulate tumor cell generation cycle, Cell differentiation inducing activity
Antitumor action is played with apoptosis.Tumor cell induction is divided into normal cell is conducive to control tumor to send out
Exhibition, inducing apoptosis of tumour cell forms apoptotic body after making cytoclasis, does not cause surrounding tissue inflammatory reaction.
Ginsenoside Rh2 can also play its antitumor action by regulation and enhancing human body immunity function.
This product with Radix Ginseng, Fructus Lycii, Semen Coicis drug matching, mixed extraction, make capsule, tablet,
The dosage forms such as granule.Containing ginsenoside Rh2, ginsenoside Rg3 and multiple efficacies in this Product mix extract
Composition, has induction, differentiation, metastasis and the function of enhancing human body immunity power to cancerous cell such that it is able to
Realize treating and preventing the purpose of tumor, and the patient of opponent's stage of rehabilitation has good effect.
The invention of this patent is to utilize β-glucose enzyme, α-amylase, three kinds of mixed enzyme systems of cellulase
Agent, hydrolyzes ginsenoside, and the ginsenoside Rh2 of isolated and the purity of ginsenoside Rg3's mixture >=
55%.
The medicine of the anti-curing oncoma of the present invention has a preventing and treating, and tumor effect is good, have no side effect, hurtless measure, treatment
The advantage of low cost.
Detailed description of the invention
The preparation method of the medicine of the anti-curing oncoma of the present invention, step is as follows:
1, Radix Ginseng, Fructus Lycii, Semen Coicis raw material (dry product) are through selected, by Radix Ginseng 120kg, Fructus Lycii
The most quantitatively, i.e. total amount 240kg is an inventory, i.e. three kinds raw materials quality ratios for 80kg, Semen Coicis 40kg
It is 3: 2: 1；
2, mixing enzyme preparation, weighs β-glucose enzyme, α-amylase, three kinds of enzyme preparations of cellulase respectively,
The ratio mixing of in mass ratio 1: 1: 1, seals pack, standby.
3, by 120kg ginseng raw material, once put in extraction pot, the ethanol extraction with 75% twice, first
Secondary ethanol addition is: 8 liters/1 kilogram Radix Ginseng, after adding ethanol, heats with jacket steam, at 45 minutes
In inside making extraction pot, temperature rises to 80 DEG C, then keeps 80 DEG C of constant temperature 2 hours, whole extraction process every 30
Minute return stream 10 minutes, homogeneous temperature upper and lower in making tank, the extracted tank bottoms 120 mesh sieve plate mistakes of extracting solution
Filter, then filter through filter 140 eye mesh screen, it is transported to storage tank with stainless steel pump stand-by.Ethanol adds for the second time
Dosage is: 6 liters/1 kilogram Radix Ginseng, adds ethanol, ibid walks operation, and extracting solution is with processing for the first time.Close
And twice ethanol extract is stand-by.
4, with the Radix Ginseng after ethanol extraction puts into the Fructus Lycii of formula ratio, Semen Coicis in extraction pot, purification is used
Water extraction twice, purified water addition is for the first time: material in 8 liters/1 kilogram tank, adds purified water, uses
Jacket steam heats, and in making tank in 1 hour, temperature rises to 95 DEG C, then keeps 95 DEG C of constant temperature 3 hours,
Whole extraction process returns stream for every 30 minutes 10 minutes, and homogeneous temperature upper and lower in making tank, extracting solution is through carrying
Take tank bottoms 120 mesh sieve plates to filter, then filter through filter 140 eye mesh screen, be transported to storage tank with stainless steel pump
Stand-by.Then carrying out second time to extract, the addition of purified water is: material in 6 liters/1 kilogram tank, ibid
Step operation, filtrate processes and ibid walks.Merge twice aqueous extract stand-by.
5, the 4th twice aqueous extract of step being carried out concentrating under reduced pressure, being concentrated into density is 1.1g/cm3, use sheet frame
Filter filters, and discards filtering residue, filtrate is transported to storage tank stand-by.
