CN102264410B - 用于从体液分离细胞的系统和方法 - Google Patents

用于从体液分离细胞的系统和方法 Download PDF

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Publication number
CN102264410B
CN102264410B CN200980149086.1A CN200980149086A CN102264410B CN 102264410 B CN102264410 B CN 102264410B CN 200980149086 A CN200980149086 A CN 200980149086A CN 102264410 B CN102264410 B CN 102264410B
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China
Prior art keywords
container
materials
blood
reservoir
aggregation
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Expired - Fee Related
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CN200980149086.1A
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English (en)
Chinese (zh)
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CN102264410A (zh
Inventor
P·米勒
B·D·波利佐蒂
R·D·史密斯
A·苏德
N·L·伍德
L·余
H·周
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Globegroup Life Technology Consulting America Co ltd
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General Electric Co
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Priority claimed from US12/325,672 external-priority patent/US8961787B2/en
Priority claimed from US12/333,926 external-priority patent/US20100151438A1/en
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Publication of CN102264410A publication Critical patent/CN102264410A/zh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
    • A61M1/3403—Regulation parameters
    • A61M1/341—Regulation parameters by measuring the filtrate rate or volume
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/02—Blood transfusion apparatus
    • A61M1/0209—Multiple bag systems for separating or storing blood components
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
    • A61M1/3403—Regulation parameters
    • A61M1/3406—Physical characteristics of the filtrate, e.g. urea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
    • A61M1/342—Adding solutions to the blood, e.g. substitution solutions
    • A61M1/3424—Substitution fluid path
    • A61M1/3431—Substitution fluid path upstream of the filter
    • A61M1/3434—Substitution fluid path upstream of the filter with pre-dilution and post-dilution
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
    • A61M1/342—Adding solutions to the blood, e.g. substitution solutions
    • A61M1/3424—Substitution fluid path
    • A61M1/3437—Substitution fluid path downstream of the filter, e.g. post-dilution with filtrate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/362—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits changing physical properties of target cells by binding them to added particles to facilitate their subsequent separation from other cells, e.g. immunoaffinity
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D36/00—Filter circuits or combinations of filters with other separating devices
    • B01D36/04—Combinations of filters with settling tanks
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/80—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood groups or blood types or red blood cells
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0605—Metering of fluids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0631—Purification arrangements, e.g. solid phase extraction [SPE]
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/10—Integrating sample preparation and analysis in single entity, e.g. lab-on-a-chip concept
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Vascular Medicine (AREA)
  • Anesthesiology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Cell Biology (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Clinical Laboratory Science (AREA)
  • Physics & Mathematics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Zoology (AREA)
  • Pathology (AREA)
  • Microbiology (AREA)
  • Virology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Food Science & Technology (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Cardiology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • External Artificial Organs (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CN200980149086.1A 2008-12-01 2009-11-24 用于从体液分离细胞的系统和方法 Expired - Fee Related CN102264410B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US12/325,672 US8961787B2 (en) 2008-12-01 2008-12-01 Systems and methods for processing complex biological materials
US12/325672 2008-12-01
US12/333926 2008-12-12
US12/333,926 US20100151438A1 (en) 2008-12-12 2008-12-12 Methods and kits for enhancing sedimentation and recovery of cells in a sample
PCT/SE2009/051327 WO2010064973A1 (en) 2008-12-01 2009-11-24 System and method for separating cells from body fluids

Publications (2)

Publication Number Publication Date
CN102264410A CN102264410A (zh) 2011-11-30
CN102264410B true CN102264410B (zh) 2016-08-03

Family

ID=42233461

Family Applications (1)

Application Number Title Priority Date Filing Date
CN200980149086.1A Expired - Fee Related CN102264410B (zh) 2008-12-01 2009-11-24 用于从体液分离细胞的系统和方法

Country Status (6)

Country Link
EP (1) EP2352533B1 (enExample)
JP (1) JP5709758B2 (enExample)
KR (1) KR101720808B1 (enExample)
CN (1) CN102264410B (enExample)
CA (1) CA2745214C (enExample)
WO (1) WO2010064973A1 (enExample)