6, filtrate being carried out concentrating under reduced pressure, being concentrated into density is 1.15g/cm3, condensed cream is released and is carried out vacuum
Crawler belt is dried, and is dried to dry cream moisture ＜ 5%, collects dry cream, pulverizes, packed for standby use.
7, the 3rd twice alcohol extract of step is carried out vacuum-concentrcted, be concentrated into without alcohol, concentrated solution feed liquid
Transport pump is stand-by to reactor.
8, the concentrated solution constant temperature in reactor is to 50 DEG C, regulates solution with NaAc_HAc buffer solution
PH=5.0, in reactor add Radix Ginseng feed intake quality 1/1000 mixing enzyme preparation, after reacting 4 hours
With NaOH regulation pH value to neutral, terminate reaction.
9, reactant liquor squeezes into D101 resin column high position storage tank after filtering, and adsorbs, and reactant liquor passes through
Gravity tank enters resin column and adsorbs；Adsorption flow rate: 0.5-1.0BV/H.
10, after reactant liquor absorption completely, with pure water, D101 resin column is carried out eluting, washes flow velocity:
2.0-4.0BV/H, washes 6 times of volumes, stops washing.
11, with the dense ethanol solution crossing 40%, resin column being carried out desorbing, ethanol consumption is 4.0BV, stripping liquid
Flow velocity: 1.5-2.0BV/H, collect eluent, concentrate, be dried, pulverize stand-by.
12, with the dense ethanol solution crossing 75%, resin column being carried out desorbing again, ethanol consumption is 6.0BV, desorbing
Flow velocity: 1.5-2.0BV/H, collects eluent stand-by.
13, the 12nd step eluent carries out concentrating under reduced pressure, and being concentrated into density is 1.2g/cm3, and condensed cream is entered
Row vacuum drying, is dried to dry cream moisture ＜ 5%, and crushing packing is stand-by.The rare saponin of Radix Ginseng in dry powder after testing
Rh2 content reaches 25%, rare saponin Rg3 content reaches 30%.
14, the 6th and the 13rd step product is mixed in 45: 0.8 or 1 or 1.5 ratios, make ebonite
Capsule, tablet, packaging is made finished product, is used for treating and preventing tumor, and the postoperative rehabilitation of tumor patient.
Application example:
Mr. Sun, 79 years old, peasant.Being found advanced lung cancer, 3*2.5cm size, old man is illiterate, family
People does not tells him what is sick.Son listens friend to say outside, and this product can improve immunity, to tumor patient energy
Enough improve the quality of living, have the medicine that the attitude tried has used some present invention to old man in arms, say old man
Healthy good, it is desirable to adhere to taking, each 4, three times a day, during taking, old man's health is also the biggest
Problem, within 2012, going inspection again is that tumor does not has, and everyone feels surprised.
Mr. Li, man, 63 years old, retired worker, people from Dalian.Frequently experience upper abdomen distending pain, time and feel sick,
Inappetence, belch and becoming thin, people appears not to spirit.My old man and child advise that old Mr. goes to hospital to do
Once check, ill promptly treatment, anosis more preferably.After having done gastroscope and abdominal CT inspection to hospital, make a definite diagnosis
It is stomach carcinoma of gastric cardia, not including the most too late of not bad discovery, and hospital just gives and arranges to perform the operation, and has done 6 phase chemotherapy.
Old man is to start to take the medicine of the present invention in the second phase of chemotherapy, each 3, three times a day, to the 3rd
During secondary chemotherapy, patient mental is fine, and appetite is also good, first light twice of the pernicious ratio that chemotherapy causes.Chemotherapy is complete
After one-tenth, old man only takes the medicine of the present invention, feels good now, and every day picks child, can do some suitable
Exercise.
Mr. Cui, man, 54 years old.Finding there is occupy-place in liver in health check-up, through area, Grade A hospital checks further
Being defined as hepatocarcinoma and be multiple, the state of an illness is heavier, and doctor said that they cannot treat at that time, allowed me transfer from one hospital to another
Go other places large hospital treatment.I have selected Beijing 302 hospital and have done liver resection, at that time my feelings
Condition is the most bad, because I is primary hepatocarcinoma belongs to multiple (three tumors), and it is quiet to be located proximate to door
Arteries and veins blood vessel and bile duct, operating difficulty is very big, and operation has been carried out eight hours, and liver failure occurs in Post operation
Symptom, has recovered normal through rescuing, 11 days Chu Liao institutes of Post operation.During rehabilitation, take actively
Life attitudes, auxiliary is taken the medicine of the present invention, each 3, three times a day, is appeared body normal.
Lu Fangmao, man, 53 years old, peasant.Discovery is hard and dry, and is difficult to discharge, sometimes stool band blood, companion
The symptoms such as with lower abdominal pain, the conscious loss of appetite of patient, gradually becomes thin simultaneously, and nothing is nauseating.Early stage thinks hemorrhoid
Failing to respond to any medical treatment, after hospital's enteroscopy, in rectal cancer mid-term, delay again a period of time due to peasant, raise money
Rectum resection can only be directly done when Hou Zaiqu hospital performs an operation.The medicine of the present invention has been taken after patient discharge,
Each 3, three times a day, health is good so far, can Out-migrant for work.
Mrs Zhao, female, 67 years old, retired worker.Often having a fever during this patient and do not move back, hospital worked as pneumonia at that time
Treatment, recurrent exerbation in two months, doctor's suggestion is done other and is checked, is the discovery that leukemia.Chemotherapy 6 after date
So far, the most useless other drug in addition to imatinib mesylate and this product, patient per 4, three times a day, at present
Being in a good state of health, life can take care of oneself, and manages daily housework.
Claims (2)
1. the medicine of an anti-curing oncoma, it is characterised in that: preparation method is as follows:
(1), mixed enzyme is prepared, by β-glucose enzyme, α-amylase, cellulase in mass ratio 1: 1
: the ratio mixing of 1, make mixed enzyme, standby after encapsulation；
(2), Radix Ginseng is put in extraction pot, with dense cross 75% ethanol extraction twice；
Wherein ethanol addition is for the first time: 8 liters/1 kilogram Radix Ginseng, heats with jacket steam, at 45 minutes
In inside making extraction pot, temperature rises to 80 DEG C, then keeps 80 DEG C of constant temperature 2 hours, whole extraction process every 30
Minute return stream 10 minutes, homogeneous temperature upper and lower in making tank, the extracted tank bottoms 120 mesh sieve plate mistakes of extracting solution
Filter, then filter through filter 140 eye mesh screen, it is transported to storage tank with stainless steel pump stand-by；
Ethanol addition is for the second time: 6 liters/1 kilogram Radix Ginseng, operational approach is the same for the previous；
Twice alcohol extract is merged stand-by；
(3), in the extraction pot equipped with the Radix Ginseng after ethanol extraction, Fructus Lycii and Semen Coicis, ginseng raw are put into
Expect that the mass ratio with Fructus Lycii and Semen Coicis is: 3: 2: 1, then use purified water extraction twice；
Wherein purified water addition is for the first time: material in 8 liters/1 kilogram tank, heats with jacket steam, 1
In making tank in hour, temperature rises to 95 DEG C, then keeps 95 DEG C of constant temperature 3 hours, whole extraction process every 30
Minute return stream 10 minutes, homogeneous temperature upper and lower in making tank, the extracted tank bottoms 120 mesh sieve plate mistakes of extracting solution
Filter, then filter through filter 140 eye mesh screen, it is transported to storage tank with stainless steel pump stand-by；