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US20150299657A1 (en) * 2014-04-16 2015-10-22 General Electric Company Gamma stabilized dextran solutions and methods of use
US20130131546A1 (en) * 2011-11-23 2013-05-23 Harvest Technologies Corporation System for collecting and processing bone marrow
GB201306810D0 (en) 2013-04-15 2013-05-29 Cells4Life Group Llp Methods of cell separation
GB2525202A (en) * 2014-04-15 2015-10-21 Cells4Life Group Llp Methods of cell separation
WO2016112349A1 (en) * 2015-01-09 2016-07-14 Aviva Biosciences Corporation Methods and devices for breaking cell aggregation and separating or enriching cells
US10859563B2 (en) * 2015-12-01 2020-12-08 General Electric Company Erythrocyte aggregation and leukocyte isolation
CN106267418B (zh) * 2016-07-01 2019-01-22 翁炳焕 母胎血型不合抗体吸附治疗仪
EP3470142A1 (de) 2017-10-11 2019-04-17 Orthogen AG Vorrichtung mit einer ersten kammer zur aufnahme eines körperfluids
CA3123386A1 (en) * 2018-12-13 2020-06-18 Tissue Genesis, Llc Cell separation apparatus and methods of use
JP7580076B2 (ja) * 2019-01-24 2024-11-11 住友ゴム工業株式会社 細胞培養装置及び細胞培養方法
JP7390677B2 (ja) * 2019-03-26 2023-12-04 キヤノン株式会社 細胞懸濁液処理装置
AU2020246463A1 (en) * 2019-03-26 2021-11-18 Megakaryon Corporation Cell suspension treatment apparatus
CN109893902A (zh) * 2019-04-11 2019-06-18 四川汇宇生物技术有限公司 一种明胶分离提纯系统
WO2023009782A1 (en) * 2021-07-30 2023-02-02 General Electric Company Techniques for isolation or analysis of bacterial pathogens from patient samples

Citations (6)

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Publication number Priority date Publication date Assignee Title
US4663058A (en) * 1983-10-11 1987-05-05 E. I. Du Pont De Nemours And Company Process for continuous separation of leukocyte/platelet-enriched fraction from whole blood
US5482829A (en) * 1993-04-26 1996-01-09 International Remote Imaging Systems, Inc. Composition and method for enrichment of white blood cells from whole human blood
US5670060A (en) * 1992-06-10 1997-09-23 Pall Corporation Method for treating a biological fluid including transition zone material
US6444471B1 (en) * 1999-10-18 2002-09-03 Research & Diagnostic Systems, Inc. Reticulocyte containing complete blood control
US20030134416A1 (en) * 2001-10-11 2003-07-17 Douglas Yamanishi Methods, compositions, and automated systems for separating rare cells from fluid samples
WO2007049286A1 (en) * 2005-10-27 2007-05-03 Tata Memorial Centre A system for ex-vivo separation of apoptotic chromatin particles from blood or plasma

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EP0653945A1 (en) * 1992-07-31 1995-05-24 WAINWRIGHT, Basil, E. Apparatus and method for inactivation of human immunodeficiency virus
EP1093720B1 (en) 1995-03-23 2009-11-04 Biopure Corporation Stable polymerized hemoglobin blood-substitute
US9144583B2 (en) * 2002-03-29 2015-09-29 Tissue Genesis, Inc. Cell separation apparatus and methods of use
HUE031517T2 (en) * 2002-06-19 2017-07-28 Northwest Biotherapeutics Inc Cross-flow filtration equipment and procedures for leukocyte enrichment
DE102004018347A1 (de) * 2004-04-06 2005-10-27 Manfred Dr. Schmolz Wundheilungsfördende Botenstoffmischung
JP4925159B2 (ja) * 2005-10-12 2012-04-25 日機装株式会社 血液浄化装置
WO2009002849A2 (en) * 2007-06-22 2008-12-31 Millennium Medical Technologies, Inc. Fluid concentrator, autologous concentrated body fluids, and uses thereof

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4663058A (en) * 1983-10-11 1987-05-05 E. I. Du Pont De Nemours And Company Process for continuous separation of leukocyte/platelet-enriched fraction from whole blood
US5670060A (en) * 1992-06-10 1997-09-23 Pall Corporation Method for treating a biological fluid including transition zone material
US5482829A (en) * 1993-04-26 1996-01-09 International Remote Imaging Systems, Inc. Composition and method for enrichment of white blood cells from whole human blood
US6444471B1 (en) * 1999-10-18 2002-09-03 Research & Diagnostic Systems, Inc. Reticulocyte containing complete blood control
US20030134416A1 (en) * 2001-10-11 2003-07-17 Douglas Yamanishi Methods, compositions, and automated systems for separating rare cells from fluid samples
WO2007049286A1 (en) * 2005-10-27 2007-05-03 Tata Memorial Centre A system for ex-vivo separation of apoptotic chromatin particles from blood or plasma

Also Published As

Publication number Publication date
JP5709758B2 (ja) 2015-04-30
EP2352533A1 (en) 2011-08-10
KR20110090995A (ko) 2011-08-10
EP2352533B1 (en) 2018-01-10
CA2745214C (en) 2017-11-21
JP2012510271A (ja) 2012-05-10
KR101720808B1 (ko) 2017-03-28
CN102264410A (zh) 2011-11-30
EP2352533A4 (en) 2013-08-07
WO2010064973A1 (en) 2010-06-10
CA2745214A1 (en) 2010-06-10

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