Second time is extracted, and the interpolation quality of purified water is: material in 6 liters/1 kilogram tank, operational approach is with front
The most identical；
Twice purified water extraction liquid is merged stand-by；
(4), twice purified water extraction liquid being carried out concentrating under reduced pressure, being concentrated into density is 1.1g/cm3, use plate
Frame filter filters, and discards filtering residue, filtrate is transported to storage tank stand-by；
(5) filtrate, to (4th) step obtained carries out concentrating under reduced pressure, and being concentrated into density is 1.15g/cm3,
Forming paste, releasing condensed cream carries out vacuum crawler and is dried, is dried to dry cream moisture ＜ 5%, collects dry cream, powder
Broken, packed for standby use；
(6), twice alcohol extract is carried out vacuum-concentrcted, be concentrated into without alcohol, concentrated solution feed pump
It is delivered to reactor, in a kettle. by concentrated solution constant temperature to 50 DEG C and keep constant temperature, uses Acetic acid-sodium acetate
Buffer solution regulation concentrated solution, makes PH=5.0, and in reactor, addition Radix Ginseng puts into the mixed of the 1/1000 of quality
Synthase, with NaOH regulation pH value to neutral after reacting 4 hours, terminates reaction；
(7) squeeze into D101 resin column high position storage tank after the reacting liquid filtering, by (6) obtained, adsorb,
Reactant liquor enters resin column by gravity tank and adsorbs；Adsorption flow rate: 0.5-1.0BV/H；
(8), after reactant liquor absorption completely, with pure water, D101 resin column is carried out eluting, washes flow velocity:
2.0-4.0BV/H (column volume/hour), washes 6 times of volumes, then with dense cross 40% ethanol solution pair
Resin column carries out desorbing, and ethanol consumption is 4.0BV, stripping liquid flow velocity: 1.5-2.0BV/H, collection eluent,
Concentrate, be dried, pulverize otherwise utilized；
(9), by the resin column after (8th) step 40% ethanol desorbing again with the dense ethanol solution of 75% of crossing to tree
Fat post carries out desorbing, and ethanol consumption is 6.0BV, stripping liquid flow velocity: 1.5-2.0BV/H, collects eluent and treats
With；
(10), (9th) step is obtained eluent carrying out concentrating under reduced pressure, being concentrated into density is 1.2g/cm3,
Condensed cream being vacuum dried, is dried to dry cream moisture ＜ 5%, crushing packing is stand-by；
(11), the product that (5th) step and (10th) step are obtained is carried out in 45: 0.8～1.5 ratios
Mixing, makes hard capsule or tablet, obtains the medicine of anti-curing oncoma.
2. the medicine of an anti-curing oncoma as claimed in claim 1 application in terms of prevention and treatment tumor.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610338818.3A CN105853826A (en) | 2016-05-23 | 2016-05-23 | Tumor preventing and treating medicine and application of medicine |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610338818.3A CN105853826A (en) | 2016-05-23 | 2016-05-23 | Tumor preventing and treating medicine and application of medicine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN105853826A true CN105853826A (en) | 2016-08-17 |
Family
ID=56635560
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610338818.3A Pending CN105853826A (en) | 2016-05-23 | 2016-05-23 | Tumor preventing and treating medicine and application of medicine |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN105853826A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109010649A (en) * | 2018-08-28 | 2018-12-18 | 岚皋县硒安生物科技有限公司 | A kind of anticancer traditional Chinese medicinal composition |
| CN110201015A (en) * | 2019-06-11 | 2019-09-06 | 长春理工大学 | Rust rot ginseng extract is preparing the application in the drug for treating tumour |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1615917A (en) * | 2003-11-12 | 2005-05-18 | 郎伟君 | Concurrent medicine for cancer in late stage or chemotherapy |
| CN102068477A (en) * | 2010-12-31 | 2011-05-25 | 浙江省中医院 | Effective parts of ginseng and preparation method and application thereof |
-
2016
- 2016-05-23 CN CN201610338818.3A patent/CN105853826A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1615917A (en) * | 2003-11-12 | 2005-05-18 | 郎伟君 | Concurrent medicine for cancer in late stage or chemotherapy |
| CN102068477A (en) * | 2010-12-31 | 2011-05-25 | 浙江省中医院 | Effective parts of ginseng and preparation method and application thereof |
Non-Patent Citations (1)
| Title |
|---|
| 刘建平: "《糖尿病吃什么速查》", 30 June 2015, 中国纺织出版社 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109010649A (en) * | 2018-08-28 | 2018-12-18 | 岚皋县硒安生物科技有限公司 | A kind of anticancer traditional Chinese medicinal composition |
| CN110201015A (en) * | 2019-06-11 | 2019-09-06 | 长春理工大学 | Rust rot ginseng extract is preparing the application in the drug for treating tumour |
| CN110201015B (en) * | 2019-06-11 | 2021-08-06 | 长春理工大学 | Application of ginseng extract with rust rot disease in preparation of drugs for treating tumors |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN100435831C (en) | Preparation for treating high blood pressure, high blood fat, obesity, and climacteric syndrome, and preparation method | |
| CN102178884B (en) | Chinese medicine preparation for regulating weakness of spleen and stomach of people with deficiency of vital energy, preparation method and application thereof | |
| CN103142950A (en) | Chinese patent drug for treating infantile diarrhea | |
| CN103989045A (en) | Brown sugar composition for menstrual period and application thereof | |
| CN103142949A (en) | Chinese patent drug for treating infantile asthma | |
| CN107441409A (en) | Chinese medicine composition for treating habitual constipation and preparation method thereof | |
| CN105853826A (en) | Tumor preventing and treating medicine and application of medicine | |
| CN102166320A (en) | Traditional Chinese medicine preparation for eliminating toxins and relieving stagnation of people with toxic stagnation physique and preparation method and application thereof | |
| CN102228620B (en) | Chinese medicinal compound preparation having the functions of supplementing iron and enriching the blood and preparation method thereof | |
| CN104666475B (en) | A kind of Chinese goldthread colla corii asini composition for treating dry syndrome and its application | |
| CN103055270A (en) | Chinese medicinal herb composition for treating hysteria | |
| CN102178866A (en) | Chinese medicinal preparation for dispelling damp, promoting blood circulation, softening hard mass and eliminating stagnation for people with qi-depression and blood-stagnation physique, preparation method thereof and application thereof | |
| CN111329969A (en) | Traditional Chinese medicine formula for treating cough and asthma and preparation method thereof | |
| CN103142918A (en) | Chinese patent drug for treating infantile diarrhea | |
| CN103908616A (en) | Medicament for relieving radiation side reactions of cancer patients and preparation method thereof | |
| CN106109953A (en) | Treatment and prevention of tumour Chinese medicine preparation and preparation method thereof | |
| CN102836315A (en) | Chinese medicinal composition for preventing and conditioning prognosis tumors and preparation method thereof | |
| CN103316289A (en) | Chinese patent medicine for treating hepatic depression syndrome type moodiness during menstruation | |
| CN102614461A (en) | Spray for rapidly relieving stenocardia and preparation method thereof | |
| CN102335314B (en) | Chinese medicinal composition for treating stomach diseases | |
| CN102133383B (en) | Ginger and fingered citron composition, preparation method thereof and application of ginger and fingered citron composition in preparation of attenuated synergistic medicaments in cancer radiotherapy and chemotherapy | |
| CN102178870A (en) | Chinese medicinal preparation for promoting qi circulation, promoting blood circulation, softening hard mass and eliminating stagnation for people with qi-depression and phlegm-damp physique, preparation method thereof and application thereof | |
| CN101829225A (en) | Micro circulation smoothing health-care product and preparation method thereof | |
| CN1977866A (en) | Poria weight-losing agent | |
| CN105687474A (en) | Preparation for cancer patient to take during chemotherapy period and preparation method |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WD01 | Invention patent application deemed withdrawn after publication | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20160817 |